Strain identifier
BacDive ID: 14344
Type strain: 
Species: Treponema denticola
Strain history: ATCC 35405 <-- E. C. S. Chan strain a.
NCBI tax ID(s): 243275 (strain), 158 (species)
version 8.1 (current version)
General
@ref: 5260
BacDive-ID: 14344
DSM-Number: 14222
keywords: genome sequence, 16S sequence, Bacteria, anaerobe, mesophilic, Gram-negative, human pathogen
description: Treponema denticola DSM 14222 is an anaerobe, mesophilic, Gram-negative human pathogen that was isolated from human periodontal pocket.
NCBI tax id
| NCBI tax id | Matching level |
|---|---|
| 243275 | strain |
| 158 | species |
strain history
| @ref | history |
|---|---|
| 5260 | <- ATCC; ATCC 35405 <- E. C. S. Chan; |
| 67770 | ATCC 35405 <-- E. C. S. Chan strain a. |
doi: 10.13145/bacdive14344.20230509.8.1
Name and taxonomic classification
LPSN
- @ref: 20215
- description: domain/bacteria
- keyword: phylum/spirochaetota
- domain: Bacteria
- phylum: Spirochaetota
- class: Spirochaetia
- order: Spirochaetales
- family: Treponemataceae
- genus: Treponema
- species: Treponema denticola
- full scientific name: Treponema denticola (ex Flügge 1886) Chan et al. 1993
@ref: 5260
domain: Bacteria
phylum: Spirochaetes
class: Spirochaetia
order: Spirochaetales
family: Treponemataceae
genus: Treponema
species: Treponema denticola
full scientific name: Treponema denticola (ex Flügge 1886) Chan et al. 1993
type strain: yes
Morphology
cell morphology
- @ref: 69480
- gram stain: negative
- confidence: 99.832
Culture and growth conditions
culture medium
- @ref: 5260
- name: TREPONEMA DENTICOLA MEDIUM (DSMZ Medium 909)
- growth: yes
- link: https://mediadive.dsmz.de/medium/909
- composition: Name: TREPONEMA DENTICOLA MEDIUM (DSMZ Medium 909) Composition: Brain heart infusion broth 11.9617 g/l Trypticase 9.56938 g/l Agar 2.87081 g/l Yeast extract 2.39234 g/l Glucose 1.91388 g/l NaHCO3 1.91387 g/l L-Cysteine HCl 0.956938 g/l Na-thioglycolate 0.478469 g/l L-Asparagine 0.239234 g/l Thiamine pyrophosphate 0.00574161 g/l Valeric acid DL-2-Methylbutyric acid Isovaleric acid KOH Isobutyric acid Rabbit serum Distilled water
culture temp
| @ref | growth | type | temperature | range |
|---|---|---|---|---|
| 5260 | positive | growth | 37 | mesophilic |
| 67770 | positive | growth | 37 | mesophilic |
Physiology and metabolism
oxygen tolerance
| @ref | oxygen tolerance | confidence |
|---|---|---|
| 5260 | anaerobe | |
| 69480 | anaerobe | 99.236 |
spore formation
| @ref | spore formation | confidence |
|---|---|---|
| 69481 | no | 100 |
| 69480 | no | 99.98 |
compound production
- @ref: 5260
- compound: proline iminopeptidase
Isolation, sampling and environmental information
isolation
| @ref | sample type | geographic location | country | origin.country | continent | latitude | longitude |
|---|---|---|---|---|---|---|---|
| 5260 | human periodontal pocket | Montreal | Canada | CAN | North America | 45.5017 | -73.5673 |
| 67770 | Human oral cavity |
isolation source categories
| Cat1 | Cat2 | Cat3 |
|---|---|---|
| #Host | #Human | |
| #Host Body-Site | #Oral cavity and airways | #Periodontal pocket |
Safety information
risk assessment
- @ref: 5260
- pathogenicity human: yes
- pathogenicity animal: yes
- biosafety level: 2
- biosafety level comment: Risk group (German classification)
Sequence information
16S sequences
| @ref | description | accession | length | database | NCBI tax ID |
|---|---|---|---|---|---|
| 20218 | Treponema denticola strain ATCC35405 16S ribosomal RNA gene, partial sequence | AF139203 | 1518 | ena | 158 |
| 20218 | Treponema denticola 16S ribosomal RNA gene, partial sequence; 16S-23S intergenic spacer and tRNA-Ile gene, complete sequence; and 23S ribosomal RNA gene, partial sequence | AF179263 | 424 | ena | 158 |
| 20218 | Treponema denticola 16S ribosomal RNA gene, partial sequence; 16S-23S intergenic spacer and tRNA-Ala gene, complete sequence; and 23S ribosomal RNA gene, partial sequence | AF179264 | 441 | ena | 158 |
| 20218 | Spirochaeta caldaria strain DSMZ7334 16S ribosomal RNA gene, partial sequence | EU580141 | 1535 | ena | 744872 |
| 20218 | Treponema denticola gene for 16S ribosomal RNA, partial sequence, strain: JCM 8153 | AB621358 | 1506 | ena | 158 |
Genome sequences
| @ref | description | accession | assembly level | database | NCBI tax ID |
|---|---|---|---|---|---|
| 66792 | Treponema denticola ATCC 35405 | GCA_000008185 | complete | ncbi | 243275 |
| 66792 | Treponema denticola ATCC 35405 | 243275.7 | complete | patric | 243275 |
| 66792 | Treponema denticola ATCC 35405 | 637000327 | complete | img | 243275 |
Genome-based predictions
predictions
| trait | prediction | confidence | training_data |
|---|---|---|---|
| spore-forming | no | 100 | no |
| motile | yes | 83.495 | no |
| flagellated | no | 89.088 | no |
| gram-positive | no | 92.718 | no |
| anaerobic | yes | 99.183 | no |
| halophile | no | 81.377 | no |
| spore-forming | no | 85.751 | no |
| thermophile | no | 97.239 | no |
| glucose-util | yes | 82.547 | no |
| aerobic | no | 98.668 | no |
| glucose-ferment | yes | 69.238 | no |
External links
@ref: 5260
culture collection no.: DSM 14222, ATCC 35405, JCM 8153, CIP 103919, KCTC 15104
straininfo link
- @ref: 83489
- straininfo: 41060
literature
| topic | Pubmed-ID | title | authors | journal | DOI | year | mesh | topic2 |
|---|---|---|---|---|---|---|---|---|
| Enzymology | 1321141 | Purification and substrate specificity of an endopeptidase from the human oral spirochete Treponema denticola ATCC 35405, active on furylacryloyl-Leu-Gly-Pro-Ala and bradykinin. | Makinen KK, Makinen PL, Syed SA | J Biol Chem | S0021-9258(19)49710-X | 1992 | Acrylates/*metabolism, Amino Acid Sequence, Amino Acids/analysis, Bradykinin/*metabolism, Chromatography, Chromatography, Gel, Durapatite, Humans, Hydroxyapatites, Kinetics, Metalloendopeptidases/*isolation & purification/*metabolism, Molecular Sequence Data, Oligopeptides/*metabolism, Periodontal Pocket/microbiology, Substrate Specificity, Treponema/*enzymology/growth & development/isolation & purification | Metabolism |
| Enzymology | 1563796 | Characterization, cloning, and binding properties of the major 53-kilodalton Treponema denticola surface antigen. | Haapasalo M, Muller KH, Uitto VJ, Leung WK, McBride BC | Infect Immun | 10.1128/iai.60.5.2058-2065.1992 | 1992 | Animals, Antigens, Bacterial/*analysis/genetics/metabolism, Antigens, Surface/analysis/genetics, Bacterial Adhesion, *Cloning, Molecular, Electrophoresis, Polyacrylamide Gel, Fibronectins/metabolism, Laminin/metabolism, Molecular Weight, Rabbits, Recombinant Proteins/analysis, Treponema/genetics/*immunology/physiology | Metabolism |
| Pathogenicity | 1639504 | Treponema denticola induces actin rearrangement and detachment of human gingival fibroblasts. | Baehni PC, Song M, McCulloch CA, Ellen RP | Infect Immun | 10.1128/iai.60.8.3360-3368.1992 | 1992 | Actins/*metabolism, Bacterial Adhesion, Cell Adhesion, Cells, Cultured, Fibroblasts/microbiology, Gingiva/cytology/*microbiology, Humans, Treponema/pathogenicity/*physiology | Metabolism |
| Metabolism | 1937780 | Sulfhydryl-dependent attachment of Treponema denticola to laminin and other proteins. | Haapasalo M, Singh U, McBride BC, Uitto VJ | Infect Immun | 10.1128/iai.59.11.4230-4237.1991 | 1991 | Amino Acid Sequence, Animals, *Bacterial Adhesion, Binding Sites, Cysteine/pharmacology, Epithelium/microbiology, Ethylmaleimide/pharmacology, Extracellular Matrix Proteins/metabolism, Glutathione/pharmacology, Hot Temperature, Hydrogen-Ion Concentration, Laminin/*metabolism, Microscopy, Electron, Scanning, Molecular Sequence Data, Oligopeptides/metabolism, Osmolar Concentration, Periodontal Ligament/microbiology, Protein Binding, Sulfhydryl Compounds/metabolism, Swine, Treponema/*pathogenicity | Stress |
| Enzymology | 2174832 | Isolation and characterization of the Treponema denticola prtA gene coding for chymotrypsinlike protease activity and detection of a closely linked gene encoding PZ-PLGPA-hydrolyzing activity. | Que XC, Kuramitsu HK | Infect Immun | 10.1128/iai.58.12.4099-4105.1990 | 1990 | Chromosome Deletion, Chymases, Cloning, Molecular, Escherichia coli/genetics, *Genes, Bacterial, Microbial Collagenase/*genetics, Serine Endopeptidases/analysis/*genetics/isolation & purification, Treponema/enzymology/*genetics | Phylogeny |
| Enzymology | 3166451 | Isolation of a chymotrypsinlike enzyme from Treponema denticola. | Uitto VJ, Grenier D, Chan EC, McBride BC | Infect Immun | 10.1128/iai.56.10.2717-2722.1988 | 1988 | Chymotrypsin, Hot Temperature, Hydrogen-Ion Concentration, Molecular Weight, Protease Inhibitors/pharmacology, Serine Endopeptidases/*isolation & purification, Serine Proteinase Inhibitors, Substrate Specificity, Sulfhydryl Reagents/pharmacology, Treponema/*enzymology | Phylogeny |
| Enzymology | 3183013 | Enzyme profiles of oral spirochetes in RapID-ANA system. | Syed SA, Salvador SL, Loesche WJ | J Clin Microbiol | 10.1128/jcm.26.10.2226-2228.1988 | 1988 | Alkaline Phosphatase/analysis, Aminopeptidases/analysis, Glycoside Hydrolases/analysis, Humans, Mouth/*microbiology, Reagent Kits, Diagnostic, Treponema/*enzymology | Pathogenicity |
| Metabolism | 7523301 | An endo-acting proline-specific oligopeptidase from Treponema denticola ATCC 35405: evidence of hydrolysis of human bioactive peptides. | Makinen PL, Makinen KK, Syed SA | Infect Immun | 10.1128/iai.62.11.4938-4947.1994 | 1994 | Amino Acid Sequence, Amino Acids/analysis, Angiotensin II/metabolism, Bradykinin/metabolism, Chelating Agents/pharmacology, Enzyme Activation/drug effects, Histidine, Humans, Hydrogen-Ion Concentration, Kinetics, Molecular Sequence Data, Molecular Weight, Oligopeptides/*metabolism, Prolyl Oligopeptidases, Sequence Alignment, Sequence Homology, Amino Acid, Serine, Serine Endopeptidases/chemistry/*metabolism, Sodium Chloride/pharmacology, Structure-Activity Relationship, Substance P/metabolism, Substrate Specificity, Sulfhydryl Compounds/pharmacology, Temperature, Treponema/*enzymology, Vasopressins/metabolism | Pathogenicity |
| Enzymology | 7534273 | Cloning and expression of a neutral phosphatase gene from Treponema denticola. | Ishihara K, Kuramitsu HK | Infect Immun | 10.1128/iai.63.4.1147-1152.1995 | 1995 | Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA, Bacterial/genetics, Gene Expression, Genes, Bacterial, Hydrogen-Ion Concentration, Molecular Sequence Data, Phosphoric Monoester Hydrolases/*genetics/metabolism, RNA, Bacterial/genetics, RNA, Messenger/genetics, Restriction Mapping, Substrate Specificity, Treponema/enzymology/*genetics | Genetics |
| Pathogenicity | 7541623 | Induction of cytoskeletal rearrangements and loss of volume regulation in epithelial cells by Treponema denticola. | De Filippo AB, Ellen RP, McCulloch CA | Arch Oral Biol | 10.1016/0003-9969(95)98809-d | 1995 | Actins/chemistry, Bacterial Adhesion, Cell Adhesion, Cell Membrane/*microbiology, Cell Movement, Cell Size, Cell Survival, Cytoskeletal Proteins/*chemistry/physiology, Cytoskeleton/chemistry/*microbiology, Desmoplakins, Epithelium/microbiology/pathology, Humans, KB Cells, Keratins/chemistry, Protein Conformation, Treponema/*physiology | |
| Metabolism | 7543886 | Role of the chymotrypsin-like membrane-associated proteinase from Treponema denticola ATCC 35405 in inactivation of bioactive peptides. | Makinen PL, Makinen KK, Syed SA | Infect Immun | 10.1128/iai.63.9.3567-3575.1995 | 1995 | Amino Acid Sequence, Amino Acids/analysis, Angiotensin I/*metabolism, Bacterial Proteins/*physiology, Bradykinin/*metabolism, Chymases, Cycloheximide/pharmacology, Humans, Molecular Sequence Data, Molecular Weight, Serine Endopeptidases/isolation & purification/*physiology, Substance P/*metabolism, Substrate Specificity, Treponema/*enzymology | Pathogenicity |
| Pathogenicity | 7642139 | Identification of a fliG homologue in Treponema denticola. | Heinzerling HF, Penders JE, Burne RA | Gene | 10.1016/0378-1119(95)00257-7 | 1995 | Adult, Amino Acid Sequence, Bacterial Proteins/chemistry/*genetics, Bacteriophage lambda/genetics, Base Sequence, DNA, Recombinant, Genes, Bacterial, Humans, Molecular Sequence Data, Periodontal Diseases/microbiology, Treponema/*genetics | Genetics |
| Phenotype | 7675518 | Evidence for two distinct locomotory phenotypes of Treponema denticola ATCC 35405. | Chan EC, Qiu YS, Siboo R, Noble P | Oral Microbiol Immunol | 10.1111/j.1399-302x.1995.tb00131.x | 1995 | Agar, Cell Movement, Chemotaxis, Culture Media, Phenotype, Sepharose, Treponema/classification/genetics/*physiology | Cultivation |
| Enzymology | 7864624 | Purification and general properties of an oligopeptidase from Treponema denticola ATCC 35405--a human oral spirochete. | Makinen KK, Makinen PL, Loesche WJ, Syed SA | Arch Biochem Biophys | 10.1006/abbi.1995.1092 | 1995 | Amino Acid Sequence, Benzoylarginine Nitroanilide/metabolism, Calcium/metabolism, Chlorhexidine/pharmacology, Diethyl Pyrocarbonate/pharmacology, Dose-Response Relationship, Drug, Humans, Hydrolysis, Isoelectric Point, Kinetics, Molecular Sequence Data, Molecular Weight, Mouth/microbiology, Peptide Hydrolases/drug effects/*isolation & purification/*metabolism, Quinolines/pharmacology, Sequence Analysis, Substrate Specificity, Treponema/*enzymology | Metabolism |
| Enzymology | 8039913 | Cloning and sequence analysis of a chymotrypsinlike protease from Treponema denticola. | Arakawa S, Kuramitsu HK | Infect Immun | 10.1128/iai.62.8.3424-3433.1994 | 1994 | Amino Acid Sequence, *Bacterial Proteins, Base Sequence, Blotting, Southern, Chymotrypsin/chemistry/*genetics/isolation & purification, Cloning, Molecular, *Genes, Bacterial, Metalloendopeptidases/*genetics, Molecular Sequence Data, Substrate Specificity, Treponema/*enzymology | Genetics |
| Enzymology | 8113954 | Isolation and characterization of a 53 kDa major cell envelope protein antigen from Treponema denticola ATCC 35405. | Kokeguchi S, Miyamoto M, Kato K, Tanimoto I, Kurihara H, Murayama Y | J Periodontal Res | 10.1111/j.1600-0765.1994.tb01093.x | 1994 | Amino Acids/analysis, Antigens, Bacterial/*chemistry, Bacterial Outer Membrane Proteins/*chemistry/isolation & purification, Chromatography, DEAE-Cellulose, Electrophoresis, Polyacrylamide Gel, Humans, Immunoblotting, Isoelectric Focusing, Microscopy, Immunoelectron, Periodontitis/immunology/*microbiology, Treponema/*chemistry | Phylogeny |
| Metabolism | 8248625 | Proteolytic and oxidoreductase activity of Treponema denticola ATCC 35405 grown in an aerobic and anaerobic gaseous environment. | Syed SA, Makinen KK, Makinen PL, Chen CY, Muhammad Z | Res Microbiol | 10.1016/0923-2508(93)90016-u | 1993 | Aerobiosis, Anaerobiosis, Catalase/metabolism, Culture Media, Dental Plaque/*microbiology, Endopeptidases/*metabolism, Humans, In Vitro Techniques, Periodontitis/*microbiology, Peroxidases/metabolism, Superoxide Dismutase/*metabolism, Treponema/*enzymology/growth & development/isolation & purification | Enzymology |
| Phylogeny | 8494734 | Treponema denticola (ex Brumpt 1925) sp. nov., nom. rev., and identification of new spirochete isolates from periodontal pockets. | Chan EC, Siboo R, Keng T, Psarra N, Hurley R, Cheng SL, Iugovaz I | Int J Syst Bacteriol | 10.1099/00207713-43-2-196 | 1993 | Agglutination Tests, DNA, Bacterial, Fatty Acids/analysis, Fluorescent Antibody Technique, Humans, Immunoblotting, Periodontal Pocket/*microbiology, Sequence Homology, Nucleic Acid, Serotyping, Treponema/*classification/immunology/*isolation & purification/ultrastructure | Pathogenicity |
| Metabolism | 8626313 | Sequence analysis, expression, and binding activity of recombinant major outer sheath protein (Msp) of Treponema denticola. | Fenno JC, Muller KH, McBride BC | J Bacteriol | 10.1128/jb.178.9.2489-2497.1996 | 1996 | Amino Acid Sequence, Bacterial Outer Membrane Proteins/*genetics/*metabolism, *Bacterial Proteins, Base Sequence, Cloning, Molecular, DNA-Directed RNA Polymerases/genetics, Escherichia coli/genetics, Fibronectins/metabolism, Gene Expression, Genes, Bacterial/genetics, Laminin/metabolism, Molecular Sequence Data, Molecular Weight, Porins/chemistry/*genetics/isolation & purification/*metabolism, Promoter Regions, Genetic/genetics, Protein Binding, RNA, Bacterial/analysis, RNA, Messenger/analysis, Recombinant Fusion Proteins, Sequence Analysis, DNA, Treponema/*genetics, Viral Proteins | Genetics |
| Enzymology | 8641769 | Proline iminopeptidase from the outer cell envelope of the human oral spirochete Treponema denticola ATCC 35405. | Makinen KK, Chen CY, Makinen PL | Infect Immun | 10.1128/iai.64.3.702-708.1996 | 1996 | Amino Acid Sequence, Amino Acids/analysis, Aminopeptidases/chemistry/*isolation & purification/metabolism, Humans, Hydrogen-Ion Concentration, Molecular Sequence Data, Molecular Weight, Mouth/*microbiology, Substrate Specificity, Temperature, Treponema/*enzymology | Pathogenicity |
| Genetics | 8655571 | Gene inactivation in the oral spirochete Treponema denticola: construction of an flgE mutant. | Li H, Ruby J, Charon N, Kuramitsu H | J Bacteriol | 10.1128/jb.178.12.3664-3667.1996 | 1996 | Bacterial Proteins/*genetics, Base Sequence, DNA, Bacterial/genetics, Flagella/ultrastructure, *Genes, Bacterial, Microscopy, Electron, Molecular Sequence Data, *Mutagenesis, Insertional, Plasmids, Treponema/*genetics | |
| Metabolism | 8757811 | The major surface protein complex of Treponema denticola depolarizes and induces ion channels in HeLa cell membranes. | Mathers DA, Leung WK, Fenno JC, Hong Y, McBride BC | Infect Immun | 10.1128/iai.64.8.2904-2910.1996 | 1996 | Anions/metabolism, *Bacterial Proteins, Cations/metabolism, Cell Membrane/*metabolism, Electric Conductivity, HeLa Cells, Humans, Patch-Clamp Techniques, Porins/chemistry/*metabolism, Protein Binding, Treponema, Treponemal Infections/etiology | Pathogenicity |
| Enzymology | 8890484 | Iron acquisition by oral hemolytic spirochetes: isolation of a hemin-binding protein and identification of iron reductase activity. | Scott D, Chan EC, Siboo R | Can J Microbiol | 10.1139/m96-137 | 1996 | Bacterial Outer Membrane Proteins/*isolation & purification, Biological Transport, Active, Carrier Proteins/*isolation & purification, Chromatography, Agarose, Culture Media/metabolism, Electrophoresis, Polyacrylamide Gel, *FMN Reductase, Hemin/metabolism/*pharmacokinetics, Iron/*metabolism/pharmacokinetics, Mouth/*microbiology, NADH, NADPH Oxidoreductases/*biosynthesis, Treponema/*enzymology/growth & development/*metabolism | Metabolism |
| Metabolism | 8941769 | Hyaluronan, a possible ligand mediating Treponema denticola binding to periodontal tissue. | Haapasalo M, Hannam P, McBride BC, Uitto VJ | Oral Microbiol Immunol | 10.1111/j.1399-302x.1996.tb00351.x | 1996 | Animals, Bacterial Adhesion/drug effects/*physiology, Bacterial Outer Membrane Proteins/metabolism, Cells, Cultured, Chymotrypsin/antagonists & inhibitors/metabolism, Collagen/metabolism, Enzyme-Linked Immunosorbent Assay, Epithelial Cells, Epithelium/microbiology, Fibrinogen/metabolism/pharmacology, Glycosaminoglycans/metabolism/pharmacology, Hot Temperature, Humans, Hyaluronic Acid/*metabolism/pharmacology, Periodontal Ligament/cytology/*microbiology, Protein Binding, Rabbits, Swine, Treponema/drug effects/enzymology/*physiology | Pathogenicity |
| Enzymology | 8945563 | Characterization of the Treponema denticola prtP gene encoding a prolyl-phenylalanine-specific protease (dentilisin). | Ishihara K, Miura T, Kuramitsu HK, Okuda K | Infect Immun | 10.1128/iai.64.12.5178-5186.1996 | 1996 | Amino Acid Sequence, Bacterial Proteins/*genetics/isolation & purification, Base Sequence, Chymotrypsin/*genetics, Cloning, Molecular, Genes, Bacterial/*genetics, Molecular Sequence Data, Peptide Hydrolases, *Serine Endopeptidases, Subtilisins/genetics, Treponema/enzymology/*genetics | Genetics |
| Enzymology | 9009331 | gamma-Glutamyltransferase from the outer cell envelope of Treponema denticola ATCC 35405. | Makinen PL, Makinen KK | Infect Immun | 10.1128/iai.65.2.685-691.1997 | 1997 | Amino Acid Sequence, Bacterial Outer Membrane Proteins/*chemistry/drug effects/isolation & purification, Chelating Agents/pharmacology, Chemical Phenomena, Chemistry, Physical, Chlorides/pharmacology, Electrophoresis, Polyacrylamide Gel, Enzyme Activation/drug effects, Hydrogen-Ion Concentration, Hydrolysis, Indicators and Reagents, Kinetics, Molecular Sequence Data, Substrate Specificity, Sulfhydryl Compounds/pharmacology, Transferases/metabolism, Treponema/chemistry/*enzymology, gamma-Glutamyltransferase/*chemistry/drug effects/isolation & purification | Pathogenicity |
| Genetics | 9023187 | Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp. | Fenno JC, Wong GW, Hannam PM, Muller KH, Leung WK, McBride BC | J Bacteriol | 10.1128/jb.179.4.1082-1089.1997 | 1997 | Amino Acid Sequence, *Bacterial Proteins, Base Sequence, Blotting, Southern, Cell Membrane/ultrastructure, *Conserved Sequence, *Genes, Bacterial, Molecular Sequence Data, Polymerase Chain Reaction, Porins/analysis/chemistry/*genetics, Protein Structure, Secondary, Sequence Alignment, Sequence Homology, Nucleic Acid, Treponema/chemistry/*genetics/ultrastructure | |
| Pathogenicity | 9169730 | Genetic and transcriptional analysis of flgB flagellar operon constituents in the oral spirochete Treponema denticola and their heterologous expression in enteric bacteria. | Heinzerling HF, Olivares M, Burne RA | Infect Immun | 10.1128/iai.65.6.2041-2051.1997 | 1997 | Amino Acid Sequence, Base Sequence, Escherichia coli/genetics, Flagella/*genetics, Humans, Immune Sera/immunology, Molecular Sequence Data, Mouth/*microbiology, Multigene Family, Open Reading Frames, *Operon, Promoter Regions, Genetic, Salmonella typhimurium/genetics, Transcription, Genetic, Treponema/*genetics/immunology | Genetics |
| Metabolism | 9227137 | Visualization of an extracellular mucoid layer of Treponema denticola ATCC 35405 and surface sugar lectin analysis of some Treponema species. | Scott D, Klitorinos A, Chan EC, Siboo R | Oral Microbiol Immunol | 10.1111/j.1399-302x.1997.tb00628.x | 1997 | Bacterial Capsules/chemistry/*ultrastructure, Lectins/metabolism, Microscopy, Electron, Polysaccharides, Bacterial/*analysis/metabolism, Treponema/*chemistry/*ultrastructure | |
| Genetics | 9317000 | Characterization of a methyl-accepting chemotaxis protein gene, dmcA, from the oral spirochete Treponema denticola. | Kataoka M, Li H, Arakawa S, Kuramitsu H | Infect Immun | 10.1128/iai.65.10.4011-4016.1997 | 1997 | Amino Acid Sequence, Bacterial Proteins/*genetics, Chemotaxis/*genetics, Escherichia coli/genetics, *Genes, Bacterial, Membrane Proteins/biosynthesis/*genetics, Methyl-Accepting Chemotaxis Proteins, Molecular Sequence Data, Mutagenesis, Insertional, Open Reading Frames/genetics, Recombinant Proteins/biosynthesis, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Treponema/*genetics | Transcriptome |
| Enzymology | 9335294 | Identification, isolation, and characterization of the 42-kilodalton major outer membrane protein (MompA) from Treponema pectinovorum ATCC 33768. | Walker SG, Ebersole JL, Holt SC | J Bacteriol | 10.1128/jb.179.20.6441-6447.1997 | 1997 | Amino Acid Sequence, Amino Acids/analysis, Antigens, Bacterial/immunology, Bacterial Outer Membrane Proteins/*chemistry/immunology/*isolation & purification, Blotting, Western, Cross Reactions, Detergents/pharmacology, Electrophoresis, Polyacrylamide Gel, Endopeptidases/metabolism, Microscopy, Immunoelectron, Molecular Sequence Data, Molecular Weight, Temperature, Treponema/*chemistry/ultrastructure | Phylogeny |
| Metabolism | 9453629 | Filamentous actin disruption and diminished inositol phosphate response in gingival fibroblasts caused by Treponema denticola. | Yang PF, Song M, Grove DA, Ellen RP | Infect Immun | 10.1128/IAI.66.2.696-702.1998 | 1998 | Actins/*metabolism, Calcium/metabolism, Cell Membrane/physiology, Cells, Cultured, Fibroblasts/metabolism, Gingiva/*metabolism, Humans, Inositol Phosphates/*metabolism, Treponema/*physiology | Pathogenicity |
| Enzymology | 9673024 | Mutagenesis of outer membrane virulence determinants of the oral spirochete Treponema denticola. | Fenno JC, Wong GW, Hannam PM, McBride BC | FEMS Microbiol Lett | 10.1111/j.1574-6968.1998.tb13047.x | 1998 | Alleles, *Bacterial Proteins, Blotting, Southern, Electrophoresis, Polyacrylamide Gel, Humans, Immunoblotting, Microscopy, Electron, Mutation, Periodontal Diseases/microbiology, Porins/*genetics, Serine Endopeptidases/*genetics/metabolism, Transformation, Bacterial, Treponema/enzymology/*genetics/*pathogenicity/ultrastructure, Virulence/*genetics | Pathogenicity |
| Pathogenicity | 9916079 | Characterization of a novel methyl-accepting chemotaxis gene, dmcB, from the oral spirochete Treponema denticola. | Li H, Arakawa S, Deng QD, Kuramitsu H | Infect Immun | 10.1128/IAI.67.2.694-699.1999 | 1999 | Amino Acid Sequence, Base Sequence, Chemotaxis/*physiology, DNA, Bacterial, Escherichia coli, Gene Expression, Humans, Molecular Sequence Data, Mouth/microbiology, Mutagenesis, Open Reading Frames, Sequence Homology, Amino Acid, Transcription, Genetic, Treponema/*genetics | Genetics |
| Metabolism | 10024564 | Treponema denticola outer membrane enhances the phagocytosis of collagen-coated beads by gingival fibroblasts. | Battikhi T, Lee W, McCulloch CA, Ellen RP | Infect Immun | 10.1128/IAI.67.3.1220-1226.1999 | 1999 | Cell Membrane/physiology, Cell Survival, Collagen/*metabolism, Cytochalasin D/pharmacology, Fibroblasts/metabolism, Gingiva/cytology/*metabolism, Hot Temperature, Humans, Periodontal Diseases/microbiology, *Phagocytosis, Treponema/*physiology | Stress |
| Metabolism | 10204483 | Oxygen metabolism by Treponema denticola. | Caldwell CE, Marquis RE | Oral Microbiol Immunol | 10.1034/j.1399-302x.1999.140109.x | 1999 | Anaerobiosis, Dental Plaque/metabolism/microbiology, Multienzyme Complexes/metabolism, NADH, NADPH Oxidoreductases/metabolism, Oxygen/metabolism, Oxygen Consumption, Peroxidases/metabolism, Superoxide Dismutase/metabolism, Treponema/*metabolism | Enzymology |
| Phylogeny | 10347901 | Mitogenic activity of the outer membrane of Treponema denticola. | Schade SZ, Yotis WW, Gopalsami C, Simonson LG | Microbios | 1998 | Animals, Cell Membrane/*chemistry, Lipopolysaccharides/analysis, Mice, Mice, Inbred C3H, Mitogens/*isolation & purification/pharmacology, Serotyping, Species Specificity, Spleen/cytology/drug effects, Sugar Acids/analysis, Treponema/*chemistry/classification | Enzymology | |
| Pathogenicity | 10481082 | Molecular characterization of a flagellar (fla) operon in the oral spirochete Treponema denticola ATCC 35405. | Stamm LV, Bergen HL | FEMS Microbiol Lett | 10.1111/j.1574-6968.1999.tb08703.x | 1999 | Bacterial Proteins/genetics, Base Sequence, Humans, Mouth Mucosa/microbiology, Movement, *Operon, Restriction Mapping, Reverse Transcriptase Polymerase Chain Reaction, Sequence Alignment, Treponema/*genetics/isolation & purification/physiology, Treponema pallidum/genetics | Enzymology |
| Metabolism | 10722578 | Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment. | Fenno JC, Tamura M, Hannam PM, Wong GW, Chan RA, McBride BC | Infect Immun | 10.1128/IAI.68.4.1884-1892.2000 | 2000 | Alleles, Amino Acid Sequence, Animals, Bacterial Adhesion, Bacterial Proteins, Blotting, Southern, Blotting, Western, Carrier Proteins/chemistry/genetics/*metabolism, Conserved Sequence, Epithelial Cells/metabolism, Escherichia coli/metabolism, Escherichia coli Proteins, Fibroblasts/metabolism, Gene Library, Gingiva/chemistry/*metabolism, Humans, Immunohistochemistry, Lipoproteins/chemistry/genetics/*metabolism, Microscopy, Electron, Molecular Sequence Data, Mutagenesis, Oligopeptides/metabolism, Protein Binding, Recombinant Fusion Proteins/metabolism, Sequence Homology, Amino Acid, Spirochaetales/metabolism, Swine, Treponema/chemistry/*metabolism/ultrastructure | Pathogenicity |
| Pathogenicity | 11075935 | Insertional inactivation of the prtP gene of Treponema denticola confirms dentilisin's disruption of epithelial junctions. | Ellen RP, Ko KS, Lo CM, Grove DA, Ishihara K | J Mol Microbiol Biotechnol | 2000 | Bacterial Adhesion/genetics, Bacterial Proteins, Cell Division, Cell Membrane/genetics/ultrastructure, Chymotrypsin/*genetics/*metabolism, Drug Resistance, Microbial/genetics, Electric Impedance, Epithelial Cells/microbiology/physiology, Fibroblasts/microbiology/physiology/ultrastructure, Gingiva/microbiology/physiology/ultrastructure, Humans, Intercellular Junctions/*microbiology/*physiology, Kinetics, Mutagenesis, Insertional, Peptide Hydrolases, Periodontal Diseases/microbiology, Treponema/cytology/genetics/*physiology, Tumor Cells, Cultured | Enzymology | |
| Pathogenicity | 11553571 | Motility and chemotaxis in tissue penetration of oral epithelial cell layers by Treponema denticola. | Lux R, Miller JN, Park NH, Shi W | Infect Immun | 10.1128/IAI.69.10.6276-6283.2001 | 2001 | Anaerobiosis, Cell Line, Chemotaxis/*physiology, Epithelial Cells/cytology, Humans, Keratinocytes/cytology, Mouth Mucosa/cytology/*microbiology, Treponema/genetics/growth & development/pathogenicity/*physiology | |
| Pathogenicity | 12472839 | Treponema denticola may stimulate both epithelial proliferation and apoptosis through MAP kinase signal pathways. | Leung WK, Wu Q, Hannam PM, McBride BC, Uitto VJ | J Periodontal Res | 10.1034/j.1600-0765.2002.01007.x | 2002 | Adenocarcinoma/pathology, Animals, Apoptosis/physiology, Blotting, Western, CHO Cells, Cell Adhesion/physiology, Cell Division/physiology, Cell Line, Cell Membrane/ultrastructure, Cell Size/physiology, Cell Survival/physiology, Cricetinae, DNA/biosynthesis, Epithelial Cells/pathology/physiology, Fibroblasts/physiology, Gingiva/cytology, Humans, In Situ Nick-End Labeling, *JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 4, MAP Kinase Signaling System/*physiology, Microscopy, Electron, Mitogen-Activated Protein Kinase Kinases/physiology, Mitogen-Activated Protein Kinases/physiology, Osteosarcoma/pathology, Periodontal Ligament/cytology/*physiology, Treponema/*physiology, Tumor Cells, Cultured, p38 Mitogen-Activated Protein Kinases | |
| Phylogeny | 12724370 | Genetic relatedness and phenotypic characteristics of Treponema associated with human periodontal tissues and ruminant foot disease. | Edwards AM, Dymock D, Woodward MJ, Jenkinson HF | Microbiology (Reading) | 10.1099/mic.0.26111-0 | 2003 | Animals, Bacterial Adhesion, Bacterial Typing Techniques, Cattle, Cattle Diseases/microbiology, DNA, Ribosomal/analysis, Foot Diseases/microbiology/*veterinary, Humans, Molecular Sequence Data, Periodontal Diseases/*microbiology, Phylogeny, RNA, Ribosomal, 16S/genetics, Ruminants/*microbiology, Sequence Analysis, DNA, Sheep, Sheep Diseases/microbiology, Treponema/*classification/*genetics/pathogenicity, Treponemal Infections/*microbiology/veterinary, Virulence | Pathogenicity |
| Metabolism | 15064399 | Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. | Seshadri R, Myers GS, Tettelin H, Eisen JA, Heidelberg JF, Dodson RJ, Davidsen TM, DeBoy RT, Fouts DE, Haft DH, Selengut J, Ren Q, Brinkac LM, Madupu R, Kolonay J, Durkin SA, Daugherty SC, Shetty J, Shvartsbeyn A, Gebregeorgis E, Geer K, Tsegaye G, Malek J, Ayodeji B, Shatsman S, McLeod MP, Smajs D, Howell JK, Pal S, Amin A, Vashisth P, McNeill TZ, Xiang Q, Sodergren E, Baca E, Weinstock GM, Norris SJ, Fraser CM, Paulsen IT | Proc Natl Acad Sci U S A | 10.1073/pnas.0307639101 | 2004 | ATP-Binding Cassette Transporters/genetics, Bacterial Proteins/genetics, Base Sequence, Borrelia burgdorferi/genetics/metabolism, Genes, Bacterial/genetics, *Genome, Bacterial, Leptospira interrogans/genetics/metabolism, Models, Genetic, Molecular Sequence Data, Mouth/*microbiology, Sequence Homology, Amino Acid, Treponema/*genetics/metabolism/pathogenicity, Treponema pallidum/genetics/metabolism | Genetics |
| Metabolism | 15256581 | Genetic analysis of Treponema denticola ATCC 35405 biofilm formation. | Vesey PM, Kuramitsu HK | Microbiology (Reading) | 10.1099/mic.0.26816-0 | 2004 | Bacterial Proteins/*genetics/*metabolism, Biofilms/*growth & development, Chymotrypsin/genetics/metabolism, Colony Count, Microbial, Humans, Microscopy, Electron, Scanning, Mutation, Peptide Hydrolases, Porphyromonas gingivalis/growth & development, Treponema/genetics/*growth & development | Pathogenicity |
| Metabolism | 15271922 | Multiple functions of the leucine-rich repeat protein LrrA of Treponema denticola. | Ikegami A, Honma K, Sharma A, Kuramitsu HK | Infect Immun | 10.1128/IAI.72.8.4619-4627.2004 | 2004 | Amino Acid Sequence, Bacterial Adhesion, Bacterial Proteins/chemistry/genetics/metabolism, Base Sequence, Cell Line, Cloning, Molecular, Humans, Leucine-Rich Repeat Proteins, Molecular Sequence Data, Movement, Proteins/chemistry/genetics/*metabolism, Recombinant Proteins/genetics/metabolism, Repetitive Sequences, Amino Acid, Sequence Analysis, DNA, Treponema/genetics/metabolism/pathogenicity/*physiology | Enzymology |
| Metabolism | 15845495 | Binding properties and adhesion-mediating regions of the major sheath protein of Treponema denticola ATCC 35405. | Edwards AM, Jenkinson HF, Woodward MJ, Dymock D | Infect Immun | 10.1128/IAI.73.5.2891-2898.2005 | 2005 | *Bacterial Adhesion, Bacterial Proteins/*chemistry/genetics/*metabolism, Escherichia coli/genetics/metabolism, Fibronectins/metabolism, *Gene Expression Regulation, Bacterial, Humans, Porins/*chemistry/genetics/*metabolism, Proteins/*metabolism, Recombinant Proteins/genetics/metabolism, Treponema denticola/metabolism/*physiology | Pathogenicity |
| Metabolism | 16815066 | Surface protease of Treponema denticola hydrolyzes C3 and influences function of polymorphonuclear leukocytes. | Yamazaki T, Miyamoto M, Yamada S, Okuda K, Ishihara K | Microbes Infect | 10.1016/j.micinf.2006.02.013 | 2006 | Bacterial Proteins, Cells, Cultured, Chymotrypsin/*physiology, Complement C3/*metabolism, Enzyme-Linked Immunosorbent Assay, Gene Deletion, Humans, Immunoblotting, Luminescent Measurements, Matrix Metalloproteinase 9/metabolism, Neutrophil Activation, Neutrophils/*immunology/metabolism, Oligopeptides/pharmacology, Peptide Hydrolases, Phagocytosis, Protease Inhibitors/pharmacology, Superoxides/metabolism, Treponema denticola/*enzymology/genetics, Virulence Factors/physiology | Pathogenicity |
| Metabolism | 17187656 | Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase. | Capone RF, Ning Y, Pakulis N, Alhazzazi T, Fenno JC | FEMS Microbiol Lett | 10.1111/j.1574-6968.2006.00589.x | 2006 | Bacterial Proteins/*genetics/*metabolism, Culture Media, Drug Resistance, Bacterial, Genetic Complementation Test, Mutation, Orotic Acid/*analogs & derivatives/pharmacology, Orotidine-5'-Phosphate Decarboxylase/genetics/*metabolism, Pyrimidines/biosynthesis, Treponema denticola/drug effects/*enzymology/growth & development, Uracil | Cultivation |
| Pathogenicity | 17533151 | Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells. | Okuda T, Kimizuka R, Miyamoto M, Kato T, Yamada S, Okuda K, Ishihara K | Microbes Infect | 10.1016/j.micinf.2007.03.009 | 2007 | Bacterial Proteins, Chemokine CCL2/*biosynthesis/genetics/immunology, Chymotrypsin/metabolism, Endothelial Cells/immunology/microbiology, Epithelial Cells/immunology/microbiology, Humans, Interleukin-8/*biosynthesis/genetics/immunology, Peptide Hydrolases, Periodontitis/*immunology/microbiology, RNA/chemistry/genetics, Reverse Transcriptase Polymerase Chain Reaction, Treponema denticola/enzymology/*immunology, Umbilical Veins/cytology | Biotechnology |
| Metabolism | 17591786 | The chymotrypsin-like protease complex of Treponema denticola ATCC 35405 mediates fibrinogen adherence and degradation. | Bamford CV, Fenno JC, Jenkinson HF, Dymock D | Infect Immun | 10.1128/IAI.00258-07 | 2007 | Bacterial Adhesion/*physiology, Bacterial Proteins/antagonists & inhibitors/metabolism, Chymases/antagonists & inhibitors/*physiology, Chymotrypsin/antagonists & inhibitors/blood/*physiology, Fibrin Fibrinogen Degradation Products/antagonists & inhibitors/*metabolism/physiology, Fibrinogen/*metabolism/physiology, Hemostasis/*physiology, Humans, Multiprotein Complexes/antagonists & inhibitors/metabolism/physiology, Peptide Hydrolases, Porins/antagonists & inhibitors/metabolism, Treponema denticola/*enzymology/growth & development/physiology | Pathogenicity |
| Metabolism | 17803630 | Steroid 5alpha-reductase activity of Treponema denticola. | Clark DT, Soory M | Oral Microbiol Immunol | 10.1111/j.1399-302X.2007.00364.x | 2007 | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/*metabolism, Androstenedione/metabolism, Buffers, Carbon Radioisotopes, Cholestanol/metabolism, Cholesterol/metabolism, Chromatography, Thin Layer, Coenzymes, Corticosterone/metabolism, Enzyme Inhibitors/pharmacology, Ethanol/pharmacology, Humans, Hydrogen-Ion Concentration, NADP/metabolism, Progesterone/metabolism, Radiopharmaceuticals, Subcellular Fractions/enzymology, Substrate Specificity, Testosterone/metabolism, Time Factors, Treponema denticola/*enzymology | Enzymology |
| Enzymology | 18279185 | Human serum antibodies recognize Treponema denticola Msp and PrtP protease complex proteins. | Capone R, Wang HT, Ning Y, Sweier DG, Lopatin DE, Fenno JC | Oral Microbiol Immunol | 10.1111/j.1399-302X.2007.00404.x | 2008 | Antibodies, Bacterial/blood/*immunology, Antigen-Antibody Reactions, Antigens, Bacterial/*immunology, Bacterial Outer Membrane Proteins/*immunology, Bacterial Proteins/*immunology, Blotting, Western, Chymotrypsin/*immunology, Electrophoresis, Polyacrylamide Gel, Humans, Immunoglobulin G/blood/physiology, Peptide Hydrolases, Porins/*immunology, Treponema denticola/*chemistry/*immunology, Virulence Factors | Pathogenicity |
| Pathogenicity | 20380884 | Mixture of periodontopathogenic bacteria influences interaction with KB cells. | Kirschbaum M, Schultze-Mosgau S, Pfister W, Eick S | Anaerobe | 10.1016/j.anaerobe.2010.03.009 | 2010 | *Bacterial Adhesion, Bacteroidetes/growth & development/*pathogenicity, Coculture Techniques, Epithelial Cells/immunology/*microbiology, Fusobacterium nucleatum/growth & development/*pathogenicity, Humans, Interleukins/*metabolism, KB Cells, Periodontal Diseases/*microbiology, Treponema denticola/growth & development/*pathogenicity | Metabolism |
| Enzymology | 21602384 | Disruption of a type II endonuclease (TDE0911) enables Treponema denticola ATCC 35405 to accept an unmethylated shuttle vector. | Bian J, Li C | Appl Environ Microbiol | 10.1128/AEM.00417-11 | 2011 | DNA Restriction Enzymes/genetics/*metabolism, DNA, Bacterial/genetics/*metabolism, *Gene Knockout Techniques, Genetic Vectors, *Transformation, Bacterial, Treponema denticola/*enzymology/genetics | Metabolism |
| Enzymology | 23253337 | Conservation and revised annotation of the Treponema denticola prcB-prcA-prtP locus encoding the dentilisin (CTLP) protease complex. | Goetting-Minesky MP, Godovikova V, Li JJ, Seshadrinathan S, Timm JC, Kamodia SS, Fenno JC | Mol Oral Microbiol | 10.1111/omi.12013 | 2012 | Bacterial Proteins/*genetics, Chymotrypsin/*genetics, Conserved Sequence, Databases, Genetic, Frameshift Mutation, Genetic Variation, Mutagenesis, Operon, Peptide Hydrolases/genetics, Subtilisins/genetics, Terminology as Topic, Treponema denticola/*enzymology/*genetics | |
| Metabolism | 25152229 | Dentilisin involvement in coaggregation between Treponema denticola and Tannerella forsythia. | Sano Y, Okamoto-Shibayama K, Tanaka K, Ito R, Shintani S, Yakushiji M, Ishihara K | Anaerobe | 10.1016/j.anaerobe.2014.08.008 | 2014 | *Bacterial Adhesion, Bacterial Proteins, Bacteroidetes/metabolism/*physiology, Chymotrypsin/*metabolism, Optical Imaging, Peptide Hydrolases, Protein Binding, Proteolysis, Spectrophotometry, Treponema denticola/metabolism/*physiology | |
| 25888173 | Kanamycin Resistance Cassette for Genetic Manipulation of Treponema denticola. | Li Y, Ruby J, Wu H | Appl Environ Microbiol | 10.1128/AEM.00478-15 | 2015 | Gene Targeting/*methods, Genetic Complementation Test, Genetics, Microbial/*methods, *Kanamycin Resistance, Molecular Biology/*methods, Selection, Genetic, Transformation, Genetic, Treponema denticola/*genetics | ||
| Pathogenicity | 26162875 | A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405. | Godovikova V, Goetting-Minesky MP, Shin JM, Kapila YL, Rickard AH, Fenno JC | Appl Environ Microbiol | 10.1128/AEM.01541-15 | 2015 | Bacterial Proteins/genetics, Cells, Cultured, DNA Methylation, DNA, Bacterial/genetics, Deoxyribonucleases, Type II Site-Specific, Fibroblasts/microbiology, Flavin Mononucleotide/*genetics, Fluorescence, Genetic Vectors, Gingiva/cytology/microbiology, Humans, Luminescent Proteins/*genetics, *Plasmids, *Transformation, Bacterial, Treponema denticola/*genetics | |
| 27375574 | Genomic and Metagenomic Analysis of Diversity-Generating Retroelements Associated with Treponema denticola. | Nimkulrat S, Lee H, Doak TG, Ye Y | Front Microbiol | 10.3389/fmicb.2016.00852 | 2016 | |||
| Enzymology | 27422166 | Characterization of a potential ABC-type bacteriocin exporter protein from Treponema denticola. | Tanaka-Kumazawa K, Kikuchi Y, Sano-Kokubun Y, Shintani S, Yakushiji M, Kuramitsu HK, Ishihara K | BMC Oral Health | 10.1186/s12903-016-0243-7 | 2016 | ATP-Binding Cassette Transporters/*isolation & purification, Amino Acid Sequence, Bacterial Proteins, Bacteriocins/*metabolism, Treponema, Treponema denticola/*chemistry | Phylogeny |
| Metabolism | 27914958 | Comparative analysis of motility and other properties of Treponema denticola strains. | Nagano K, Hasegawa Y, Yoshida Y, Yoshimura F | Microb Pathog | 10.1016/j.micpath.2016.11.021 | 2016 | *Bacterial Physiological Phenomena, Bacterial Proteins/chemistry/genetics/metabolism, Cell Line, Computational Biology/methods, Epithelial Cells/microbiology, Gene Expression Regulation, Bacterial, Gram-Negative Bacterial Infections/microbiology, Humans, In Vitro Techniques, Peptide Hydrolases/metabolism, Periodontal Diseases/microbiology, Phenotype, Transcription, Genetic, Treponema denticola/*physiology/ultrastructure | Pathogenicity |
| Phylogeny | 28453906 | Oral treponeme major surface protein: Sequence diversity and distributions within periodontal niches. | You M, Chan Y, Lacap-Bugler DC, Huo YB, Gao W, Leung WK, Watt RM | Mol Oral Microbiol | 10.1111/omi.12185 | 2017 | Adult, Amino Acid Sequence, Bacterial Proteins/classification/*genetics, Cloning, Molecular, Cohort Studies, DNA, Bacterial/genetics, Dental Plaque/microbiology, Female, *Genetic Variation, Genotype, Hong Kong, Humans, Male, Membrane Proteins/classification/*genetics, Middle Aged, Multigene Family, Periodontitis/microbiology, Phylogeny, Porins/classification/*genetics, Protein Domains, Sequence Alignment, Sequence Analysis, Protein, Treponema/classification/*genetics, Treponema denticola/genetics, Virulence Factors/genetics | Enzymology |
| 28748041 | Effect of azithromycin on a red complex polymicrobial biofilm. | Ong HS, Oettinger-Barak O, Dashper SG, Darby IB, Tan KH, Reynolds EC | J Oral Microbiol | 10.1080/20002297.2017.1339579 | 2017 | |||
| Pathogenicity | 30333370 | Treponema denticola Induces Epithelial Barrier Dysfunction in Polarized Epithelial Cells. | Kikuchi Y, Kimizuka R, Kato T, Okuda K, Kokubu E, Ishihara K | Bull Tokyo Dent Coll | 10.2209/tdcpublication.2017-0052 | 2018 | Animals, Bacterial Proteins/genetics/*toxicity, Bacterial Toxins, Cell Survival/drug effects, Dogs, Electric Impedance, Epithelial Cells/*drug effects/*metabolism/microbiology/pathology, Humans, Intercellular Junctions/drug effects, Madin Darby Canine Kidney Cells/*drug effects/metabolism/microbiology, Occludin/*metabolism, Peptide Hydrolases/genetics/metabolism/*toxicity, Tight Junction Proteins/*metabolism, Treponema denticola/genetics/*metabolism/pathogenicity, Virulence Factors, Zonula Occludens-1 Protein/*metabolism | Metabolism |
| Enzymology | 30373754 | Immunotopological Analysis of the Treponema denticola Major Surface Protein (Msp). | Godovikova V, Goetting-Minesky MP, Timm JC, Fenno JC | J Bacteriol | 10.1128/JB.00528-18 | 2018 | Bacterial Proteins/*chemistry/genetics, Escherichia coli/enzymology/genetics, Membrane Proteins/*chemistry/genetics, Models, Molecular, Porins/*chemistry/genetics, Protein Conformation, Treponema denticola/*enzymology/genetics | |
| 33149843 | Investigation of the potential regulator proteins associated with the expression of major surface protein and dentilisin in Treponema denticola. | Arai Y, Kikuchi Y, Okamoto-Shibayama K, Kokubu E, Shintani S, Ishihara K | J Oral Microbiol | 10.1080/20002297.2020.1829404 | 2020 | |||
| 34393436 | Identification of aspirin and diclofenac binding proteins in the red complex pathogens. | Babu G, Priya VV, Krishnaa PK, Gayathri R, Priyadharsini JV | Bioinformation | 10.6026/97320630017192 | 2021 | |||
| 34675462 | Protein targets in the red complex organisms binding with an herbal compound silymarin. | Faiz N, Pothapur KK, Vishnupriya V, Gayathri R, Priyadharsini JV | Bioinformation | 10.6026/97320630016759 | 2020 | |||
| 34803257 | Identification of protein targets in red complex organisms binding with resveratrol. | Pothapur KK, Vishnu Priya V, Rengasamy G, Jayaseelan VP | Bioinformation | 10.6026/97320630016837 | 2020 | |||
| 35749516 | Characterization of a Treponema denticola ATCC 35405 mutant strain with mutation accumulation, including a lack of phage-derived genes. | Yokogawa T, Nagano K, Fujita M, Miyakawa H, Iijima M | PLoS One | 10.1371/journal.pone.0270198 | 2022 | Bacterial Proteins/genetics, Bacterial Typing Techniques, *Bacteriophages/genetics, Mutation Accumulation, Treponema/genetics, *Treponema denticola/genetics |
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