Strain identifier

BacDive ID: 14451

Type strain: No

Species: Staphylococcus aureus

Strain Designation: SA113

Strain history: CIP <- 2002, NCTC

NCBI tax ID(s): 93061 (strain), 1280 (species)

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General

@ref: 1872

BacDive-ID: 14451

DSM-Number: 4910

keywords: genome sequence, Bacteria, aerobe, mesophilic, Gram-positive, human pathogen

description: Staphylococcus aureus SA113 is an aerobe, mesophilic, Gram-positive human pathogen of the family Staphylococcaceae.

NCBI tax id

NCBI tax idMatching level
93061strain
1280species

strain history

@refhistory
1872<- S. Iordanescu, SA113
373752002, NCTC
116610CIP <- 2002, NCTC

doi: 10.13145/bacdive14451.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/bacillota
  • domain: Bacteria
  • phylum: Bacillota
  • class: Bacilli
  • order: Caryophanales
  • family: Staphylococcaceae
  • genus: Staphylococcus
  • species: Staphylococcus aureus
  • full scientific name: Staphylococcus aureus Rosenbach 1884 (Approved Lists 1980)

  • synonyms

    • @ref: 20215
    • synonym: Staphylococcus aureus subsp. anaerobius

@ref: 1872

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Bacillales

family: Staphylococcaceae

genus: Staphylococcus

species: Staphylococcus aureus

full scientific name: Staphylococcus aureus Rosenbach 1884

strain designation: SA113

type strain: no

Morphology

cell morphology

@refgram stainconfidencecell shapemotility
69480positive100
116610positivecoccus-shapedno

Culture and growth conditions

culture medium

@refnamegrowthlinkcomposition
1872NUTRIENT AGAR (DSMZ Medium 1)yeshttps://mediadive.dsmz.de/medium/1Name: NUTRIENT AGAR (DSMZ Medium 1) Composition: Agar 15.0 g/l Peptone 5.0 g/l Meat extract 3.0 g/l Distilled water
37375MEDIUM 72- for trypto casein soja agaryesDistilled water make up to (1000.000 ml);Trypto casein soy agar (40.000 g)
116610CIP Medium 72yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=72

culture temp

@refgrowthtypetemperaturerange
1872positivegrowth37mesophilic
37375positivegrowth30mesophilic
55133positivegrowth37mesophilic
116610positivegrowth22-45
116610nogrowth10psychrophilic

Physiology and metabolism

oxygen tolerance

@refoxygen tolerance
55133aerobe
116610facultative anaerobe

antibiogram

  • @ref: 1872
  • medium: Mueller-Hinton Agar
  • incubation temperature: 37
  • Penicillin G: 28
  • oxacillin: 18
  • ampicillin: 20
  • ticarcillin: 28
  • mezlocillin: 22-24
  • cefalotin: 28
  • cefazolin: 28
  • cefotaxime: 24
  • aztreonam: 10
  • imipenem: 30
  • tetracycline: 16
  • chloramphenicol: 16
  • gentamycin: 14
  • amikacin: 14
  • vancomycin: 12
  • erythromycin: 16
  • lincomycin: 16
  • ofloxacin: 18
  • norfloxacin: 18
  • colistin: 0
  • pipemidic acid: 10
  • nitrofurantoin: 12
  • bacitracin: 12
  • polymyxin b: 6
  • kanamycin: 14
  • neomycin: 14
  • doxycycline: 14
  • ceftriaxone: n.d.
  • clindamycin: n.d.
  • fosfomycin: n.d.
  • moxifloxacin: n.d.
  • linezolid: n.d.
  • nystatin: n.d.
  • quinupristin/dalfopristin: n.d.
  • teicoplanin: n.d.
  • piperacillin/tazobactam: n.d.

spore formation

@refspore formationconfidence
69481no99
69480no99.3

metabolite utilization

@refChebi-IDmetaboliteutilization activitykind of utilization tested
116610606565hippurate+hydrolysis
11661017632nitrate+reduction
11661016301nitrite+reduction
6837516199urea-hydrolysis
6837529016arginine+hydrolysis
6837518257ornithine-degradation
683754853esculin-hydrolysis
6837517634D-glucose+fermentation
6837515824D-fructose+fermentation
6837516024D-mannose+fermentation
6837517306maltose+fermentation
6837517716lactose+fermentation
6837527082trehalose+fermentation
6837516899D-mannitol+fermentation
6837516634raffinose-fermentation
6837516988D-ribose-fermentation
6837517057cellobiose-fermentation
6837517632nitrate+reduction
6837517992sucrose+fermentation
6837559640N-acetylglucosamine+fermentation
6837532528turanose+fermentation
6837522599arabinose-fermentation

antibiotic resistance

  • @ref: 68375
  • ChEBI: 28368
  • metabolite: novobiocin
  • is antibiotic: yes
  • is sensitive: yes
  • sensitivity conc.: 1.8 µg

metabolite production

@refChebi-IDmetaboliteproduction
6837515688acetoinyes
11661035581indoleno
116610polysaccharidesyes

metabolite tests

@refChebi-IDmetabolitevoges-proskauer-test
6837515688acetoin+
11661015688acetoin+

enzymes

@refvalueactivityec
68375beta-glucuronidase-3.2.1.31
68375pyrrolidonyl arylamidase-3.4.19.3
68375alkaline phosphatase+3.1.3.1
68375L-arginine arylamidase-
68375beta-galactosidase-3.2.1.23
68375beta-glucosidase-3.2.1.21
68375ornithine decarboxylase-4.1.1.17
68375arginine dihydrolase+3.5.3.6
68375urease-3.5.1.5
116610oxidase-
116610beta-galactosidase+3.2.1.23
116610alcohol dehydrogenase+1.1.1.1
116610gelatinase+/-
116610amylase-
116610DNase+
116610caseinase+3.4.21.50
116610catalase+1.11.1.6
116610tween esterase+
116610gamma-glutamyltransferase-2.3.2.2
116610lecithinase+
116610lipase+
116610lysine decarboxylase-4.1.1.18
116610ornithine decarboxylase-4.1.1.17
116610phenylalanine ammonia-lyase-4.3.1.24
116610protease+
116610tryptophan deaminase-
116610urease+3.5.1.5
68382alkaline phosphatase+3.1.3.1
68382esterase (C 4)+
68382esterase lipase (C 8)+
68382lipase (C 14)-
68382leucine arylamidase+3.4.11.1
68382valine arylamidase-
68382cystine arylamidase-3.4.11.3
68382trypsin-3.4.21.4
68382alpha-chymotrypsin-3.4.21.1
68382acid phosphatase+3.1.3.2
68382naphthol-AS-BI-phosphohydrolase+
68382alpha-galactosidase-3.2.1.22
68382beta-galactosidase-3.2.1.23
68382beta-glucuronidase-3.2.1.31
68382alpha-glucosidase+3.2.1.20
68382beta-glucosidase-3.2.1.21
68382N-acetyl-beta-glucosaminidase-3.2.1.52
68382alpha-mannosidase-3.2.1.24
68382alpha-fucosidase-3.2.1.51

API zym

@refControlAlkaline phosphataseEsteraseEsterase LipaseLipaseLeucine arylamidaseValine arylamidaseCystine arylamidaseTrypsinalpha- ChymotrypsinAcid phosphataseNaphthol-AS-BI-phosphohydrolasealpha- Galactosidasebeta- Galactosidasebeta- Glucuronidasealpha- Glucosidasebeta- GlucosidaseN-acetyl-beta- glucosaminidasealpha- Mannosidasealpha- Fucosidase
116610-+++-+----++---+----

API ID32STA

@refUREADH ArgODCESCGLUFRUMNEMALLACTREMANRAFRIBCELNITVPbeta GALArgAPALPyrANOVOSACNAGTURARAbeta GUR
55133-+--+++++++---++--+--+++--

API biotype100

@refGLUFRUGALTREMNESBEMELSACRAFMTEMALLACLTEMbGaMaGaCELGENMbGuESCRIBARAXYLPLERHAFUCMLZDARLLARLXLTDULTAGGLYINOMANMTLTURSORADOHBGLYXERYMDG3MDGSATMUCLTATDTATMTATDMLTLMLTCATETATETTECITGRTGAT2KG5KGTRYNAGGNTPACPATpOBEQATGTEmOBEBATPPATCMTTGEBETPCEABTHINLATCAPCYTHISSUCFUMGREGYTAVTETNTTNGLNITA3OBUAPTGTTPRODALALALASERMNTPROPTYR2KT
116610+++++--+-++++----+-------------+-+-------------------------++--------------+---+------+----+-------

Safety information

risk assessment

@refpathogenicity humanpathogenicity animalbiosafety levelbiosafety level comment
1872yesyes2Risk group (German classification)
1166102Risk group (French classification)

Sequence information

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Staphylococcus aureus subsp. aureus NCTC 8325GCA_000013425completencbi93061
66792Staphylococcus aureus subsp. aureus NCTC 8325GCA_900475245completencbi93061
66792Staphylococcus aureus subsp. aureus NCTC 832593061.5completepatric93061
66792Staphylococcus aureus subsp. aureus NCTC 8325 strain NCTC832593061.132completepatric93061
66792Staphylococcus aureus subsp. aureus strain HG00346170.125wgspatric1280
66792Staphylococcus aureus aureus NCTC 8325637000279completeimg93061
66792Staphylococcus aureus SA113GCA_024454545contigncbi1280

Genome-based predictions

predictions

traitpredictionconfidencetraining_data
spore-formingno99no
motileno90.078no
flagellatedno90.999no
gram-positiveyes89.436no
anaerobicno99.48no
halophileyes93.501no
spore-formingno92.948no
glucose-utilyes87.971no
aerobicyes89.483yes
thermophileno99.717yes
glucose-fermentyes85.53yes

External links

@ref: 1872

culture collection no.: CCUG 41582, DSM 4910, ATCC 35556, NCTC 8325, CIP 107700

straininfo link

  • @ref: 83594
  • straininfo: 28647

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Pathogenicity93615Mechanism of the inhibitory action of linoleic acid on the growth of Staphylococcus aureus.Greenway DL, Dyke KGJ Gen Microbiol10.1099/00221287-115-1-2331979Bacterial Proteins/biosynthesis, Cell Membrane Permeability/drug effects, DNA, Bacterial/biosynthesis, Linoleic Acids/metabolism/*pharmacology, Oxygen Consumption/drug effects, RNA, Bacterial/biosynthesis, Staphylococcus aureus/*drug effects/growth & development/metabolism, Stearic Acids/pharmacologyMetabolism
Metabolism136497Two restriction and modification systems in Staphylococcus aureus NCTC8325.Iordanescu S, Surdeanu MJ Gen Microbiol10.1099/00221287-96-2-2771976DNA, Bacterial/*metabolism, *Genes, Mutation, Phenotype, *Staphylococcus Phages, Staphylococcus aureus/*metabolismPhenotype
Pathogenicity1332589Comparative in vitro activities of a new quinolone, OPC-17116, possessing potent activity against gram-positive bacteria.Wakebe H, Mitsuhashi SAntimicrob Agents Chemother10.1128/AAC.36.10.21851992Anti-Infective Agents/*pharmacology, Ciprofloxacin/pharmacology, DNA Topoisomerases, Type II/metabolism, *Fluoroquinolones, Gram-Positive Bacteria/*drug effects, Microbial Sensitivity Tests, Norfloxacin/pharmacology, Ofloxacin/pharmacology, Piperazines/*pharmacology, Quinolones/*pharmacology, Staphylococcus aureus/drug effectsMetabolism
Enzymology1356965Analysis of a peptidoglycan hydrolase gene from Staphylococcus aureus NCTC 8325.Wang X, Mani N, Pattee PA, Wilkinson BJ, Jayaswal RKJ Bacteriol10.1128/jb.174.19.6303-6306.19921992Chromosome Mapping, DNA Mutational Analysis, N-Acetylmuramoyl-L-alanine Amidase/*genetics, Recombinant Proteins/biosynthesis, Staphylococcus aureus/enzymology/*genetics
Metabolism1510429Mapping and characterization of multiple chromosomal factors involved in methicillin resistance in Staphylococcus aureus.Berger-Bachi B, Strassle A, Gustafson JE, Kayser FHAntimicrob Agents Chemother10.1128/AAC.36.7.13671992Autolysis, Autoradiography, Cell Wall/metabolism, Chromosomes, Bacterial/*metabolism, Genetic Markers, Methicillin Resistance/*genetics, Staphylococcus aureus/*genetics/ultrastructure
Metabolism1556088Proline transport in Staphylococcus aureus: a high-affinity system and a low-affinity system involved in osmoregulation.Townsend DE, Wilkinson BJJ Bacteriol10.1128/jb.174.8.2702-2710.19921992Biological Transport/drug effects, Kinetics, Proline/*metabolism, Sodium/metabolism, Staphylococcus aureus/*metabolism, Water-Electrolyte BalanceEnzymology
Enzymology1667255Mechanisms of clinical resistance to fluoroquinolones in Staphylococcus aureus.Nakanishi N, Yoshida S, Wakebe H, Inoue M, Yamaguchi T, Mitsuhashi SAntimicrob Agents Chemother10.1128/AAC.35.12.256219914-Quinolones, Anti-Infective Agents/pharmacokinetics/*pharmacology, DNA Topoisomerases, Type II/drug effects/isolation & purification, Drug Resistance, Microbial, Staphylococcus aureus/*drug effects/metabolismPathogenicity
Metabolism2430940Characterization and genetic mapping of a mutation affecting apurinic endonuclease activity in Staphylococcus aureus.Tam JE, Pattee PAJ Bacteriol10.1128/jb.168.2.708-714.198619864-Nitroquinoline-1-oxide/pharmacology, Chromosome Mapping, Chromosomes, Bacterial, DNA Repair, DNA-(Apurinic or Apyrimidinic Site) Lyase, Deoxyribonuclease IV (Phage T4-Induced), Endodeoxyribonucleases/genetics/*metabolism, Ethyl Methanesulfonate/pharmacology, *Genes, Bacterial, Methyl Methanesulfonate/pharmacology, Methylnitronitrosoguanidine/pharmacology, Mitomycin, Mitomycins/pharmacology, Mutation, Nitrous Acid/pharmacology, Recombination, Genetic, Staphylococcus aureus/enzymology/*genetics, Ultraviolet RaysEnzymology
Cultivation2531257[Bacteriophage conversion as a factor modifying the intensity of phagocytosis of Staphylococcus aureus by human leukocytes].Mlynarczyk G, Garlinski P, Mlynarczyk A, Zabuska K, Sawicka-Grzelak A, Machowska G, Osowiecki H, Roszkowski WMed Dosw Mikrobiol1989Culture Media, Humans, In Vitro Techniques, Leukocytes/*immunology, Lysogeny/genetics/*immunology, Phagocytosis/*immunology, Staphylococcus Phages/genetics/*immunology, Staphylococcus aureus/genetics/growth & development/*immunologyPathogenicity
Enzymology2541309Construction, transfer and properties of a novel temperature-sensitive integrable plasmid for genomic analysis of Staphylococcus aureus.Luchansky JB, Benson AK, Atherly AGMol Microbiol10.1111/j.1365-2958.1989.tb00105.x1989Chromosomes, Cloning, Molecular/methods, DNA Transposable Elements, DNA, Bacterial/genetics, DNA, Recombinant, Drug Resistance, Microbial/genetics, Molecular Weight, Nucleic Acid Hybridization, *Plasmids, Restriction Mapping, Staphylococcus aureus/*genetics, Temperature, Transfection, *Transformation, BacterialPhylogeny
Genetics2549004Transformation of a conditionally peptidoglycan-deficient mutant of Staphylococcus aureus with plasmid DNA.Nieuwlandt DT, Pattee PAJ Bacteriol10.1128/jb.171.9.4906-4913.19891989Bacteriophages/genetics, DNA Transposable Elements, DNA, Bacterial/*genetics, Genetic Linkage, Genotype, Kinetics, *Mutation, Osmotic Fragility, Peptidoglycan/*genetics, Phenotype, *Plasmids, Restriction Mapping, Staphylococcus Phages/genetics, Staphylococcus aureus/*genetics/growth & development, Temperature, *Transformation, BacterialEnzymology
Enzymology3770955Chromosomal map location of the alpha-hemolysin structural gene in Staphylococcus aureus NCTC 8325.Pattee PAInfect Immun10.1128/iai.54.2.593-596.19861986Alleles, Bacterial Toxins/*genetics, Chromosome Mapping, Chromosomes, Bacterial/*physiology, Cloning, Molecular, *Genes, *Genes, Bacterial, Genotype, Hemolysin Proteins/*genetics, Staphylococcus aureus/*genetics, Transformation, BacterialGenetics
Enzymology3781623Specific attachment of Staphylococcus aureus to immobilized fibronectin.Maxe I, Ryden C, Wadstrom T, Rubin KInfect Immun10.1128/iai.54.3.695-704.19861986Amino Acid Sequence, *Bacterial Adhesion, Bacterial Proteins/isolation & purification/metabolism, Fibronectins/*metabolism, Kinetics, Molecular Weight, Solubility, Staphylococcus aureus/growth & development/*physiologyMetabolism
Pathogenicity4005150Some effects of plasmids coding for antibiotic resistance on the virulence of Staphylococcus aureus.Kinsman OS, Naidoo J, Noble WCBr J Exp Pathol1985Animals, Animals, Newborn, Anti-Bacterial Agents/pharmacology, Body Weight, Drug Resistance, Microbial, Mice, *R Factors, Staphylococcus aureus/drug effects/genetics/*pathogenicity, Transduction, Genetic, Virulence
Enzymology4040889Virulence of Staphylococcus aureus in a mouse mastitis model: studies of alpha hemolysin, coagulase, and protein A as possible virulence determinants with protoplast fusion and gene cloning.Jonsson P, Lindberg M, Haraldsson I, Wadstrom TInfect Immun10.1128/iai.49.3.765-769.19851985Animals, *Bacterial Toxins, *Cloning, Molecular, Coagulase/*analysis, Disease Models, Animal, Female, Hemolysin Proteins/*analysis, Mastitis/*etiology, Mice, Mutation, Pregnancy, Protoplasts, Staphylococcal Protein A/*analysis, Staphylococcus aureus/*pathogenicity, VirulencePathogenicity
Phylogeny4270444Isolation of a suppressor host bacterium in Staphylococcus aureus.Kretschmer PJ, Egan JBJ Bacteriol10.1128/jb.116.1.84-87.19731973Carbohydrate Metabolism, Fermentation, Genetic Complementation Test, Hydroxylamines, Lactose/metabolism, Mutagens, *Mutation, Nitrosoguanidines, Staphylococcus/*isolation & purification/metabolism, Staphylococcus Phages/growth & development/*isolation & purification, *Suppression, Genetic, Ultraviolet RaysMetabolism
Metabolism4270449Effect of the prophage and penicillinase plasmid of the recipient strain upon the transduction and the stability of methicillin resistance in Staphylococcus aureus.Cohen S, Sweeney HMJ Bacteriol10.1128/jb.116.2.803-811.19731973Chromosomes, Bacterial, *Extrachromosomal Inheritance, *Lysogeny, Methicillin/*pharmacology, *Penicillin Resistance, Penicillinase/*metabolism, Staphylococcus/drug effects/*enzymology, Staphylococcus Phages/*metabolism, *Transduction, GeneticEnzymology
Genetics6090397Isolation of transposon Tn551 insertions near chromosomal markers of interest in Staphylococcus aureus.Luchansky JB, Pattee PAJ Bacteriol10.1128/jb.159.3.894-899.19841984Chromosome Mapping, Chromosomes, Bacterial/*physiology, *DNA Transposable Elements, Drug Resistance, Microbial, Erythromycin/toxicity, Genetic Linkage, Genotype, Phenotype, Staphylococcus aureus/drug effects/*genetics, Transformation, BacterialPhenotype
Pathogenicity6254884Identification of a chromosomal determinant of alpha-toxin production in Staphylococcus aureus.Brown DR, Pattee PAInfect Immun10.1128/iai.30.1.36-42.19801980Bacterial Toxins/*genetics, Chromosome Mapping, Chromosomes, Bacterial, DNA Transposable Elements, Enterotoxins/genetics, Fibrinolysin/biosynthesis, *Genes, Mutation, Staphylococcus aureus/*geneticsBiotechnology
Biotechnology6277247Chromosomal mapping of a gene affecting enterotoxin A production in Staphylococcus aureus.Mallonee DH, Glatz BA, Pattee PAAppl Environ Microbiol10.1128/aem.43.2.397-402.19821982Chromosome Mapping, Chromosomes, Bacterial, DNA Transposable Elements, Enterotoxins/biosynthesis/*genetics, *Genes, Bacterial, Genetic Linkage, Staphylococcus aureus/*genetics/metabolism, Transformation, BacterialPathogenicity
6572624Computer-assisted chromosome mapping by protoplast fusion in Staphylococcus aureus.Stahl ML, Pattee PAJ Bacteriol10.1128/jb.154.1.395-405.19831983*Chromosome Mapping, *Chromosomes, Bacterial, *Computers, Genetic Markers, *Protoplasts, Recombination, Genetic, Staphylococcus aureus/*genetics
6572625Confirmation of protoplast fusion-derived linkages in Staphylococcus aureus by transformation with protoplast DNA.Stahl ML, Pattee PAJ Bacteriol10.1128/jb.154.1.406-412.19831983Chromosome Mapping, Chromosomes, Bacterial/analysis, DNA, Bacterial/*analysis, *Genetic Linkage, Genetic Markers, *Protoplasts, Recombination, Genetic, Staphylococcus aureus/*genetics, *Transformation, Bacterial
Enzymology6605415The effect of membrane-bound beta-lactamase on linoleic acid sensitivity in Staphylococcus aureus.Greenway DL, Dyke KGJ Gen Microbiol10.1099/00221287-129-8-24571983Cell Membrane/enzymology, Drug Resistance, Microbial, Enzyme Induction, Genes, Bacterial, Linoleic Acid, Linoleic Acids/*pharmacology, Microbial Sensitivity Tests, Penicillin Resistance, Penicillinase/biosynthesis/*metabolism/pharmacology, R Factors, Staphylococcus aureus/*drug effects/enzymology/genetics, Tetracycline/pharmacologyMetabolism
Genetics6631412Plasmid replication in a temperature-sensitive chromosome replication mutant of Staphylococcus aureus.Summers DK, Dyke KGJ Gen Microbiol10.1099/00221287-129-7-22511983Chromosomes, Bacterial/physiology, *DNA Replication, DNA, Bacterial/genetics, Electrophoresis, Agar Gel, Mutation, *R Factors, Staphylococcus aureus/*genetics, TemperatureEnzymology
Stress6754862Characterization of a temperature-sensitive DNA replication mutant of Staphylococcus aureus.Summers DK, Dyke KGJ Gen Microbiol10.1099/00221287-128-8-17351982Chloramphenicol/pharmacology, DNA, Bacterial/*biosynthesis, Escherichia coli/drug effects, Hot Temperature, Mutation, Staphylococcus aureus/*genetics, Thymidine/metabolismGenetics
Metabolism7217918Effect of thymidine auxotrophy, thymidine starvation and nalidixic acid inhibition on the properties of DNA labelled by a pulse of [3H]thymidine in Staphylococcus aureus.Thomas CM, Dyke KGJ Gen Microbiol10.1099/00221287-120-1-1611980Centrifugation, Density Gradient, DNA, Bacterial/*biosynthesis, Molecular Weight, Nalidixic Acid/*pharmacology, Staphylococcus aureus/drug effects/*metabolism, Thymidine/*metabolismPathogenicity
Biotechnology7356315Identification of a chromosomal determinant of enterotoxin A production in Staphylococcus aureus.Pattee PA, Glatz BAAppl Environ Microbiol10.1128/aem.39.1.186-193.19801980Chromosome Mapping, *Chromosomes, Bacterial, Enterotoxins/biosynthesis/*genetics, *Genes, Genetic Linkage, Staphylococcus aureus/*genetics/metabolism, Transformation, BacterialPathogenicity
Phylogeny7420054Isolation and properties of a linoleic acid-resistant mutant of Staphylococcus aureus.Greenway DL, Dyke KGJ Gen Microbiol10.1099/00221287-118-1-2671980Cell Membrane/metabolism, Drug Resistance, Microbial, Linoleic Acids/metabolism/*pharmacology, Mutation, Staphylococcus aureus/drug effects/*genetics/isolation & purificationMetabolism
Enzymology7489915Characterization and overexpression of the gene encoding Staphylococcus aureus DNA polymerase III.Pacitti DF, Barnes MH, Li DH, Brown NCGene10.1016/0378-1119(95)00377-i1995Base Sequence, Cloning, Molecular, DNA Polymerase III/*genetics, Escherichia coli/genetics, Gene Expression, Molecular Sequence Data, Plasmids/genetics, Sequence Analysis, Staphylococcus aureus/*enzymology/geneticsGenetics
Enzymology7509336The femC locus of Staphylococcus aureus required for methicillin resistance includes the glutamine synthetase operon.Gustafson J, Strassle A, Hachler H, Kayser FH, Berger-Bachi BJ Bacteriol10.1128/jb.176.5.1460-1467.19941994Amino Acid Sequence, Base Sequence, Blotting, Northern, Chromosomes, Bacterial, Cloning, Molecular, *DNA Transposable Elements, DNA, Bacterial/chemistry/metabolism, Glutamate-Ammonia Ligase/*genetics, Methicillin Resistance/*genetics, Molecular Sequence Data, *Mutagenesis, Insertional, Open Reading Frames, *Operon, RNA, Bacterial/analysis/biosynthesis, Restriction Mapping, Sequence Homology, Amino Acid, Staphylococcus aureus/enzymology/*genetics/growth & developmentGenetics
Pathogenicity7516614Phage-related conversion of enterotoxin A, staphylokinase and beta-toxin in Staphylococcus aureus.Zabicka D, Mlynarczyk A, Windyga B, Mlynarczyk GActa Microbiol Pol1993Bacterial Toxins/*biosynthesis, Enterotoxins/*biosynthesis, Hemolysin Proteins/analysis, Humans, Lysogeny, Metalloendopeptidases/*biosynthesis, *Sphingomyelin Phosphodiesterase, Staphylococcus Phages/*genetics/isolation & purification, Staphylococcus aureus/genetics/*metabolism, Virus ActivationEnzymology
Transcriptome7905453Sequence analysis of the region downstream from a peptidoglycan hydrolase-encoding gene from Staphylococcus aureus NCTC8325.Borchardt SA, Babwah AV, Jayaswal RKGene10.1016/0378-1119(93)90016-v1993Amino Acid Sequence, Base Sequence, Cloning, Molecular, Codon, Consensus Sequence, DNA, Bacterial, Molecular Sequence Data, N-Acetylmuramoyl-L-alanine Amidase/*genetics, Open Reading Frames, Restriction Mapping, Sequence Analysis, DNA, Sequence Homology, Nucleic Acid, Staphylococcus aureus/enzymology/*geneticsEnzymology
7975852Vaccination against Staphylococcus aureus mastitis: immunological response of mice vaccinated with fibronectin-binding protein (FnBP-A) to challenge with S. aureus.Mamo W, Jonsson P, Flock JI, Lindberg M, Muller HP, Wadstrom T, Nelson LVaccine10.1016/0264-410x(94)90333-61994*Adhesins, Bacterial, Animals, Bacterial Outer Membrane Proteins/*immunology, *Bacterial Proteins, *Carrier Proteins, Cattle, Disease Models, Animal, Female, Mammary Glands, Animal/microbiology/pathology, Mastitis/microbiology/pathology/*prevention & control, Mastitis, Bovine/prevention & control, Mice, Mice, Inbred Strains, Staphylococcal Infections/pathology/*prevention & control, Staphylococcal Vaccines/*immunology, Staphylococcus aureus/*immunology
Enzymology8092836Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome.Ng EY, Trucksis M, Hooper DCAntimicrob Agents Chemother10.1128/AAC.38.6.13451994Amino Acid Sequence, Anti-Infective Agents/*pharmacology, Base Sequence, Biological Transport, Chromosome Mapping, *Chromosomes, Bacterial, Cloning, Molecular, Drug Resistance, Microbial/*genetics, Magnesium/pharmacology, Molecular Sequence Data, Norfloxacin/*pharmacokinetics, RNA, Messenger/analysis, Reserpine/pharmacology, Staphylococcus aureus/drug effects/*genetics, Verapamil/pharmacologyGenetics
Phylogeny8226696Molecular cloning and mapping of 16S-23S rRNA gene complexes of Staphylococcus aureus.Wada A, Ohta H, Kulthanan K, Hiramatsu KJ Bacteriol10.1128/jb.175.22.7483-7487.19931993Base Sequence, Chromosome Mapping, Chromosomes, Bacterial, *Genes, Bacterial, Geobacillus stearothermophilus/genetics, Molecular Sequence Data, *Operon, RNA, Ribosomal/*genetics, RNA, Ribosomal, 16S/*genetics, RNA, Ribosomal, 23S/*genetics, Restriction Mapping, Sequence Homology, Nucleic Acid, Staphylococcus aureus/*geneticsGenetics
Pathogenicity8478265Implication of cohesive binding of a macrolide antibiotic, rokitamycin, to ribosomes from Staphylococcus aureus.Endou K, Matsuoka M, Taniguchi H, Nakajima YJ Antibiot (Tokyo)10.7164/antibiotics.46.4781993Binding, Competitive, Cell Survival/drug effects, Erythromycin/pharmacology, Josamycin/pharmacology, Microbial Sensitivity Tests, Miocamycin/*analogs & derivatives/metabolism/pharmacology, Ribosomes/*metabolism, Staphylococcus aureus/*drug effects/growth & development, Streptomycin/pharmacologyMetabolism
Enzymology8550490Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.Brunskill EW, Bayles KWJ Bacteriol10.1128/jb.178.3.611-618.19961996Amino Acid Sequence, Bacterial Proteins/*genetics, Bacteriolysis/*genetics, Base Sequence, Cloning, Molecular, *Genes, Bacterial, *Genes, Regulator, Molecular Sequence Data, Staphylococcus aureus/*genetics, Transcription, GeneticGenetics
Pathogenicity8593463A mechanism of resistance to partial macrolide and streptogramin B antibiotics in Staphylococcus aureus clinically isolated in Hungary.Matsuoka M, Endou K, Saitoh S, Katoh M, Nakajima YBiol Pharm Bull10.1248/bpb.18.14821995Amino Acid Sequence, Anti-Bacterial Agents/*pharmacology, Cell Membrane/drug effects/metabolism, Drug Resistance, Microbial, Humans, Hungary, Hydrogen-Ion Concentration, Molecular Sequence Data, Plasmids, Ribosomes/drug effects/metabolism, Staphylococcal Infections/*microbiology, Staphylococcus aureus/*drug effects/genetics, Virginiamycin/*pharmacologyMetabolism
Enzymology8626329Sequence, expression in Escherichia coli, and analysis of the gene encoding a novel intracellular protease (PfpI) from the hyperthermophilic archaeon Pyrococcus furiosus.Halio SB, Blumentals II, Short SA, Merrill BM, Kelly RMJ Bacteriol10.1128/jb.178.9.2605-2612.19961996Amino Acid Sequence, Archaea/*enzymology/genetics, *Archaeal Proteins, Bacterial Proteins/chemistry/*genetics/isolation & purification/*metabolism, Base Sequence, Cloning, Molecular, Enzyme Stability, Escherichia coli/genetics, Gene Expression, Genes, Bacterial/*genetics, Hot Temperature, Molecular Sequence Data, Molecular Weight, Peptide Hydrolases/chemistry/*genetics/isolation & purification/*metabolism, Promoter Regions, Genetic/genetics, Protein Conformation, Recombinant Fusion Proteins/biosynthesis/chemistry, Restriction Mapping, Sequence Analysis, DNA, Sequence Homology, Nucleic AcidGenetics
Metabolism8704988Proline is biosynthesized from arginine in Staphylococcus aureus.Townsend DE, Kaenjak A, Jayaswal RK, Wilkinson BJMicrobiology (Reading)10.1099/13500872-142-6-14911996Arginine/*metabolism, Bacterial Proteins/metabolism, Carbon/metabolism, DNA Transposable Elements, Glutamic Acid/metabolism, Ornithine/metabolism, Proline/*biosynthesis, Pyrroles/metabolism, Staphylococcus aureus/genetics/*metabolism
Phylogeny8837473Localization of prophages of serological group B and F on restriction fragments defined in the restriction map of Staphylococcus aureus NCTC 8325.Borecka P, Rosypal S, Pantucek R, Doskar JFEMS Microbiol Lett10.1111/j.1574-6968.1996.tb08481.x1996Attachment Sites, Microbiological/genetics, DNA, Bacterial/genetics/isolation & purification, DNA, Viral/genetics/isolation & purification, Electrophoresis, Gel, Pulsed-Field, Genetic Variation, Lysogeny/genetics, Restriction Mapping, Serotyping, Species Specificity, Staphylococcus Phages/*classification/*genetics, Staphylococcus aureus/*genetics/*virologyEnzymology
Metabolism8843290Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus.Takenouchi T, Tabata F, Iwata Y, Hanzawa H, Sugawara M, Ohya SAntimicrob Agents Chemother10.1128/AAC.40.8.18351996Anti-Infective Agents/*chemistry/metabolism/*pharmacology, Bacterial Proteins/genetics/*physiology, Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology, DNA Gyrase, DNA Topoisomerase IV, DNA Topoisomerases, Type II/genetics, Drug Resistance, Microbial, Escherichia coli/*drug effects/metabolism, *Fluoroquinolones, Microbial Sensitivity Tests, Multidrug Resistance-Associated Proteins, Norfloxacin/chemistry/metabolism/pharmacology, Piperazines/chemistry/metabolism/pharmacology, Point Mutation, Quinolones/chemistry/metabolism/pharmacology, Staphylococcus aureus/*drug effects/metabolism, Structure-Activity RelationshipPathogenicity
Phylogeny8955305Construction of a chromosome map for the phage group II Staphylococcus aureus Ps55.Bannantine JP, Pattee PAJ Bacteriol10.1128/jb.178.23.6842-6848.19961996Bacteriophage Typing, *Chromosomes, Bacterial, DNA Transposable Elements, Electrophoresis, Gel, Pulsed-Field, Genes, Bacterial, *Genome, Bacterial, Nucleic Acid Hybridization, Operon, RNA, Bacterial/genetics, RNA, Ribosomal/genetics, *Restriction Mapping, Staphylococcus aureus/classification/*genetics, Transduction, GeneticEnzymology
Pathogenicity9145842Increased expression of fibronectin-binding proteins by fluoroquinolone-resistant Staphylococcus aureus exposed to subinhibitory levels of ciprofloxacin.Bisognano C, Vaudaux PE, Lew DP, Ng EY, Hooper DCAntimicrob Agents Chemother10.1128/AAC.41.5.9061997*Adhesins, Bacterial, Anti-Infective Agents/*pharmacology, Bacterial Adhesion/*drug effects, Bacterial Proteins/*biosynthesis, Carrier Proteins/*biosynthesis, Ciprofloxacin/*pharmacology, Drug Resistance, Microbial, Microbial Sensitivity Tests, Staphylococcus aureus/*drug effects/genetics/metabolismMetabolism
Genetics9245821The Staphylococcus aureus allelic genetic loci for serotype 5 and 8 capsule expression contain the type-specific genes flanked by common genes.Sau S, Bhasin N, Wann ER, Lee JC, Foster TJ, Lee CYMicrobiology (Reading)10.1099/00221287-143-7-23951997Amino Acid Sequence, *Bacterial Proteins, Biological Transport/genetics, Fungal Proteins/*genetics, *Genes, Bacterial, Molecular Sequence Data, *Multigene Family, Polysaccharides, Bacterial/*genetics, Sequence Alignment, Sequence Analysis, Staphylococcus aureus/*geneticsTranscriptome
Genetics9308171The Staphylococcus aureus scdA gene: a novel locus that affects cell division and morphogenesis.Brunskill EW, de Jonge BLM, Bayles KWMicrobiology (Reading)10.1099/00221287-143-9-28771997Bacterial Proteins/chemistry/genetics, Base Sequence, Cell Division/genetics, Cell Wall/chemistry/genetics, DNA, Bacterial/genetics, *Genes, Bacterial, Microscopy, Electron, Molecular Sequence Data, Morphogenesis/genetics, Mutation, Peptidoglycan/chemistry/genetics, Staphylococcus aureus/cytology/*genetics/growth & development, Transcription, Genetic
Phylogeny9411067[Lysogenic conversion as a factor influencing tolerance to vancomycin in Staphylococcus aureus].Mlynarczyk G, Mlynarczyk A, Zabicka D, Jeljaszewicz JMed Dosw Mikrobiol1997Anti-Bacterial Agents/*pharmacology, Bacteriophage Typing, Drug Resistance, Microbial, *Lysogeny, Microbial Sensitivity Tests, Staphylococcus Phages/*classification, Staphylococcus aureus/*drug effects, Vancomycin/*pharmacologyPathogenicity
Phenotype9517933Introduction of the mec element (methicillin resistance) into Staphylococcus aureus alters in vitro functional activities of fibrinogen and fibronectin adhesins.Vaudaux PE, Monzillo V, Francois P, Lew DP, Foster TJ, Berger-Bachi BAntimicrob Agents Chemother10.1128/AAC.42.3.5641998Adhesins, Bacterial/genetics/*metabolism, *Bacterial Adhesion, Fibrinogen, Fibronectins, Genes, Bacterial/*genetics, *Methicillin Resistance/genetics, Mutation, Phenotype, Plasmids/genetics, Staphylococcus aureus/genetics/*physiology, Transformation, BacterialMetabolism
Pathogenicity9602979N-terminal sequence polymorphism in the coagulase gene of Staphylococcus aureus and its potential use as an epidemiological marker.el-Adhami W, Stewart PJ Hosp Infect10.1016/s0195-6701(98)90079-21998Biomarkers, Coagulase/*genetics, DNA Primers, Humans, *Methicillin Resistance, Microbial Sensitivity Tests, Polymerase Chain Reaction, *Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Staphylococcus aureus/*enzymology/isolation & purificationEnzymology
Metabolism9683656Teichoic acid content in different lineages of Staphylococcus aureus NCTC8325.Jenni R, Berger-Bachi BArch Microbiol10.1007/s0020300506301998Acetylglucosamine/analysis, Alanine/analysis, Attachment Sites, Microbiological/genetics, Bacteriolysis, Cell Wall/*chemistry/genetics, Chromosome Deletion, Deoxyribonucleases, Type II Site-Specific, Glycerol/analysis, Lipopolysaccharides/*analysis/chemistry, Lysogeny, Methicillin Resistance/genetics, Phosphates/analysis, Ribitol/analysis, Staphylococcus Phages/metabolism, Staphylococcus aureus/*chemistry/drug effects, Teichoic Acids/*analysis/chemistry/genetics, Transduction, Genetic, Transformation, BacterialPathogenicity
Pathogenicity9687384Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus.Fukuda H, Hori S, Hiramatsu KAntimicrob Agents Chemother10.1128/AAC.42.8.19171998Anti-Infective Agents/*pharmacology, DNA Gyrase, DNA Topoisomerases, Type II/genetics, Drug Resistance, Microbial, *Fluoroquinolones, Gatifloxacin, Piperazines/*pharmacology, Quinolones/*pharmacology, Staphylococcus aureus/*drug effects/genetics, Transformation, Bacterial
Phylogeny9986829Validation of binary typing for Staphylococcus aureus strains.van Leeuwen W, Verbrugh H, van der Velden J, van Leeuwen N, Heck M, van Belkum AJ Clin Microbiol10.1128/JCM.37.3.664-674.19991999Base Sequence, Coagulase/genetics, DNA Probes, DNA, Bacterial/genetics/isolation & purification, Electrophoresis, Gel, Pulsed-Field, Europe, Genes, Bacterial, Genes, Regulator, Humans, Phylogeny, Polymerase Chain Reaction/methods, Polymorphism, Genetic, Random Amplified Polymorphic DNA Technique, Reproducibility of Results, Sequence Alignment, Sequence Homology, Nucleic Acid, Serotyping/methods, Staphylococcal Infections/diagnosis/microbiology, Staphylococcus aureus/*classification/genetics/isolation & purification, United StatesEnzymology
Phylogeny10323238Regulation of sigmaB-dependent transcription of sigB and asp23 in two different Staphylococcus aureus strains.Gertz S, Engelmann S, Schmid R, Ohlsen K, Hacker J, Hecker MMol Gen Genet10.1007/s0043800510011999Bacillus subtilis/genetics, Bacterial Proteins/*genetics/isolation & purification, Base Sequence, DNA Primers/genetics, DNA, Bacterial/genetics, Escherichia coli/genetics, Gene Expression Regulation, Bacterial, Genes, Bacterial, Molecular Sequence Data, Operon, *Phosphoric Monoester Hydrolases, Promoter Regions, Genetic, Sigma Factor/*genetics, Species Specificity, Staphylococcus aureus/*genetics/metabolism, Transcription, GeneticGenetics
Metabolism10735256The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil).Cox SD, Mann CM, Markham JL, Bell HC, Gustafson JE, Warmington JR, Wyllie SGJ Appl Microbiol10.1046/j.1365-2672.2000.00943.x2000Anti-Bacterial Agents, Anti-Infective Agents/*pharmacology, Candida albicans/*drug effects/growth & development/metabolism, Cell Membrane Permeability, Cell Respiration/physiology, Escherichia coli/*drug effects/growth & development/metabolism, Microbial Sensitivity Tests, Potassium/metabolism, Propidium/metabolism, Staphylococcus aureus/*drug effects/growth & development/metabolism, Tea Tree Oil/*pharmacologyPathogenicity
Pathogenicity10774259[Study of macrolide, lincosamide, and streptogramin B antibiotics resistance in Staphylococcus aureus].Matsuoka MYakugaku Zasshi10.1248/yakushi1947.120.4_3742000ATP-Binding Cassette Transporters, Amino Acid Sequence, *Anti-Bacterial Agents/pharmacology, Bacterial Proteins, Base Sequence, Drug Resistance, Microbial/genetics, Erythromycin/metabolism, Genes, Bacterial, Lincosamides, *Macrolides, Membrane Proteins, Molecular Conformation, Molecular Sequence Data, RNA, Bacterial, RNA, Ribosomal, 23S, *Staphylococcus aureus/*drug effects/genetics, *Virginiamycin/pharmacologyGenetics
Pathogenicity10816464Identification of an immunodominant ABC transporter in methicillin-resistant Staphylococcus aureus infections.Burnie JP, Matthews RC, Carter T, Beaulieu E, Donohoe M, Chapman C, Williamson P, Hodgetts SJInfect Immun10.1128/IAI.68.6.3200-3209.20002000ATP-Binding Cassette Transporters/genetics/*immunology, Amino Acid Sequence, Animals, Antibodies, Bacterial/blood, *Antigens, Bacterial/biosynthesis/*genetics, Bacteremia/drug therapy/*immunology, Disease Outbreaks, Epitope Mapping, Female, Genes, Bacterial, Humans, Immunoblotting, *Immunodominant Epitopes/biosynthesis/genetics, Kidney/microbiology, Liver/microbiology, *Methicillin Resistance, Mice, Molecular Sequence Data, Recombinant Proteins/biosynthesis, Sequence Homology, Amino Acid, Spleen/microbiology, Staphylococcal Infections/drug therapy/*immunology, United KingdomGenetics
Metabolism10817688Induction of fibronectin-binding proteins and increased adhesion of quinolone-resistant Staphylococcus aureus by subinhibitory levels of ciprofloxacin.Bisognano C, Vaudaux P, Rohner P, Lew DP, Hooper DCAntimicrob Agents Chemother10.1128/AAC.44.6.1428-1437.20002000Anti-Infective Agents/*pharmacology, Bacterial Adhesion/*drug effects, Bacterial Proteins/*metabolism, Ciprofloxacin/*pharmacology, Drug Resistance, Microbial, Fibronectins/*metabolism, *Staphylococcus aureusPathogenicity
Phylogeny10865424[Characteristics of penicillinase plasmids from Staphylococcus aureus strains].Mlynarczyk A, Mlynarczyk G, Jeljaszewicz JMed Dosw Mikrobiol1999Drug Resistance, Microbial, Penicillinase/*genetics, Phenotype, Plasmids/*genetics, Species Specificity, Staphylococcus aureus/*classification/geneticsPhenotype
Phylogeny10913874Rapid isolation and identification of staphylococcal exoproteins by reverse phase capillary high performance liquid chromatography-electrospray ionization mass spectrometry.Kawano Y, Ito Y, Yamakawa Y, Yamashino T, Horii T, Hasegawa T, Ohta MFEMS Microbiol Lett10.1111/j.1574-6968.2000.tb09214.x2000Amino Acid Sequence, Bacterial Proteins/*chemistry/classification/*isolation & purification, Chromatography, Liquid/methods, Exotoxins/*chemistry/classification/*isolation & purification, Humans, Mass Spectrometry, Molecular Sequence Data, Staphylococcal Infections/microbiology, Staphylococcus aureus/*chemistryPathogenicity
Metabolism11222581Sigma(B) activity depends on RsbU in Staphylococcus aureus.Giachino P, Engelmann S, Bischoff MJ Bacteriol10.1128/JB.183.6.1843-1852.20012001Bacterial Proteins/genetics/*metabolism, Gene Expression Regulation, Bacterial, Genetic Complementation Test, Heat-Shock Response, Hemolysin Proteins/metabolism, Hydrogen Peroxide/pharmacology, Mutation, *Phosphoric Monoester Hydrolases, Pigments, Biological/metabolism, Sigma Factor/genetics/*metabolism, Staphylococcus aureus/genetics/growth & development/*metabolism
Enzymology11386418Proteolytic cleavage of staphylococcal exoproteins analyzed by two-dimensional gel electrophoresis.Kawano Y, Kawagishi M, Nakano M, Mase K, Yamashino T, Hasegawa T, Ohta MMicrobiol Immunol10.1111/j.1348-0421.2001.tb02620.x2001Amino Acid Sequence, Bacterial Proteins/genetics/*isolation & purification, Binding Sites, Electrophoresis, Gel, Two-Dimensional, Endopeptidases/genetics/*isolation & purification, Humans, Lipase/genetics/isolation & purification, Molecular Sequence Data, Staphylococcus aureus/*enzymology/genetics/pathogenicity, VirulencePhylogeny
Metabolism11489871Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus.Bischoff M, Entenza JM, Giachino PJ Bacteriol10.1128/JB.183.17.5171-5179.20012001Alleles, Bacterial Proteins/*genetics, Fibronectins/metabolism, Genes, Reporter, Operon, *Phosphoric Monoester Hydrolases, RNA, Antisense/metabolism, RNA, Bacterial/metabolism, Sigma Factor/*genetics, Staphylococcus aureus/*genetics, *Trans-Activators, Transcription Factors/*genetics, Transcription, Genetic
Phylogeny11735296Identification of Staphylococcus aureus based on PCR amplification of species specific genomic 826 bp sequence derived from a common 44-kb Sma I restriction fragment.Stepan J, Pantucek R, Ruzickova V, Rosypal S, Hajek V, Doskar JMol Cell Probes10.1006/mcpr.2001.03682001DNA Primers, DNA Probes, Deoxyribonucleases, Type II Site-Specific/*metabolism, Genome, Bacterial, Humans, Nucleic Acid Hybridization, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Sensitivity and Specificity, Staphylococcus aureus/*classification/*geneticsGenetics
Enzymology11864945In vitro and in vivo antibacterial activity of T-3912, a novel non-fluorinated topical quinolone.Yamakawa T, Mitsuyama J, Hayashi KJ Antimicrob Chemother10.1093/jac/49.3.4552002Animals, Anti-Infective Agents/pharmacology/therapeutic use, Clindamycin/pharmacology/therapeutic use, Colony Count, Microbial, DNA Topoisomerase IV/antagonists & inhibitors, Drug Resistance, Bacterial/genetics, Erythromycin/pharmacology/therapeutic use, *Fluoroquinolones, Gene Frequency, Genes, Bacterial, Gentamicins/pharmacology/therapeutic use, Levofloxacin, Male, Mice, Mice, Inbred ICR, Microbial Sensitivity Tests, Mutation, Ofloxacin/pharmacology/therapeutic use, Quinolines/*pharmacology/*therapeutic use, Quinolizines/pharmacology/therapeutic use, Staphylococcal Skin Infections/*drug therapy, Staphylococcus aureus/*drug effects/enzymology/genetics, Staphylococcus epidermidis/*drug effects/enzymology/genetics, Topoisomerase II InhibitorsPathogenicity
Genetics12057957Type 1 capsule genes of Staphylococcus aureus are carried in a staphylococcal cassette chromosome genetic element.Luong TT, Ouyang S, Bush K, Lee CYJ Bacteriol10.1128/JB.184.13.3623-3629.200220023' Flanking Region, 5' Flanking Region, Base Sequence, Chromosome Mapping, Chromosomes, Bacterial, Enterotoxins/genetics/metabolism, Gene Order, *Genes, Bacterial, Molecular Sequence Data, Physical Chromosome Mapping, Polysaccharides, Bacterial/biosynthesis/genetics, *Regulatory Sequences, Nucleic Acid, Sequence Analysis, DNA, Staphylococcus aureus/*geneticsTranscriptome
Enzymology12670694Characteristic expression of three genes, msr(A), mph(C) and erm(Y), that confer resistance to macrolide antibiotics on Staphylococcus aureus.Matsuoka M, Inoue M, Endo Y, Nakajima YFEMS Microbiol Lett10.1016/S0378-1097(03)00134-42003Anti-Bacterial Agents/classification/*pharmacology, Bacterial Proteins/biosynthesis/genetics, Cloning, Molecular, Drug Resistance, Bacterial/*genetics, Erythromycin/pharmacology, *Gene Expression Regulation, Bacterial, Genes, Bacterial, Lincosamides, *Macrolides, Microbial Sensitivity Tests, Models, Genetic, Plasmids/genetics, Staphylococcus aureus/*drug effects/*genetics/metabolism, Streptogramin B/pharmacologyPhylogeny
12819120Mutation of sarA in Staphylococcus aureus limits biofilm formation.Beenken KE, Blevins JS, Smeltzer MSInfect Immun10.1128/IAI.71.7.4206-4211.20032003Bacterial Proteins/genetics/*physiology, Biofilms/*growth & development, Staphylococcus aureus/*physiology, Trans-Activators/genetics/*physiology, Transcription, Genetic
Pathogenicity12870123Alanylation of teichoic acids protects Staphylococcus aureus against Toll-like receptor 2-dependent host defense in a mouse tissue cage infection model.Kristian SA, Lauth X, Nizet V, Goetz F, Neumeister B, Peschel A, Landmann RJ Infect Dis10.1086/3765332003Animals, Anti-Bacterial Agents/pharmacology, Bacteriocins, Chemokine CXCL2, Disease Models, Animal, Female, Inflammation/immunology/microbiology, Leukocyte Count, Leukocytes/immunology, Membrane Glycoproteins/deficiency/genetics/*physiology, Mice, Mice, Inbred C57BL, Mice, Knockout, Monokines/analysis, Mutation, *Peptides, Receptors, Cell Surface/deficiency/genetics/*physiology, Staphylococcal Infections/blood/*immunology, Staphylococcus aureus/drug effects/growth & development/*pathogenicity, Teichoic Acids/*immunology/metabolism, Toll-Like Receptor 2, Toll-Like Receptors, Tumor Necrosis Factor-alpha/analysis, VirulenceMetabolism
Metabolism12874354Correlation of acetate catabolism and growth yield in Staphylococcus aureus: implications for host-pathogen interactions.Somerville GA, Said-Salim B, Wickman JM, Raffel SJ, Kreiswirth BN, Musser JMInfect Immun10.1128/IAI.71.8.4724-4732.20032003Acetic Acid/*metabolism, Aconitate Hydratase/metabolism, Bacterial Proteins/genetics, Bacterial Toxins/biosynthesis, Base Sequence, Biological Evolution, Carbon/metabolism, Citric Acid Cycle, DNA, Bacterial/genetics, Genes, Bacterial, Genotype, Hemolysin Proteins/biosynthesis, Models, Biological, Mutation, Phenotype, Phosphoric Monoester Hydrolases/genetics, RNA, Antisense/genetics, RNA, Bacterial/genetics, Staphylococcal Protein A/biosynthesis, Staphylococcus aureus/genetics/*growth & development/*metabolism/pathogenicity, Transcription, Genetic, Virulence/genetics/physiologyPathogenicity
Phylogeny14702661[Changes in Staphylococcus aureus susceptibility to bactericidal action of teicoplanin in the presence of different prophages in the bacterial genome].Mlynarczyk G, Mlynarczyk A, Zabicka D, Luczak MMed Dosw Mikrobiol2003Animals, Anti-Bacterial Agents/*pharmacology, Bacteriophage Typing, Drug Resistance, Bacterial, *Lysogeny, Microbial Sensitivity Tests, Staphylococcus Phages/*classification, Staphylococcus aureus/*drug effects, Teicoplanin/*pharmacologyPathogenicity
Genetics14729698Control of glucose- and NaCl-induced biofilm formation by rbf in Staphylococcus aureus.Lim Y, Jana M, Luong TT, Lee CYJ Bacteriol10.1128/JB.186.3.722-729.20042004Amino Acid Sequence, Biofilms/*growth & development, DNA Transposable Elements, Ethanol/pharmacology, Genes, Bacterial/*physiology, Glucose/*pharmacology, Molecular Sequence Data, Operon, Sodium Chloride/*pharmacology, Staphylococcus aureus/genetics/*physiology
Pathogenicity14760974Mutations are involved in emergence of aminoglycoside-induced small colony variants of Staphylococcus aureus.Schaaff F, Bierbaum G, Baumert N, Bartmann P, Sahl HGInt J Med Microbiol10.1078/1438-4221-002822003Amino Acid Sequence, Anti-Bacterial Agents/*pharmacology, Bacterial Proteins/chemistry/genetics/metabolism, Base Sequence, Colony Count, Microbial, Culture Media, Gentamicins/*pharmacology, Hemin/metabolism, Humans, Molecular Sequence Data, *Mutation, Operon, Sequence Analysis, DNA, Staphylococcal Infections/microbiology, Staphylococcus aureus/*drug effects/genetics/*growth & developmentMetabolism
Pathogenicity15043859The ability of biofilm formation does not influence virulence of Staphylococcus aureus and host response in a mouse tissue cage infection model.Kristian SA, Golda T, Ferracin F, Cramton SE, Neumeister B, Peschel A, Gotz F, Landmann RMicrob Pathog10.1016/j.micpath.2003.12.0042004Animals, Bacterial Adhesion/genetics/physiology, Biofilms/*growth & development, Cell Count, Chemokine CXCL2, Chemokines/analysis/immunology, Colony Count, Microbial, Diffusion Chambers, Culture, Mice, Mice, Inbred C57BL, Phagocytes/immunology, Polysaccharides, Bacterial/*biosynthesis/genetics, Staphylococcal Infections/*microbiology, Staphylococcus aureus/genetics/growth & development/immunology/*pathogenicity, Tumor Necrosis Factor-alpha/analysis/immunology, Virulence
Genetics15126456TcaR, a putative MarR-like regulator of sarS expression.McCallum N, Bischoff M, Maki H, Wada A, Berger-Bachi BJ Bacteriol10.1128/JB.186.10.2966-2972.20042004Amino Acid Sequence, Bacterial Proteins/*genetics/*physiology, Blotting, Northern, DNA-Binding Proteins/*genetics, *Gene Expression Regulation, Bacterial, Molecular Sequence Data, Oligonucleotide Array Sequence Analysis, Salicylic Acid/pharmacology, Staphylococcus aureus/*geneticsTranscriptome
Enzymology15231800Global gene expression in Staphylococcus aureus biofilms.Beenken KE, Dunman PM, McAleese F, Macapagal D, Murphy E, Projan SJ, Blevins JS, Smeltzer MSJ Bacteriol10.1128/JB.186.14.4665-4684.20042004Adaptation, Physiological/genetics, Anaerobiosis, Animals, Bacterial Proteins/*genetics/physiology, Biofilms/*growth & development, Catheterization, Colony Count, Microbial, Down-Regulation, Female, *Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Genes, Bacterial, Hydrogen-Ion Concentration, Mice, Mice, Inbred BALB C, Mutation, Plankton/genetics/growth & development, RNA, Bacterial/analysis/isolation & purification, RNA, Messenger/analysis/isolation & purification, Staphylococcus aureus/*genetics/*physiology, Trans-Activators/*genetics/physiology, Up-RegulationPhylogeny
Pathogenicity15273121Regulation of the expression of cell wall stress stimulon member gene msrA1 in methicillin-susceptible or -resistant Staphylococcus aureus.Pechous R, Ledala N, Wilkinson BJ, Jayaswal RKAntimicrob Agents Chemother10.1128/AAC.48.8.3057-3063.20042004Bacterial Proteins/biosynthesis/genetics, Blotting, Northern, Cell Wall/drug effects, DNA, Bacterial/genetics, Glycerides/pharmacology, Lac Operon, Laurates/pharmacology, Methicillin/*pharmacology, Methicillin Resistance/*genetics, Methionine Sulfoxide Reductases, Monoglycerides, Mutation/genetics, Oxidoreductases/*genetics, Plasmids/genetics, Promoter Regions, Genetic/genetics, RNA, Bacterial/biosynthesis/isolation & purification, Signal Transduction/drug effects, Staphylococcus aureus/*drug effects/genetics, Trans-Activators/geneticsEnzymology
Phylogeny15629929Comparative genomics of Staphylococcus aureus musculoskeletal isolates.Cassat JE, Dunman PM, McAleese F, Murphy E, Projan SJ, Smeltzer MSJ Bacteriol10.1128/JB.187.2.576-592.20052005Adhesins, Bacterial/genetics, Antigens, Bacterial/genetics, Bacterial Proteins/genetics, DNA, Bacterial/genetics/isolation & purification, DNA-Binding Proteins/genetics, Genes, Bacterial, *Genome, Bacterial, *Genomics, Muscle, Skeletal/*microbiology, Nucleic Acid Hybridization, Phylogeny, Repressor Proteins/genetics, Staphylococcal Infections/*microbiology, Staphylococcus aureus/*genetics/*isolation & purificationGenetics
Metabolism15664928Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model.Begun J, Sifri CD, Goldman S, Calderwood SB, Ausubel FMInfect Immun10.1128/IAI.73.2.872-877.20052005Animals, Caenorhabditis elegans/metabolism/*microbiology, Chromosome Mapping, Mutation, Staphylococcus aureus/genetics/metabolism/*pathogenicity, Time Factors, Virulence Factors/genetics/*metabolism
Genetics15784587Staphylococcus aureus deficient in lipidation of prelipoproteins is attenuated in growth and immune activation.Stoll H, Dengjel J, Nerz C, Gotz FInfect Immun10.1128/IAI.73.4.2411-2423.20052005Genome, Bacterial, Humans, Interleukin-1/biosynthesis, Lipoproteins/*metabolism, Monocytes/immunology, Operon, Protein Sorting Signals, Staphylococcus aureus/genetics/growth & development/*immunology, Transferases/genetics/*physiology, Tumor Necrosis Factor-alpha/biosynthesisPathogenicity
Metabolism15838806Lack of wall teichoic acids in Staphylococcus aureus leads to reduced interactions with endothelial cells and to attenuated virulence in a rabbit model of endocarditis.Weidenmaier C, Peschel A, Xiong YQ, Kristian SA, Dietz K, Yeaman MR, Bayer ASJ Infect Dis10.1086/4296922005Animals, Cell Adhesion, Cell Wall/metabolism, Endocarditis, Bacterial/*microbiology, Endothelial Cells/*physiology, Humans, Mutation, Neutrophils, Phagocytosis, Rabbits, Staphylococcal Infections/*microbiology, Staphylococcus aureus/genetics/*pathogenicity, Teichoic Acids/genetics/*metabolism, VirulencePathogenicity
16559089Transduction of Methicillin Resistance in Staphylococcus aureus Dependent on an Unusual Specificity of the Recipient Strain.Cohen S, Sweeney HMJ Bacteriol10.1128/jb.104.3.1158-1167.19701970
Proteome16801412In vivo survival of teicoplanin-resistant Staphylococcus aureus and fitness cost of teicoplanin resistance.McCallum N, Karauzum H, Getzmann R, Bischoff M, Majcherczyk P, Berger-Bachi B, Landmann RAntimicrob Agents Chemother10.1128/AAC.00073-062006Animals, Anti-Bacterial Agents/*pharmacology, Bacterial Proteins/genetics/metabolism, *Drug Resistance, Bacterial, Gene Expression Regulation, Bacterial, Male, Mice, Mice, Inbred C57BL, Microbial Sensitivity Tests, Mutation, Proteome, Staphylococcal Infections/microbiology, Staphylococcus aureus/*drug effects/genetics/*growth & development/pathogenicity, Teicoplanin/*pharmacology, VirulenceMetabolism
Transcriptome17005987Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390.Cassat J, Dunman PM, Murphy E, Projan SJ, Beenken KE, Palm KJ, Yang SJ, Rice KC, Bayles KW, Smeltzer MSMicrobiology (Reading)10.1099/mic.0.29033-02006Adaptation, Physiological, Bacterial Proteins/*genetics, Biofilms, Gene Deletion, *Gene Expression Profiling, Gene Expression Regulation, Bacterial, Oligonucleotide Array Sequence Analysis, RNA, Bacterial/analysis/genetics, RNA, Messenger/analysis/genetics, Regulon/genetics, Staphylococcal Infections/microbiology, Staphylococcus aureus/*genetics, Trans-Activators/*genetics
Metabolism17012389SarA is a repressor of hla (alpha-hemolysin) transcription in Staphylococcus aureus: its apparent role as an activator of hla in the prototype strain NCTC 8325 depends on reduced expression of sarS.Oscarsson J, Kanth A, Tegmark-Wisell K, Arvidson SJ Bacteriol10.1128/JB.00866-062006Bacterial Proteins/genetics/*metabolism, Bacterial Toxins/genetics/*metabolism, Culture Media, DNA-Binding Proteins/genetics/*metabolism, *Gene Expression Regulation, Bacterial, Hemolysin Proteins/genetics/*metabolism, Humans, Molecular Sequence Data, Mutation, Repressor Proteins/genetics/*metabolism, Sequence Analysis, DNA, Staphylococcus aureus/genetics/*metabolism, Transcription, GeneticPathogenicity
Pathogenicity17640274A Staphylococcus aureus ypfP mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activity.Fedtke I, Mader D, Kohler T, Moll H, Nicholson G, Biswas R, Henseler K, Gotz F, Zahringer U, Peschel AMol Microbiol10.1111/j.1365-2958.2007.05854.x2007Adaptation, Physiological/drug effects, Antimicrobial Cationic Peptides/pharmacology, Biofilms/drug effects, Cell Wall/chemistry/drug effects, Disaccharides/metabolism, Gene Deletion, *Genes, Bacterial, Glucosyltransferases/genetics, Glycolipids/metabolism, Hydrophobic and Hydrophilic Interactions, Lipopolysaccharides/chemistry/isolation & purification/*metabolism, Magnetic Resonance Spectroscopy, Microbial Viability/drug effects, Mutation/*genetics, N-Acetylmuramoyl-L-alanine Amidase/*metabolism, Sodium Chloride/pharmacology, Staphylococcus aureus/drug effects/*enzymology/*genetics/physiology, Surface Properties, Teichoic Acids/chemistry/isolation & purification/*metabolismMetabolism
Pathogenicity17720780Inhibition of staphylococcal biofilm formation by nitrite.Schlag S, Nerz C, Birkenstock TA, Altenberend F, Gotz FJ Bacteriol10.1128/JB.00598-072007Bacterial Adhesion/drug effects/physiology, Biofilms/*drug effects, Gene Deletion, Kinetics, Nitrates/metabolism, Nitrites/*pharmacology, Oxidation-Reduction, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Staphylococcus aureus/drug effects/genetics/*physiology, Staphylococcus epidermidis/drug effects/genetics/*physiology, Transcription, GeneticEnzymology
Phylogeny17951380Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands.Baba T, Bae T, Schneewind O, Takeuchi F, Hiramatsu KJ Bacteriol10.1128/JB.01000-072007Base Sequence, Chromosomes, Bacterial, DNA, Bacterial/genetics, Drug Resistance, Bacterial/genetics, *Genome, Bacterial, Nucleic Acid Hybridization, Open Reading Frames, Phylogeny, *Polymorphism, Genetic, RNA, Bacterial/genetics, RNA, Messenger/genetics, Sequence Homology, Nucleic Acid, Staphylococcus/*genetics, Staphylococcus aureus/classification/*genetics/*pathogenicity, VirulenceGenetics
Metabolism18281399Late-stage polyribitol phosphate wall teichoic acid biosynthesis in Staphylococcus aureus.Meredith TC, Swoboda JG, Walker SJ Bacteriol10.1128/JB.01880-072008Bacterial Proteins/metabolism, *Biosynthetic Pathways, Cell Wall/chemistry/genetics/*metabolism, Electrophoresis, Polyacrylamide Gel, Gene Deletion, Gene Order, Genes, Bacterial, Genetic Complementation Test, Polysaccharides/*biosynthesis, Staphylococcus Phages/growth & development, Staphylococcus aureus/genetics/*metabolism, Teichoic Acids/*biosynthesis/chemistry/isolation & purification, Trans-Activators/metabolism, Transferases (Other Substituted Phosphate Groups)/metabolism, Virus AttachmentEnzymology
Metabolism18310041Regulatory organization of the staphylococcal sae locus.Adhikari RP, Novick RPMicrobiology (Reading)10.1099/mic.0.2007/012245-02008Artificial Gene Fusion, Bacterial Proteins/*genetics, DNA Transposable Elements, Gene Deletion, Genes, Reporter, Genetic Complementation Test, Hemolysin Proteins/biosynthesis/genetics, Mutagenesis, Insertional, Operon, Promoter Regions, Genetic, Protein Kinases/genetics, *Regulon, Staphylococcus aureus/*genetics, Transcription Factors, Transcription, Genetic, beta-Galactosidase/genetics/metabolism
Metabolism18347047Staphylococcus aureus CcpA affects biofilm formation.Seidl K, Goerke C, Wolz C, Mack D, Berger-Bachi B, Bischoff MInfect Immun10.1128/IAI.00035-082008Bacterial Adhesion, Bacterial Proteins/genetics/metabolism/*physiology, Biofilms/drug effects/*growth & development, DNA, Bacterial/metabolism, DNA-Binding Proteins/genetics/*physiology, Deoxyribonuclease I/metabolism, Endopeptidase K/metabolism, Gene Deletion, Gene Expression Profiling, Genetic Complementation Test, Periodic Acid/metabolism, Polysaccharides, Bacterial/metabolism, Repressor Proteins/genetics/*physiology, Staphylococcus aureus/genetics/growth & development/*physiologyPathogenicity
Metabolism18466610Sequence diversity in the A domain of Staphylococcus aureus fibronectin-binding protein A.Loughman A, Sweeney T, Keane FM, Pietrocola G, Speziale P, Foster TJBMC Microbiol10.1186/1471-2180-8-742008Adhesins, Bacterial/*genetics, Amino Acid Sequence, Animals, Antibodies, Monoclonal, Conserved Sequence, Cross Reactions, Elastin/metabolism, Fibrinogen/metabolism, Genetic Variation, Mice, Molecular Sequence Data, Phylogeny, Protein Isoforms/genetics, Rabbits, Staphylococcus aureus/*geneticsGenetics
Metabolism18518949The GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses.Kraus D, Herbert S, Kristian SA, Khosravi A, Nizet V, Gotz F, Peschel ABMC Microbiol10.1186/1471-2180-8-852008Alanine/metabolism, Animals, Antimicrobial Cationic Peptides/immunology, Cathelicidins, Cell Membrane/metabolism, Cells, Cultured, Cytochromes c/metabolism, Female, Gene Deletion, Genes, Bacterial, *Genes, Regulator, Humans, Immunity, Innate, Kidney/microbiology, Lysine/metabolism, Mice, Mice, Inbred BALB C, Neutrophils/immunology, Operon, Phosphatidylglycerols/metabolism, Staphylococcal Infections/*immunology, Staphylococcus aureus/*genetics/*pathogenicity, Teichoic Acids/metabolism, VirulencePathogenicity
Pathogenicity19104009Identification by genomic and genetic analysis of two new genes playing a key role in intermediate glycopeptide resistance in Staphylococcus aureus.Renzoni A, Kelley WL, Barras C, Monod A, Huggler E, Francois P, Schrenzel J, Studer R, Vaudaux P, Lew DPAntimicrob Agents Chemother10.1128/AAC.01287-082008Anti-Bacterial Agents/*pharmacology, Comparative Genomic Hybridization, Drug Resistance, Microbial, Genome, Bacterial/*drug effects, Glycopeptides/*genetics/metabolism, Humans, Microbial Sensitivity Tests, Mutation/drug effects, Staphylococcus aureus/*drug effects/*genetics/metabolism, Teicoplanin/pharmacology, Vancomycin Resistance/drug effectsGenetics
Pathogenicity19380471The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner.Shang F, Xue T, Sun H, Xing L, Zhang S, Yang Z, Zhang L, Sun BInfect Immun10.1128/IAI.01405-082009Bacterial Proteins/genetics/*physiology, Cyclic GMP/*analogs & derivatives/metabolism, Gene Deletion, Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Gene Order, Genetic Complementation Test, Humans, Models, Biological, Oligonucleotide Array Sequence Analysis, Staphylococcal Protein A/*biosynthesis, Staphylococcus aureus/*physiology, Trans-Activators/genetics/*physiology, Virulence Factors/biosynthesisMetabolism
Pathogenicity19411679The inability of a bacteriophage to infect Staphylococcus aureus does not prevent it from specifically delivering a photosensitizer to the bacterium enabling its lethal photosensitization.Hope CK, Packer S, Wilson M, Nair SPJ Antimicrob Chemother10.1093/jac/dkp1572009Anti-Bacterial Agents/*pharmacology, Bacteriophages/*chemistry/*growth & development, Darkness, Humans, Lasers, Microbial Viability, Photosensitizing Agents/chemistry/*pharmacology, Staphylococcus aureus/drug effects/*radiation effects/*virology
Pathogenicity19454708Lipoproteins in Staphylococcus aureus mediate inflammation by TLR2 and iron-dependent growth in vivo.Schmaler M, Jann NJ, Ferracin F, Landolt LZ, Biswas L, Gotz F, Landmann RJ Immunol10.4049/jimmunol.08042922009Animals, Growth, Inflammation/*microbiology, Inflammation Mediators, Iron/*metabolism, Iron Overload/etiology, Lipoproteins/*adverse effects, Macrophages, Peritoneal/microbiology, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Differentiation Factor 88/metabolism, Signal Transduction, Staphylococcal Infections/*pathology, Staphylococcus aureus/chemistry/*physiology, Toll-Like Receptor 2/*metabolismMetabolism
Pathogenicity19456837Caenorhabditis elegans as a host model for community-associated methicillin-resistant Staphylococcus aureus.Wu K, Conly J, McClure JA, Elsayed S, Louie T, Zhang KClin Microbiol Infect10.1111/j.1469-0691.2009.02765.x2009Animals, Bacterial Proteins/genetics, Caenorhabditis elegans/*microbiology, Community-Acquired Infections/microbiology, *Disease Models, Animal, Humans, Methicillin-Resistant Staphylococcus aureus/genetics/isolation & purification/*pathogenicity, Staphylococcal Infections/microbiology, Survival Analysis, Virulence, Virulence Factors/geneticsEnzymology
Pathogenicity19665927Growth phase-dependent regulation of the global virulence regulator Rot in clinical isolates of Staphylococcus aureus.Jelsbak L, Hemmingsen L, Donat S, Ohlsen K, Boye K, Westh H, Ingmer H, Frees DInt J Med Microbiol10.1016/j.ijmm.2009.07.0032009Bacterial Proteins/*biosynthesis, Bacterial Toxins/biosynthesis, Blotting, Western, Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Hemolysin Proteins/biosynthesis, Humans, RNA, Bacterial/biosynthesis, Repressor Proteins/*biosynthesis, Serine Endopeptidases/biosynthesis, Sphingomyelin Phosphodiesterase/biosynthesis, Staphylococcal Infections/microbiology, Staphylococcal Protein A/biosynthesis, Staphylococcus aureus/growth & development/isolation & purification/*physiology, Virulence Factors/biosynthesisEnzymology
Enzymology19923729Cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of an atypical two-cysteine peroxiredoxin (SAOUHSC_01822) from Staphylococcus aureus NCTC 8325.Bhattacharyya S, Dutta D, Ghosh AK, Das AKActa Crystallogr Sect F Struct Biol Cryst Commun10.1107/S17443091090375802009Cloning, Molecular, Crystallization, Crystallography, X-Ray, Cysteine/*chemistry, Molecular Sequence Data, Oxidation-Reduction, Oxidative Stress, Peroxiredoxins/*chemistry/genetics/isolation & purification, Staphylococcus aureus/*chemistry, X-Ray DiffractionGenetics
Genetics20138093Development of pooled suppression subtractive hybridization to analyze the pangenome of Staphylococcus aureus.Gerrish RS, Gill AL, Fowler VG, Gill SRJ Microbiol Methods10.1016/j.mimet.2010.01.0222010Bacteremia/microbiology, Comparative Genomic Hybridization/*methods, DNA, Bacterial/*genetics, Endocarditis/microbiology, *Genome, Bacterial, Humans, Osteomyelitis/microbiology, Staphylococcal Infections/microbiology, Staphylococcus aureus/*geneticsPathogenicity
Metabolism20188576Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.Opperman TJ, Williams JD, Houseweart C, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TLBioorg Med Chem10.1016/j.bmc.2010.02.0052010Bacterial Proteins/genetics/*metabolism, *Drug Resistance, Bacterial/genetics, Indoles/chemistry/*pharmacology, Microbial Sensitivity Tests, Mutation, Repressor Proteins/genetics/*metabolism, Reverse Transcriptase Polymerase Chain Reaction, Staphylococcus aureus/*drug effects/genetics/metabolism, Structure-Activity Relationship, Substrate SpecificityPathogenicity
Pathogenicity20202345Synergistic effects of ethanol and UV radiation to reduce levels of selected foodborne pathogenic bacteria.Ha JH, Ha SDJ Food Prot10.4315/0362-028x-73.3.5562010Bacteria/*drug effects/*radiation effects, Colony Count, Microbial, Consumer Product Safety, Disinfection/*methods, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Ethanol/*pharmacology, Food Contamination/prevention & control, *Food Irradiation, Food Microbiology, Humans, Ultraviolet RaysBiotechnology
Pathogenicity20212089Repair of global regulators in Staphylococcus aureus 8325 and comparative analysis with other clinical isolates.Herbert S, Ziebandt AK, Ohlsen K, Schafer T, Hecker M, Albrecht D, Novick R, Gotz FInfect Immun10.1128/IAI.00088-102010Animals, Bacterial Proteins/*biosynthesis/genetics, Female, *Gene Expression Regulation, Bacterial, Hemolysis, Humans, Mice, Mice, Inbred BALB C, Staphylococcal Infections/mortality, Staphylococcus aureus/genetics/pathogenicity/*physiology, Survival Analysis, Virulence Factors/*biosynthesis/genetics
Pathogenicity20370801Immune evasion cluster-positive bacteriophages are highly prevalent among human Staphylococcus aureus strains, but they are not essential in the first stages of nasal colonization.Verkaik NJ, Benard M, Boelens HA, de Vogel CP, Nouwen JL, Verbrugh HA, Melles DC, van Belkum A, van Wamel WJClin Microbiol Infect10.1111/j.1469-0691.2010.03227.x2011Adult, Animals, Bacterial Proteins/genetics, Bacterial Toxins/metabolism, Colony Count, Microbial, Enterotoxins/genetics, Female, *Genes, Viral, Hemolysin Proteins/metabolism, Humans, Immune Evasion/*genetics, Male, Metalloendopeptidases/genetics, Middle Aged, Multigene Family, Nasal Mucosa/*microbiology, Pets, Sphingomyelin Phosphodiesterase/metabolism, Staphylococcal Infections/*virology, Staphylococcus Phages/*genetics, Staphylococcus aureus/genetics/isolation & purification/*virology, Young AdultMetabolism
Metabolism20498265Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence.Zhao L, Xue T, Shang F, Sun H, Sun BInfect Immun10.1128/IAI.00131-102010Bacterial Proteins/genetics/*metabolism, Blood/microbiology, Carbon-Sulfur Lyases/genetics, Cell Line, *Gene Expression Regulation, Bacterial, Gene Knockout Techniques, Homoserine/*analogs & derivatives/metabolism, Humans, Lactones/*metabolism, Macrophages/microbiology, Microbial Viability, Polysaccharides, Bacterial/*biosynthesis, Protein Kinases/*metabolism, Quorum Sensing, *Signal Transduction, Staphylococcus aureus/metabolism/*pathogenicity, Trans-Activators/*metabolism, VirulencePathogenicity
Genetics20618890Staphylococcus aureus SH1000 and 8325-4: comparative genome sequences of key laboratory strains in staphylococcal research.O'Neill AJLett Appl Microbiol10.1111/j.1472-765X.2010.02885.x2010Base Sequence, DNA, Bacterial/*chemistry/*genetics, *Genome, Bacterial, Molecular Sequence Data, Point Mutation, *Polymorphism, Genetic, Sequence Analysis, DNA, Sequence Deletion, Staphylococcus aureus/*geneticsTranscriptome
Pathogenicity20659164Generation of ramoplanin-resistant Staphylococcus aureus.Schmidt JW, Greenough A, Burns M, Luteran AE, McCafferty DGFEMS Microbiol Lett10.1111/j.1574-6968.2010.02051.x2010Anti-Bacterial Agents/*pharmacology, Cell Wall, Depsipeptides/*pharmacology, Detergents/pharmacology, Drug Resistance, Bacterial/drug effects, Microbial Sensitivity Tests, Nisin/pharmacology, Octoxynol/pharmacology, Phenotype, Staphylococcus aureus/cytology/*drug effects/growth & development, Time Factors, Vancomycin/pharmacologyPhenotype
Metabolism21122114The heme sensing response regulator HssR in Staphylococcus aureus but not the homologous RR23 in Listeria monocytogenes modulates susceptibility to the antimicrobial peptide plectasin.Thomsen LE, Gottlieb CT, Gottschalk S, Wodskou TT, Kristensen HH, Gram L, Ingmer HBMC Microbiol10.1186/1471-2180-10-3072010Anti-Bacterial Agents/*pharmacology, Bacterial Proteins/genetics/*metabolism, Drug Resistance, Bacterial, Gene Expression Regulation, Bacterial/drug effects, Genes, Regulator, Heme/*metabolism, Listeria monocytogenes/drug effects/genetics/*metabolism, Peptides/*pharmacology, Staphylococcus aureus/drug effects/genetics/*metabolismPathogenicity
Enzymology21157683Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition.Ettefagh KA, Burns JT, Junio HA, Kaatz GW, Cech NBPlanta Med10.1055/s-0030-12506062010Alkaloids/isolation & purification/*pharmacology, Anti-Bacterial Agents/isolation & purification/*pharmacology, Bacterial Proteins/*antagonists & inhibitors, Benzylisoquinolines/isolation & purification/pharmacology, Berberine/analogs & derivatives/chemistry/isolation & purification/pharmacokinetics/pharmacology, Drug Synergism, Ethidium/pharmacokinetics/pharmacology, Hydrastis/*chemistry, Multidrug Resistance-Associated Proteins/*antagonists & inhibitors, Plant Components, Aerial/chemistry, Plant Extracts/isolation & purification/*pharmacology, Plant Roots/chemistry, Staphylococcus aureus/*drug effects/metabolismPhylogeny
Pathogenicity21204702Synergistic effects of sodium hypochlorite and ultraviolet radiation in reducing the levels of selected foodborne pathogenic bacteria.Ha JH, Ha SDFoodborne Pathog Dis10.1089/fpd.2010.07612011Bacillus cereus/drug effects/growth & development/radiation effects, Bacteria/*drug effects/growth & development/*radiation effects, Bacterial Load, Consumer Product Safety, Disinfectants/*pharmacology, Disinfection/methods, Enterobacteriaceae/drug effects/growth & development/radiation effects, Food Microbiology, Foodborne Diseases/microbiology/*prevention & control, Sodium Hypochlorite/*pharmacology, Staphylococcus aureus/drug effects/growth & development/radiation effects, *Ultraviolet RaysBiotechnology
Proteome21205202Structural evidence of alpha-aminoacylated lipoproteins of Staphylococcus aureus.Asanuma M, Kurokawa K, Ichikawa R, Ryu KH, Chae JH, Dohmae N, Lee BL, Nakayama HFEBS J10.1111/j.1742-4658.2010.07990.x2011Bacterial Proteins/*chemistry, Lipoproteins, HDL/*chemistry, Staphylococcus aureus/*metabolism, Tandem Mass SpectrometryMetabolism
Pathogenicity21357297Impact of ciprofloxacin exposure on Staphylococcus aureus genomic alterations linked with emergence of rifampin resistance.Didier JP, Villet R, Huggler E, Lew DP, Hooper DC, Kelley WL, Vaudaux PAntimicrob Agents Chemother10.1128/AAC.01407-102011Anti-Bacterial Agents/*pharmacology, Ciprofloxacin/*pharmacology, Drug Resistance, Bacterial/genetics, Microbial Sensitivity Tests, Rifampin/*pharmacology, Staphylococcus aureus/*drug effects
Genetics21378186Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain.Nair D, Memmi G, Hernandez D, Bard J, Beaume M, Gill S, Francois P, Cheung ALJ Bacteriol10.1128/JB.00027-112011Chromosome Mapping, Chromosomes, Bacterial, Gene Expression Regulation, Bacterial/physiology, *Genetic Fitness, *Genome, Bacterial, Mutation, Staphylococcus aureus/*classification/*genetics/pathogenicity, Stress, Physiological, Virulence, Virulence Factors/*genetics/*metabolismPhylogeny
Metabolism21474443Multiple peptide resistance factor (MprF)-mediated Resistance of Staphylococcus aureus against antimicrobial peptides coincides with a modulated peptide interaction with artificial membranes comprising lysyl-phosphatidylglycerol.Andra J, Goldmann T, Ernst CM, Peschel A, Gutsmann TJ Biol Chem10.1074/jbc.M111.2268862011Aminoacyltransferases/chemistry/genetics/*metabolism, Anti-Infective Agents/chemistry/*pharmacology, Antimicrobial Cationic Peptides/chemistry/*pharmacology, Bacterial Proteins/chemistry/genetics/*metabolism, Cell Membrane/chemistry/genetics/*metabolism/ultrastructure, Drug Resistance, Bacterial/*physiology, Lipid Bilayers/chemistry/*metabolism, Lysine/chemistry/genetics/*metabolism, Mutation, Phosphatidylglycerols/chemistry/genetics/*metabolism, Staphylococcus aureus/chemistry/genetics/*metabolism/ultrastructure
Metabolism21701848Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325.Xue T, You Y, Shang F, Sun BMed Microbiol Immunol10.1007/s00430-011-0208-z2011Adhesins, Bacterial/genetics/*metabolism, Bacterial Proteins/genetics/*metabolism, Coagulase/genetics/metabolism, Fibrinogen/genetics/*metabolism, *Gene Expression Regulation, Bacterial, Humans, Protein Binding, Quorum Sensing, RNA, Bacterial/genetics/metabolism, Repressor Proteins/genetics/*metabolism, Staphylococcus aureus/genetics/*growth & development/metabolism, Trans-Activators/genetics/*metabolism, VirulencePathogenicity
Metabolism22112206New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564.Frees D, Andersen JH, Hemmingsen L, Koskenniemi K, Baek KT, Muhammed MK, Gudeta DD, Nyman TA, Sukura A, Varmanen P, Savijoki KJ Proteome Res10.1021/pr200956s2011Bacterial Proteins/genetics/isolation & purification/metabolism, Carrier Proteins/genetics/metabolism, DNA-Binding Proteins/genetics/metabolism, Endopeptidase Clp/*genetics, Gene Expression, Gene Expression Regulation, Bacterial, Gene Knockout Techniques, Phenotype, Prophages, Proteome/genetics/isolation & purification/metabolism, Staphylococcus aureus/enzymology/genetics/metabolism/*physiology, *Stress, Physiological, Trans-Activators/genetics/metabolism, Two-Dimensional Difference Gel Electrophoresis, Urease/metabolism, Virulence, Virulence Factors/*geneticsEnzymology
Genetics22417616Revisiting the genomes of the Staphylococcus aureus strains NCTC 8325 and RN4220.Berscheid A, Sass P, Weber-Lassalle K, Cheung AL, Bierbaum GInt J Med Microbiol10.1016/j.ijmm.2012.01.0022012Genetic Variation, *Genome, Bacterial, Sequence Analysis, DNA, Staphylococcus aureus/*geneticsTranscriptome
Metabolism22447899Type I signal peptidase and protein secretion in Staphylococcus aureus.Schallenberger MA, Niessen S, Shao C, Fowler BJ, Romesberg FEJ Bacteriol10.1128/JB.00064-122012Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/*metabolism, Gene Expression Profiling, Gene Expression Regulation, Bacterial/drug effects/*physiology, Gene Expression Regulation, Enzymologic/*physiology, Membrane Proteins/antagonists & inhibitors/genetics/*metabolism, Oligopeptides/chemistry/pharmacology, Peptides, Cyclic/chemistry/pharmacology, Point Mutation, Protein Conformation, Serine Endopeptidases/genetics/*metabolism, Staphylococcus aureus/*enzymology/genetics/*metabolism, Virulence FactorsPathogenicity
Pathogenicity22479621Involvement of iron in biofilm formation by Staphylococcus aureus.Lin MH, Shu JC, Huang HY, Cheng YCPLoS One10.1371/journal.pone.00343882012Anti-Bacterial Agents/*pharmacology, Biofilms/*drug effects, Humans, Hydrolyzable Tannins/*pharmacology, Iron/*metabolism, Iron Chelating Agents/*pharmacology, Staphylococcal Infections/prevention & control, Staphylococcus aureus/drug effects/*physiologyMetabolism
Metabolism22829830WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation.Mauthe M, Yu W, Krut O, Kronke M, Gotz F, Robenek H, Proikas-Cezanne TInt J Cell Biol10.1155/2012/1792072012
Metabolism22986269Staphylococcus aureus persisters tolerant to bactericidal antibiotics.Lechner S, Lewis K, Bertram RJ Mol Microbiol Biotechnol10.1159/0003424492012Anti-Bacterial Agents/*pharmacology, Bacterial Load, Bacteriological Techniques/methods, Cell Culture Techniques/methods, Colony Count, Microbial, Culture Media/metabolism, Daptomycin/*pharmacology, *Drug Resistance, Multiple, Bacterial, Microbial Sensitivity Tests, Microbial Viability, Phenotype, Sensitivity and Specificity, Staphylococcus aureus/*drug effects/growth & development/isolation & purification/metabolism, Time Factors, Tobramycin/pharmacologyPhenotype
Metabolism23084594LuxS/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC 8325.Xue T, Zhao L, Sun BInt J Antimicrob Agents10.1016/j.ijantimicag.2012.08.0162012Anti-Bacterial Agents/*pharmacology, *Autolysis, Bacterial Proteins/genetics/*metabolism, Carbon-Sulfur Lyases/genetics/*metabolism, Gene Knockout Techniques, Homoserine/*analogs & derivatives/metabolism, Humans, Lactones/*metabolism, Microbial Sensitivity Tests, Mutant Proteins/genetics/metabolism, Signal Transduction, Staphylococcus aureus/*drug effects/*physiologyPathogenicity
Pathogenicity23138703Electrochemically deposited gentamicin-loaded calcium phosphate coatings for bone tissue integration.Altomare L, Visai L, Bloise N, Arciola CR, Ulivi L, Candiani G, Cigada A, Chiesa R, De Nardo LInt J Artif Organs10.5301/ijao.50001622012Alloys, Anti-Bacterial Agents/*pharmacology, Bacterial Adhesion/drug effects, Calcium Phosphates/*pharmacology, *Coated Materials, Biocompatible, Crystallography, X-Ray, Disk Diffusion Antimicrobial Tests, Dose-Response Relationship, Drug, *Electrochemical Techniques, Gentamicins/*pharmacology, Joint Prosthesis/*adverse effects/microbiology, Microscopy, Electron, Scanning, Osseointegration/*drug effects, Prosthesis Design, Prosthesis-Related Infections/microbiology/*prevention & control, Spectrum Analysis, Staphylococcus aureus/drug effects/growth & development, Surface Properties, Titanium
23181353Evaluation of adhesion forces of Staphylococcus aureus along the length of Candida albicans hyphae.Ovchinnikova ES, Krom BP, Busscher HJ, van der Mei HCBMC Microbiol10.1186/1471-2180-12-2812012*Bacterial Adhesion, Candida albicans/*physiology, Hyphae/physiology, Microbial Interactions, Microscopy, Atomic Force, Staphylococcus aureus/*physiology
Metabolism23253041Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus.Feng J, Michalik S, Varming AN, Andersen JH, Albrecht D, Jelsbak L, Krieger S, Ohlsen K, Hecker M, Gerth U, Ingmer H, Frees DJ Proteome Res10.1021/pr300394r2013Bacterial Outer Membrane Proteins/genetics/metabolism, Bacterial Proteins/*genetics/metabolism, Cytoskeletal Proteins/genetics/metabolism, DNA Repair/*genetics, *DNA, Bacterial, Drug Resistance, Bacterial/genetics, Endopeptidase Clp/*genetics/metabolism, *Gene Expression Regulation, Bacterial, Heat-Shock Response/genetics, Penicillin-Binding Proteins, Peptide Elongation Factor Tu/genetics/metabolism, Protein Binding, Protein Kinases/genetics/metabolism, Proteolysis, Proteome/*genetics/metabolism, Recombinant Fusion Proteins/genetics/metabolism, Repressor Proteins/genetics/metabolism, Staphylococcus aureus/*genetics/metabolismProteome
Pathogenicity23363876Interplay between population dynamics and drug tolerance of Staphylococcus aureus persister cells.Lechner S, Patra P, Klumpp S, Bertram RJ Mol Microbiol Biotechnol10.1159/0003460732013Anti-Bacterial Agents/*pharmacology, Ciprofloxacin/pharmacology, Colony Count, Microbial, Daptomycin/pharmacology, *Drug Tolerance, Microbial Viability/drug effects, Models, Theoretical, Population Dynamics, Staphylococcus aureus/*drug effects/*growth & development, Tobramycin/pharmacology
Pathogenicity23462081Antimicrobial activity of nanodispersed thymol in tryptic soy broth.Shah B, Davidson PM, Zhong QJ Food Prot10.4315/0362-028X.JFP-12-3542013Anti-Infective Agents/*pharmacology, Colony Count, Microbial/*methods, Dose-Response Relationship, Drug, Escherichia coli O157/drug effects/growth & development, *Food Microbiology, Food Safety, Hydrogen-Ion Concentration, Listeria monocytogenes/drug effects/growth & development, Microbial Sensitivity Tests, Microbial Viability/*drug effects, Nanocapsules, Salmonella typhimurium/drug effects/growth & development, Staphylococcus aureus/drug effects/growth & development, Temperature, Thymol/*pharmacologyBiotechnology
Pathogenicity23517692Distribution and infection-related functions of bacillithiol in Staphylococcus aureus.Pother DC, Gierok P, Harms M, Mostertz J, Hochgrafe F, Antelmann H, Hamilton CJ, Borovok I, Lalk M, Aharonowitz Y, Hecker MInt J Med Microbiol10.1016/j.ijmm.2013.01.0032013Animals, Anti-Bacterial Agents/pharmacology, Antioxidants, Bacterial Load, Cell Line, Chromatography, High Pressure Liquid, Cysteine/*analogs & derivatives/biosynthesis/genetics, Diamide/pharmacology, Drug Resistance, Bacterial, Epithelial Cells/microbiology, Fosfomycin/pharmacology, Gene Expression, Glucosamine/*analogs & derivatives/biosynthesis/genetics, Humans, Hydrogen Peroxide/pharmacology, Hypochlorous Acid/pharmacology, Macrophages/microbiology, Mice, Oxidants/pharmacology, Staphylococcus aureus/chemistry/genetics/*metabolism/*pathogenicity, Virulence Factors/*biosynthesis/geneticsMetabolism
Pathogenicity23663080Design, synthesis and antistaphylococcal activity of marine pyrrole alkaloid derivatives.Rane RA, Sahu NU, Shah CP, Shah NKJ Enzyme Inhib Med Chem10.3109/14756366.2013.7931832013Alkaloids/*chemical synthesis/chemistry/pharmacology, Animals, Anti-Bacterial Agents/*chemical synthesis/chemistry/pharmacology, Biofilms/*drug effects/growth & development, Drug Design, Drug Resistance, Bacterial, Hydrazones/chemistry, Methicillin-Resistant Staphylococcus aureus/*drug effects/growth & development, Microbial Sensitivity Tests, Microbial Viability/drug effects, Porifera/chemistry, Pyrroles/*chemical synthesis/chemistry/pharmacology, Staphylococcus epidermidis/*drug effects/growth & development, Thiazolidines/chemistry, Vancomycin/pharmacology
Metabolism23774059Role of Rot in bacterial autolysis regulation of Staphylococcus aureus NCTC8325.Chu X, Xia R, He N, Fang YRes Microbiol10.1016/j.resmic.2013.06.0012013Bacterial Proteins/genetics/*metabolism, *Bacteriolysis, Gene Expression Regulation, Bacterial, N-Acetylmuramoyl-L-alanine Amidase/genetics, Repressor Proteins/genetics/*metabolism, Staphylococcus aureus/*cytology/genetics/*metabolism
Transcriptome24116120RNA-Seq reveals differential gene expression in Staphylococcus aureus with single-nucleotide resolution.Osmundson J, Dewell S, Darst SAPLoS One10.1371/journal.pone.00765722013Base Sequence, Gene Expression Profiling/*methods, *Gene Expression Regulation, Bacterial, Genome, Bacterial/genetics, Humans, Inverted Repeat Sequences/genetics, Mutation, Oligonucleotide Array Sequence Analysis, *Polymorphism, Single Nucleotide, Reproducibility of Results, Sequence Analysis, RNA/*methods, Species Specificity, Staphylococcal Infections/microbiology, Staphylococcus aureus/classification/*genetics, Transcription Factors/genetics, Viral Proteins/geneticsPhylogeny
Enzymology24151763Porcine models of non-bacterial thrombotic endocarditis (NBTE) and infective endocarditis (IE) caused by Staphylococcus aureus: a preliminary study.Christiansen JG, Jensen HE, Johansen LK, Kochl J, Koch J, Aalbaek B, Nielsen OL, Leifsson PSJ Heart Valve Dis2013Animals, Cardiac Catheterization, Disease Models, Animal, Echocardiography, *Endocarditis, Bacterial/diagnosis/microbiology/pathology/physiopathology, *Endocarditis, Non-Infective/diagnosis/pathology/physiopathology, Models, Cardiovascular, Monitoring, Physiologic, Staphylococcus aureus/*isolation & purification/pathogenicity, *Swine, Symptom AssessmentPhylogeny
Pathogenicity24320748Modulation of cell wall synthesis and susceptibility to vancomycin by the two-component system AirSR in Staphylococcus aureus NCTC8325.Sun H, Yang Y, Xue T, Sun BBMC Microbiol10.1186/1471-2180-13-2862013Anti-Bacterial Agents/*pharmacology, Bacteriolysis/drug effects, Cell Wall/*metabolism, Electrophoretic Mobility Shift Assay, Gene Deletion, Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Humans, Microbial Sensitivity Tests, Microbial Viability/drug effects, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, *Signal Transduction, Staphylococcus aureus/drug effects/*genetics/metabolism, Transcription, Genetic, Vancomycin/*pharmacology, *Vancomycin ResistanceMetabolism
Enzymology24419617Expression, purification, crystallization and preliminary X-ray diffraction studies of phosphoglycerate mutase from Staphylococcus aureus NCTC8325.Roychowdhury A, Kundu A, Gujar A, Bose M, Das AKActa Crystallogr F Struct Biol Commun10.1107/S2053230X130314762013Bacterial Proteins/*chemistry/*isolation & purification, Crystallization, Phosphoglycerate Mutase/*chemistry/*isolation & purification, Staphylococcus aureus/*enzymology, *X-Ray DiffractionPhylogeny
Pathogenicity24490920Antimicrobial activity of Hibiscus sabdariffa aqueous extracts against Escherichia coli O157:H7 and Staphylococcus aureus in a microbiological medium and milk of various fat concentrations.Higginbotham KL, Burris KP, Zivanovic S, Davidson PM, Stewart CN JrJ Food Prot10.4315/0362-028X.JFP-13-3132014Animals, Anti-Bacterial Agents/*pharmacology, Beverages/*microbiology, Colony Count, Microbial, Dietary Fats/pharmacology, Dose-Response Relationship, Drug, Escherichia coli O157/*drug effects/growth & development, Food Microbiology, Hibiscus/*chemistry, Microbial Sensitivity Tests, Milk/microbiology, Plant Extracts/*pharmacology, Staphylococcus aureus/*drug effects/growth & developmentBiotechnology
Metabolism24836943Staphylococcus aureus glucose-induced biofilm accessory proteins, GbaAB, influence biofilm formation in a PIA-dependent manner.You Y, Xue T, Cao L, Zhao L, Sun H, Sun BInt J Med Microbiol10.1016/j.ijmm.2014.04.0032014Bacterial Adhesion, Bacterial Proteins/genetics/*metabolism, Biofilms/*growth & development, Electrophoretic Mobility Shift Assay, Gene Deletion, Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Glucose/*metabolism, Operon, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Staphylococcus aureus/genetics/*physiology
Pathogenicity24918490Leonurus cardiaca L. herb--a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis.Micota B, Sadowska B, Podsedek A, Redzynia M, Rozalska BActa Biochim Pol2013_6512014Anti-Bacterial Agents/*pharmacology, Bacterial Adhesion/drug effects, Biofilms/*drug effects/growth & development, Collagen/chemistry, Endocarditis/microbiology, Fibrinogen/chemistry, Fibronectins/chemistry, Humans, Leonurus/*chemistry, Microbial Sensitivity Tests, Plant Extracts/isolation & purification/*pharmacology, Staphylococcal Infections/microbiology, Staphylococcus aureus/*drug effects/isolation & purification/physiology, Triterpenes/*pharmacologyEnzymology
Metabolism24980509Metabolic and transcriptional activities of Staphylococcus aureus challenged with high-doses of daptomycin.Lechner S, Prax M, Lange B, Huber C, Eisenreich W, Herbig A, Nieselt K, Bertram RInt J Med Microbiol10.1016/j.ijmm.2014.05.0082014Anti-Bacterial Agents/*pharmacology, Citric Acid Cycle/genetics, Daptomycin/*pharmacology, *Drug Tolerance, *Gene Expression Profiling, Glucose/metabolism, Isotope Labeling, Microarray Analysis, Protein Biosynthesis, Staphylococcus aureus/*drug effects/genetics/metabolism, *Stress, PhysiologicalPathogenicity
Metabolism25040609Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains.Kneuper H, Cao ZP, Twomey KB, Zoltner M, Jager F, Cargill JS, Chalmers J, van der Kooi-Pol MM, van Dijl JM, Ryan RP, Hunter WN, Palmer TMol Microbiol10.1111/mmi.127072014Animals, Bacterial Proteins/genetics/*metabolism, *Bacterial Secretion Systems, Female, *Gene Expression Regulation, Bacterial, Humans, Mice, Mice, Inbred C57BL, Staphylococcal Infections/*microbiology, Staphylococcus aureus/genetics/*metabolism/*pathogenicity, VirulencePathogenicity
Genetics25103491Generation of a vancomycin-intermediate Staphylococcus aureus (VISA) strain by two amino acid exchanges in VraS.Berscheid A, Francois P, Strittmatter A, Gottschalk G, Schrenzel J, Sass P, Bierbaum GJ Antimicrob Chemother10.1093/jac/dku2972014*Amino Acid Substitution, Bacterial Proteins/*genetics, Genetic Loci, Genome, Bacterial, Microbial Sensitivity Tests, Mutant Proteins/genetics, *Mutation, Missense, Sequence Analysis, DNA, Staphylococcus aureus/*drug effects/*genetics, Vancomycin/*pharmacology, *Vancomycin ResistanceTranscriptome
Pathogenicity25156723NOD2 stimulation by Staphylococcus aureus-derived peptidoglycan is boosted by Toll-like receptor 2 costimulation with lipoproteins in dendritic cells.Schaffler H, Demircioglu DD, Kuhner D, Menz S, Bender A, Autenrieth IB, Bodammer P, Lamprecht G, Gotz F, Frick JSInfect Immun10.1128/IAI.02043-142014Animals, Bone Marrow Cells/drug effects, Cells, Cultured, Dendritic Cells/*drug effects/metabolism, Gene Expression Regulation/drug effects, Humans, Lipoproteins/*pharmacology, Mice, Mice, Knockout, Nod2 Signaling Adaptor Protein/genetics/*metabolism, Peptidoglycan/chemistry/*pharmacology, Staphylococcus aureus/*chemistry/metabolism, Toll-Like Receptor 2/genetics/*metabolismMetabolism
Genetics25169861Draft Genome Sequence of Staphylococcus aureus subsp. aureus Strain HG003, an NCTC8325 Derivative.Sassi M, Felden B, Augagneur YGenome Announc10.1128/genomeA.00855-142014
Metabolism25187407Pfs promotes autolysis-dependent release of eDNA and biofilm formation in Staphylococcus aureus.Bao Y, Zhang X, Jiang Q, Xue T, Sun BMed Microbiol Immunol10.1007/s00430-014-0357-y2014Bacterial Adhesion, Bacterial Proteins/biosynthesis, *Bacteriolysis, Biofilms/*growth & development, DNA, Bacterial/*metabolism, Endopeptidases/biosynthesis, Gene Deletion, Gene Expression Profiling, Gene Expression Regulation, Bacterial, N-Glycosyl Hydrolases/genetics/*metabolism, Staphylococcus aureus/*enzymology/genetics/*physiologyEnzymology
Pathogenicity25283555New antibacterial xanthone from the marine sponge-derived Micrococcus sp. EG45.Eltamany EE, Abdelmohsen UR, Ibrahim AK, Hassanean HA, Hentschel U, Ahmed SABioorg Med Chem Lett10.1016/j.bmcl.2014.09.0402014Animals, Anti-Bacterial Agents/isolation & purification/*pharmacology, Enterococcus faecalis/*drug effects, Magnetic Resonance Spectroscopy, Micrococcus/*drug effects, Porifera/*chemistry, Staphylococcus aureus/*drug effects, Tandem Mass Spectrometry, Xanthones/chemistry/*isolation & purificationEnzymology
Pathogenicity25530997Antibacterial activity of Mulinum spinosum extracts against slime-producing Staphylococcus aureus and methicillin-resistant Staphylococcus aureus isolated from nasal carriers.Daniela E, Alejandra C, Pedro R, Claudia M, Lucia A, Carlos T, Analia L, Sara SScientificWorldJournal10.1155/2014/3421432014Agar, Anti-Bacterial Agents/*pharmacology, Apiaceae/*chemistry, Colony Count, Microbial, Congo Red, Genes, Bacterial, Humans, Methicillin-Resistant Staphylococcus aureus/drug effects/genetics/*growth & development/*isolation & purification, Microbial Sensitivity Tests, Nose/*microbiology, Plant Extracts/*pharmacology, Polymerase Chain ReactionEnzymology
Pathogenicity25753642A putative cro-like repressor contributes to arylomycin resistance in Staphylococcus aureus.Craney A, Romesberg FEAntimicrob Agents Chemother10.1128/AAC.04597-142015Anti-Bacterial Agents/*pharmacology, Bacterial Proteins/genetics, Cell Wall/drug effects, Microbial Sensitivity Tests, Peptides, Cyclic/pharmacology, Staphylococcus aureus/*drug effects/*metabolismMetabolism
Genetics25805861SRD: a Staphylococcus regulatory RNA database.Sassi M, Augagneur Y, Mauro T, Ivain L, Chabelskaya S, Hallier M, Sallou O, Felden BRNA10.1261/rna.049346.1142015Base Sequence, Chromosome Mapping, Computational Biology, *Databases, Nucleic Acid, Gene Expression Regulation, Bacterial/*genetics, Genome, Bacterial, Phylogeny, RNA, Bacterial/*genetics, RNA, Small Untranslated, Sequence Analysis, RNA, Software, Staphylococcus aureus/*geneticsPhylogeny
Metabolism25876106Elucidating the crucial role of poly N-acetylglucosamine from Staphylococcus aureus in cellular adhesion and pathogenesis.Lin MH, Shu JC, Lin LP, Chong KY, Cheng YW, Du JF, Liu STPLoS One10.1371/journal.pone.01242162015Animals, Bacterial Adhesion/*genetics, Bacterial Load/genetics, Bacterial Proteins/genetics/metabolism, Base Sequence, Biofilms/*growth & development, Cell Line, Tumor, Disease Models, Animal, Epithelial Cells/microbiology/pathology, *Gene Expression Regulation, Bacterial, Genetic Complementation Test, Humans, Lung/microbiology/pathology, Mice, Molecular Sequence Data, Operon, Plasmids/chemistry/metabolism, Polysaccharides, Bacterial/*metabolism, Sequence Deletion, Staphylococcal Infections/microbiology/*pathology, Staphylococcus aureus/*genetics/metabolism/*pathogenicity, Transformation, Bacterial, beta-Glucans/metabolismPathogenicity
Metabolism26056387The Staphylococcus aureus protein-coding gene gdpS modulates sarS expression via mRNA-mRNA interaction.Chen C, Zhang X, Shang F, Sun H, Sun B, Xue TInfect Immun10.1128/IAI.00159-1520155' Untranslated Regions, Bacterial Proteins/*genetics/metabolism, Base Sequence, DNA-Binding Proteins/*genetics/metabolism, *Gene Expression Regulation, Bacterial, Molecular Sequence Data, RNA, Bacterial/genetics/metabolism, RNA, Messenger/genetics/*metabolism, Staphylococcal Infections/*microbiology, Staphylococcus aureus/genetics/*metabolismGenetics
Pathogenicity26083414The nuSaalpha Specific Lipoprotein Like Cluster (lpl) of S. aureus USA300 Contributes to Immune Stimulation and Invasion in Human Cells.Nguyen MT, Kraft B, Yu W, Demircioglu DD, Hertlein T, Burian M, Schmaler M, Boller K, Bekeredjian-Ding I, Ohlsen K, Schittek B, Gotz FPLoS Pathog10.1371/journal.ppat.10049842015Animals, Cells, Cultured, DNA, Bacterial/genetics, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Female, Gene Knockout Techniques, Genomic Islands/*genetics, Humans, Mice, Mice, Inbred BALB C, Microscopy, Electron, Transmission, Microscopy, Fluorescence, Staphylococcal Infections/*genetics, Staphylococcus aureus/*genetics/*pathogenicity, Virulence/*genetics, Virulence Factors/genetics
Pathogenicity26440039Low efficacy of tobramycin in experimental Staphylococcus aureus endocarditis.Lerche CJ, Christophersen LJ, Trostrup H, Thomsen K, Jensen PO, Hougen HP, Bundgaard H, Hoiby N, Moser CEur J Clin Microbiol Infect Dis10.1007/s10096-015-2488-52015Animals, Anti-Bacterial Agents/*administration & dosage, Aortic Valve/microbiology/pathology, Bacterial Load, Cytokines/analysis, Disease Models, Animal, Endocarditis, Bacterial/*drug therapy/pathology, Myocardium/pathology, Rats, Wistar, Spleen/microbiology, Staphylococcal Infections/*drug therapy/pathology, Staphylococcus aureus/*drug effects, Tobramycin/*administration & dosage, Treatment Outcome
Genetics26861020Genome-wide Annotation, Identification, and Global Transcriptomic Analysis of Regulatory or Small RNA Gene Expression in Staphylococcus aureus.Carroll RK, Weiss A, Broach WH, Wiemels RE, Mogen AB, Rice KC, Shaw LNmBio10.1128/mBio.01990-152016Computational Biology, *Gene Expression Profiling, Gene Expression Regulation, Bacterial, *Genome, Bacterial, Genomics, Humans, Methicillin-Resistant Staphylococcus aureus/genetics, *Molecular Sequence Annotation, RNA, Bacterial/genetics, RNA, Small Untranslated/*genetics, Sequence Analysis, RNA, Staphylococcus aureus/*genetics/growth & developmentPathogenicity
Pathogenicity26924733The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells.Askarian F, Ajayi C, Hanssen AM, van Sorge NM, Pettersen I, Diep DB, Sollid JU, Johannessen MSci Rep10.1038/srep221342016Bacterial Adhesion/genetics/*physiology, Bacterial Proteins/genetics/*physiology, Calcium-Binding Proteins/genetics/*physiology, Cell Line, Desmoglein 1/genetics/*physiology, Genes, Bacterial, HEK293 Cells, Host-Pathogen Interactions/genetics/physiology, Humans, Lactococcus lactis/genetics/physiology, Ligands, Recombinant Proteins/genetics/metabolism, Staphylococcus aureus/genetics/*pathogenicity/*physiologyMetabolism
Transcriptome27035918Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.Mader U, Nicolas P, Depke M, Pane-Farre J, Debarbouille M, van der Kooi-Pol MM, Guerin C, Derozier S, Hiron A, Jarmer H, Leduc A, Michalik S, Reilman E, Schaffer M, Schmidt F, Bessieres P, Noirot P, Hecker M, Msadek T, Volker U, van Dijl JMPLoS Genet10.1371/journal.pgen.10059622016Binding Sites, Blotting, Northern, Gene Expression, Genes, Bacterial, Promoter Regions, Genetic, Staphylococcus aureus/*genetics, Transcription Factors/metabolism, *TranscriptomeMetabolism
27148197In Vitro Activities of Nisin and Nisin Derivatives Alone and In Combination with Antibiotics against Staphylococcus Biofilms.Field D, O' Connor R, Cotter PD, Ross RP, Hill CFront Microbiol10.3389/fmicb.2016.005082016
Pathogenicity27282779Structure of the host-recognition device of Staphylococcus aureus phage varphi11.Koc C, Xia G, Kuhner P, Spinelli S, Roussel A, Cambillau C, Stehle TSci Rep10.1038/srep275812016Cell Wall/genetics/virology, Crystallography, X-Ray, Host-Pathogen Interactions/*genetics, Lysogeny/genetics, Microscopy, Electron, Staphylococcus Phages/genetics/pathogenicity/*ultrastructure, Staphylococcus aureus/genetics/*virology, Virion/pathogenicity/*ultrastructure
Metabolism27488131Penicillin binding protein 3 of Staphylococcus aureus NCTC 8325-4 binds and activates human plasminogen.Kylvaja R, Ojalehto T, Kainulainen V, Virkola R, Westerlund-Wikstrom BBMC Res Notes10.1186/s13104-016-2190-42016Bacterial Proteins/*metabolism, Fibrinolysin/metabolism, Humans, Immobilized Proteins/metabolism, Penicillin-Binding Proteins/*metabolism, Plasminogen/*metabolism, Protein Binding, Recombinant Proteins/metabolism, Solubility, Staphylococcus aureus/*metabolismPathogenicity
Metabolism27795358Serine-Aspartate Repeat Protein D Increases Staphylococcus aureus Virulence and Survival in Blood.Askarian F, Uchiyama S, Valderrama JA, Ajayi C, Sollid JUE, van Sorge NM, Nizet V, van Strijp JAG, Johannessen MInfect Immun10.1128/IAI.00559-162016Adhesins, Bacterial/metabolism, Animals, Bacterial Adhesion/physiology, Bacterial Proteins/*metabolism, Calcium-Binding Proteins/*metabolism, Female, Humans, Immunity, Innate/immunology, Lactococcus lactis/immunology/metabolism, Mice, Neutrophils/immunology/metabolism/microbiology, Recombinant Proteins/metabolism, Staphylococcal Infections/*blood/immunology/*microbiology, Staphylococcus aureus/immunology/*metabolism/*pathogenicity, Virulence/immunology/*physiologyPathogenicity
Metabolism28143981A Novel Repressor of the ica Locus Discovered in Clinically Isolated Super-Biofilm-Elaborating Staphylococcus aureus.Yu L, Hisatsune J, Hayashi I, Tatsukawa N, Sato'o Y, Mizumachi E, Kato F, Hirakawa H, Pier GB, Sugai MmBio10.1128/mBio.02282-162017Biofilms/*growth & development, Codon, Nonsense, Gene Deletion, Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Genetic Complementation Test, *Genetic Loci, Genome, Bacterial, Microarray Analysis, Multigene Family, Mutant Proteins/genetics/metabolism, Operon, Polysaccharides, Bacterial/metabolism, Repressor Proteins/genetics/*metabolism, Sequence Analysis, DNA, Staphylococcal Infections/microbiology, Staphylococcus aureus/*genetics/isolation & purification/*physiologyPhylogeny
28149057Predictive characterization of hypothetical proteins in Staphylococcus aureus NCTC 8325.School K, Marklevitz J, K Schram W, K Harris LBioinformation10.6026/973206300122092016
28197063Prediction driven functional annotation of hypothetical proteins in the major facilitator superfamily of S. aureus NCTC 8325.Marklevitz J, Harris LKBioinformation10.6026/973206300122542016
Metabolism28301954The Role of Bacillithiol in Gram-Positive Firmicutes.Chandrangsu P, Loi VV, Antelmann H, Helmann JDAntioxid Redox Signal10.1089/ars.2017.70572017Anti-Bacterial Agents/chemistry/metabolism, Bacillus subtilis/enzymology/metabolism, Cysteine/*analogs & derivatives/chemistry/metabolism, Firmicutes/enzymology/*metabolism, Glucosamine/*analogs & derivatives/chemistry/metabolism, *Oxidative Stress, Staphylococcus aureus/enzymology/metabolism, Sulfhydryl Compounds/metabolism, Sulfur/metabolismEnzymology
Metabolism28416278AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus.Ma R, Qiu S, Jiang Q, Sun H, Xue T, Cai G, Sun BInt J Med Microbiol10.1016/j.ijmm.2017.03.0032017Bacterial Proteins/genetics/*metabolism, *Biofilms, Carbon-Sulfur Lyases/genetics, *Gene Expression Regulation, Bacterial, Homoserine/*analogs & derivatives/pharmacology, Lactones/*pharmacology, Pentanes/metabolism, Polysaccharides, Bacterial/genetics/metabolism, Promoter Regions, Genetic, Quorum Sensing/*drug effects, Staphylococcus aureus/*genetics, beta-Galactosidase/genetics/metabolismPathogenicity
Metabolism28653102Identification of Set11 from Staphylococcus aureus Mu50 strain as a ortholog of SSL7 via bioinformatic analysis and determination of its possible targets from human serum using CNBr-pull down assays.Li Y, Chen X, Jia N, Zhang X, Zang JBiotechnol Lett10.1007/s10529-017-2374-62017Albumins/metabolism, Alpha-Globulins/metabolism, Bacterial Proteins/chemistry/*genetics/*metabolism, Cloning, Molecular, Complement C3/metabolism, Complement C5/*metabolism, Computational Biology, Cytokines/metabolism, Fibronectins, Gene Expression, Humans, Mass Spectrometry, Models, Molecular, Protein Binding, Protein Conformation, Sequence Homology, Amino Acid, Serum/chemistry, Staphylococcus aureus/*enzymology/*genetics, Substrate Specificity, Superantigens/chemistry/*genetics/*metabolismEnzymology
Metabolism28802679Impact of cell wall peptidoglycan O-acetylation on the pathogenesis of Staphylococcus aureus in septic arthritis.Baranwal G, Mohammad M, Jarneborn A, Reddy BR, Golla A, Chakravarty S, Biswas L, Gotz F, Shankarappa S, Jin T, Biswas RInt J Med Microbiol10.1016/j.ijmm.2017.08.0022017Acetylation, Acetyltransferases/genetics/metabolism, Animals, Arthritis, Infectious/*microbiology/physiopathology, Cell Wall/chemistry/metabolism, Disease Models, Animal, Female, Knee Joint/microbiology/pathology/physiopathology, Locomotion, Mice, Mice, Inbred BALB C, Muramic Acids/metabolism, Muramidase/metabolism, Mutation, Peptidoglycan/*metabolism, Single-Blind Method, Staphylococcal Infections/*microbiology/physiopathology, Staphylococcus aureus/enzymology/genetics/*physiologyEnzymology
Metabolism28822698Staphylococcus aureus from atopic dermatitis skin alters cytokine production triggered by monocyte-derived Langerhans cell.Iwamoto K, Moriwaki M, Niitsu Y, Saino M, Takahagi S, Hisatsune J, Sugai M, Hide MJ Dermatol Sci10.1016/j.jdermsci.2017.08.0012017Adult, Cells, Cultured, Coculture Techniques, Cytokines/immunology/*metabolism, Dermatitis, Atopic/*immunology/microbiology, Healthy Volunteers, Humans, Immunity, Cellular/immunology, Langerhans Cells/immunology, Lymphocyte Activation/immunology, Monocytes/immunology, Severity of Illness Index, Skin/immunology/microbiology, Staphylococcus aureus/*immunology/isolation & purification, Staphylococcus epidermidis/immunology, T-Box Domain Proteins, Th1 Cells/*immunology/metabolism, Th2 Cells/*immunology/metabolismPathogenicity
Genetics29198880AureoWiki The repository of the Staphylococcus aureus research and annotation community.Fuchs S, Mehlan H, Bernhardt J, Hennig A, Michalik S, Surmann K, Pane-Farre J, Giese A, Weiss S, Backert L, Herbig A, Nieselt K, Hecker M, Volker U, Mader UInt J Med Microbiol10.1016/j.ijmm.2017.11.0112017*Bacterial Proteins, Computational Biology, *Databases as Topic, *Genes, Bacterial, Genome, Bacterial, Internet, *Molecular Sequence Annotation, Staphylococcal Infections/microbiology, Staphylococcus aureus/*genetics
29229527Surface proteins and the formation of biofilms by Staphylococcus aureus.Kim SJ, Chang J, Rimal B, Yang H, Schaefer JBiochim Biophys Acta Biomembr10.1016/j.bbamem.2017.12.0032017Bacterial Proteins/chemistry/*physiology, *Biofilms, Carbon Isotopes, Cell Wall/chemistry, Glycine/chemistry, Leucine/chemistry, Membrane Proteins/chemistry/*physiology, Nitrogen Isotopes, Nuclear Magnetic Resonance, Biomolecular, Staphylococcus aureus/pathogenicity/*physiology, Threonine/chemistry
29375518Rifampicin-Manuka Honey Combinations Are Superior to Other Antibiotic-Manuka Honey Combinations in Eradicating Staphylococcus aureus Biofilms.Liu MY, Cokcetin NN, Lu J, Turnbull L, Carter DA, Whitchurch CB, Harry EJFront Microbiol10.3389/fmicb.2017.026532018
29459853Does Treatment Order Matter? Investigating the Ability of Bacteriophage to Augment Antibiotic Activity against Staphylococcus aureus Biofilms.Kumaran D, Taha M, Yi Q, Ramirez-Arcos S, Diallo JS, Carli A, Abdelbary HFront Microbiol10.3389/fmicb.2018.001272018
29515534Assessment of Bona Fide sRNAs in Staphylococcus aureus.Liu W, Rochat T, Toffano-Nioche C, Le Lam TN, Bouloc P, Morvan CFront Microbiol10.3389/fmicb.2018.002282018
Phylogeny29661152Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers.Ajayi C, Aberg E, Askarian F, Sollid JUE, Johannessen M, Hanssen AMBMC Microbiol10.1186/s12866-018-1179-72018Amino Acid Sequence, Bacterial Adhesion, Bacterial Proteins/classification/*genetics/isolation & purification, Calcium-Binding Proteins/classification/*genetics/isolation & purification, Cell Line, *Genetic Variation, Humans, Keratinocytes/microbiology, Models, Molecular, Multilocus Sequence Typing, Nose/*microbiology, Phylogeny, Protein Conformation, Protein Domains, Staphylococcal Infections/microbiology, Staphylococcus aureus/*genetics/isolation & purification, Virulence/geneticsEnzymology
Pathogenicity29940104Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion.Tian T, Wang C, Wu M, Zhang X, Zang JBiochemistry10.1021/acs.biochem.8b000282018Allosteric Regulation, Crystallography, X-Ray, Humans, Models, Molecular, Phosphofructokinase-1/*chemistry/metabolism, Protein Conformation, Protein Multimerization, Staphylococcal Infections/microbiology, Staphylococcus aureus/chemistry/*enzymology/metabolism, Substrate SpecificityMetabolism
Pathogenicity30321108A Novel Method to Eliminate Preservatives in Eye Drops.Stanton D, Batich C, Schultz G, Gibson D, Guidi C, Yang Q, Bechtle A, Eiferman RJ Ocul Pharmacol Ther10.1089/jop.2018.00422018Anti-Bacterial Agents/*pharmacology, Bacteria/*drug effects, Humans, Microbial Sensitivity Tests, Moxifloxacin/*pharmacology, Ophthalmic Solutions/*pharmacology, *Preservatives, Pharmaceutical, Sulfonamides/*pharmacology, Thiophenes/*pharmacology, Timolol/*pharmacology
Pathogenicity30863385Essential Oil, Extracts, and Sesquiterpenes Obtained From the Heartwood of Pilgerodendron uviferum Act as Potential Inhibitors of the Staphylococcus aureus NorA Multidrug Efflux Pump.Espinoza J, Urzua A, Sanhueza L, Walter M, Fincheira P, Munoz P, Mendoza L, Wilkens MFront Microbiol10.3389/fmicb.2019.003372019
Pathogenicity30903976Development of Mangifera indica leaf extract incorporated carbopol hydrogel and its antibacterial efficacy against Staphylococcus aureus.Chirayath RB, A AV, Jayakumar R, Biswas R, Vijayachandran LSColloids Surf B Biointerfaces10.1016/j.colsurfb.2019.03.0342019Acrylic Resins/*chemistry, Anti-Bacterial Agents/chemistry/pharmacology, Hydrogels/*chemistry, Mangifera/*chemistry, Plant Extracts/*chemistry, Plant Leaves/*chemistry, Staphylococcus aureus/drug effects
Pathogenicity31671904Antibacterial Property of Composites of Reduced Graphene Oxide with Nano-Silver and Zinc Oxide Nanoparticles Synthesized Using a Microwave-Assisted Approach.Hsueh YH, Hsieh CT, Chiu ST, Tsai PH, Liu CY, Ke WJInt J Mol Sci10.3390/ijms202153942019Anti-Bacterial Agents/chemistry/*pharmacology, Drug Delivery Systems/methods, Escherichia coli/drug effects, Graphite/chemistry/*pharmacology, Metal Nanoparticles/*chemistry, Microbial Sensitivity Tests, Microscopy, Electron, Scanning, Microwaves, Nanocomposites/chemistry, Particle Size, Silver/chemistry/*pharmacology, Spectroscopy, Fourier Transform Infrared, Staphylococcus aureus/drug effects, X-Ray Diffraction, Zinc Oxide/chemistry/*pharmacology
Pathogenicity33356046[Inhibitory effect of Ningmitai Capsules on the proliferation and biofilm formation of Staphylococcus sp. and Escherichia coli].Chen X, Zheng L, Chen DKZhonghua Nan Ke Xue2020Anti-Bacterial Agents/*pharmacology, Biofilms/*drug effects, Capsules, Cholinergic Agents/*pharmacology, Escherichia coli/*drug effects, Staphylococcus/*drug effects
33529773Effectiveness of topical adjuvants in reducing biofilm formation on orthopedic implants: an in vitro analysis.Kia C, Cusano A, Messina J, Muench LN, Chadayammuri V, McCarthy MB, Umejiego E, Mazzocca ADJ Shoulder Elbow Surg10.1016/j.jse.2020.12.0092021Animals, Biofilms, Prostheses and Implants, *Prosthesis-Related Infections/prevention & control, Sheep, Staphylococcus aureus, Staphylococcus epidermidis
Metabolism33683394Protein A of Staphylococcus aureus strain NCTC8325 interacted with heparin.Shi H, Tang J, An C, Yang L, Zhou XArch Microbiol10.1007/s00203-021-02255-02021Amino Acid Motifs, Animals, Cell Wall/metabolism, Heparin/*metabolism, Humans, N-Acetylmuramoyl-L-alanine Amidase/metabolism, Protein Binding, Staphylococcal Infections/microbiology, Staphylococcal Protein A/chemistry/genetics/*metabolism, Staphylococcus aureus/genetics/*metabolism/pathogenicity, Virulence Factors/metabolismPathogenicity
Pathogenicity33914790Acidic amino acids as counterions of ciprofloxacin: Effect on growth and pigment production in Staphylococcus aureus NCTC 8325 and Pseudomonas aeruginosa PAO1.Warraich AA, Mohammed AUR, Gibson H, Hussain M, Rahman ASPLoS One10.1371/journal.pone.02507052021Amino Acids, Acidic/*pharmacology, Ciprofloxacin/*pharmacology, Pigments, Biological/*biosynthesis, Pseudomonas aeruginosa/drug effects/*growth & development/*metabolism, Staphylococcus aureus/drug effects/*growth & development/*metabolismMetabolism
34107344Prostaglandin E2 promotes Staphylococcus aureus infection via EP4 receptor in bovine endometrium.Liu K, Mao W, Liu B, Li T, Wang X, Pei L, Cao J, Wang FMicrob Pathog10.1016/j.micpath.2021.1050192021Animals, Cattle, *Dinoprostone, Endometrium, Female, Receptors, Prostaglandin E, EP2 Subtype, *Staphylococcal Infections/veterinary, Staphylococcus aureus
Metabolism34192601DNA glycosylases for 8-oxoguanine repair in Staphylococcus aureus.Endutkin AV, Panferova EP, Barmatov AE, Zharkov DODNA Repair (Amst)10.1016/j.dnarep.2021.1031602021Bacterial Proteins/genetics/metabolism, Base Sequence, *DNA Damage, DNA Glycosylases/genetics/*metabolism, DNA, Bacterial/metabolism, DNA-Formamidopyrimidine Glycosylase/genetics/*metabolism, Guanine/*analogs & derivatives/metabolism, Hydrogen-Ion Concentration, Phylogeny, Sequence Alignment, Staphylococcus aureus/*enzymology/genetics/metabolism, Substrate SpecificityPhylogeny
34354456Sponge-associated sp. RM66 metabolome induction with N-acetylglucosamine: Antibacterial, antifungal and anti-trypanosomal activities.Alkhalifah DHMSaudi J Biol Sci10.1016/j.sjbs.2021.04.0822021
Pathogenicity34500813Nutraceutical Potential of Leaf Hydro-Ethanolic Extract of the Edible Halophyte Crithmum maritimum L.Souid A, Della Croce CM, Frassinetti S, Gabriele M, Pozzo L, Ciardi M, Abdelly C, Hamed KB, Magne C, Longo VMolecules10.3390/molecules261753802021Anti-Bacterial Agents/chemistry/pharmacology, Antimutagenic Agents/chemistry/pharmacology, Antioxidants/chemistry/pharmacology, *Dietary Supplements, Magnoliopsida/*chemistry, Plant Extracts/*chemistry/pharmacology, Plant Leaves/chemistry, Plants, Edible/*chemistry, Salt-Tolerant Plants/chemistry, Staphylococcus aureus/drug effects
Pathogenicity34600674Effect of biofilm on the survival of Staphylococcus aureus isolated from raw milk in high temperature and drying environment.Shen J, Wang H, Zhu C, Zhang M, Shang F, Xue TFood Res Int10.1016/j.foodres.2021.1106722021Animals, Biofilms, Humans, Milk, *Staphylococcal Infections, *Staphylococcus aureus/genetics, Temperature
Metabolism34963446Heterologous production of active form of beta-lytic protease by Bacillus subtilis and improvement of staphylolytic activity by protein engineering.Hioki T, Yamashita D, Tohata M, Endo K, Kawahara A, Okuda MMicrob Cell Fact10.1186/s12934-021-01724-x2021Bacillus subtilis/genetics/*metabolism, Bacterial Proteins/*genetics/*metabolism/*pharmacology, Lysobacter/genetics, Metalloendopeptidases/*genetics/*metabolism/*pharmacology, Models, Molecular, Mutation, Protein Conformation, Protein Disulfide Reductase (Glutathione)/metabolism, Protein Engineering/methods, Staphylococcus aureus/drug effectsBiotechnology
Pathogenicity35234502Clemastine Inhibits the Biofilm and Hemolytic of Staphylococcus aureus through the GdpP Protein.Shang Y, Guo J, Zhao Y, Chen J, Meng Q, Qu D, Zheng J, Yu Z, Wu Y, Deng QMicrobiol Spectr10.1128/spectrum.00541-212022Anti-Bacterial Agents/pharmacology/therapeutic use, Biofilms, Clemastine/pharmacology/therapeutic use, Hemolysis, Humans, *Methicillin-Resistant Staphylococcus aureus/genetics, Microbial Sensitivity Tests, Molecular Docking Simulation, Oxacillin/pharmacology/therapeutic use, *Staphylococcal Infections/microbiology, Staphylococcus aureus
35356518Lipoproteins Cause Bone Resorption in a Mouse Model of Staphylococcus aureus Septic Arthritis.Schultz M, Mohammad M, Nguyen MT, Hu Z, Jarneborn A, Wienken CM, Froning M, Pullerits R, Ali A, Hayen H, Gotz F, Jin TFront Microbiol10.3389/fmicb.2022.8437992022
Metabolism35801715Identification of responsible amino acid residues in staphylococcal superantigen-like 12 for the activation of mast cells.Kim G, Itoh S, Ito Y, Ohya S, Hida SGenes Cells10.1111/gtc.129732022Amino Acids/metabolism, Animals, Mast Cells/metabolism, Mice, *Staphylococcal Infections/metabolism, Staphylococcus aureus/chemistry/genetics/metabolism, *Superantigens/genetics/metabolism
Metabolism35988643Discovery of an L-amino acid ligase implicated in Staphylococcal sulfur amino acid metabolism.Pederick JL, Horsfall AJ, Jovcevski B, Klose J, Abell AD, Pukala TL, Bruning JBJ Biol Chem10.1016/j.jbc.2022.1023922022Adenosine Triphosphate/metabolism, Aspartic Acid/chemistry/metabolism, Dipeptides/biosynthesis, *Methionine/chemistry/metabolism, Phylogeny, *Staphylococcus aureus/enzymology, *Bacterial Proteins/chemistry/classification/genetics, *Peptide Synthases/chemistry/classification/genetics, *Cysteine/chemistry/metabolismPhylogeny
36144410Impact of Environmental Conditions on the Protein Content of Staphylococcus aureus and Its Derived Extracellular Vesicles.da Luz BSR, de Rezende Rodovalho V, Nicolas A, Chabelskaya S, Jardin J, Briard-Bion V, Le Loir Y, de Carvalho Azevedo VA, Guedon EMicroorganisms10.3390/microorganisms100918082022
Pathogenicity36178801Berberine at sub-inhibitory concentration inhibits biofilm dispersal in Staphylococcus aureus.Zhang C, Li Z, Pan Q, Fan L, Pan T, Zhu F, Pan Q, Shan L, Zhao LMicrobiology (Reading)10.1099/mic.0.0012432022Anti-Bacterial Agents/pharmacology, *Berberine/pharmacology, Biofilms, Humans, Methicillin/pharmacology, *Methicillin-Resistant Staphylococcus aureus, Microbial Sensitivity Tests, *Staphylococcal Infections/microbiology, Staphylococcus aureus
36462098Evaluation of the Effect of Leaf Development in Plectranthus amboinicus L. on Antimicrobial Activity and Virulence Factors of Pseudomonas aeruginosa PAO1 and Staphylococcus aureus NCTC8325.Sawant S, Baldwin TC, Khan H, Rahman ACurr Microbiol10.1007/s00284-022-03126-72022Staphylococcus aureus, Pseudomonas aeruginosa, Virulence Factors, *Plectranthus, *Staphylococcal Infections, *Oils, Volatile/pharmacology

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1872Curators of the DSMZLeibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 4910)https://www.dsmz.de/collection/catalogue/details/culture/DSM-4910
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37375Curators of the CIPhttps://brclims.pasteur.fr/brcWeb/souche/detail/1/5164
55133Curators of the CCUGCulture Collection University of Gothenburg (CCUG) (CCUG 41582)https://www.ccug.se/strain?id=41582
66792Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesAutomatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
66794Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg10.1093/nar/gkaa1025BRENDA, the ELIXIR core data resource in 2021: new developments and updatesNucleic Acids Res. 49: D498-D508 202033211880
68375Automatically annotated from API ID32STA
68382Automatically annotated from API zym
69480Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesPredictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
69481Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch10.21203/rs.3.rs-2527258/v1Predictions based on the model GenomeNet Sporulation v. 1
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116610Curators of the CIPCollection of Institut Pasteur (CIP 107700)https://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%20107700