Strain identifier

BacDive ID: 138353

Type strain: No

Species: Staphylococcus aureus

Strain history: CIP <- 2000, K. Hiramatsu, Juntendo Univ., Tokyo, Japan: strain Mu50

NCBI tax ID(s): 1280 (species)

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For citation purpose refer to the digital object identifier (doi) of the current version.
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General

@ref: 39523

BacDive-ID: 138353

keywords: genome sequence, Bacteria, facultative anaerobe, mesophilic, Gram-positive

description: Staphylococcus aureus CIP 106414 is a facultative anaerobe, mesophilic, Gram-positive bacterium of the family Staphylococcaceae.

NCBI tax id

  • NCBI tax id: 1280
  • Matching level: species

strain history

@refhistory
395232000, K. Hiramatsu, Tokyo, Japan: strain Mu 50
39523CIP <- 2000, K. Hiramatsu, Juntendo Univ., Tokyo, Japan: strain Mu50

doi: 10.13145/bacdive138353.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/bacillota
  • domain: Bacteria
  • phylum: Bacillota
  • class: Bacilli
  • order: Caryophanales
  • family: Staphylococcaceae
  • genus: Staphylococcus
  • species: Staphylococcus aureus
  • full scientific name: Staphylococcus aureus Rosenbach 1884 (Approved Lists 1980)

  • synonyms

    • @ref: 20215
    • synonym: Staphylococcus aureus subsp. anaerobius

@ref: 39523

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Caryophanales

family: Staphylococcaceae

genus: Staphylococcus

species: Staphylococcus aureus

type strain: no

Morphology

cell morphology

@refgram stainconfidencecell shapemotility
69480positive100
39523positivecoccus-shapedno

colony morphology

  • @ref: 39523

Culture and growth conditions

culture medium

@refnamegrowthcompositionlink
39523MEDIUM 3 - Columbia agaryesColumbia agar (39.000 g);distilled water (1000.000 ml)
39523CIP Medium 72yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=72
39523CIP Medium 3yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=3

culture temp

@refgrowthtypetemperaturerange
39523positivegrowth30mesophilic
39523positivegrowth22-45
39523nogrowth10psychrophilic

Physiology and metabolism

oxygen tolerance

  • @ref: 39523
  • oxygen tolerance: facultative anaerobe

spore formation

@refspore formationconfidence
69481no98
69480no99.7

metabolite utilization

@refChebi-IDmetaboliteutilization activitykind of utilization tested
39523606565hippurate+hydrolysis
3952317632nitrate+reduction
3952316301nitrite-reduction

metabolite production

  • @ref: 39523
  • Chebi-ID: 35581
  • metabolite: indole
  • production: no

metabolite tests

  • @ref: 39523
  • Chebi-ID: 15688
  • metabolite: acetoin
  • voges-proskauer-test: -

enzymes

@refvalueactivityec
39523oxidase-
39523beta-galactosidase-3.2.1.23
39523alcohol dehydrogenase-1.1.1.1
39523gelatinase-
39523amylase-
39523DNase+
39523caseinase-3.4.21.50
39523catalase+1.11.1.6
39523coagulase+
39523tween esterase+
39523gamma-glutamyltransferase-2.3.2.2
39523lecithinase-
39523lipase-
39523lysine decarboxylase-4.1.1.18
39523ornithine decarboxylase-4.1.1.17
39523protease+
39523urease+3.5.1.5
68382alkaline phosphatase+3.1.3.1
68382esterase (C 4)+
68382esterase lipase (C 8)+
68382lipase (C 14)-
68382leucine arylamidase-3.4.11.1
68382valine arylamidase-
68382cystine arylamidase-3.4.11.3
68382trypsin-3.4.21.4
68382alpha-chymotrypsin-3.4.21.1
68382acid phosphatase+3.1.3.2
68382naphthol-AS-BI-phosphohydrolase+
68382alpha-galactosidase-3.2.1.22
68382beta-galactosidase-3.2.1.23
68382beta-glucuronidase-3.2.1.31
68382alpha-glucosidase-3.2.1.20
68382beta-glucosidase-3.2.1.21
68382N-acetyl-beta-glucosaminidase-3.2.1.52
68382alpha-mannosidase-3.2.1.24
68382alpha-fucosidase-3.2.1.51

API zym

@refControlAlkaline phosphataseEsteraseEsterase LipaseLipaseLeucine arylamidaseValine arylamidaseCystine arylamidaseTrypsinalpha- ChymotrypsinAcid phosphataseNaphthol-AS-BI-phosphohydrolasealpha- Galactosidasebeta- Galactosidasebeta- Glucuronidasealpha- Glucosidasebeta- GlucosidaseN-acetyl-beta- glucosaminidasealpha- Mannosidasealpha- Fucosidase
39523-+++------++--------

API biotype100

@refGLUFRUGALTREMNESBEMELSACRAFMTEMALLACLTEMbGaMaGaCELGENMbGuESCRIBARAXYLPLERHAFUCMLZDARLLARLXLTDULTAGGLYINOMANMTLTURSORADOHBGLYXERYMDG3MDGSATMUCLTATDTATMTATDMLTLMLTCATETATETTECITGRTGAT2KG5KGTRYNAGGNTPACPATpOBEQATGTEmOBEBATPPATCMTTGEBETPCEABTHINLATCAPCYTHISSUCFUMGREGYTAVTETNTTNGLNITA3OBUAPTGTTPRODALALALASERMNTPROPTYR2KT
39523++++---+-----------+-----------+------------------+---------+---------------------------------+----

Isolation, sampling and environmental information

isolation

@refcountryorigin.countrycontinentsample type
39523JapanJPNAsia
39523JapanJPNAsiaHuman

Safety information

risk assessment

  • @ref: 39523
  • biosafety level: 2
  • biosafety level comment: Risk group (French classification)

Sequence information

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Staphylococcus aureus strain NRS11280.4808completepatric1280
66792Staphylococcus aureus ATCC 7006992852001951completeimg1280

Genome-based predictions

predictions

traitpredictionconfidencetraining_data
spore-formingno98no
motileno90.294no
gram-positiveyes90.326no
anaerobicno99.543no
aerobicyes89.841no
halophileyes93.115no
spore-formingno92.728no
glucose-utilyes87.968no
flagellatedno91.453no
thermophileno99.692no
glucose-fermentyes86.59no

External links

@ref: 39523

culture collection no.: CIP 106414, ATCC 700699, MU 50

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Pathogenicity16337789Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus.Wiles JA, Song Y, Wang Q, Lucien E, Hashimoto A, Cheng J, Marlor CW, Ou Y, Podos SD, Thanassi JA, Thoma CL, Deshpande M, Pucci MJ, Bradbury BJBioorg Med Chem Lett10.1016/j.bmcl.2005.11.0642005Anti-Bacterial Agents/chemical synthesis/*chemistry/*pharmacology/toxicity, Azo Compounds/chemical synthesis/chemistry/*pharmacology/toxicity, Cell Line, Tumor, Cyclization, Fluorine/chemistry, Humans, *Methicillin Resistance, Molecular Structure, Quinolones/chemical synthesis/chemistry/*pharmacology/toxicity, Staphylococcus aureus/*drug effects/physiology, Structure-Activity Relationship, Sulfhydryl Compounds/*chemistry
Pathogenicity22713953Synergy of flavone with vancomycin and oxacillin against vancomycin-intermediate Staphyloccus aureus.Bakar NS, Zin NM, Basri DFPak J Pharm Sci2012Anti-Bacterial Agents/*pharmacology, Drug Combinations, Drug Synergism, Flavonoids/*pharmacology, Microbial Sensitivity Tests, Oxacillin/*pharmacology, Staphylococcus aureus/*drug effects, Vancomycin/*pharmacology
Pathogenicity26677253Synergy of beta-Lactams with Vancomycin against Methicillin-Resistant Staphylococcus aureus: Correlation of Disk Diffusion and Checkerboard Methods.Sy CL, Huang TS, Chen CS, Chen YS, Tsai HC, Wann SR, Wu KS, Chen JK, Lee SS, Liu YCJ Clin Microbiol10.1128/JCM.01779-152015Anti-Bacterial Agents/*pharmacology, *Drug Synergism, Humans, Methicillin-Resistant Staphylococcus aureus/*drug effects, Microbial Sensitivity Tests/methods, Vancomycin/*pharmacology, beta-Lactams/*pharmacology
Pathogenicity27070198Metabolites from the Fungal Endophyte Aspergillus austroafricanus in Axenic Culture and in Fungal-Bacterial Mixed Cultures.Ebrahim W, El-Neketi M, Lewald LI, Orfali RS, Lin W, Rehberg N, Kalscheuer R, Daletos G, Proksch PJ Nat Prod10.1021/acs.jnatprod.5b009752016Animals, Anti-Bacterial Agents/chemistry, Aspergillus/*chemistry, Bacillus subtilis/drug effects, Mice, Microbial Sensitivity Tests, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Sesquiterpenes/chemistry/*isolation & purification, Staphylococcus aureus/drug effects, Xanthones/chemistry/*isolation & purificationEnzymology
27471750Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus.Zhao J, Cheah SE, Roberts KD, Nation RL, Thompson PE, Velkov T, Du Z, Johnson MD, Li JmSphere10.1128/mSphere.00119-162016
Pathogenicity28981793Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to linezolid in an in vitro dynamic model.Firsov AA, Alieva KN, Strukova EN, Golikova MV, Portnoy YA, Dovzhenko SA, Kobrin MB, Romanov AV, Edelstein MV, Zinner SHJ Antimicrob Chemother10.1093/jac/dkx2492017Anti-Bacterial Agents/pharmacokinetics/*pharmacology, Area Under Curve, Drug Resistance, Bacterial/genetics, Humans, Linezolid/*pharmacokinetics/*pharmacology, Microbial Sensitivity Tests/*methods, Models, Biological, *Mutation, RNA, Ribosomal, 23S/genetics, *Selection, Genetic, Staphylococcus aureus/*drug effects/geneticsEnzymology
Metabolism29353732Cunninghamella blakesleeana-mediated biotransformation of a contraceptive drug, desogestrel, and anti-MDR-Staphylococcus aureus activity of its metabolites.Atia-Tul-Wahab, Siddiqui M, Ibrahim I, Hussain A, Ajandouz EH, Hijazi A, Baydoun E, Choudhary MIBioorg Chem10.1016/j.bioorg.2017.12.0272018Anti-Bacterial Agents/chemistry/metabolism/*pharmacokinetics, Biotransformation, Contraceptive Agents/chemistry/metabolism/*pharmacokinetics, Cunninghamella/*metabolism, Desogestrel/chemistry/metabolism/*pharmacokinetics, Dose-Response Relationship, Drug, Methicillin-Resistant Staphylococcus aureus/*drug effects, Microbial Sensitivity Tests, Molecular Structure, Structure-Activity RelationshipEnzymology
32457238The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study.Hussein M, Karas JA, Schneider-Futschik EK, Chen F, Swarbrick J, Paulin OKA, Hoyer D, Baker M, Zhu Y, Li J, Velkov TmSystems10.1128/mSystems.00077-202020
33907810Anti-mutant efficacy of antibiotic combinations: in vitro model studies with linezolid and daptomycin.Zinner SH, Alieva KN, Golikova MV, Strukova EN, Portnoy YA, Firsov AAJ Antimicrob Chemother10.1093/jac/dkab0952021Anti-Bacterial Agents/pharmacology, *Daptomycin/pharmacology, Drug Resistance, Bacterial, Linezolid/pharmacology, *Methicillin-Resistant Staphylococcus aureus, Microbial Sensitivity Tests, Staphylococcus aureus/genetics
35025433Executing a Series of Zinc(II) Complexes of Homologous Schiff Base Ligands for a Comparative Analysis on Hydrolytic, Antioxidant, and Antibacterial Activities.Chowdhury T, Dasgupta S, Khatua S, Acharya K, Das DACS Appl Bio Mater10.1021/acsabm.0c003722020
35044759Synthesis, Crystal Structure, and Antibacterial Properties of Silver-Functionalized Low-Dimensional Layered Zirconium Phosphonates.Nocchetti M, Donnadio A, Vischini E, Posati T, Albonetti C, Campoccia D, Arciola CR, Ravaioli S, Mariani V, Montanaro L, Vivani RInorg Chem10.1021/acs.inorgchem.1c035652022*Silver

Reference

@idauthorstitledoi/urlcatalogue
20215Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ10.1099/ijsem.0.004332
39523Curators of the CIPhttps://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%20106414Collection of Institut Pasteur (CIP 106414)
66792Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg OvermannAutomatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)https://diaspora-project.de/progress.html#genomes
68382Automatically annotated from API zym
69480Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg OvermannPredictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)https://diaspora-project.de/progress.html#genomes
69481Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. MünchPredictions based on the model GenomeNet Sporulation v. 110.21203/rs.3.rs-2527258/v1