Strain identifier

BacDive ID: 12506

Type strain: Yes

Species: Porphyromonas gingivalis

Strain Designation: 2561

Strain history: CIP 103683 <-- J. P. Carlier AIP 10005 <-- ATCC 33277 <-- A. L. Coykendall 2561 <-- J. Slots.

NCBI tax ID(s): 431947 (strain), 837 (species)

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General

@ref: 9020

BacDive-ID: 12506

DSM-Number: 20709

keywords: genome sequence, 16S sequence, Bacteria, anaerobe, mesophilic, Gram-negative, human pathogen

description: Porphyromonas gingivalis 2561 is an anaerobe, mesophilic, Gram-negative human pathogen that was isolated from human gingival sulcus.

NCBI tax id

NCBI tax idMatching level
431947strain
837species

strain history

@refhistory
9020<- ATCC; ATCC 33277 <- A. L. Coykendall; <- J. Slots; 2561
67770CIP 103683 <-- J. P. Carlier AIP 10005 <-- ATCC 33277 <-- A. L. Coykendall 2561 <-- J. Slots.

doi: 10.13145/bacdive12506.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/bacteroidota
  • domain: Bacteria
  • phylum: Bacteroidota
  • class: Bacteroidia
  • order: Bacteroidales
  • family: Porphyromonadaceae
  • genus: Porphyromonas
  • species: Porphyromonas gingivalis
  • full scientific name: Porphyromonas gingivalis (Coykendall et al. 1980) Shah and Collins 1988

  • synonyms

    • @ref: 20215
    • synonym: Bacteroides gingivalis

@ref: 9020

domain: Bacteria

phylum: Bacteroidetes

class: Bacteroidia

order: Bacteroidales

family: Porphyromonadaceae

genus: Porphyromonas

species: Porphyromonas gingivalis

full scientific name: Porphyromonas gingivalis (Coykendall et al. 1980) Shah and Collins 1988 emend. Hahnke et al. 2016

strain designation: 2561

type strain: yes

Morphology

cell morphology

  • @ref: 69480
  • gram stain: negative
  • confidence: 99.937

colony morphology

  • @ref: 9020
  • incubation period: 1-2 days

Culture and growth conditions

culture medium

@refnamegrowthlinkcomposition
9020COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)yeshttps://mediadive.dsmz.de/medium/693Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
9020CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110)yeshttps://mediadive.dsmz.de/medium/110Name: CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110) Composition: Ground beef 500.0 g/l Casitone 30.0 g/l Agar 15.0 g/l K2HPO4 5.0 g/l Yeast extract 5.0 g/l D-Glucose 4.0 g/l Starch 1.0 g/l Maltose 1.0 g/l Cellobiose 1.0 g/l L-Cysteine HCl 0.5 g/l Ethanol 0.19 g/l Vitamin K3 0.05 g/l Hemin 0.005 g/l Sodium resazurin 0.0005 g/l Vitamin K1 NaOH Distilled water
41891MEDIUM 20 - for Anaerobic bacteriayesAgar (15.000 g);Glucose (5.000 g);Yeast extract (20.000 g);Tryptone (30.000 g);Cysteine hydrochloride (0.500 g);distilled water (1000.000 ml);Hemin solution -M00149 (25.000 ml)

culture temp

@refgrowthtypetemperaturerange
9020positivegrowth37mesophilic
41891positivegrowth37mesophilic
67770positivegrowth37mesophilic

Physiology and metabolism

oxygen tolerance

@refoxygen toleranceconfidence
9020anaerobe
69480anaerobe98.944

spore formation

@refspore formationconfidence
69481no100
69480no99.999

metabolite utilization

@refChebi-IDmetaboliteutilization activitykind of utilization tested
6836727082trehalose-builds acid from
6836762345L-rhamnose-builds acid from
6836730911sorbitol-builds acid from
6836716634raffinose-builds acid from
683676731melezitose-builds acid from
6836716024D-mannose-builds acid from
6836717057cellobiose-builds acid from
6836717754glycerol-builds acid from
683674853esculin-hydrolysis
683675291gelatin+hydrolysis
6836730849L-arabinose-builds acid from
6836765327D-xylose-builds acid from
6836717814salicin-builds acid from
6836717306maltose-builds acid from
6836717992sucrose-builds acid from
6836717716lactose-builds acid from
6836716899D-mannitol-builds acid from
6836717634D-glucose-builds acid from
6836716199urea-hydrolysis
6836727897tryptophan+energy source
6838016199urea-hydrolysis
6838016024D-mannose-fermentation
6838016634raffinose-fermentation
6838029985L-glutamate-degradation
6838017632nitrate-reduction
6838027897tryptophan+energy source

metabolite production

@refChebi-IDmetaboliteproduction
6836735581indoleyes
6838035581indoleyes

metabolite tests

@refChebi-IDmetaboliteindole test
6838035581indole+
6836735581indole+

enzymes

@refvalueactivityec
68380serine arylamidase-
68380histidine arylamidase-
68380alanine arylamidase+3.4.11.2
68380leucine arylamidase-3.4.11.1
68380leucyl glycin arylamidase+3.4.11.1
68380proline-arylamidase-3.4.11.5
68380alkaline phosphatase+3.1.3.1
68380tryptophan deaminase+4.1.99.1
68380glutamate decarboxylase-4.1.1.15
68380N-acetyl-beta-glucosaminidase+3.2.1.52
68380beta-glucuronidase-3.2.1.31
68380alpha-arabinosidase-3.2.1.55
68380beta-glucosidase-3.2.1.21
68380alpha-glucosidase-3.2.1.20
68380alpha-galactosidase-3.2.1.22
68380urease-3.5.1.5
68367catalase-1.11.1.6
68367beta-glucosidase-3.2.1.21
68367gelatinase+
68367urease-3.5.1.5

API 20A

@refINDUREGLUMANLACSACMALSALXYLARAGELESCGLYCELMNEMLZRAFSORRHATRECAT
9020+---------+----------
9020+---------+----------
9020+---------+----------

API rID32A

@refUREADH Argalpha GALbeta GALbeta GPalpha GLUbeta GLUalpha ARAbeta GURbeta NAGMNERAFGDCalpha FUCNITINDPALArgAProALGAPheALeuAPyrATyrAAlaAGlyAHisAGGASerA
9020---+-----+-----++--+--+-+--+-
9020---+/------+-----++--+--+/--+--+-
9020-+-++/-----+-----++--+--+/--++/--+/--
9020-+/--++/-----+-----++--+----+--+-
9020-+/--++----+---+-++--+--+/--+--+-
9020-+-++/-----+-----++--+----+--+-
9020-+-+-----+-----++--+--+/--+--+-
9020---+-----+-----++--+--+/--+--+/--
9020---+-----+-----+++/--+----+--+-
9020---+/------+-----++--+----+--+-
9020-+/--+/------+-----+++-+--+-+--+-
9020-+/--++/-----+-----++--++/--++/-++/--+-

Isolation, sampling and environmental information

isolation

@refsample type
9020human gingival sulcus
67770Human gingival sulcus

isolation source categories

Cat1Cat2Cat3
#Host#Human
#Host Body-Site#Oral cavity and airways#Gingiva
#Infection#Patient
#Host Body-Site#Other#Wound

taxonmaps

  • @ref: 69479
  • File name: preview.99_847.png
  • url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_15851;96_508;97_586;98_673;99_847&stattab=map
  • Last taxonomy: Porphyromonas gingivalis subclade
  • 16S sequence: X73964
  • Sequence Identity:
  • Total samples: 35027
  • soil counts: 1092
  • aquatic counts: 1398
  • animal counts: 32086
  • plant counts: 451

Safety information

risk assessment

  • @ref: 9020
  • pathogenicity human: yes
  • pathogenicity animal: yes
  • biosafety level: 2
  • biosafety level comment: Risk group (German classification)

Sequence information

16S sequences

@refdescriptionaccessionlengthdatabaseNCBI tax ID
20218Porphyromonas gingivalis gene for 16S rRNA, partial sequence, strain:ATCC33277AB0354591472ena431947
20218Porphyromonas gingivalis isolate ATCC 33277 16S-23S intergenic spacer region, complete sequenceAF118635729ena431947
20218Porphyromonas gingivalis 16S ribosomal RNA gene, partial sequenceAF2858701462ena431947
20218Porphyromonas gingivalis strain ATCC 33277 16S ribosomal RNA gene, partial sequenceAF4148091363ena431947
20218Porphyromonas gingivalis strain ATCC 33277 16S-23S ribosomal RNA intergenic spacer, partial sequenceAY546475873ena431947
20218Porphyromonas gingivalis ATCC 33277 16S ribosomal RNA gene, complete sequenceL164921474ena837
20218P.gingivalis gene for 16S rRNAX739641453ena837
9020Porphyromonas gingivalis gene for 16S rRNA, partial sequence, strain:SUNY1021AB0354571472ena837
67770Porphyromonas gingivalis gene for 16S ribosomal RNA, partial sequence, strain: JCM 12257AB5476601493ena837

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Porphyromonas gingivalis ATCC 33277GCA_000010505completencbi431947
66792Porphyromonas gingivalis ATCC 33277GCA_002892575completencbi431947
66792Porphyromonas gingivalis ATCC 33277431947.7completepatric431947
66792Porphyromonas gingivalis ATCC 33277431947.23completepatric431947
66792Porphyromonas gingivalis strain W83837.134completepatric837
66792Porphyromonas gingivalis ATCC 332772843222565completeimg431947
66792Porphyromonas gingivalis ATCC 33277642555148completeimg431947

GC content

@refGC-contentmethod
902047.1
902048.4sequence analysis
6777047.1thermal denaturation, midpoint method (Tm)

Genome-based predictions

predictions

traitpredictionconfidencetraining_data
spore-formingno100no
motileno90.343no
flagellatedno96.776no
gram-positiveno97.402no
anaerobicyes99.321yes
halophileno79.236no
spore-formingno96.183no
thermophileno97.531no
glucose-utilyes80.441no
aerobicno98.745yes
glucose-fermentno53.2no

External links

@ref: 9020

culture collection no.: DSM 20709, ATCC 33277, CIP 103683, JCM 12257, CCUG 25893, CCUG 25928, NCTC 11834

straininfo link

  • @ref: 81725
  • straininfo: 40424

literature

Pubmed-IDtitleauthorsjournalDOIyearmeshtopictopic2
1312516Porphyromonas gingivalis virulence in mice: induction of immunity to bacterial components.Kesavalu L, Ebersole JL, Machen RL, Holt SCInfect Immun10.1128/iai.60.4.1455-1464.19921992Animals, Antigens, Bacterial/*immunology/therapeutic use, Antigens, Surface/*immunology/therapeutic use, Bacteroides Infections/*prevention & control, Cross Reactions, Cytotoxicity, Immunologic, Dexamethasone/pharmacology, Disease Models, Animal, Dose-Response Relationship, Immunologic, Enzyme-Linked Immunosorbent Assay, Female, Galactosamine/pharmacology, Immunization, Immunoglobulin G/biosynthesis, Immunoglobulin M/biosynthesis, Lipopolysaccharides/immunology, Membrane Proteins/immunology, Mice, Mice, Inbred BALB C, Neutrophils/immunology, Porphyromonas gingivalis/*pathogenicity, Vaccination, Vaccines, Inactivated/immunology, Virulence
1314221Inactivation of human serum bactericidal activity by a trypsinlike protease isolated from Porphyromonas gingivalis.Grenier DInfect Immun10.1128/iai.60.5.1854-1857.19921992Blood Bactericidal Activity/*drug effects, Endopeptidases/isolation & purification/*toxicity, Humans, In Vitro Techniques, Porphyromonas gingivalis/*enzymology/pathogenicityPathogenicityEnzymology
1328455Dentin as inhibitor of bacterial toxicity on pulpal cells in vitro.Pissiotis E, Spangberg LJ Endod10.1016/S0099-2399(06)81412-31992Bacterial Proteins/*metabolism, Biological Transport, Dental Pulp/*microbiology, Dentin/microbiology/*physiology, Dentin Permeability, Diffusion Chambers, Culture, Humans, Porphyromonas gingivalis/pathogenicityPathogenicityMetabolism
1328998Comparative studies of three proteases of Porphyromonas gingivalis.Fujimura S, Shibata Y, Nakamura TOral Microbiol Immunol10.1111/j.1399-302x.1992.tb00027.x1992Bacterial Proteins/*chemistry/isolation & purification, Electrophoresis, Polyacrylamide Gel, Molecular Weight, Peptide Hydrolases/*chemistry/isolation & purification, Porphyromonas gingivalis/*enzymologyEnzymologyPhylogeny
1338601Evaluation of a non-radioactive DNA probe for detecting Porphyromonas gingivalis in subgingival specimens.Tay F, Liu YB, Flynn MJ, Slots JOral Microbiol Immunol10.1111/j.1399-302x.1992.tb00634.x1992Colony Count, Microbial, Culture Media, *DNA Probes, Dental Plaque/*microbiology, Humans, Periodontal Pocket/microbiology, Porphyromonas gingivalis/*isolation & purification, Sensitivity and Specificity, Time FactorsCultivationPathogenicity
1338602Expression of Porphyromonas gingivalis proteolytic activity in Escherichia coli.Madden TE, Thompson TM, Clark VLOral Microbiol Immunol10.1111/j.1399-302x.1992.tb00635.x1992Amino Acid Sequence, Bacterial Proteins/*genetics, Caseins/metabolism, Cloning, Molecular, Collagen/metabolism, Endopeptidases/*genetics/metabolism, Escherichia coli/genetics, Fibrinogen/metabolism, Fibronectins/metabolism, Gene Expression, Molecular Sequence Data, Porphyromonas gingivalis/*enzymology/*genetics, Substrate SpecificityMetabolismEnzymology
1363734Correlation between cell-adherent activity and surface structure in Porphyromonas gingivalis.Watanabe K, Yamaji Y, Umemoto TOral Microbiol Immunol10.1111/j.1399-302x.1992.tb00636.x1992Bacterial Adhesion/*physiology, Cell Wall/ultrastructure, Epithelial Cells, Fibroblasts/microbiology, Fimbriae, Bacterial/*physiology, Gingiva/cytology, Hemagglutination/immunology, Hot Temperature, Humans, Microscopy, Electron, Scanning, Periodontal Ligament/cytology, Porphyromonas gingivalis/*physiology/*ultrastructure, WaterStressPathogenicity
1667409Toxicity of sonicated extracts of Bacteroides gingivalis on human pulpal cells and L929 cells in vitro.Pissiotis E, Spangberg LSJ Endod10.1016/s0099-2399(06)81721-81991Animals, Bacterial Proteins/*toxicity, Cell Line, Cells, Cultured, DNA/biosynthesis, Dental Pulp/drug effects/*microbiology, Fibroblasts/drug effects/microbiology, Humans, Mice, Microscopy, Electron, Scanning, Porphyromonas gingivalis/chemistry/*pathogenicity, SonicationPathogenicity
1668246Identification of the major surface protein antigens of Porphyromonas gingivalis using IgG antibody reactivity of periodontal case-control serum.Curtis MA, Slaney JM, Carman RJ, Johnson NWOral Microbiol Immunol10.1111/j.1399-302x.1991.tb00502.x1991Antigens, Bacterial/*analysis, Bacterial Outer Membrane Proteins/analysis/*immunology, Case-Control Studies, Electrophoresis, Polyacrylamide Gel, Humans, Immunoblotting, Immunoglobulin G/immunology, Periodontitis/immunology/*microbiology, Porphyromonas gingivalis/*immunologyEnzymologyPathogenicity
1679428Evidence that Porphyromonas (Bacteroides) gingivalis fimbriae function in adhesion to Actinomyces viscosus.Goulbourne PA, Ellen RPJ Bacteriol10.1128/jb.173.17.5266-5274.19911991Actinomyces, *Bacterial Adhesion, Bacteroides/*physiology, Blotting, Western, Chromatography, Liquid, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Fimbriae, Bacterial/*physiology/ultrastructure, Microscopy, ElectronEnzymology
1691266Chemical, immunobiological and antigenic characterizations of lipopolysaccharides from Bacteroides gingivalis strains.Fujiwara T, Ogawa T, Sobue S, Hamada SJ Gen Microbiol10.1099/00221287-136-2-3191990Animals, Antigens, Bacterial/*immunology, Bacteroides/analysis/*immunology, Electrophoresis, Polyacrylamide Gel, Epitopes/analysis, Lipopolysaccharides/*immunology, Lymphocyte Activation, Mice, Precipitin TestsEnzymology
1706826Comparative studies of the outer membranes of Bacteroides gingivalis, strains ATCC 33277, W50, W83, 381.Kennell W, Holt SCOral Microbiol Immunol10.1111/j.1399-302x.1990.tb00409.x1990Autoradiography, Bacterial Outer Membrane Proteins/*isolation & purification, Bacteroides/*classification/immunology, Cell Membrane/drug effects, Electrophoresis, Polyacrylamide Gel, Hot Temperature, Octoxynol, Periodontal Diseases/microbiology, Polyethylene Glycols/pharmacology, Sarcosine/analogs & derivatives/pharmacology, Species SpecificityPhylogenyEnzymology
1708119SDS-PAGE analysis of protein and lipopolysaccharide of extracellular vesicules and Sarkosyl-insoluble membranes from Bacteroides gingivalis.Deslauriers M, ni Eidhin D, Lamonde L, Mouton COral Microbiol Immunol10.1111/j.1399-302x.1990.tb00217.x1990Bacterial Outer Membrane Proteins/*analysis, Bacteroides/*immunology, Cell Fractionation/methods, Electrophoresis, Polyacrylamide Gel, Lipopolysaccharides/*analysis, Malate Dehydrogenase, Muramic Acids, Sarcosine/analogs & derivativesEnzymology
1830621Serological studies of Porphyromonas (Bacteroides) gingivalis and correlation with enzyme activity.Nagata A, Man-yoshi T, Sato M, Nakamura RJ Periodontal Res10.1111/j.1600-0765.1991.tb01644.x1991Anti-Bacterial Agents/pharmacology, Antibodies, Bacterial, Antigens, Bacterial/analysis, Bacteroides/classification/drug effects/enzymology/*immunology, DNA, Bacterial/analysis, Gingival Crevicular Fluid/microbiology, Humans, Immunodiffusion, Immunoelectrophoresis, Microbial Sensitivity Tests, Peptide Hydrolases/metabolism, Periodontitis/*microbiology, SerotypingEnzymologyPathogenicity
1855992Humoral immune response to an antigen from Porphyromonas gingivalis 381 in periodontal disease.Kurihara H, Nishimura F, Nakamura T, Nakagawa M, Tanimoto I, Nomura Y, Kokeguchi S, Kato K, Murayama YInfect Immun10.1128/iai.59.8.2758-2762.19911991Antibodies, Bacterial/*immunology, Antibodies, Monoclonal/immunology, Antigens, Bacterial/blood/*immunology, Bacteroides/*immunology, Bacteroides Infections/*immunology/microbiology, Blotting, Western, Humans, Immunohistochemistry, Periodontitis/*microbiologyPathogenicity
2037355Hemolytic activity in the periodontopathogen Porphyromonas gingivalis: kinetics of enzyme release and localization.Chu L, Bramanti TE, Ebersole JL, Holt SCInfect Immun10.1128/iai.59.6.1932-1940.19911991Animals, Bacterial Outer Membrane Proteins/metabolism, Bacteroides/*enzymology/physiology, Heme/pharmacology, Hemolysin Proteins/*metabolism/physiology, Hemolysis/*drug effects, Hemolytic Plaque Technique, Humans, Kinetics, Oligopeptides/pharmacology, Rabbits, Serine Proteinase Inhibitors/pharmacology, Sheep, Sulfhydryl Reagents/pharmacologyEnzymologyPathogenicity
2098697Effect of Actinobacillus actinomycetemcomitans, Wolinella recta and Bacteroides gingivalis on the viability of retinoic acid-induced and dimethyl sulfoxide-induced HL-60 cells.Armitage GC, Holt SCOral Microbiol Immunol10.1111/j.1399-302x.1990.tb00420.x1990Actinobacillus/*immunology, Bacteroides/*immunology, Cell Differentiation, Dimethyl Sulfoxide, Granulocytes/*immunology, Humans, Leukemia, Promyelocytic, Acute, Opsonin Proteins, Periodontal Diseases/microbiology, Tretinoin, Tumor Cells, CulturedPathogenicity
2098698Interaction of gram-negative periodontal pathogens with retinoic acid-induced and dimethyl sulfoxide-induced HL-60 cells.Armitage GC, Holt SCOral Microbiol Immunol10.1111/j.1399-302x.1990.tb00421.x1990Actinobacillus/*immunology, Bacterial Adhesion, Bacteroides/*immunology, Cell Differentiation, Dimethyl Sulfoxide, Granulocytes/*immunology, Humans, Immunohistochemistry, Leukemia, Promyelocytic, Acute, Opsonin Proteins, Periodontal Diseases/microbiology, Tretinoin, Tumor Cells, CulturedPathogenicity
2098717Purification and characterization of a 43-kDa protease of Bacteroides gingivalis.Fujimura S, Nakamura TOral Microbiol Immunol10.1111/j.1399-302x.1990.tb00441.x1990Bacteroides/*enzymology, Electrophoresis, Polyacrylamide Gel, Endopeptidases/*isolation & purification, Molecular WeightEnzymologyPhylogeny
2099288Purification and characterization of two major outer membrane proteins from Porphyromonas gingivalis.Kokeguchi S, Kato K, Kurihara H, Nishimura F, Murayama YDent Jpn (Tokyo)1990Bacterial Outer Membrane Proteins/*isolation & purification, *Bacteroides, Electrophoresis, Electrophoresis, Polyacrylamide Gel, Humans, Periodontitis/*microbiologyEnzymologyPathogenicity
2524566Failure of Bacteroides gingivalis W83 to accumulate bound C3 following opsonization with serum.Schenkein HAJ Periodontal Res10.1111/j.1600-0765.1989.tb00853.x1989Actinobacillus/metabolism, Bacteroides/enzymology/*metabolism, Blood, Complement Activation/drug effects, Complement C3/*metabolism, Humans, Iodine Radioisotopes, Opsonin Proteins, Peptide Hydrolases/metabolism, Protease Inhibitors/pharmacology, Protein Binding/drug effectsMetabolismPathogenicity
2562410[Serological classification of Bacteroides gingivalis and purification of group specific antigens].Ishikawa E, Kumada H, Umemoto TShika Kiso Igakkai Zasshi10.2330/joralbiosci1965.31.6471989Antigens, Bacterial/*isolation & purification, Immunodiffusion, Porphyromonas gingivalis/*classification/immunology, SerotypingPhylogenyEnzymology
2563258Immunochemical identification and preliminary characterization of a nonfimbrial hemagglutinating adhesin of Bacteroides gingivalis.Mouton C, Bouchard D, Deslauriers M, Lamonde LInfect Immun10.1128/iai.57.2.566-573.19891989Antibodies, Bacterial/biosynthesis, Antibody Specificity, Antigens, Bacterial/analysis/immunology, Bacterial Outer Membrane Proteins/*analysis/immunology/physiology, Bacteroides/*analysis/immunology, Binding, Competitive, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Fimbriae, Bacterial, Hemagglutination Tests, Hemagglutinins/*analysis/immunology/physiology, Humans, Immunoblotting, Immunoelectrophoresis, Two-DimensionalEnzymologyPathogenicity
2640312Chemical characterization and biologic properties of lipopolysaccharide from Bacteroides gingivalis strains W50, W83, and ATCC 33277.Bramanti TE, Wong GG, Weintraub ST, Holt SCOral Microbiol Immunol10.1111/j.1399-302x.1989.tb00250.x1989Bacterial Outer Membrane Proteins/analysis, *Bacteroides, Interleukin-1/metabolism, Lipopolysaccharides/*analysis/metabolism, Prostaglandins/metabolism, Tumor Necrosis Factor-alpha/metabolismMetabolism
2656978Antibodies to Bacteroides gingivalis in patients with treated and untreated periodontal disease.Murray PA, Burstein DA, Winkler JRJ Periodontol10.1902/jop.1989.60.2.961989Adult, Antibodies, Bacterial/*analysis, Antigens, Bacterial/analysis, Bacteroides/*immunology, Blood, Blotting, Western, Electrophoresis, Polyacrylamide Gel, Gingival Crevicular Fluid/immunology, Gingivitis/immunology/*microbiology, Humans, Immunoglobulin G/*analysis, Middle Aged, Periodontitis/immunology/*microbiology/therapyEnzymologyPathogenicity
2701119Multiple forms of proteases of Bacteroides gingivalis and their cellular location.Fujimura S, Nakamura TOral Microbiol Immunol10.1111/j.1399-302x.1989.tb00257.x1989Bacteroides/*enzymology, Peptide Hydrolases/*analysisEnzymology
2807524Surface location of a Bacteroides gingivalis glycylprolyl protease.Grenier D, McBride BCInfect Immun10.1128/iai.57.11.3265-3269.19891989Bacterial Outer Membrane Proteins/metabolism, Bacteroides/*enzymology/ultrastructure, Blotting, Western, Cell Compartmentation, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/immunology/*metabolism, Endopeptidase K, Enzyme-Linked Immunosorbent Assay, Extracellular Space/enzymology, Immunohistochemistry, Molecular Weight, Serine Endopeptidases/pharmacologyMetabolismEnzymology
3316034Isolation of a membrane-associated Bacteroides gingivalis glycylprolyl protease.Grenier D, McBride BCInfect Immun10.1128/iai.55.12.3131-3136.19871987Bacterial Outer Membrane Proteins/*isolation & purification, Bacteroides/*enzymology, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/*isolation & purification, Electrophoresis, Polyacrylamide Gel, Glycine, Hot Temperature, Hydrogen-Ion Concentration, Metals/pharmacology, Peptide Hydrolases, Proline, Protease Inhibitors, Serine Endopeptidases/*isolation & purification, Substrate Specificity, TemperatureEnzymologyPhylogeny
3546137Isolation and characterization of a protease from Bacteroides gingivalis.Fujimura S, Nakamura TInfect Immun10.1128/iai.55.3.716-720.19871987Arginine/analogs & derivatives/metabolism, Bacterial Proteins/antagonists & inhibitors/*isolation & purification/metabolism, Bacteroides/*enzymology, Cations, Divalent/pharmacology, Molecular Weight, Peptide Hydrolases/*isolation & purification/metabolism, Protease Inhibitors/pharmacology, Substrate SpecificityPhylogenyMetabolism
7559528Construction and characterization of arginine-specific cysteine proteinase (Arg-gingipain)-deficient mutants of Porphyromonas gingivalis. Evidence for significant contribution of Arg-gingipain to virulence.Nakayama K, Kadowaki T, Okamoto K, Yamamoto KJ Biol Chem10.1074/jbc.270.40.236191995Adhesins, Bacterial, Adult, Amino Acid Sequence, Bacteroidaceae Infections/etiology, Base Sequence, Coumarins/chemistry, Cysteine Endopeptidases/*genetics/metabolism, DNA Probes/genetics, DNA, Bacterial/genetics, Genes, Bacterial, Gingipain Cysteine Endopeptidases, Hemagglutinins/genetics, Humans, Molecular Sequence Data, Mutation, Oligopeptides/chemistry, Periodontitis/etiology, Plasmids/genetics, Porphyromonas gingivalis/*enzymology/*genetics/pathogenicity, Substrate Specificity, Virulence/genetics/physiologyPathogenicityGenetics
7623254Protective immunity to Porphyromonas gingivalis infection in a murine model.Bird PS, Gemmell E, Polak B, Paton RG, Sosroseno W, Seymour GJJ Periodontol10.1902/jop.1995.66.5.3511995Analysis of Variance, Animals, Antibodies, Bacterial/biosynthesis/blood, Antigens, Bacterial/isolation & purification, Bacterial Outer Membrane Proteins/immunology, *Bacterial Vaccines, Bacteroidaceae Infections/immunology/*prevention & control, Blotting, Western, CD4 Lymphocyte Count, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Female, Male, Mice, Mice, Inbred BALB C, Periodontal Abscess/immunology/microbiology/*prevention & control, Porphyromonas gingivalis/*immunology, VaccinationEnzymologyPhylogeny
7623256Serum antibodies to Porphyromonas gingivalis in children.Sixou JL, Bonnaure-Mallet M, Mouton CJ Periodontol10.1902/jop.1995.66.5.3691995Adolescent, Antibodies, Bacterial/*blood, Antigens, Bacterial/immunology, Antigens, Surface/immunology, Cell Membrane/immunology, Child, Child, Preschool, Dentition, Mixed, Enzyme-Linked Immunosorbent Assay, Female, Fluorescent Antibody Technique, Humans, Immunoglobulin A/blood, Immunoglobulin G/blood, Immunoglobulin M/blood, Infant, Lipopolysaccharides/immunology, Male, Mouth/*microbiology, Porphyromonas gingivalis/*immunology/isolation & purification, Tooth, DeciduousPathogenicityEnzymology
7740086Sensitivity of Porphyromonas and Prevotella species in liquid media to argon laser.Henry CA, Judy M, Dyer B, Wagner M, Matthews JLPhotochem Photobiol10.1111/j.1751-1097.1995.tb08631.x1995Argon, In Vitro Techniques, Lasers, Periodontal Diseases/etiology/therapy, Phototherapy, Porphyromonas/metabolism/pathogenicity/*radiation effects, Prevotella/metabolism/pathogenicity/*radiation effects, Protoporphyrins/metabolismMetabolism
7823276Contaminated implant surfaces: an in vitro comparison of implant surface coating and treatment modalities for decontamination.Dennison DK, Huerzeler MB, Quinones C, Caffesse RGJ Periodontol10.1902/jop.1994.65.10.9421994Air, Chlorhexidine/administration & dosage, Citrates/administration & dosage, Citric Acid, Decontamination/*methods, *Dental Implants, Dental Polishing/methods, Dental Prosthesis Design, Durapatite/chemistry, Equipment Contamination/prevention & control, Iodine Radioisotopes, Lipopolysaccharides/chemistry, Porphyromonas gingivalis, Powders, Surface Properties, Titanium/chemistry, Water
7894713Congo red binding by Porphyromonas gingivalis is mediated by a 66 kDa outer-membrane protein.Smalley JW, Birss AJ, McKee AS, Marsh PDMicrobiology (Reading)10.1099/00221287-141-1-2051995Bacterial Outer Membrane Proteins/isolation & purification/*metabolism, Congo Red/*metabolism, Electrophoresis, Polyacrylamide Gel, Endopeptidases/pharmacology, Genetic Variation, Kinetics, Molecular Weight, Polymyxin B/pharmacology, Porphyromonas/metabolism, Porphyromonas gingivalis/genetics/*metabolism/pathogenicity, Protein Binding, Species SpecificityEnzymologyMetabolism
7909537Construction and characterization of a fimA mutant of Porphyromonas gingivalis.Hamada N, Watanabe K, Sasakawa C, Yoshikawa M, Yoshimura F, Umemoto TInfect Immun10.1128/iai.62.5.1696-1704.19941994Bacterial Adhesion, Bacterial Proteins/*genetics, Fibroblasts/microbiology, *Fimbriae Proteins, *Fimbriae, Bacterial, Gingiva/microbiology, Hemagglutination, Humans, Mutation, Porphyromonas gingivalis/*genetics/pathogenicityPathogenicity
7936722Polymerase chain reaction for the identification of Porphyromonas gingivalis collagenase genes.Bodinka A, Schmidt H, Henkel B, Flemmig TF, Klaiber B, Karch HOral Microbiol Immunol10.1111/j.1399-302x.1994.tb00053.x1994Bacterial Proteins/*genetics, Collagenases/*genetics, DNA Probes, Dental Plaque/microbiology, *Genes, Bacterial, Humans, Periodontitis/*microbiology, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Porphyromonas gingivalis/*genetics/pathogenicity, VirulencePathogenicity
7981094Porphyromonas gingivicanis sp. nov. and Porphyromonas crevioricanis sp. nov., isolated from beagles.Hirasawa M, Takada KInt J Syst Bacteriol10.1099/00207713-44-4-6371994Animals, DNA, Bacterial/analysis, Dogs/*microbiology, Gingiva/microbiology, Porphyromonas/genetics/*isolation & purification/metabolismPhylogenyEnzymology
7996082Dentin permeability to bacterial proteins in vitro.Pissiotis E, Spangberg LSJ Endod10.1016/S0099-2399(06)80055-51994Bacterial Proteins/*metabolism, Biological Transport, *Dentin Permeability, Diffusion, Humans, Hydrostatic Pressure, Models, Biological, *Porphyromonas gingivalisPathogenicityMetabolism
8008436Clonal analysis of Porphyromonas gingivalis by the arbitrarily primed polymerase chain reaction.Chen C, Slots JOral Microbiol Immunol10.1111/j.1399-302x.1994.tb00042.x1994Bacterial Typing Techniques, Base Sequence, DNA Fingerprinting/*methods, DNA Primers, Electrophoresis, Polyacrylamide Gel, Genotype, Molecular Sequence Data, Polymerase Chain Reaction/*methods, Polymorphism, Genetic, Porphyromonas gingivalis/classification/*geneticsGeneticsEnzymology
8106951Distribution of Porphyromonas gingivalis in adult periodontitis patients.Kojima T, Yasui S, Ishikawa IJ Periodontol10.1902/jop.1993.64.12.12311993Adult, Aged, Cross-Sectional Studies, DNA Probes, Dental Plaque/microbiology, Female, Humans, Male, Middle Aged, Periodontal Index, Periodontitis/*microbiology, Porphyromonas gingivalis/genetics/*isolation & purificationPathogenicityEnzymology
8186085Porphyromonas canoris sp. nov., an asaccharolytic, black-pigmented species from the gingival sulcus of dogs.Love DN, Karjalainen J, Kanervo A, Forsblom B, Sarkiala E, Bailey GD, Wigney DI, Jousimies-Somer HInt J Syst Bacteriol10.1099/00207713-44-2-2041994Animals, Bacterial Typing Techniques, Carbohydrate Metabolism, DNA, Bacterial, Dental Plaque/*microbiology, Dogs, Fatty Acids/analysis, Gingiva/*microbiology, Gingival Diseases/microbiology/*veterinary, Nucleic Acid Hybridization, Pigments, Biological, Porphyromonas/*classification/isolation & purificationPhylogenyMetabolism
8195974Flow-cytometric identification and detection of Porphyromonas gingivalis by a LPS specific monoclonal antibody.Kamiya I, Okuda K, Hara KJ Periodontol10.1902/jop.1994.65.4.3091994Analysis of Variance, Antibodies, Monoclonal, Colony Count, Microbial/*methods, Confidence Intervals, Dental Plaque/*microbiology, Flow Cytometry/*methods, Fluorescein-5-isothiocyanate, Fluorescent Antibody Technique, Linear Models, Lipopolysaccharides/*immunology, Porphyromonas gingivalis/immunology/*isolation & purification, Sensitivity and SpecificityEnzymologyPhylogeny
8208139Biochemical properties of the major outer membrane proteins of Porphyromonas gingivalis.Kokeguchi S, Miyamoto M, Ohyama H, Hongyo H, Takigawa M, Kurihara H, Murayama Y, Kato KMicrobios1994Amino Acid Sequence, Amino Acids/analysis, Antibodies, Monoclonal, Antibody Specificity, Bacterial Outer Membrane Proteins/*chemistry/immunology/isolation & purification, Humans, Immune Sera, Molecular Sequence Data, Molecular Weight, Periodontitis/immunology, Porphyromonas gingivalis/*chemistry, Sequence Analysis, Sequence Homology, Amino AcidPathogenicityGenetics
8258706Inhibition of C3 and IgG proteolysis enhances phagocytosis of Porphyromonas gingivalis.Cutler CW, Arnold RR, Schenkein HAJ Immunol1993Antibodies, Bacterial/metabolism, Bacteroidaceae Infections/etiology, Cold Temperature, Complement C3/*metabolism, Complement Pathway, Classical, Endopeptidases/metabolism, Humans, Immunoglobulin G/*metabolism, In Vitro Techniques, Isoflurophate/pharmacology, Neutrophils/enzymology/immunology, Opsonin Proteins/metabolism, Periodontitis/etiology, *Phagocytosis, Porphyromonas gingivalis/*immunology/pathogenicity, Species Specificity, VirulenceMetabolismPathogenicity
8288103Hemolytic toxin produced by Porphyromonas gingivalis.Hoshi M, Kato I, Goto N, Hasegawa KFEMS Microbiol Lett10.1111/j.1574-6968.1993.tb06585.x1993Cold Temperature, Erythrocytes/*drug effects, Hemoglobins/pharmacology, Hemolysin Proteins/drug effects/*metabolism/pharmacology, Hemolysis/drug effects/*physiology, Hot Temperature, Porphyromonas gingivalis/*metabolism, Trypsin/pharmacologyPathogenicityMetabolism
8392971Characterization of recombinant and native forms of a cell surface antigen of Porphyromonas (Bacteroides) gingivalis.Joe A, Yamamoto A, McBride BCInfect Immun10.1128/iai.61.8.3294-3303.19931993Amino Acid Sequence, Antigens, Bacterial/*analysis/chemistry/genetics, Antigens, Surface/analysis/chemistry/genetics, Blotting, Southern, Blotting, Western, Molecular Sequence Data, Porphyromonas gingivalis/genetics/*immunology, Promoter Regions, Genetic, Recombinant Proteins/analysis/chemistry/genetics, Species SpecificityGeneticsPhylogeny
8569538Effect of Porphyromonas gingivalis ATCC 33277 vesicle on adherence of Streptococcus mutans OMZ 70 to the experimental pellicle.Kamaguchi A, Baba H, Hoshi M, Inomata KMicrobiol Immunol10.1111/j.1348-0421.1995.tb02237.x1995Animals, Bacterial Adhesion/*physiology, Bacterial Outer Membrane Proteins/metabolism, Blood/metabolism, Collagen/metabolism, *Durapatite, Organelles/*metabolism, Porphyromonas gingivalis/*metabolism, Rabbits, Rats, Saliva/metabolism, Streptococcus mutans/*physiologyMetabolism
8602330Immunodominant antigens of Porphyromonas gingivalis in patients with rapidly progressive periodontitis.Chen HA, Weinberg A, Darveau RP, Engel D, Page RCOral Microbiol Immunol10.1111/j.1399-302x.1995.tb00142.x1995Adult, Antibodies, Bacterial/blood, Antigens, Bacterial/analysis/*immunology, Bacterial Outer Membrane Proteins/analysis/immunology, Binding Sites, Antibody, Binding, Competitive, Blotting, Western, Case-Control Studies, Humans, Immunoblotting, Immunodominant Epitopes/analysis/*immunology, Immunoglobulin G/blood, Lipopolysaccharides/immunology, Male, Periodontal Pocket/immunology/microbiology, Periodontitis/*immunology/*microbiology, Polysaccharides, Bacterial/immunology, Porphyromonas gingivalis/*immunology, SerotypingPathogenicity
8631659Analysis of the prtP gene encoding porphypain, a cysteine proteinase of Porphyromonas gingivalis.Barkocy-Gallagher GA, Han N, Patti JM, Whitlock J, Progulske-Fox A, Lantz MSJ Bacteriol10.1128/jb.178.10.2734-2741.19961996Amino Acid Sequence, Bacterial Proteins, Binding Sites, Cloning, Molecular, Cysteine Endopeptidases/*genetics/metabolism, Gene Dosage, *Genes, Bacterial, Molecular Sequence Data, Porphyromonas gingivalis/enzymology/*genetics, Repetitive Sequences, Nucleic Acid, Sequence Analysis, Sequence Homology, Amino Acid, Species Specificity, Substrate SpecificityEnzymologyGenetics
8641806Selection and phenotypic characterization of nonhemagglutinating mutants of Porphyromonas gingivalis.Chandad F, Mayrand D, Grenier D, Hinode D, Mouton CInfect Immun10.1128/iai.64.3.952-958.19961996Adhesins, Bacterial/analysis, Animals, Bacterial Proteins/analysis, Fimbriae, Bacterial/physiology, Hemagglutination, Lectins/metabolism, Microscopy, Immunoelectron, Mutation, Phenotype, Porphyromonas gingivalis/chemistry/immunology/*physiology, RabbitsPhenotypeMetabolism
8689741Cell surface polysaccharide and protein antigens of an encapsulated Porphyromonas gingivalis 16-1 strain.Ro M, Naito Y, Okuda KBull Tokyo Dent Coll1995Antigens, Bacterial/*chemistry/immunology/isolation & purification, Bacterial Outer Membrane Proteins/*chemistry/immunology/isolation & purification, Humans, Immunodiffusion, Immunodominant Epitopes, Lipopolysaccharides/chemistry, Molecular Weight, Polysaccharides, Bacterial/*chemistry/isolation & purification, Porphyromonas gingivalis/chemistry/*immunology/pathogenicity, VirulenceEnzymologyPhylogeny
8705837Modulation of host matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases.Ding Y, Uitto VJ, Firth J, Salo T, Haapasalo M, Konttinen YT, Sorsa TOral Dis10.1111/j.1601-0825.1995.tb00194.x1995Adult, Animals, Bacterial Proteins/metabolism/*pharmacology, Cell Degranulation, Cells, Cultured, Dental Plaque/microbiology, Enzyme Induction, Gelatinases/biosynthesis, Gingiva/enzymology, Gingival Crevicular Fluid/enzymology, Humans, Metalloendopeptidases/*biosynthesis, Neutrophils/drug effects/metabolism, Periodontal Ligament/enzymology, Periodontitis/*enzymology/*microbiology, Phosphatidylinositol Diacylglycerol-Lyase, Phosphatidylinositols, Phosphoinositide Phospholipase C, Phosphoric Diester Hydrolases/*pharmacology, Porphyromonas gingivalis/enzymology/pathogenicity, Swine, Treponema/enzymology/pathogenicity, Type C Phospholipases/metabolism/*pharmacology, VirulenceEnzymologyPathogenicity
8724707In vitro permeability evaluation and colonization of membranes for periodontal regeneration by Porphyromonas gingivalis.Ricci G, Rasperini G, Silvestri M, Cocconcelli PSJ Periodontol10.1902/jop.1996.67.5.4901996*Bacterial Adhesion, Biofilms/*growth & development, Colony Count, Microbial, Guided Tissue Regeneration, Periodontal, Humans, *Membranes, Artificial, Microscopy, Electron, Scanning, Periodontal Diseases/*microbiology/surgery, Permeability, Porosity, Porphyromonas gingivalis/isolation & purification/*physiologyPathogenicityEnzymology
8890240Isolation and characterization of a minor fimbria from Porphyromonas gingivalis.Hamada N, Sojar HT, Cho MI, Genco RJInfect Immun10.1128/iai.64.11.4788-4794.19961996Amino Acids/analysis, Bacterial Adhesion, Bacterial Proteins/analysis/*chemistry/isolation & purification/physiology, *Fimbriae Proteins, Fimbriae, Bacterial/chemistry/physiology/*ultrastructure, Hemagglutination, Hot Temperature, Immunoblotting, Immunohistochemistry, Isoelectric Point, Molecular Weight, Porphyromonas gingivalis/chemistry/*ultrastructurePhylogenyStress
8915950Strong cytotoxicity to human gingival fibroblasts by Porphyromonas gingivalis ATCC 33277.Johansson A, Bergenholtz A, Holm SEJ Periodontal Res10.1111/j.1600-0765.1996.tb01412.x1996Aggregatibacter actinomycetemcomitans/*pathogenicity, Cell Death, Cells, Cultured, Culture Media, Conditioned/toxicity, Cytotoxins, Epithelial Cells, Epithelium/drug effects/microbiology, Fibroblasts/drug effects/metabolism/microbiology, Fusobacterium nucleatum/*pathogenicity, Gingiva/cytology/drug effects/*microbiology, HeLa Cells/drug effects/metabolism/microbiology, Humans, Immune Sera, Neutral Red, Porphyromonas gingivalis/*pathogenicityPathogenicityCultivation
8935092Characterization of coaggregation and fibrinogen-binding by Porphyromonas gingivalis.Nagata H, Tazaki K, Amano A, Hanioka T, Tamagawa H, Shizukuishi SJ Osaka Univ Dent Sch1994Adhesins, Bacterial/physiology, Amino Acids/metabolism, Bacterial Adhesion/drug effects/*physiology, Carbohydrate Metabolism, Ecosystem, Endopeptidases/metabolism, Fibrinogen/*metabolism, Fimbriae, Bacterial/physiology, Hot Temperature, Hydrogen-Ion Concentration, Metals/pharmacology, Porphyromonas gingivalis/chemistry/drug effects/*physiology, Protein Binding/drug effects/physiology, Species Specificity, Streptococcus/chemistry/drug effects/physiologyMetabolismPathogenicity
8997682Porphyromonas gingivalis reduces mitogenic and chemotactic responses of human periodontal ligament cells to platelet-derived growth factor in vitro.Matsuda N, Takemura A, Taniguchi S, Amano A, Shizukuishi SJ Periodontol10.1902/jop.1996.67.12.13351996Bacterial Proteins/*metabolism, Becaplermin, Binding Sites, Cells, Cultured, Chemotaxis/*drug effects, Culture Media, Conditioned/pharmacology, Fibroblasts/cytology/drug effects/physiology, Humans, Mitosis/drug effects, Periodontal Ligament/cytology/drug effects/*physiology, Platelet-Derived Growth Factor/*antagonists & inhibitors, Porphyromonas gingivalis/chemistry/*pathogenicity, Proto-Oncogene Proteins c-sis, Receptors, Platelet-Derived Growth Factor/drug effects/*metabolism, Recombinant Proteins/antagonists & inhibitors, Regeneration/drug effects/physiology, Stimulation, Chemical, VirulencePathogenicityMetabolism
9284166Fimbriae and the hemagglutinating adhesin HA-Ag2 mediate adhesion of Porphyromonas gingivalis to epithelial cells.Du L, Pellen-Mussi P, Chandad F, Mouton C, Bonnaure-Mallet MInfect Immun10.1128/iai.65.9.3875-3881.19971997Adhesins, Bacterial/chemistry/*immunology, Animals, Antibodies, Bacterial/immunology, Antibodies, Monoclonal/immunology, *Bacterial Adhesion, Blotting, Western, Cells, Cultured, Epithelium/microbiology, Fimbriae, Bacterial/*physiology, Flow Cytometry, Humans, Immunoelectrophoresis, Two-Dimensional, Isoelectric Point, Mice, Microscopy, Electron, Scanning, Porphyromonas gingivalis/*pathogenicity, RabbitsPathogenicityEnzymology
9345789Fermentation product analysis in the identification of black-pigmented bacteria from periodontitis.Takada K, Hirasawa MMicrobios1997Antibodies, Bacterial/analysis/immunology, Antigens, Bacterial/analysis/immunology, Bacteriological Techniques, Chromatography, Gas, Culture Media/*analysis/metabolism, Electrophoresis, Polyacrylamide Gel, Fatty Acids/*analysis/metabolism, Fermentation, Gram-Negative Anaerobic Bacteria/growth & development/immunology/*metabolism, Humans, Immunodiffusion, Periodontitis/*microbiologyMetabolismEnzymology
9354029Anti-bacterial action of onion (Allium cepa L.) extracts against oral pathogenic bacteria.Kim JHJ Nihon Univ Sch Dent10.2334/josnusd1959.39.13619971-Butanol/chemistry, Acetic Acid, Adult, Alkalies/pharmacology, Anti-Bacterial Agents/analysis/antagonists & inhibitors/*pharmacology, Cellulose, Chromatography, Thin Layer, Culture Media, Cysteine/pharmacology, Dental Caries/microbiology, Humans, Indicators and Reagents, Ninhydrin, *Onions/chemistry, Periodontitis/microbiology, Plant Extracts/analysis/antagonists & inhibitors/*pharmacology, Porphyromonas gingivalis/*drug effects, Prevotella intermedia/*drug effects, Solvents/chemistry, Steam, Streptococcus mutans/*drug effects, Streptococcus sobrinus/*drug effects, Time FactorsPathogenicityCultivation
9467382Immunohistological study of lesions induced by Porphyromonas gingivalis in a murine model.Gemmell E, Bird PS, Bowman JJ, Xu L, Polak B, Walsh LJ, Seymour GJOral Microbiol Immunol10.1111/j.1399-302x.1997.tb00393.x1997Analysis of Variance, Animals, Antigens, Bacterial/immunology, Bacterial Outer Membrane Proteins/immunology, CD4-CD8 Ratio, CD4-Positive T-Lymphocytes/*immunology, CD8-Positive T-Lymphocytes/*immunology, Disease Models, Animal, Female, Macrophage Activation, Macrophages/enzymology/immunology, Male, Mice, Mice, Inbred BALB C, Neutrophils/enzymology/immunology, Porphyromonas gingivalis/*immunology, Time Factors, Wound Healing/immunologyEnzymology
9524073Genetic variation of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity.Mikolajczyk-Pawlinska J, Kordula T, Pavloff N, Pemberton PA, Chen WC, Travis J, Potempa JBiol Chem10.1515/bchm.1998.379.2.2051998Adhesins, Bacterial, Amino Acid Sequence, Arginine/*genetics, Base Sequence, Binding Sites, Cloning, Molecular, Cysteine Endopeptidases/*genetics, DNA, Bacterial, *Genes, Bacterial, *Genetic Variation, Gingipain Cysteine Endopeptidases, Hemagglutinins/*genetics, Humans, Lysine/*genetics, Molecular Sequence Data, Porphyromonas gingivalis/*enzymology/genetics, Sequence Analysis, DNAEnzymologyPathogenicity
9573091Binding of Porphyromonas gingivalis fimbriae to proline-rich glycoproteins in parotid saliva via a domain shared by major salivary components.Amano A, Shizukuishi S, Horie H, Kimura S, Morisaki I, Hamada SInfect Immun10.1128/IAI.66.5.2072-2077.19981998Adult, Amino Acid Sequence, *Bacterial Adhesion, Fimbriae, Bacterial/*physiology, Humans, Male, Molecular Sequence Data, Parotid Gland/*microbiology, Peptides/*physiology, Porphyromonas gingivalis/*physiology, Proline-Rich Protein Domains, Saliva/*microbiology, Salivary Proteins and Peptides/*physiologyPathogenicityGenetics
9579624Dynamics of serum immunoglobulin G avidity for Porphyromonas gingivalis in adult periodontitis.Takahashi J, Saito A, Nakagawa T, Yamada S, Ishihara K, Okuda KJ Periodontol10.1902/jop.1998.69.3.3671998Adult, Antibodies, Bacterial/biosynthesis/*blood/immunology, *Antibody Affinity, Antigens, Bacterial/immunology, Antigens, Surface/immunology, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Female, Fimbriae, Bacterial/immunology, Humans, Immunoblotting, Immunoglobulin G/biosynthesis/*blood/immunology, Lipopolysaccharides/immunology, Male, Middle Aged, Periodontitis/immunology/*microbiology, Periodontium/immunology/microbiology, Porphyromonas gingivalis/growth & development/*immunology, Sodium Dodecyl SulfateEnzymologyPathogenicity
9786323Adherence of Porphyromonas gingivalis to epithelial cells: analysis by flow cytometry.Huard-Delcourt A, Menard C, Du L, Pellen-Mussi P, Tricot-Doleux S, Bonnaure-Mallet MEur J Oral Sci10.1046/j.0909-8836.1998.eos106506.x1998*Bacterial Adhesion, Carcinoma/pathology, Carcinoma, Squamous Cell/pathology, Cell Count, Cells, Cultured, Epithelial Cells/cytology, Fibroblasts/cytology, Flow Cytometry, Fluorescein-5-isothiocyanate, Fluorescent Antibody Technique, Fluorescent Dyes, Gingiva/*cytology, Humans, Keratinocytes/cytology, Periodontitis/microbiology, Porphyromonas gingivalis/*physiology, Receptors, Cell Surface/physiology, Temperature, Time Factors, Tumor Cells, CulturedPathogenicity
9835745[A comparative in-vitro study of the bactericidal efficacy of sodium hypochlorite and chlorhexidine gluconate plus cetrimide on root canal anaerobic bacterial flora].D'Arcangelo C, Varvara GMinerva Stomatol1998Anti-Bacterial Agents/*pharmacology, Bacteria, Anaerobic/*drug effects, Cetrimonium, Cetrimonium Compounds/*pharmacology, Chlorhexidine/*analogs & derivatives/pharmacology, Dental Pulp Cavity/*microbiology, Humans, Microbial Sensitivity Tests/methods/statistics & numerical data, Root Canal Irrigants/*pharmacology, Sodium Hypochlorite/*pharmacology, Time FactorsPathogenicity
9842506Induction of matrix metalloproteinases and a collagen-degrading phenotype in fibroblasts and epithelial cells by secreted Porphyromonas gingivalis proteinase.DeCarlo AA, Grenett HE, Harber GJ, Windsor LJ, Bodden MK, Birkedal-Hansen B, Birkedal-Hansen HJ Periodontal Res10.1111/j.1600-0765.1998.tb02337.x1998Adhesins, Bacterial, Animals, Bacterial Proteins/metabolism, Base Sequence, Cells, Cultured, Collagen/metabolism, Culture Media, Conditioned, Cysteine Endopeptidases/*metabolism, Epithelial Cells/metabolism, Extracellular Matrix/metabolism, Fibroblasts/metabolism, Gingipain Cysteine Endopeptidases, Hemagglutinins/metabolism, Humans, Metalloendopeptidases/*biosynthesis, Molecular Sequence Data, Mouth Mucosa/metabolism, Periodontal Ligament/cytology/*metabolism, Periodontitis/*enzymology/microbiology, Porphyromonas gingivalis/*enzymology/pathogenicity, RNA, Messenger/analysis, Rats, Up-RegulationMetabolismCultivation
9864337Activities of the Porphyromonas gingivalis PrtP proteinase determined by construction of prtP-deficient mutants and expression of the gene in Bacteroides species.Barkocy-Gallagher GA, Foley JW, Lantz MSJ Bacteriol10.1128/JB.181.1.246-255.19991999Animals, Bacterial Proteins, Bacteroides/*genetics, Cloning, Molecular, Cysteine Endopeptidases/*genetics/*metabolism, Escherichia coli/genetics, Gene Expression, *Genes, Bacterial, Hemagglutination Tests, In Vitro Techniques, *Mutation, Plasmids/genetics, Porphyromonas gingivalis/*enzymology/*genetics, Recombinant Proteins/genetics/metabolismEnzymologyMetabolism
9871998Comparative study of two outer membrane protein genes from Porphyromonas gingivalis.Hongyo H, Kokeguchi S, Kurihara H, Miyamoto M, Maeda H, Takashiba S, Murayama YMicrobios1998Amino Acid Sequence, Antigens, Bacterial/genetics, Bacterial Outer Membrane Proteins/*genetics, Base Sequence, Cloning, Molecular, *Genes, Bacterial, Molecular Sequence Data, Open Reading Frames/genetics, Porphyromonas gingivalis/chemistry/*genetics/immunologyEnzymologyGenetics
9881462Tn4351-generated non-haemolytic and/or non-pigmented mutants of Porphyromonas gingivalis.Takada K, Hirasawa MMicrobios1998Blotting, Southern, DNA Transposable Elements/genetics, Drug Resistance, Microbial/genetics, Electrophoresis, Polyacrylamide Gel, Endopeptidases/genetics/metabolism, Escherichia coli/genetics, Genetic Vectors/genetics, Hemolysin Proteins/genetics/metabolism, Mutagenesis, Insertional, Phenotype, Pigments, Biological/deficiency, Porphyromonas gingivalis/enzymology/*genetics, Transformation, Bacterial/*geneticsEnzymologyMetabolism
10377121Genomic loci of the Porphyromonas gingivalis insertion element IS1126.Dong H, Chen T, Dewhirst FE, Fleischmann RD, Fraser CM, Duncan MJInfect Immun10.1128/IAI.67.7.3416-3423.19991999*DNA Transposable Elements, *Genome, Bacterial, Phylogeny, Porphyromonas gingivalis/*geneticsGeneticsPhylogeny
10384401Flow cytometry to monitor phagocytosis and oxidative burst of anaerobic periodontopathogenic bacteria by human polymorphonuclear leukocytes.Conrads G, Herrler A, Moonen I, Lampert F, Schnitzler NJ Periodontal Res10.1111/j.1600-0765.1999.tb02234.x1999Bacteria, Anaerobic/pathogenicity/*physiology, Coloring Agents, *Flow Cytometry, Fluorescence, Humans, Lasers, Microscopy, Confocal, Mouth/*microbiology, *Neutrophil Activation, Neutrophils/*metabolism, Periodontal Diseases/microbiology, Phagocytosis/*physiology, Porphyromonas gingivalis/pathogenicity/physiology, Prevotella/pathogenicity/physiology, Respiratory Burst, Rhodamines, Statistics, Nonparametric, VirulencePathogenicityMetabolism
10440639Soluble CD14-dependent intercellular adhesion molecular-1 induction by Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts.Masaka T, Hayashi J, Ishikawa IJ Periodontol10.1902/jop.1999.70.7.7721999Antibodies, Monoclonal, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Escherichia coli, Fibroblasts/*immunology, Gingiva/cytology/*immunology, Humans, Intercellular Adhesion Molecule-1/*biosynthesis, Lipopolysaccharide Receptors/*biosynthesis/blood, Lipopolysaccharides/*immunology, Macrophages/immunology, Monocytes/immunology, Periodontitis/immunology, Porphyromonas gingivalis/*immunologyPathogenicity
10530260An evaluation of the action of different root canal irrigants on facultative aerobic-anaerobic, obligate anaerobic, and microaerophilic bacteria.D'Arcangelo C, Varvara G, De Fazio PJ Endod10.1016/S0099-2399(06)81170-21999Anti-Infective Agents, Local/administration & dosage/*pharmacology, Bacteria, Anaerobic/*drug effects, Cetrimonium, Cetrimonium Compounds/administration & dosage/pharmacology, Chlorhexidine/administration & dosage/pharmacology, Colony Count, Microbial, Dose-Response Relationship, Drug, Edetic Acid/administration & dosage/pharmacology, Root Canal Irrigants/administration & dosage/*pharmacology, Sodium Hypochlorite/administration & dosage/pharmacologyPathogenicity
10531208Identification by subtractive hybridization of a novel insertion sequence specific for virulent strains of Porphyromonas gingivalis.Sawada K, Kokeguchi S, Hongyo H, Sawada S, Miyamoto M, Maeda H, Nishimura F, Takashiba S, Murayama YInfect Immun10.1128/IAI.67.11.5621-5625.19991999Amino Acid Sequence, Base Sequence, *DNA Transposable Elements, DNA, Bacterial/isolation & purification, Molecular Sequence Data, Nucleic Acid Hybridization, Porphyromonas gingivalis/*genetics/pathogenicity, VirulencePhylogenyGenetics
10553676Fimbria-mediated coaggregation between human oral anaerobes Treponema medium and Porphyromonas gingivalis.Umemoto T, Yoshimura F, Kureshiro H, Hayashi J, Noguchi T, Ogawa TMicrobiol Immunol10.1111/j.1348-0421.1999.tb01218.x1999Animals, Bacterial Adhesion/*physiology, Bacterial Proteins/chemistry, Blotting, Western, Electrophoresis, Polyacrylamide Gel, Fimbriae, Bacterial/*physiology/ultrastructure, Hot Temperature, Humans, Microscopy, Immunoelectron, Mouth Mucosa/*microbiology, Porphyromonas gingivalis/*physiology/ultrastructure, Rabbits, Treponema/chemistry/*physiology/ultrastructureEnzymologyStress
10603421Identification and cloning of genes from Porphyromonas gingivalis after mutagenesis with a modified Tn4400 transposon from Bacteroides fragilis.Chen T, Dong H, Tang YP, Dallas MM, Malamy MH, Duncan MJInfect Immun10.1128/IAI.68.1.420-423.20002000Adult, Bacteroides fragilis/*genetics, Base Sequence, Cloning, Molecular, DNA Primers/genetics, DNA Transposable Elements/*genetics, DNA, Bacterial/genetics, Escherichia coli/genetics, *Genes, Bacterial, Humans, Mutagenesis, Insertional, Mutation, Periodontitis/microbiology, Phenotype, Pigmentation/genetics, Porphyromonas gingivalis/*genetics/pathogenicity, Virulence/geneticsEnzymologyPathogenicity
10635221Survey for collagenase gene prtC in Porphyromonas gingivalis and Porphyromonas endodontalis isolated from endodontic infections.Odell LJ, Baumgartner JC, Xia T, David LLJ Endod10.1016/S0099-2399(99)80379-31999*Bacterial Proteins, Bacterial Typing Techniques, Bacteroidaceae Infections/microbiology, Collagenases/*genetics, DNA, Bacterial/genetics, Dental Pulp Cavity/microbiology, Dental Pulp Diseases/*microbiology, *Genes, Bacterial, Humans, Microbial Collagenase/*genetics, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Porphyromonas/classification/*enzymology/*genetics, Porphyromonas gingivalis/classification/enzymology/genetics, RNA, Ribosomal, 16S/geneticsPhylogenyPathogenicity
10678948Coinvasion of dentinal tubules by Porphyromonas gingivalis and Streptococcus gordonii depends upon binding specificity of streptococcal antigen I/II adhesin.Love RM, McMillan MD, Park Y, Jenkinson HFInfect Immun10.1128/IAI.68.3.1359-1365.20002000Adhesins, Bacterial/*physiology, Antigens, Bacterial/*physiology, Bacterial Adhesion, Fimbriae, Bacterial/physiology, Humans, Lectins/*physiology, Porphyromonas gingivalis/*pathogenicity, Streptococcus/*pathogenicity, Tooth/*microbiologyPathogenicity
10764615Pleiotropic pigmentation mutants of Porphyromonas gingivalis.Chen T, Dong H, Yong R, Duncan MJMicrob Pathog10.1006/mpat.1999.03382000Adhesins, Bacterial, Adult, Bacterial Adhesion, Blotting, Southern, Cysteine Endopeptidases/metabolism, DNA Transposable Elements, Epithelial Cells/microbiology, Fibrillins, Gingipain Cysteine Endopeptidases, Hemagglutination, Hemagglutinins/metabolism, Hemolysin Proteins/biosynthesis, Humans, Microfilament Proteins/metabolism, Microscopy, Electron, Mouth Mucosa/microbiology, *Mutation, Pigments, Biological/*genetics/metabolism, Porphyromonas gingivalis/genetics/metabolism/*pathogenicity/ultrastructureMetabolismPathogenicity
10790120Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene.Nakagawa I, Amano A, Kimura RK, Nakamura T, Kawabata S, Hamada SJ Clin Microbiol10.1128/JCM.38.5.1909-1914.20002000Adult, Amino Acid Sequence, Bacterial Proteins/chemistry/*genetics, Cloning, Molecular, Dental Plaque/*microbiology, *Fimbriae Proteins, Genetic Variation, Humans, Molecular Sequence Data, Periodontitis/*microbiology, *Phylogeny, Pili, Sex/genetics, Polymerase Chain Reaction, Porphyromonas gingivalis/classification/*genetics/isolation & purification, Sensitivity and Specificity, Sequence Alignment, Sequence Homology, Amino AcidPhylogenyEnzymology
10832973Identification of a two-component signal transduction system involved in fimbriation of Porphyromonas gingivalis.Hayashi J, Nishikawa K, Hirano R, Noguchi T, Yoshimura FMicrobiol Immunol10.1111/j.1348-0421.2000.tb02496.x2000Amino Acid Sequence, Bacterial Proteins/chemistry/genetics/metabolism, Base Sequence, DNA Transposable Elements, *DNA-Binding Proteins, Fimbriae, Bacterial/*genetics/*metabolism, Genes, Regulator, Molecular Sequence Data, Mutagenesis, Insertional, Mutation, Open Reading Frames, Porphyromonas gingivalis/genetics/*metabolism, *Repressor Proteins, Sequence Analysis, DNA, *Signal TransductionMetabolismGenetics
10940008Metabolic pathways for cytotoxic end product formation from glutamate- and aspartate-containing peptides by Porphyromonas gingivalis.Takahashi N, Sato T, Yamada TJ Bacteriol10.1128/JB.182.17.4704-4710.20002000Acetic Acid/metabolism, Acyl Coenzyme A/metabolism, Adenosine Triphosphate/biosynthesis, Amino Acids/metabolism, Ammonia/metabolism, Aspartic Acid/*metabolism, Butyrates/metabolism, Culture Media, Cytotoxins/*metabolism, Dipeptides/metabolism, Enzymes/metabolism, Glutamic Acid/*metabolism, NADP/metabolism, Oxidation-Reduction, Paraquat/metabolism, Peptides/*metabolism, Porphyromonas gingivalis/growth & development/*metabolism, Propionates/metabolismMetabolismCultivation
10951380Influence of surface modifications to titanium on oral bacterial adhesion in vitro.Yoshinari M, Oda Y, Kato T, Okuda K, Hirayama AJ Biomed Mater Res10.1002/1097-4636(200011)52:2<388::aid-jbm20>3.0.co;2-e2000Aggregatibacter actinomycetemcomitans, *Bacterial Adhesion, *Dental Materials, Humans, Oral Health, Porphyromonas gingivalis, Surface Properties, *TitaniumPathogenicity
11020256Clindamycin promotes phagocytosis and intracellular killing of periodontopathogenic bacteria by crevicular granulocytes: an in vitro study.Eick S, Pfister W, Fiedler D, Straube EJ Antimicrob Chemother10.1093/jac/46.4.5832000Adult, Aggregatibacter actinomycetemcomitans/*drug effects, Anti-Bacterial Agents/*pharmacology/therapeutic use, Clindamycin/*pharmacology/therapeutic use, Granulocytes/*drug effects/microbiology/physiology, Humans, Periodontitis/drug therapy/*microbiology, Phagocytosis/*drug effects, Porphyromonas gingivalis/*drug effects, Statistics, NonparametricPathogenicity
11073137Phagocytosis of periodontopathogenic bacteria by crevicular granulocytes is depressed in progressive periodontitis.Eick S, Pfister W, Sigusch B, Straube EInfection10.1007/s1501000700232000Aggregatibacter actinomycetemcomitans/*pathogenicity, Aggressive Periodontitis/*immunology/microbiology, Gingival Crevicular Fluid/*immunology, Humans, Neutrophils/*immunology, Phagocytosis, Porphyromonas gingivalis/*pathogenicityPathogenicity
11094282Purification and characterization of a novel secondary fimbrial protein from Porphyromonas gingivalis strain 381.Arai M, Hamada N, Umemoto TFEMS Microbiol Lett10.1111/j.1574-6968.2000.tb09405.x2000Amino Acid Sequence, Bacterial Proteins/*chemistry/genetics/*isolation & purification, *Fimbriae Proteins, Fimbriae, Bacterial/*chemistry/ultrastructure, Immunohistochemistry, Molecular Sequence Data, Molecular Weight, Mutation, Porphyromonas gingivalis/*chemistry/genetics/ultrastructureEnzymologyGenetics
11154423In vitro evaluation of the retention of three species of pathogenic microorganisms by three different types of toothbrush.Bunetel L, Tricot-Doleux S, Agnani G, Bonnaure-Mallet MOral Microbiol Immunol10.1034/j.1399-302x.2000.150508.x2000Candida albicans/*growth & development, Colony Count, Microbial, *Equipment Contamination, Equipment Design, Humans, Porphyromonas gingivalis/*growth & development, Risk Factors, Statistics as Topic, Streptococcus mutans/*growth & development, Surface Properties, Temperature, Time Factors, Toothbrushing/*instrumentationPathogenicity
11155164Adherence of Porphyromonas gingivalis to gingival epithelial cells: modulation of bacterial protein expression.Agnani G, Tricot-Doleux S, Du L, Bonnaure-Mallet MOral Microbiol Immunol10.1034/j.1399-302x.2000.150108.x2000Adhesins, Bacterial/*biosynthesis/chemistry, *Bacterial Adhesion, Epithelial Cells/*microbiology, Gene Expression Regulation, Bacterial, Humans, KB Cells, Microscopy, Electron, Scanning, Molecular Weight, Porphyromonas gingivalis/metabolism/*physiology, Substrate SpecificityPathogenicityMetabolism
11179300Interleukin-8 and intercellular adhesion molecule 1 regulation in oral epithelial cells by selected periodontal bacteria: multiple effects of Porphyromonas gingivalis via antagonistic mechanisms.Huang GT, Kim D, Lee JK, Kuramitsu HK, Haake SKInfect Immun10.1128/IAI.69.3.1364-1372.20012001Bacteroidaceae Infections/*immunology, Cells, Cultured, Coculture Techniques, Down-Regulation, Fusobacterium nucleatum/immunology, Gingiva/cytology/immunology, Intercellular Adhesion Molecule-1/*biosynthesis/genetics, Interleukin-8/genetics/*metabolism, Mouth Mucosa/cytology/*immunology, Porphyromonas gingivalis/*immunology, RNA, Messenger/biosynthesisMetabolism
11240860Acquisition of iron from human transferrin by Porphyromonas gingivalis: a role for Arg- and Lys-gingipain activities.Brochu V, Grenier D, Nakayama K, Mayrand DOral Microbiol Immunol10.1034/j.1399-302x.2001.016002079.x2001Adhesins, Bacterial/*metabolism, Cysteine Endopeptidases/*metabolism, Gingipain Cysteine Endopeptidases, Hemagglutinins/*metabolism, Humans, Iron/*metabolism, Mutagenesis, Site-Directed, Porphyromonas gingivalis/*enzymology/growth & development, Protease Inhibitors/metabolism, Transferrin/*metabolismMetabolismPathogenicity
11358538Kinetics of coaggregation of Porphyromonas gingivalis with Fusobacterium nucleatum using an automated microtiter plate assay.Metzger Z, Featherstone LG, Ambrose WW, Trope M, Arnold RROral Microbiol Immunol10.1034/j.1399-302x.2001.016003163.x2001Automation, Bacterial Adhesion/drug effects, *Bacteriological Techniques, Dose-Response Relationship, Drug, Fusobacterium nucleatum/classification/*cytology/drug effects, Galactose/administration & dosage/pharmacology, Humans, Kinetics, Porphyromonas gingivalis/classification/*cytology/drug effects, Sensitivity and Specificity, Statistics as Topic, TitrimetryPathogenicityEnzymology
11376959Comparative phospholipid analogue distributions of Porphyromonas gingivalis isolated from cats in Australia and the USA.Korachi M, Love D, Goldstein EJ, Citron DM, Blinkhorn AS, Boote V, Drucker DBVet Microbiol10.1016/s0378-1135(01)00310-82001Animals, Australia, Bacteroidaceae Infections/microbiology/*veterinary, Cat Diseases/*microbiology, Cats, Gas Chromatography-Mass Spectrometry/veterinary, Humans, Phospholipids/*metabolism, Porphyromonas gingivalis/*classification/*metabolism, Statistics, Nonparametric, United StatesPathogenicityMetabolism
11408950Inhibitory effect of lactoperoxidase-generated hypothiocyanite upon black pigmented anaerobe growth.Fadel M, Courtois PInt J Mol Med2001Analysis of Variance, Cell Division/drug effects, Glucose Oxidase/metabolism/pharmacology, Hydrogen Peroxide/metabolism, Hydrogen-Ion Concentration, Lactoperoxidase/metabolism/*pharmacology, Porphyromonas gingivalis/*drug effects/growth & development/metabolism, Prevotella/*drug effects/growth & development/metabolism, Prevotella melaninogenica/drug effects/growth & development/metabolism, Thiocyanates/metabolism/*pharmacology, Time FactorsMetabolismPathogenicity
11426884Influence of surface modifications to titanium on antibacterial activity in vitro.Yoshinari M, Oda Y, Kato T, Okuda KBiomaterials10.1016/s0142-9612(00)00392-62001Aggregatibacter actinomycetemcomitans/*drug effects/growth & development/physiology, Animals, Bacterial Adhesion/*drug effects, Biocompatible Materials/*chemistry/pharmacology/toxicity, Calcium/pharmacology, Coated Materials, Biocompatible/chemistry/pharmacology/toxicity, Fluorine/pharmacology, L Cells/drug effects, Materials Testing, Mice, Mouth/microbiology, Nitrogen/pharmacology, Oxidation-Reduction, Porphyromonas gingivalis/*drug effects/growth & development/physiology, Surface Properties, Titanium/analysis/*chemistry/pharmacology/toxicityPathogenicity
11447200Role of gingipains in growth of Porphyromonas gingivalis in the presence of human serum albumin.Grenier D, Imbeault S, Plamondon P, Grenier G, Nakayama K, Mayrand DInfect Immun10.1128/IAI.69.8.5166-5172.20012001Adhesins, Bacterial, Collagen/metabolism/pharmacology, Cysteine Endopeptidases/*physiology, Gingipain Cysteine Endopeptidases, Hemagglutinins/*physiology, Humans, Immunoglobulin G/metabolism/pharmacology, Porphyromonas gingivalis/drug effects/*growth & development/metabolism, Serum Albumin/*metabolism/pharmacology, Transferrin/metabolism/pharmacologyMetabolismPathogenicity
11597031The capacity of Porphyromonas gingivalis to multiply under iron-limiting conditions correlates with its pathogenicity in an animal model.Grenier D, Goulet V, Mayrand DJ Dent Res10.1177/002203450108000715012001Animals, Cell Division, Culture Media, Disease Models, Animal, Hemin/metabolism, Horses, Humans, Iron/*metabolism, Iron Radioisotopes/metabolism, Periodontitis/microbiology, Porphyromonas gingivalis/*metabolism/*pathogenicity, Transferrin/metabolism, VirulenceMetabolismCultivation
11953385Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model.Rajapakse PS, O'Brien-Simpson NM, Slakeski N, Hoffmann B, Reynolds ECInfect Immun10.1128/IAI.70.5.2480-2486.20022002Adhesins, Bacterial, Alveolar Bone Loss/*prevention & control, Animals, Antibodies, Bacterial/biosynthesis, Bacterial Vaccines/*immunology, Cysteine Endopeptidases/*immunology, Gingipain Cysteine Endopeptidases, Gingival Crevicular Fluid/microbiology, Hemagglutinins/*immunology, Immunization, Immunoglobulin A, Secretory/biosynthesis, Immunoglobulin G/classification, Male, Periodontitis/*complications, Porphyromonas gingivalis/*immunology, Rats, Rats, Sprague-DawleyPhylogeny
11985513Effect of Fusobacterium nucleatum on the T and B cell responses to Porphyromonas gingivalis in a mouse model.Gemmell E, Bird PS, Carter CL, Drysdale KE, Seymour GJClin Exp Immunol10.1046/j.1365-2249.2002.01852.x2002Animals, Antibodies, Bacterial/blood/immunology, Antibody Specificity, Antigens, Bacterial/immunology, B-Lymphocytes/*immunology, Bacteroidaceae Infections/blood/*immunology, Cross Reactions, Female, Fusobacterium Infections/blood/*immunology, Fusobacterium nucleatum/*immunology, Humans, Immunity, Mice, Mice, Inbred BALB C, Porphyromonas gingivalis/*immunology, T-Lymphocyte Subsets/*immunologyPathogenicity
12030974Cytokine production induced by a 67-kDa fimbrial protein from Porphyromonas gingivalis.Hamada N, Watanabe K, Arai M, Hiramine H, Umemoto TOral Microbiol Immunol10.1034/j.1399-302x.2002.170311.x2002Amino Acid Sequence, Animals, Bacterial Proteins/analysis/classification/*metabolism, Chemical Precipitation, Chromatography, Agarose, Coloring Agents, Cytokines/*biosynthesis, Electrophoresis, Polyacrylamide Gel, Fimbriae Proteins/classification/genetics, Fimbriae, Bacterial/classification/*metabolism, Inflammation Mediators/metabolism, Interleukin-1/biosynthesis, Interleukin-6/biosynthesis, Macrophages, Peritoneal/metabolism, Mice, Mice, Inbred BALB C, Microscopy, Electron, Mutation/genetics, Pili, Sex/classification, Porphyromonas gingivalis/genetics/*metabolism, Tumor Necrosis Factor-alpha/biosynthesisMetabolismPhylogeny
12121469Interaction of Porphyromonas gingivalis with KB cells: comparison of different clinical isolates.Eick S, Rodel J, Einax JW, Pfister WOral Microbiol Immunol10.1034/j.1399-302x.2002.170401.x2002*Bacterial Adhesion, Cluster Analysis, Endopeptidases/genetics, Fimbriae Proteins/genetics, Fimbriae, Bacterial, Genes, Bacterial, Humans, Interleukin-6/biosynthesis, Interleukin-8/biosynthesis, KB Cells/metabolism/*microbiology, Periodontitis/*microbiology, Porphyromonas gingivalis/enzymology/genetics/*physiology, Principal Component Analysis, Species Specificity, Statistics, Nonparametric, Virulence Factors/*biosynthesisPathogenicityPhylogeny
12228316Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling.Hintermann E, Haake SK, Christen U, Sharabi A, Quaranta VInfect Immun10.1128/IAI.70.10.5846-5856.20022002Adherens Junctions/physiology, Adhesins, Bacterial, Aggregatibacter actinomycetemcomitans/pathogenicity/physiology, Bacteroidaceae Infections/etiology/pathology, Cell Adhesion/*physiology, Cell Line, Cell Movement/*physiology, Cysteine Endopeptidases/physiology, Endopeptidases/physiology, Focal Adhesions/physiology, Gingipain Cysteine Endopeptidases, Gingival Pocket/etiology/pathology, Hemagglutinins/physiology, Humans, Keratinocytes/*microbiology/pathology/physiology, Periodontitis/etiology/pathology, Porphyromonas gingivalis/*pathogenicity/physiology, Species Specificity, Virulence/physiologyPathogenicityPhylogeny
12593606Characterization of biologically active cell surface components of a periodontal pathogen. The roles of major and minor fimbriae of Porphyromonas gingivalis.Umemoto T, Hamada NJ Periodontol10.1902/jop.2003.74.1.1192003Alveolar Bone Loss/microbiology, Analysis of Variance, Animals, Bacterial Adhesion/physiology, Bacteroidaceae Infections/physiopathology, DNA, Recombinant/genetics, Disease Models, Animal, Epithelial Cells/microbiology, Fimbriae Proteins/genetics/physiology, Fimbriae, Bacterial/genetics/*physiology, Humans, KB Cells, Microscopy, Electron, Mutation/genetics, Pili, Sex/genetics/physiology, Porphyromonas gingivalis/genetics/*physiology, RatsPathogenicity
12636253Serum antibodies of periodontitis patients compared to the lipopolysaccharides of Porphyromonas gingivalis and Fusobacterium nucleatum.Onoue S, Imai T, Kumada H, Umemoto T, Kaca W, Isshiki Y, Kaneko A, Kawahara KMicrobiol Immunol10.1111/j.1348-0421.2003.tb02785.x2003Adult, Antibodies, Bacterial/*blood, Bacteroidaceae Infections/blood/*immunology/microbiology, Female, Fusobacterium Infections/blood/*immunology, Fusobacterium nucleatum/*immunology, Humans, Lipopolysaccharides/immunology, Male, Middle Aged, Periodontitis/blood/*immunology/microbiology, Porphyromonas gingivalis/*immunologyPathogenicity
12760772[Cloning and polymorphism analysis of prtH gene from Porphyromonas gingivalis].Zheng Y, Yang SH, Zhou W, Zhang CM, Zhang FP, Dong XPZhonghua Kou Qiang Yi Xue Za Zhi2003*Bacterial Proteins, Blotting, Southern, Cloning, Molecular, Cysteine Endopeptidases/*genetics, DNA, Bacterial/genetics/metabolism, Deoxyribonuclease BamHI/metabolism, Deoxyribonuclease HindIII/metabolism, Polymorphism, Genetic, Porphyromonas gingivalis/*genetics, Species SpecificityEnzymologyMetabolism
12874356Effect of inactivation of the Arg- and/or Lys-gingipain gene on selected virulence and physiological properties of Porphyromonas gingivalis.Grenier D, Roy S, Chandad F, Plamondon P, Yoshioka M, Nakayama K, Mayrand DInfect Immun10.1128/IAI.71.8.4742-4748.20032003Adhesins, Bacterial, Animals, Bacteroidaceae Infections/microbiology/pathology, Cells, Cultured, Cysteine Endopeptidases/*genetics, *Genes, Bacterial, Gingipain Cysteine Endopeptidases, Gingiva/microbiology/pathology, Hemagglutination, Hemagglutinins/*genetics, Hemolysis, Humans, In Vitro Techniques, Mutation, Porphyromonas gingivalis/*genetics/growth & development/*pathogenicity/physiology, Sheep, Virulence/genetics/physiologyPathogenicity
14515152Inhibitors of benzamidine type influence the virulence properties of Porphyromonas gingivalis strains.Eick S, Pfister W, Sturzebecher U, Jarema S, Sturzebecher JActa Biochim Pol0350037252003Animals, Arginine/metabolism, Benzamidines/analysis/*pharmacology, Cells, Cultured, Cysteine Endopeptidases/drug effects/*metabolism, Enzyme Inhibitors/pharmacology, Granulocytes/*metabolism/microbiology, Humans, Periodontitis/microbiology, Phagocytosis/drug effects, Porphyromonas gingivalis/drug effects/*enzymology/*pathogenicity, Virulence/drug effectsPathogenicityMetabolism
14638996A novel type of two-component regulatory system affecting gingipains in Porphyromonas gingivalis.Hasegawa Y, Nishiyama S, Nishikawa K, Kadowaki T, Yamamoto K, Noguchi T, Yoshimura FMicrobiol Immunol10.1111/j.1348-0421.2003.tb03451.x2003Adhesins, Bacterial, Amino Acid Sequence, Cysteine Endopeptidases/genetics/*metabolism, *Genes, Bacterial, Genome, Bacterial, Gingipain Cysteine Endopeptidases, Hemagglutinins/genetics/*metabolism, Molecular Sequence Data, Porphyromonas gingivalis/genetics/growth & development/*metabolism, Sequence Homology, Amino Acid, Transcription FactorsGeneticsMetabolism
14659542Porphyromonas gingivalis 67-kDa fimbriae induced cytokine production and osteoclast differentiation utilizing TLR2.Hiramine H, Watanabe K, Hamada N, Umemoto TFEMS Microbiol Lett10.1016/S0378-1097(03)00788-22003Animals, Antibodies/pharmacology, Cell Differentiation, Cell Line, Cytokines/*biosynthesis, Dentin/immunology/microbiology, Female, Fimbriae Proteins/immunology/*metabolism, Macrophages, Peritoneal/metabolism/microbiology, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Osteoclasts/*cytology/metabolism, Periodontitis/immunology/*metabolism/microbiology, Porphyromonas gingivalis/*metabolism, Specific Pathogen-Free OrganismsMetabolismBiotechnology
14757234Effects of various culture environments on expression of major outer membrane proteins from Porphyromonas gingivalis.Murakami Y, Imai M, Mukai Y, Ichihara S, Nakamura H, Yoshimura FFEMS Microbiol Lett10.1016/S0378-1097(03)00896-62004Amino Acid Sequence, Bacterial Outer Membrane Proteins/*metabolism, *Bacterial Proteins, Culture Media, *Gene Expression Regulation, Bacterial, Humans, Hydrogen-Ion Concentration, Molecular Sequence Data, Monomeric GTP-Binding Proteins/chemistry/metabolism, Osmolar Concentration, Porphyromonas gingivalis/*growth & development/metabolismMetabolismCultivation
14966939[Cloning and expression of Porphyromonas gingivalis pgmA gene encoding outer membrane protein associated with fimbria].Zhuang CY, Chen LL, Yan J, Sun WLZhejiang Da Xue Xue Bao Yi Xue Ban10.3785/j.issn.1008-9292.2004.01.0102004Animals, Bacterial Outer Membrane Proteins/*genetics/immunology, Base Sequence, Cloning, Molecular, Enzyme-Linked Immunosorbent Assay, Molecular Sequence Data, Rabbits, Recombinant Fusion Proteins/*geneticsEnzymologyGenetics
15057477The induction of intercellular adhesion molecule-1 on human umbilical vein endothelial cells by a heat-stable component of Porphyromonas gingivalis.Mao S, Maeno N, Matayoshi S, Yoshiie K, Fujimura T, Oda HCurr Microbiol10.1007/s00284-003-4071-z2004Bacterial Proteins/immunology, Cells, Cultured, Colony Count, Microbial, Endothelial Cells/*metabolism/*microbiology, Gene Expression Regulation, Hot Temperature, Humans, Intercellular Adhesion Molecule-1/*biosynthesis, Kinetics, Lipids/immunology, Lipopolysaccharides/immunology, Polymyxin B/pharmacology, Polysaccharides, Bacterial/immunology, Porphyromonas gingivalis/*chemistry/growth & development/*pathogenicity, Sonication, Ultraviolet Rays, Umbilical VeinsStressPathogenicity
15086620Efficacy of antibiotics to strains of periodontopathogenic bacteria within a single species biofilm - an in vitro study.Eick S, Seltmann T, Pfister WJ Clin Periodontol10.1111/j.0303-6979.2004.00490.x2004Aggregatibacter actinomycetemcomitans/*drug effects, Anti-Bacterial Agents/*pharmacology, Anti-Infective Agents/pharmacology, Aza Compounds/pharmacology, Biofilms/*drug effects, Clindamycin/pharmacology, Doxycycline/pharmacology, Fluoroquinolones, Humans, Metronidazole/pharmacology, Microbial Sensitivity Tests, Microscopy, Electron, Scanning, Moxifloxacin, Porphyromonas gingivalis/*drug effects, Quinolines/pharmacology, Saliva, Artificial, Streptococcus constellatus/*drug effects, Time FactorsPathogenicity
15271890Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes growth and formation of hydroxyl radicals.Goulet V, Britigan B, Nakayama K, Grenier DInfect Immun10.1128/IAI.72.8.4351-4356.20042004Adhesins, Bacterial, Bacteroidaceae Infections/microbiology, Cysteine Endopeptidases/*metabolism, Gingipain Cysteine Endopeptidases, Gingival Crevicular Fluid/metabolism, Hemagglutinins/*metabolism, Humans, Hydroxyl Radical/*metabolism, Iron/metabolism, Periodontitis/microbiology, Porphyromonas gingivalis/enzymology/genetics/growth & development/*pathogenicity, Transferrin/*metabolismMetabolismPathogenicity
15292149Comparative whole-genome analysis of virulent and avirulent strains of Porphyromonas gingivalis.Chen T, Hosogi Y, Nishikawa K, Abbey K, Fleischmann RD, Walling J, Duncan MJJ Bacteriol10.1128/JB.186.16.5473-5479.20042004Bacterial Capsules/genetics, Bacterial Proteins/*genetics/metabolism, Biological Evolution, DNA Transposable Elements, Gene Transfer, Horizontal, Genes, Bacterial, Genetic Variation, *Genome, Bacterial, Genomic Islands/genetics, Integrases/genetics, Oligonucleotide Array Sequence Analysis, Operon, Polysaccharides, Bacterial/genetics, Porphyromonas gingivalis/*genetics/*pathogenicity, RNA, Transfer/genetics, Virulence/*genetics, Virulence Factors/*genetics/metabolismMetabolismGenetics
15295953Effect of enamel matrix derivative on periodontal ligament cells in vitro is diminished by Porphyromonas gingivalis.Inaba H, Kawai S, Nakayama K, Okahashi N, Amano AJ Periodontol10.1902/jop.2004.75.6.8582004Adhesins, Bacterial, Cell Division/drug effects, Cell Line, Cysteine Endopeptidases/pharmacology, Cytoskeletal Proteins/adverse effects, Dental Enamel Proteins/*antagonists & inhibitors/*pharmacology, Gingipain Cysteine Endopeptidases, Growth Substances/biosynthesis, Hemagglutinins/pharmacology, Humans, Mitogen-Activated Protein Kinases/metabolism, Paxillin, Periodontal Ligament/cytology/*drug effects/metabolism/*microbiology, Phosphoproteins/adverse effects, Porphyromonas gingivalis/enzymology/*pathogenicity, Wound Healing/drug effectsPathogenicityMetabolism
15346883Anti-phagocytic role of surface fibrous structure of an invasive Porphyromonas gingivalis strain.Miyabe H, Ishihara K, Kigure T, Okuda KBull Tokyo Dent Coll10.2209/tdcpublication.45.472004Academic Dissertations as Topic, Adult, Animals, Bacterial Capsules/physiology, Cell Death, Fimbriae, Bacterial/physiology, Guinea Pigs, Humans, L-Lactate Dehydrogenase/metabolism, Macrophages/pathology/ultrastructure, Macrophages, Peritoneal/diagnostic imaging/immunology/*microbiology, Male, Microscopy, Electron, Neutrophils/immunology/*microbiology/ultrastructure, Periodontitis/blood/microbiology, Phagocytes/immunology/microbiology/ultrastructure, Phagocytosis, Phagosomes/microbiology, Porphyromonas gingivalis/immunology/*pathogenicity/ultrastructure, Statistics, Nonparametric, UltrasonographyPathogenicityEnzymology
15562909Efficacy of antibiotics against periodontopathogenic bacteria within epithelial cells: an in vitro study.Eick S, Pfister WJ Periodontol10.1902/jop.2004.75.10.13272004Aggregatibacter actinomycetemcomitans/*drug effects/growth & development, Anti-Bacterial Agents/administration & dosage/*pharmacology, Anti-Infective Agents/administration & dosage/pharmacology, Aza Compounds/administration & dosage/pharmacology, Clindamycin/administration & dosage/pharmacology, Colony Count, Microbial, Doxycycline/administration & dosage/pharmacology, Fluoroquinolones, Humans, Intracellular Space/*microbiology, KB Cells, Metronidazole/administration & dosage/pharmacology, Microbial Sensitivity Tests, Moxifloxacin, Periodontitis/microbiology, Periodontium/*microbiology/ultrastructure, Porphyromonas gingivalis/*drug effects/growth & development, Quinolines/administration & dosage/pharmacology, Streptococcus constellatus/*drug effects/growth & development, Time FactorsPathogenicity
15642029In vitro evaluation of the biocompatibility of contaminated implant surfaces treated with an Er : YAG laser and an air powder system.Kreisler M, Kohnen W, Christoffers AB, Gotz H, Jansen B, Duschner H, d'Hoedt BClin Oral Implants Res10.1111/j.1600-0501.2004.01056.x2005Adolescent, Air Abrasion, Dental, Biocompatible Materials, Cell Proliferation, Cells, Cultured, Decontamination/instrumentation/*methods, Dental Implants/*microbiology, Erbium, Fibroblasts/cytology, Fluorescence, Gingiva/cytology, Humans, *Lasers, Porphyromonas gingivalis/radiation effects, Powders, Surface PropertiesPathogenicity
15659668Trimeric structure of major outer membrane proteins homologous to OmpA in Porphyromonas gingivalis.Nagano K, Read EK, Murakami Y, Masuda T, Noguchi T, Yoshimura FJ Bacteriol10.1128/JB.187.3.902-911.20052005Bacterial Outer Membrane Proteins/chemistry/*genetics, Base Sequence, DNA Primers, Humans, Molecular Sequence Data, Multiprotein Complexes, Mutagenesis, Insertional, Periodontitis/microbiology, Porphyromonas gingivalis/*genetics/growth & development/isolation & purification, Sequence DeletionPathogenicityGenetics
15948693Outer membrane vesicles from Porphyromonas gingivalis affect the growth and function of cultured human gingival fibroblasts and umbilical vein endothelial cells.Bartruff JB, Yukna RA, Layman DLJ Periodontol10.1902/jop.2005.76.6.9722005Analysis of Variance, Angiogenesis Inhibitors/*pharmacology, Bacterial Outer Membrane Proteins/*pharmacology, Capillaries/drug effects, Cell Culture Techniques, Cell Proliferation/drug effects, Endothelial Cells/cytology/*drug effects/metabolism, Fibroblasts/cytology/*drug effects, Gingiva/cytology, Humans, *Porphyromonas gingivalis, Umbilical Veins/cytologyPathogenicityMetabolism
15972517Sequence diversity and antigenic variation at the rag locus of Porphyromonas gingivalis.Hall LM, Fawell SC, Shi X, Faray-Kele MC, Aduse-Opoku J, Whiley RA, Curtis MAInfect Immun10.1128/IAI.73.7.4253-4262.20052005Alleles, Amino Acid Sequence, Animals, *Antigenic Variation, Bacterial Proteins/*genetics, *Chromosome Mapping, Genome, Bacterial, Molecular Sequence Data, Polymorphism, Genetic, Porphyromonas gingivalis/genetics/*immunology/pathogenicity, Rabbits, VirulenceGenetics
16035237Genetic variation of a fimbrial protein from Porphyromonas gingivalis and its distribution in patients with periodontal diseases.Asai Y, Yasuda K, Ohyama Y, Ogawa TMicrobiol Res10.1016/j.micres.2004.11.0042005Adolescent, Adult, Aged, Aged, 80 and over, Bacteroidaceae Infections/*microbiology, Base Sequence, DNA, Bacterial/analysis, Dental Plaque/microbiology, Female, Fimbriae Proteins/chemistry/*genetics/*metabolism, *Genetic Variation, Humans, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Porphyromonas gingivalis/*genetics/metabolism/pathogenicity, Sequence Analysis, DNAMetabolismPathogenicity
16202026Major outer membrane proteins from Porphyromonas gingivalis: strain variation, distribution, and clinical significance in periradicular lesions.Imai M, Murakami Y, Nagano K, Nakamura H, Yoshimura FEur J Oral Sci10.1111/j.1600-0722.2005.00235.x2005Adhesins, Bacterial/analysis, Adult, Amino Acids/analysis, Antigens, Bacterial/blood, Bacterial Outer Membrane Proteins/*analysis/classification, Bacterial Proteins/analysis, Bacteroidaceae Infections/microbiology, Blotting, Western, Cysteine Endopeptidases/analysis, Electrophoresis, Polyacrylamide Gel, Female, Gingipain Cysteine Endopeptidases, Hemagglutinins/analysis, Humans, Male, Middle Aged, Periapical Diseases/*microbiology, Porphyromonas gingivalis/immunology/*metabolism/pathogenicity, Virulence Factors/analysisEnzymologyPathogenicity
16409255Porphyromonas gingivalis affects host collagen degradation by affecting expression, activation, and inhibition of matrix metalloproteinases.Zhou J, Windsor LJJ Periodontal Res10.1111/j.1600-0765.2005.00835.x2006Cells, Cultured, Collagen/*metabolism, Collagen Type I/metabolism, Culture Media, Conditioned, Enzyme Activation, Fibroblasts/enzymology/metabolism, Gingiva/cytology/enzymology/*metabolism, Humans, Matrix Metalloproteinase 1/analysis, Matrix Metalloproteinase 2/analysis, Matrix Metalloproteinase 3/analysis, Matrix Metalloproteinases/analysis/*physiology, Porphyromonas gingivalis/*enzymology, RNA, Messenger/analysis, Tissue Inhibitor of Metalloproteinase-1/analysis, Tissue Inhibitor of Metalloproteinases/analysisMetabolismPathogenicity
16476562Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis.Ohno T, Okahashi N, Kawai S, Kato T, Inaba H, Shibata Y, Morisaki I, Abiko Y, Amano AMicrobes Infect10.1016/j.micinf.2005.10.0212006Adhesins, Bacterial/genetics, Animals, Bacteroidaceae Infections/*metabolism/microbiology, Cell Line, Collagenases/genetics/metabolism, Cysteine Endopeptidases/deficiency/genetics, Cytokines/genetics/metabolism, Fimbriae, Bacterial/genetics, Gene Deletion, *Gene Expression Profiling, Genes/*genetics, Gingipain Cysteine Endopeptidases, Hemagglutinins/genetics, Matrix Metalloproteinase 13, Mice, *Oligonucleotide Array Sequence Analysis, *Porphyromonas gingivalis/genetics, RNA, Messenger/genetics, Stromal Cells/metabolism/microbiology, Up-RegulationMetabolismPathogenicity
16490986The efficacy of povidone-iodine products against periodontopathic bacteria.Nakagawa T, Hosaka Y, Ishihara K, Hiraishi T, Sato S, Ogawa T, Kamoi KDermatology10.1159/0000892082006Aggregatibacter actinomycetemcomitans/drug effects, Anti-Infective Agents, Local/*pharmacology, Fusobacterium nucleatum/drug effects, Gram-Negative Bacteria/*drug effects, Humans, Mouth/*microbiology, Porphyromonas gingivalis/drug effects, Povidone-Iodine/*pharmacology, Prevotella intermedia/drug effects, Streptococcus anginosus/*drug effectsPathogenicity
16499710A tumor necrosis factor-alpha antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice.Suzuki Y, Aoki K, Saito H, Umeda M, Nitta H, Baron R, Ohya KJ Periodontal Res10.1111/j.1600-0765.2005.00812.x2006Analysis of Variance, Animals, Anti-Inflammatory Agents, Non-Steroidal/*chemical synthesis, Bone Density, Bone Resorption/etiology/*prevention & control, Carrier Proteins/metabolism, Drug Design, Infusion Pumps, Implantable, Male, Membrane Glycoproteins/metabolism, Mice, Mice, Inbred BALB C, Osteitis/complications/drug therapy/microbiology, Osteoclasts/drug effects, Peptides, Cyclic/*administration & dosage/chemical synthesis/pharmacokinetics, Porphyromonas gingivalis/pathogenicity, Protein Binding, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Skull, Tumor Necrosis Factor-alpha/*antagonists & inhibitorsPathogenicityMetabolism
16640926[Effect of fibrinogen on the adherence of Porphyromonas gingivalis to human oral epithelial cells].Ge S, Wu YF, Liu TJ, Zhao L, Fei XLZhonghua Kou Qiang Yi Xue Za Zhi2006Bacterial Adhesion/drug effects, Fibrinogen/administration & dosage/*pharmacology, Humans, KB Cells, Mouth Mucosa/*drug effects/microbiology, Periodontitis/*etiology, Porphyromonas gingivalis/*pathogenicityPathogenicity
16672491Effects of various growth conditions in a chemostat on expression of virulence factors in Porphyromonas gingivalis.Masuda T, Murakami Y, Noguchi T, Yoshimura FAppl Environ Microbiol10.1128/AEM.72.5.3458-3467.20062006Aerobiosis, Anaerobiosis, Bacterial Proteins/genetics/*metabolism, Culture Media, Fimbriae Proteins/genetics/metabolism, Fimbriae, Bacterial, *Gene Expression Regulation, Bacterial, Hemin/metabolism, Humans, Peptides/metabolism, Porphyromonas gingivalis/genetics/*growth & development/metabolism/pathogenicity, Virulence Factors/genetics/*metabolismMetabolismCultivation
16673792Antimicrobial effect in vitro of chlorhexidine and calcium hydroxide impregnated gutta-percha points.Bozza FL, Molgatini SL, Perez SB, Tejerina DP, Perez Tito RI, Kaplan AEActa Odontol Latinoam2005Anti-Infective Agents, Local/*pharmacology, Calcium Hydroxide/*pharmacology, Candida albicans/drug effects, Chlorhexidine/*pharmacology, Colony Count, Microbial, Culture Media, Enterococcus faecalis/drug effects, Fusobacterium nucleatum/drug effects, *Gutta-Percha, Humans, Hydrogen-Ion Concentration, Materials Testing, Oxygen, Porphyromonas gingivalis/drug effects, Prevotella intermedia/drug effects, *Root Canal Filling Materials, Staphylococcus aureus/drug effects, Streptococcus mutans/drug effects, Temperature, Time FactorsPathogenicityCultivation
16677293Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis subgingival presence, species-specific serum immunoglobulin G antibody levels, and periodontitis disease recurrence.Rams TE, Listgarten MA, Slots JJ Periodontal Res10.1111/j.1600-0765.2005.00860.x2006Adult, Aggregatibacter actinomycetemcomitans/immunology/*isolation & purification, Antibodies, Bacterial/*blood, Antibody Specificity/*immunology, Bacteriological Techniques, Colony Count, Microbial, Follow-Up Studies, Gingiva/*microbiology, Humans, Immunoglobulin G/*blood, Periodontal Pocket/microbiology, Periodontitis/immunology/*microbiology, Porphyromonas gingivalis/immunology/*isolation & purification, Prospective Studies, Recurrence, SerotypingEnzymologyPhylogeny
16685369[An in vitro experiment on the antimicrobial effects of ethanol extract from salvia miltiorrhiza bunge on several oral pathogenic microbes].Deng J, Zhang DZ, Yang WJShanghai Kou Qiang Yi Xue18682006Actinomyces, Anti-Bacterial Agents/*isolation & purification/*pharmacology, Ethanol, Gram-Negative Bacteria/*drug effects, Gram-Positive Bacteria/*drug effects, Microbial Sensitivity Tests, Phytotherapy, Plant Roots/chemistry, Porphyromonas gingivalis/drug effects, Salvia/chemistry, Salvia miltiorrhiza/*chemistry, Streptococcus mutans/drug effectsPathogenicityEnzymology
16758451In vitro attachment of osteoblasts on contaminated rough titanium surfaces treated by Er:YAG laser.Friedmann A, Antic L, Bernimoulin JP, Purucker PJ Biomed Mater Res A10.1002/jbm.a.306992006Biocompatible Materials, Cell Adhesion/physiology, Cells, Cultured, Humans, *Lasers, Osteoblasts/*physiology, *TitaniumPathogenicity
16783744Bacterial colonisation of interior implant threads with and without sealing.Proff P, Steinmetz I, Bayerlein T, Dietze S, Fanghanel J, Gedrange TFolia Morphol (Warsz)2006Colony Count, Microbial, Dental Abutments/*microbiology, Dental Implants/*microbiology, Dental Prosthesis Retention/*methods, Equipment Contamination/*prevention & control, Gutta-Percha, Microscopy, Electron, Scanning, *Pit and Fissure Sealants, Porphyromonas gingivalis/*growth & development/isolation & purificationEnzymologyPhylogeny
16809197Bone powder enhances the effectiveness of bioactive glass S53P4 against strains of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in suspension.Waltimo T, Zehnder M, Soderling EActa Odontol Scand10.1080/000163505005707002006Aggregatibacter actinomycetemcomitans/*drug effects/growth & development, Animals, Anti-Bacterial Agents/*pharmacology, Biocompatible Materials/chemistry/*pharmacology, *Bone and Bones, Boron Compounds/pharmacology, Cattle, Colony Count, Microbial, Decalcification Technique, Durapatite/pharmacology, *Glass/chemistry, Materials Testing, Particle Size, Porphyromonas gingivalis/*drug effects/growth & development, Powders, Silicates/pharmacologyPathogenicity
16842507Porphyromonas gingivalis survives within KB cells and modulates inflammatory response.Eick S, Reissmann A, Rodel J, Schmidt KH, Pfister WOral Microbiol Immunol10.1111/j.1399-302X.2006.00282.x2006Adhesins, Bacterial/analysis, Cell Count, Coculture Techniques, Colony Count, Microbial, Cysteine Endopeptidases/analysis, Gingipain Cysteine Endopeptidases, Humans, Interleukin-1/analysis/genetics, Interleukin-6/analysis/genetics, Interleukin-8/analysis/genetics, Intracellular Space/microbiology, KB Cells/immunology/*microbiology, Porphyromonas gingivalis/enzymology/immunology/*physiology, RNA, Messenger/analysis, RNA, Ribosomal, 16S/analysis, Time Factors, Tumor Necrosis Factor-alpha/analysis/genetics, VirulencePathogenicityEnzymology
16887507Catalytic site targeted mutagenesis of the alpha-gingivain gene of Porphyromonas gingivalis using Tn-4351 to generate isogenic mutants.Gharbia SE, Shah HN, Sreedharan S, Brocklehurst KAnaerobe10.1016/s1075-9964(95)80431-51995
16887668Susceptibility of Prevotella intermedia/Prevotella nigrescens (and Porphyromonas gingivalis) to propolis (bee glue) and other antimicrobial agents.Santos FA, Bastos EM, Rodrigues PH, de Uzeda M, de Carvalho MA, Farias Lde M, Moreira ESAnaerobe10.1006/anae.2002.04112002
17064397Characterizing the specific coaggregation between Actinobacillus actinomycetemcomitans serotype c strains and Porphyromonas gingivalis ATCC 33277.Suzuki N, Nakano Y, Kiyoura YOral Microbiol Immunol10.1111/j.1399-302X.2006.00309.x2006Aggregatibacter actinomycetemcomitans/*genetics/*physiology, Antigens, Bacterial/biosynthesis, Bacterial Adhesion/*genetics, Ecosystem, Fimbriae, Bacterial, Mutagenesis, Insertional, Polysaccharides, Bacterial/biosynthesis, Porphyromonas gingivalis/*genetics/*physiology, Quorum Sensing/genetics, Serotyping, Species SpecificityPhylogeny
17064402Adhesion and invasion to epithelial cells by fimA genotypes of Porphyromonas gingivalis.Umeda JE, Missailidis C, Longo PL, Anzai D, Wikstrom M, Mayer MPOral Microbiol Immunol10.1111/j.1399-302X.2006.00312.x2006Cell Adhesion/genetics, Endocytosis, Epithelial Cells/*microbiology, Fimbriae Proteins/genetics/*physiology, Fimbriae, Bacterial/genetics/*physiology, Genetic Variation, Genotype, Humans, KB Cells, Porphyromonas gingivalis/genetics/*physiologyGeneticsPathogenicity
17067453[kgp genotypes of Porphyromonas gingivalis in subgingival plaque in puberty gingivitis].Chen X, Liu J, Pan YPZhonghua Kou Qiang Yi Xue Za Zhi2006Adolescent, Case-Control Studies, Dental Plaque/*microbiology, Female, Genotype, Gingivitis/*microbiology, Humans, Male, Polymerase Chain Reaction, Porphyromonas gingivalis/*geneticsGeneticsPathogenicity
17076781Cytokine production in human periodontal ligament cells stimulated with Porphyromonas gingivalis.Yamamoto T, Kita M, Oseko F, Nakamura T, Imanishi J, Kanamura NJ Periodontal Res10.1111/j.1600-0765.2006.00905.x2006Adult, Animals, Cattle, Cytokines/analysis/*biosynthesis, Female, Humans, Interleukins/biosynthesis, Male, Osteoprotegerin/analysis/biosynthesis, Periodontal Ligament/cytology/*metabolism, Porphyromonas gingivalis/*physiology, Prevotella intermedia/*physiology, RANK Ligand/biosynthesis, RNA, Messenger/analysisPathogenicityBiotechnology
17081195Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype.Kato T, Kawai S, Nakano K, Inaba H, Kuboniwa M, Nakagawa I, Tsuda K, Omori H, Ooshima T, Yoshimori T, Amano ACell Microbiol10.1111/j.1462-5822.2006.00825.x2006Abscess/blood/microbiology, Animals, Bacterial Adhesion/genetics, Bacteroidaceae Infections/blood/metabolism/microbiology, Cell Line, Epithelial Cells/metabolism/microbiology, Female, Fimbriae Proteins/*genetics, Fimbriae, Bacterial/*genetics, Focal Adhesion Protein-Tyrosine Kinases/metabolism, Genotype, HeLa Cells, Humans, Immunoblotting, Integrin alpha5beta1/metabolism, Interleukin-1beta/blood, Interleukin-6/blood, Mice, Mice, Inbred BALB C, Microscopy, Confocal, Microscopy, Electron, Transmission, Mutation, Paxillin/metabolism, Porphyromonas gingivalis/*genetics/pathogenicity/ultrastructure, Virulence/geneticsMetabolismGenetics
17134590Antimicrobial effect of acidified nitrate and nitrite on six common oral pathogens in vitro.Xia DS, Liu Y, Zhang CM, Yang SH, Wang SLChin Med J (Engl)2006Anti-Infective Agents/*pharmacology, Candida albicans/drug effects, Fusobacterium nucleatum/drug effects, Hydrogen-Ion Concentration, Lactobacillus acidophilus/drug effects, Microbial Sensitivity Tests, Mouth/*microbiology, Nitrates/analysis/blood/*pharmacology, Nitrites/analysis/blood/*pharmacology, Porphyromonas gingivalis/drug effects, Saliva/chemistry, Streptococcus mutans/drug effectsPathogenicity
17214643Heterogeneity in the collagen-degrading ability of Porphyromonas gingivalis-stimulated human gingival fibroblasts.Zhou J, Windsor LJJ Periodontal Res10.1111/j.1600-0765.2006.00918.x2007Cell Line, Collagen/*metabolism, Collagen Type I/metabolism, Culture Media, Conditioned, Fibroblasts/*metabolism, Genetic Heterogeneity, Gingiva/cytology/*metabolism, Humans, Matrix Metalloproteinase 1/metabolism, Matrix Metalloproteinase 14/metabolism, Matrix Metalloproteinase 2/metabolism, Matrix Metalloproteinase 3/metabolism, Porphyromonas gingivalis/*metabolism, Tissue Inhibitor of Metalloproteinase-1/metabolism, Tissue Inhibitor of Metalloproteinase-2/metabolismMetabolismCultivation
17226791Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by Porphyromonas gingivalis in an engineered human oral mucosa model.Andrian E, Mostefaoui Y, Rouabhia M, Grenier DJ Cell Physiol10.1002/jcp.208942007*Gene Expression Regulation, Enzymologic, Humans, Matrix Metalloproteinase 2/*genetics/metabolism, Matrix Metalloproteinase 9/*genetics/metabolism, Mouth Mucosa/enzymology/*microbiology, Porphyromonas gingivalis/*physiology, RNA, Messenger/genetics/metabolism, Tissue Engineering, Tissue Inhibitor of Metalloproteinase-1/*genetics/metabolism, Tissue Inhibitor of Metalloproteinase-2/*genetics/metabolism, Transcriptional ActivationMetabolismPathogenicity
17296756Role for gingipains in Porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells.Yamatake K, Maeda M, Kadowaki T, Takii R, Tsukuba T, Ueno T, Kominami E, Yokota S, Yamamoto KInfect Immun10.1128/IAI.01013-062007Adhesins, Bacterial/*metabolism, Aorta/cytology/*microbiology, Bacteroidaceae Infections/microbiology, Cathepsin B/metabolism, Cells, Cultured, Cysteine Endopeptidases/*metabolism, Endocytosis, Endothelial Cells/*microbiology, Gingipain Cysteine Endopeptidases, Humans, Phagosomes/*microbiology, *Porphyromonas gingivalis/growth & development/pathogenicity/physiologyMetabolismPathogenicity
17305868Dense fimbrial meshwork enhances Porphyromonas gingivalis adhesiveness: a scanning electron microscopic study.Hongo H, Takano H, Morita MJ Periodontal Res10.1111/j.1600-0765.2006.00922.x2007Bacterial Adhesion/*physiology, Dental Plaque/*microbiology, Fimbriae, Bacterial/*physiology, Hemagglutination Tests, Microscopy, Electron, Scanning, Porphyromonas gingivalis/*cytology/*physiology, Virulence
17339349Flow cytometric analysis of adherence of Porphyromonas gingivalis to oral epithelial cells.Pathirana RD, O'Brien-Simpson NM, Visvanathan K, Hamilton JA, Reynolds ECInfect Immun10.1128/IAI.02004-062007Adhesins, Bacterial/genetics/metabolism, *Bacterial Adhesion, Cysteine Endopeptidases/genetics/metabolism, Epithelial Cells/*microbiology, Flow Cytometry/*methods, Gingipain Cysteine Endopeptidases, Humans, KB Cells/microbiology, Mouth/cytology/*microbiology, Porphyromonas gingivalis/genetics/pathogenicity/*physiologyMetabolismPathogenicity
17349195[Comparison between genes of highly toxic strain and minimally toxic strain of Porphyromonas gingivalis].Lin L, Pan YP, Li CZhonghua Kou Qiang Yi Xue Za Zhi2006Genes, Bacterial, *Genome, Bacterial, Nucleic Acid Hybridization, Porphyromonas gingivalis/*genetics/*pathogenicity, Sequence Analysis, DNA, Virulence/geneticsGeneticsPhylogeny
17451542Nicotine increases the collagen-degrading ability of human gingival fibroblasts.Zhou J, Olson BL, Windsor LJJ Periodontal Res10.1111/j.1600-0765.2006.00937.x2007Blotting, Western/methods, Cells, Cultured/drug effects, Collagen/drug effects, Fibroblasts/*drug effects/enzymology, Ganglionic Stimulants/*adverse effects, Gingiva/cytology/*drug effects, Humans, Matrix Metalloproteinases/drug effects/metabolism, Nicotine/*adverse effects, Porphyromonas gingivalis/*metabolism, RNA, Messenger/drug effects/metabolism, Reverse Transcriptase Polymerase Chain Reaction/methods, Tissue Inhibitor of Metalloproteinases/drug effects/metabolismPathogenicityMetabolism
17451545Susceptibility of type 2 diabetic mice to low-virulence bacterial infection: induction of abscess formation by gingipain-deficient Porphyromonas gingivalis.Ishihara Y, Anan H, Yoneda M, Maeda K, Hirofuji TJ Periodontal Res10.1111/j.1600-0765.2006.00941.x2007Abscess/*microbiology, Adhesins, Bacterial, Animals, Cysteine Endopeptidases/deficiency, Diabetes Mellitus, Type 2/complications/*microbiology, Disease Susceptibility/microbiology, Female, Gingipain Cysteine Endopeptidases, Macrophages, Mice, Mice, Inbred BALB C, Porphyromonas gingivalis/*pathogenicity, Virulence
17526848Involvement of minor components associated with the FimA fimbriae of Porphyromonas gingivalis in adhesive functions.Nishiyama SI, Murakami Y, Nagata H, Shizukuishi S, Kawagishi I, Yoshimura FMicrobiology (Reading)10.1099/mic.0.2006/005561-02007Bacterial Adhesion/*physiology, Bacterial Proteins/genetics/*metabolism, Cloning, Molecular, Collagen Type I/metabolism, DNA, Bacterial/chemistry/genetics, Fibronectins/metabolism, Fimbriae Proteins/genetics/*metabolism, Fimbriae, Bacterial/*chemistry/genetics/physiology, Gene Deletion, Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism, Molecular Sequence Data, Mutagenesis, Insertional, Operon/genetics, Porphyromonas gingivalis/chemistry/genetics/*physiology, Protein Binding, Sequence Analysis, DNA, Streptococcus oralisMetabolismEnzymology
17675516Porphyromonas gingivalis selectively up-regulates the HIV-1 coreceptor CCR5 in oral keratinocytes.Giacaman RA, Nobbs AH, Ross KF, Herzberg MCJ Immunol10.4049/jimmunol.179.4.25422007Adhesins, Bacterial/immunology/metabolism, Antibodies/immunology/pharmacology, Bacteroidaceae Infections/genetics/*immunology/pathology, Cell Line, Transformed, Cysteine Endopeptidases/deficiency/immunology/metabolism, Gingipain Cysteine Endopeptidases, HIV Infections/genetics/*immunology/metabolism/pathology, HIV-1/*immunology/metabolism, Humans, Keratinocytes/*immunology/metabolism/pathology, Lipopolysaccharides/pharmacology, Mouth/*immunology/metabolism/pathology, Mutation/immunology, Porphyromonas gingivalis/genetics/*immunology/metabolism, RNA, Messenger/biosynthesis/genetics/metabolism, Receptor, PAR-1/immunology/metabolism, Receptor, PAR-2/immunology/metabolism, Receptors, CCR5/biosynthesis/*immunology, Receptors, CXCR4/biosynthesis/genetics/immunology, Signal Transduction/drug effects/genetics/immunology, Toll-Like Receptor 2/antagonists & inhibitors/genetics/immunology/metabolism, Toll-Like Receptor 4/antagonists & inhibitors/genetics/immunology/metabolism, Up-Regulation/drug effects/*immunologyMetabolismPathogenicity
17760821Effect of gamma-immunoglobulin on the asaccharolytic growth of Porphyromonas gingivalis.Oda H, Saiki K, Numabe Y, Konishi KJ Periodontal Res10.1111/j.1600-0765.2006.00966.x2007Adhesins, Bacterial/genetics/pharmacology, Animals, Cattle, Chlorides, *Culture Media, Cysteine Endopeptidases/genetics/pharmacology, Ferric Compounds/pharmacology, Gingipain Cysteine Endopeptidases, Hemagglutinins/pharmacology, Immunoglobulin gamma-Chains/*pharmacology, Ketoglutaric Acids/pharmacology, Mutation/genetics, Porphyromonas gingivalis/drug effects/genetics/*growth & development, Serum Albumin, Bovine/pharmacologyCultivationPathogenicity
17803635Further evidence that major outer membrane proteins homologous to OmpA in Porphyromonas gingivalis stabilize bacterial cells.Iwami J, Murakami Y, Nagano K, Nakamura H, Yoshimura FOral Microbiol Immunol10.1111/j.1399-302X.2007.00363.x2007Adhesins, Bacterial/analysis, Bacterial Outer Membrane Proteins/genetics/*physiology, Cell Membrane/physiology/ultrastructure, Cysteine Endopeptidases/analysis, Cytoplasmic Vesicles/ultrastructure, Gene Deletion, Gingipain Cysteine Endopeptidases, Humans, Microscopy, Electron, Transmission, Mutation/genetics, Porphyromonas gingivalis/*physiology/ultrastructurePathogenicity
17956474Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis.Yamanaka A, Kouchi T, Kasai K, Kato T, Ishihara K, Okuda KJ Periodontal Res10.1111/j.1600-0765.2007.00982.x2007Adhesins, Bacterial, Biofilms/*drug effects, Cysteine Endopeptidases, Flavonoids/*pharmacology, Fusobacterium nucleatum/drug effects, Gingipain Cysteine Endopeptidases, Phenols/*pharmacology, Polyphenols, Porphyromonas gingivalis/*drug effects/*enzymology, Protease Inhibitors/pharmacology, *Vaccinium macrocarponPathogenicityEnzymology
17979175Quantitative proteomics of intracellular Porphyromonas gingivalis.Xia Q, Wang T, Taub F, Park Y, Capestany CA, Lamont RJ, Hackett MProteomics10.1002/pmic.2007005432007Adhesins, Bacterial/analysis/metabolism, Bacterial Proteins/analysis/*metabolism, Cells, Cultured, Chromatography, High Pressure Liquid, Databases, Protein, Down-Regulation, Epithelial Cells/microbiology, Gingiva/cytology, Humans, Intracellular Space/microbiology, Peptide Hydrolases/analysis/metabolism, Porphyromonas gingivalis/chemistry/*metabolism, Proteome/analysis/*metabolism, Proteomics/*methods, Reproducibility of Results, Tandem Mass Spectrometry, Transcription Factors/analysis/metabolism, Up-RegulationMetabolismProteome
18086848Resistance of Porphyromonas gingivalis ATCC 33277 to direct killing by antimicrobial peptides is protease independent.Bachrach G, Altman H, Kolenbrander PE, Chalmers NI, Gabai-Gutner M, Mor A, Friedman M, Steinberg DAntimicrob Agents Chemother10.1128/AAC.01271-072007Amino Acid Sequence, Antimicrobial Cationic Peptides/chemistry/*pharmacology, *Drug Resistance, Bacterial, Histatins/chemistry/pharmacology, Humans, Microbial Sensitivity Tests, Molecular Sequence Data, Mutation, Peptide Hydrolases/genetics/*metabolism, Porphyromonas gingivalis/*drug effects/enzymology/genetics/growth & developmentPathogenicityGenetics
18173795Heterogenic virulence and related factors among clinical isolates of Porphyromonas gingivalis with type II fimbriae.Inaba H, Nakano K, Kato T, Nomura R, Kawai S, Kuboniwa M, Ishihara K, Ooshima T, Amano AOral Microbiol Immunol10.1111/j.1399-302X.2007.00386.x2008Abscess/microbiology, Adhesins, Bacterial/analysis, Animals, Bacterial Adhesion/physiology, Bacterial Capsules/analysis, Bacteroidaceae Infections/microbiology, Cells, Cultured, Cysteine Endopeptidases/analysis, Disease Models, Animal, Female, Fimbriae Proteins/genetics, Fimbriae, Bacterial/*classification/genetics, Genetic Heterogeneity, Genotype, Gingipain Cysteine Endopeptidases, Hemagglutinins/analysis, Humans, Hydrophobic and Hydrophilic Interactions, Mice, Mice, Inbred BALB C, N-Acetylneuraminic Acid/blood, Porphyromonas gingivalis/genetics/*pathogenicity, Random Allocation, Skin Diseases, Bacterial/microbiology, Virulence/genetics/*physiologyGeneticsPathogenicity
18173797Reduction of periodontal pathogens adhesion by antagonistic strains.Van Hoogmoed CG, Geertsema-Doornbusch GI, Teughels W, Quirynen M, Busscher HJ, Van der Mei HCOral Microbiol Immunol10.1111/j.1399-302X.2007.00388.x2008Actinomyces/physiology, Aggregatibacter actinomycetemcomitans/*physiology, Antibiosis/*physiology, Bacterial Adhesion/*physiology, Bacteriological Techniques, Colony Count, Microbial, Haemophilus parainfluenzae/physiology, Humans, Periodontitis/microbiology, Porphyromonas gingivalis/*physiology, Prevotella intermedia/*physiology, Streptococcus/classification/physiology, Streptococcus mitis/physiology, Streptococcus sanguis/physiologyPathogenicityPhylogeny
18173803Identification of the genes associated with a virulent strain of Porphyromonas gingivalis using the subtractive hybridization technique.Tachibana-Ono M, Yoshida A, Kataoka S, Ansai T, Shintani Y, Takahashi Y, Toyoshima K, Takehara TOral Microbiol Immunol10.1111/j.1399-302X.2007.00396.x2008Bacterial Capsules/genetics, Bacterial Proteins/genetics, Blotting, Southern, DNA Helicases/genetics, DNA, Bacterial/genetics, Fibronectins/genetics, Genes, Bacterial/*genetics, Glycosyltransferases/genetics, Humans, Nucleic Acid Hybridization, Polymerase Chain Reaction, Polysaccharides, Bacterial/genetics, Porphyromonas gingivalis/genetics/*pathogenicity, Sequence Homology, Nucleic Acid, Transposases/genetics, Virulence/*geneticsPathogenicityPhylogeny
18279176Signaling pathways in osteoblast proinflammatory responses to infection by Porphyromonas gingivalis.Ohno T, Okahashi N, Morisaki I, Amano AOral Microbiol Immunol10.1111/j.1399-302X.2007.00393.x2008Animals, Blotting, Western, Bone Marrow Cells/metabolism/microbiology, Cell Line, Chemokine CCL5/*biosynthesis, Chemokine CXCL10/*biosynthesis, Inflammation/*metabolism, Matrix Metalloproteinase 9/*biosynthesis, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Knockout, Myeloid Differentiation Factor 88/metabolism, NF-kappa B/*metabolism, Osteoblasts/*metabolism/*microbiology, Porphyromonas gingivalis/*physiology, *Signal Transduction, Stromal Cells/metabolism/microbiology, Transcription Factor AP-1/metabolismMetabolismPathogenicity
18279184Porphyromonas gingivalis gingipains cause G(1) arrest in osteoblastic/stromal cells.Kato T, Tsuda T, Inaba H, Kawai S, Okahashi N, Shibata Y, Abiko Y, Amano AOral Microbiol Immunol10.1111/j.1399-302X.2007.00405.x2008Adhesins, Bacterial/*physiology, Animals, Bacterial Proteins/*physiology, Bone Marrow Cells, Cell Line, Cyclins/biosynthesis, Cysteine Endopeptidases/*physiology, Down-Regulation, Flow Cytometry, G1 Phase, Gingipain Cysteine Endopeptidases, Mice, Oligonucleotide Array Sequence Analysis, Osteoblasts, Porphyromonas gingivalis/*enzymology, Stromal CellsTranscriptomeEnzymology
18355778Colonization of maternal and fetal tissues by Porphyromonas gingivalis is strain-dependent in a rodent animal model.Belanger M, Reyes L, von Deneen K, Reinhard MK, Progulske-Fox A, Brown MBAm J Obstet Gynecol10.1016/j.ajog.2007.11.0672008Animals, Bacteroidaceae Infections/*transmission, Chorioamnionitis/*microbiology, Disease Models, Animal, Female, *Infectious Disease Transmission, Vertical, Placenta/*microbiology, Porphyromonas gingivalis/*isolation & purification, Pregnancy, Rats, Rats, Sprague-DawleyEnzymologyPhylogeny
18402608An acute injection of Porphyromonas gingivalis lipopolysaccharide modulates the OPG/RANKL system and interleukin-6 in an ovariectomized mouse model.Lu HK, Yeh KC, Wu MF, Li CL, Tseng CCOral Microbiol Immunol10.1111/j.1399-302X.2007.00415.x2008Animals, Disease Models, Animal, Escherichia coli, Female, Homeostasis/drug effects/physiology, Injections, Intraperitoneal, Interleukin-6/*blood, Lipopolysaccharides/administration & dosage/*pharmacology, Mice, Mice, Inbred ICR, Osteoporosis/physiopathology, Osteoprotegerin/*blood/drug effects, *Ovariectomy, *Porphyromonas gingivalis, RANK Ligand/*blood/drug effects, Random Allocation, Time FactorsPathogenicity
18470422[The role of Porphyromonas gingivalis invasion on E-selectin expression in endothelial cells].Zhang DM, Pan YP, Lin L, Zhao J, Li CShanghai Kou Qiang Yi Xue21732008*Atherosclerosis, Cells, Cultured, E-Selectin/*biosynthesis, Endothelial Cells, Humans, Porphyromonas gingivalis/*pathogenicity, Tumor Necrosis Factor-alphaPathogenicity
18524787Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis.Naito M, Hirakawa H, Yamashita A, Ohara N, Shoji M, Yukitake H, Nakayama K, Toh H, Yoshimura F, Kuhara S, Hattori M, Hayashi T, Nakayama KDNA Res10.1093/dnares/dsn0132008Bacterial Proteins/genetics, Base Sequence, *DNA Transposable Elements, Gene Rearrangement, Genes, Bacterial, *Genome, Bacterial, Models, Genetic, Molecular Sequence Data, Porphyromonas gingivalis/classification/*geneticsGeneticsPhylogeny
18564729Serum antibody levels against Porphyromonas gingivalis extract and its chromatographic fraction in chronic and aggressive periodontitis.Trindade SC, Gomes-Filho IS, Meyer RJ, Vale VC, Pugliese L, Freire SMJ Int Acad Periodontol2008Adult, Antibodies, Bacterial/analysis/*blood, Antigens, Bacterial/immunology, Bacteroidaceae Infections/*immunology, Blotting, Western, Chromatography, Chronic Disease, Electrophoresis, Polyacrylamide Gel, Female, Gingival Hemorrhage/immunology/microbiology, Gingivitis/immunology/microbiology, Humans, Immunoglobulin A/blood, Immunoglobulin G/blood/classification, Male, Periodontal Attachment Loss/immunology/microbiology, Periodontal Pocket/immunology/microbiology, Periodontitis/immunology/*microbiology, Porphyromonas gingivalis/*immunology, Subcellular Fractions/immunologyEnzymologyPathogenicity
18784879[The effect of extracellular protein from Porphyromonas gingivalis ATCC 33277 on viability of bovine aortic endothelial cells].Tian N, Ouyang XYShanghai Kou Qiang Yi Xue22242008Animals, Cattle, Cell Survival, Cells, Cultured, Endothelial Cells/*drug effects, Porphyromonas gingivalis/*chemistryPathogenicity
18793369Single gavage with Porphyromonas gingivalis reduces acute systemic nitric oxide response in mice.Nemec A, Pavlica Z, Sentjurc M, Crossley DA, Jerin A, Erzen D, Zdovc I, Petelin M, Skaleric UOral Microbiol Immunol10.1111/j.1399-302X.2008.00454.x2008Animals, Aorta/metabolism, Brain/metabolism, Female, Free Radical Scavengers/*analysis/immunology, Kidney/metabolism, Liver/metabolism, Lung/metabolism, Mice, Mice, Inbred BALB C, Myocardium/metabolism, Nitrates/blood, Nitric Oxide/*analysis/immunology, Nitrites/blood, Porphyromonas gingivalis/immunology/*physiology, Random Allocation, Spleen/metabolism, Time FactorsMetabolism
18832297The role of the RgpA-Kgp proteinase-adhesin complexes in the adherence of Porphyromonas gingivalis to fibroblasts.Pathirana RD, O'Brien-Simpson NM, Visvanathan K, Hamilton JA, Reynolds ECMicrobiology (Reading)10.1099/mic.0.2008/019943-02008Adhesins, Bacterial/drug effects/*metabolism, *Bacterial Adhesion, Cell Line, Cysteine Endopeptidases/drug effects/*metabolism, Escherichia coli/metabolism, Fibroblasts/microbiology, Flow Cytometry, Fluorescein-5-isothiocyanate, Gingipain Cysteine Endopeptidases, Humans, Microscopy, Fluorescence, Porphyromonas gingivalis/*metabolism, Tosyllysine Chloromethyl Ketone/pharmacologyPathogenicityMetabolism
18953909[Monocyte chemoattractant protein-1 regulations of human gingival fibroblasts by Porphyromonas gingivalis with different fimA genotypes].Zhao L, Wu YF, Ouyang YL, Zhang JY, Chen BZhonghua Kou Qiang Yi Xue Za Zhi2008Cells, Cultured, Chemokine CCL2/*metabolism, Fibroblasts/*metabolism, Fimbriae Proteins/*genetics, Genotype, Gingiva/cytology/*microbiology, Humans, Porphyromonas gingivalis/*geneticsGeneticsMetabolism
19031495Variability in the response of human dendritic cells stimulated with Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans.Vernal R, Leon R, Herrera D, Garcia-Sanz JA, Silva, Sanz MJ Periodontal Res10.1111/j.1600-0765.2007.01073.x2008Aggregatibacter actinomycetemcomitans/*immunology, B7-1 Antigen/biosynthesis, B7-2 Antigen/biosynthesis, Bacteriological Techniques, Cell Differentiation, Cytokines/*biosynthesis, Dendritic Cells/cytology/*immunology/metabolism/*microbiology, Humans, Interleukins/biosynthesis, Lymphotoxin-alpha/biosynthesis, Porphyromonas gingivalis/*immunology, Reverse Transcriptase Polymerase Chain Reaction, Th1 Cells/immunology, Tumor Necrosis Factor-alpha/biosynthesisPathogenicityMetabolism
19031784[Experimental study of Porphyromonas gingivalis on the proliferation and apoptosis of vascular endothelial cells].Zhang DM, Pan YP, Zhao J, Lin L, Li CZhonghua Kou Qiang Yi Xue Za Zhi2008*Apoptosis, Bacteroidaceae Infections/*physiopathology, *Cell Proliferation, Cells, Cultured, Endothelial Cells/*cytology, Humans, *Porphyromonas gingivalisPathogenicity
19084124Characterization of coaggregation of Fusobacterium nucleatum PK1594 with six Porphyromonas gingivalis strains.Metzger Z, Blasbalg J, Dotan M, Tsesis I, Weiss EIJ Endod10.1016/j.joen.2008.09.0162008Adhesins, Bacterial/physiology, Bacterial Adhesion/drug effects/*physiology, Biofilms/*growth & development, Fucose/pharmacology, Fusobacterium nucleatum/*physiology, Galactose/pharmacology, Lactose/pharmacology, Porphyromonas gingivalis/*physiologyPathogenicity
19084961[Effect of Porphyromonas gingivalis lipopolysaccharide on induced secretion of inflammatory cytokines by different cell lines].Chen YF, Yan J, Zhang DY, Chen LLZhejiang Da Xue Xue Bao Yi Xue Ban10.3785/j.issn.1008-9292.2008.06.0132008Cell Line, Epithelial Cells/cytology/metabolism, Fibroblasts/cytology/metabolism, Humans, Interleukin-1beta/*metabolism, Interleukin-6/metabolism, Interleukin-8/metabolism, Lipopolysaccharides/*pharmacology, Porphyromonas gingivalis/*chemistry, Tumor Necrosis Factor-alpha/*metabolismMetabolismPathogenicity
19089132Humoral immune response to antigens of Porphyromonas gingivalis ATCC 33277 in chronic periodontitis.Franca M, Moura-Costa L, Meyer RJ, Trindade SC, Tunes Uda R, Freire SMJ Appl Oral Sci10.1590/s1678-775720070003000112007
19134348[Matrix metalloproteinases regulations of human gingival fibroblasts by Porphyromonas gingivalis with different fimA genotypes].Zhao L, Yang H, Wu YF, Ouyang YL, Meng SZhonghua Kou Qiang Yi Xue Za Zhi2008Cells, Cultured, Coculture Techniques, Fibroblasts/*metabolism, Fimbriae Proteins/*genetics, Genotype, Gingiva/cytology, Humans, Matrix Metalloproteinase 1/*metabolism, Matrix Metalloproteinase 2/*metabolism, Porphyromonas gingivalis/*genetics, RNA, Messenger/geneticsGeneticsMetabolism
19186864[Interleukin-8 regulations of oral epithelial cells by porphyromonas gingivalis with different fimA genotypes].Guo YH, Wu YF, Liu TJ, Zhang JY, Xiao XR, Zhao LHua Xi Kou Qiang Yi Xue Za Zhi2008Cells, Cultured, Coculture Techniques, Epithelial Cells, Genotype, Humans, Interleukin-6, *Interleukin-8, *Porphyromonas gingivalisGeneticsPathogenicity
19210340Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.Guentsch A, Puklo M, Preshaw PM, Glockmann E, Pfister W, Potempa J, Eick SJ Periodontal Res10.1111/j.1600-0765.2008.01113.x2009Adult, Aggregatibacter actinomycetemcomitans/*immunology, Aggressive Periodontitis/blood/*immunology/microbiology, Antibodies, Bacterial/immunology, Case-Control Studies, Chronic Periodontitis/blood/*immunology/microbiology, Female, Humans, Immunoglobulin G/immunology, Leukocyte Elastase/blood/metabolism, Luminescence, Male, Middle Aged, Neutrophils/*immunology, Phagocytosis, Porphyromonas gingivalis/*immunology, Reactive Oxygen Species/metabolismPathogenicityMetabolism
19416449Chronic ingestion of Porphyromonas gingivalis induces systemic nitric oxide response in mice.Nemec A, Pavlica Z, Crossley DA, Sentjurc M, Jerin A, Erzen D, Vrecl M, Majdic G, Zdovc I, Petelin M, Skaleric UOral Microbiol Immunol10.1111/j.1399-302X.2008.00496.x2009Amidines/pharmacology, Animals, Aorta/chemistry/pathology, Benzylamines/pharmacology, Enzyme Activation, Enzyme Inhibitors/pharmacology, Female, Free Radical Scavengers/*metabolism, Gingiva/chemistry/pathology, Immunohistochemistry, Kidney/chemistry/pathology, Liver/chemistry/pathology, Lung/chemistry/pathology, Mice, Mice, Inbred BALB C, Mouth/*microbiology, Nitrates/analysis/blood, Nitric Oxide/analysis/*biosynthesis, Nitric Oxide Synthase Type II/analysis/antagonists & inhibitors, Nitrites/analysis/blood, Porphyromonas gingivalis/*metabolism, Random Allocation, Specific Pathogen-Free Organisms, Spleen/chemistry/pathology, Time Factors, Tissue Distribution, Tumor Necrosis Factor-alpha/analysisMetabolism
19457170IL-17 is involved in bone resorption in mouse periapical lesions.Oseko F, Yamamoto T, Akamatsu Y, Kanamura N, Iwakura Y, Imanishi J, Kita MMicrobiol Immunol10.1111/j.1348-0421.2009.00123.x2009Animals, Bacteroidaceae Infections/diagnostic imaging/*immunology/microbiology/physiopathology, *Bone Resorption, Female, Gene Expression, Interleukin-17/genetics/*immunology, Male, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Mice, Knockout, Periapical Diseases/diagnostic imaging/*immunology/microbiology/physiopathology, Porphyromonas gingivalis/immunology, Prevotella intermedia/immunology, Tomography, X-Ray Computed
19472891[Matrix metalloproteinase 8 and 9 regulations of polymorphonuclear leukocytes stimulated by Porphyromonas gingivalis with different fimA genotypes].Ouyang YL, Wu YF, Zhao L, Xiao XR, Zhang JY, Li XYHua Xi Kou Qiang Yi Xue Za Zhi2009Coculture Techniques, Fimbriae Proteins, Genotype, Humans, *Matrix Metalloproteinase 8, Neutrophils, *Porphyromonas gingivalisGeneticsPathogenicity
19489254[Effect of Porphyromonas gingivalis on nitric oxide in cultured human umbilical vein endothelial cells].Wu J, Sun WB, Ji YZhonghua Kou Qiang Yi Xue Za Zhi2009Cells, Cultured, Endothelial Cells/*metabolism, Humans, Nitric Oxide/*biosynthesis, Porphyromonas gingivalis/*isolation & purification, Umbilical Veins/cytologyPathogenicityMetabolism
19589838Anchoring and length regulation of Porphyromonas gingivalis Mfa1 fimbriae by the downstream gene product Mfa2.Hasegawa Y, Iwami J, Sato K, Park Y, Nishikawa K, Atsumi T, Moriguchi K, Murakami Y, Lamont RJ, Nakamura H, Ohno N, Yoshimura FMicrobiology (Reading)10.1099/mic.0.028928-02009Bacterial Outer Membrane Proteins/genetics/*metabolism, Bacterial Proteins/genetics/*metabolism, DNA, Bacterial/chemistry/genetics, Fimbriae Proteins/*metabolism, Fimbriae, Bacterial/*metabolism, Gene Deletion, *Gene Expression Regulation, Bacterial, Gene Order, Genetic Complementation Test, Immunoprecipitation, Microscopy, Immunoelectron, Molecular Sequence Data, Porphyromonas gingivalis/genetics/*physiology, Protein Binding, Protein Interaction Mapping, Sequence Analysis, DNA, Virulence Factors/*metabolismMetabolismGenetics
19608609Cleavage of protease-activated receptors on an immortalized oral epithelial cell line by Porphyromonas gingivalis gingipains.Giacaman RA, Asrani AC, Ross KF, Herzberg MCMicrobiology (Reading)10.1099/mic.0.029132-02009Adhesins, Bacterial/genetics/*metabolism, Antibodies/pharmacology, Cell Line, Cysteine Endopeptidases/genetics/*metabolism, Epithelial Cells/*drug effects/*immunology, Flow Cytometry, Gene Deletion, Gingipain Cysteine Endopeptidases, Humans, Indicators and Reagents/pharmacology, Porphyromonas gingivalis/*enzymology/*immunology, Receptor, PAR-1/*metabolism, Receptor, PAR-2/*metabolism, Staining and Labeling/methodsMetabolismPathogenicity
19619243Inhibitory effect of galectin-3 on the cytokine-inducing activity of periodontopathic Aggregatibacter actinomycetemcomitans endotoxin in splenocytes derived from mice.Kato T, Uzawa A, Ishihara KFEMS Immunol Med Microbiol10.1111/j.1574-695X.2009.00577.x2009Age Factors, Animals, Cells, Cultured, Cytokines/*metabolism, Endotoxins/*antagonists & inhibitors/*immunology/isolation & purification, Galectin 3/*immunology, Interferon-gamma/metabolism, Interleukin-6/metabolism, Leukocytes, Mononuclear/*immunology, Mice, Mice, Inbred C57BL, Pasteurellaceae/chemistry/*immunology, Porphyromonas gingivalis/chemistry/immunology, Protein Binding, Spleen/cytology/*immunologyMetabolismEnzymology
19667049Identification of a gingipain-sensitive surface ligand of Porphyromonas gingivalis that induces Toll-like receptor 2- and 4-independent NF-kappaB activation in CHO cells.Haruyama K, Yoshimura A, Naito M, Kishimoto M, Shoji M, Abiko Y, Hara Y, Nakayama KInfect Immun10.1128/IAI.00140-092009Adhesins, Bacterial/*metabolism, Amino Acid Sequence, Animals, Bacterial Proteins/chemistry/*immunology/isolation & purification/metabolism, CHO Cells, Cricetinae, Cricetulus, Cysteine Endopeptidases/*metabolism, Gene Deletion, Genes, Bacterial, Gingipain Cysteine Endopeptidases, Mass Spectrometry, Membrane Proteins/chemistry/*immunology/isolation & purification/metabolism, Molecular Sequence Data, Molecular Weight, NF-kappa B/*metabolism, Porphyromonas gingivalis/*immunology, Toll-Like Receptor 2/*immunology, Toll-Like Receptor 4/*immunologyMetabolismEnzymology
19712925The effects of nicotine and cotinine on Porphyromonas gingivalis colonisation of epithelial cells.Cogo K, Calvi BM, Mariano FS, Franco GC, Goncalves RB, Groppo FCArch Oral Biol10.1016/j.archoralbio.2009.08.0012009Cell Survival/drug effects, Cotinine/*pharmacology, Epithelial Cells/drug effects/*microbiology, Humans, Indicators and Reagents/pharmacology, KB Cells, Nicotine/*pharmacology, Nicotinic Agonists/*pharmacology, Porphyromonas gingivalis/*drug effects/physiologyPathogenicity
19723305Pathway analysis for intracellular Porphyromonas gingivalis using a strain ATCC 33277 specific database.Hendrickson EL, Xia Q, Wang T, Lamont RJ, Hackett MBMC Microbiol10.1186/1471-2180-9-1852009Bacteroidaceae Infections/*microbiology, Cell Line, Databases, Protein, Humans, Metabolic Networks and Pathways, Porphyromonas gingivalis/genetics/*metabolism/pathogenicity, Proteome/*metabolism, Proteomics/*methods, VirulencePathogenicityMetabolism
19749049Mutualistic biofilm communities develop with Porphyromonas gingivalis and initial, early, and late colonizers of enamel.Periasamy S, Kolenbrander PEJ Bacteriol10.1128/JB.01006-092009Actinomyces/growth & development, Aggregatibacter actinomycetemcomitans/growth & development, Biofilms/*growth & development, Dental Enamel/microbiology, Fusobacterium nucleatum/growth & development, Humans, Polymerase Chain Reaction, Porphyromonas gingivalis/*growth & development, Saliva/microbiology, Streptococcus gordonii/growth & development, Streptococcus oralis/growth & development, Veillonella/growth & developmentPathogenicity
19778328Influence of serum on interaction of Porphyromonas gingivalis ATCC 33277 and Aggregatibacter actinomycetemcomitans Y4 with an epithelial cell line.Guentsch A, Ronnebeck M, Puklo M, Preshaw PM, Pfister W, Eick SJ Periodontal Res10.1111/j.1600-0765.2009.01224.x2009Adhesins, Bacterial/metabolism, Aggregatibacter actinomycetemcomitans/*physiology, Bacterial Adhesion/drug effects, *Blood, Blood Bactericidal Activity/physiology, Colony Count, Microbial, Cysteine Endopeptidases/metabolism, Gingipain Cysteine Endopeptidases, Hemagglutinins/metabolism, Humans, Interleukin-6/analysis, Interleukin-8/analysis, KB Cells/immunology/*microbiology, Porphyromonas gingivalis/*physiology, Serum Albumin/*pharmacology, Time FactorsMetabolismPathogenicity
19842848Lack of soluble tumor necrosis factor alpha receptor 1 and 2 and interleukin-1beta compartmentalization in lungs of mice after a single intratracheal inoculation with live Porphyromonas gingivalis.Nemec A, Pavlica Z, Svete AN, Erzen D, Crossley DA, Petelin MExp Lung Res10.1080/019021409027833812009Animals, Bacteroidaceae Infections/blood/*immunology/microbiology/pathology, Colony Count, Microbial, Disease Models, Animal, Interleukin-1beta/blood/*metabolism, Interleukin-6/blood/metabolism, Lung/immunology/microbiology/pathology, Male, Mice, Mice, Inbred BALB C, Pneumonia, Bacterial/blood/*immunology/microbiology/pathology, Porphyromonas gingivalis/*pathogenicity, Receptors, Tumor Necrosis Factor, Type I/blood/*metabolism, Receptors, Tumor Necrosis Factor, Type II/blood/*metabolism, Solubility, Tumor Necrosis Factor-alpha/blood/metabolismMetabolism
19931406The identification of genes specific to Prevotella intermedia and Prevotella nigrescens using genomic subtractive hybridization.Masakiyo Y, Yoshida A, Shintani Y, Takahashi Y, Ansai T, Takehara TAnaerobe10.1016/j.anaerobe.2009.11.0032009Acyltransferases/*genetics, DNA Transposable Elements/genetics, Genes, Bacterial, Nucleic Acid Hybridization/methods, Periodontitis/microbiology, Prevotella intermedia/*genetics/pathogenicity, Prevotella nigrescens/enzymology/*genetics, Site-Specific DNA-Methyltransferase (Adenine-Specific)/genetics, Species Specificity, Virulence/geneticsPhylogenyEnzymology
20005509Vitamin C attenuates the cytotoxic effects of Porphyromonas gingivalis on human gingival fibroblasts.Staudte H, Guntsch A, Volpel A, Sigusch BWArch Oral Biol10.1016/j.archoralbio.2009.11.0092009Apoptosis, Ascorbic Acid/*pharmacology, Cell Survival, Cytochromes c/metabolism, Fibroblasts/*drug effects, Gingiva/*drug effects/*microbiology, Humans, Porphyromonas gingivalis/*pathogenicity, Statistics, Nonparametric, Superoxides/metabolismPathogenicityMetabolism
20061484FimR and FimS: biofilm formation and gene expression in Porphyromonas gingivalis.Lo A, Seers C, Dashper S, Butler C, Walker G, Walsh K, Catmull D, Hoffmann B, Cleal S, Lissel P, Boyce J, Reynolds EJ Bacteriol10.1128/JB.01211-092010Amino Acid Sequence, Bacterial Proteins/genetics/*physiology, Base Sequence, Biofilms/*growth & development, Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Gene Knockout Techniques, Histidine Kinase, Humans, Molecular Sequence Data, Oligonucleotide Array Sequence Analysis, Porphyromonas gingivalis/*physiology, Protein Kinases/genetics/*physiology, Reverse Transcriptase Polymerase Chain Reaction/methods, *Signal TransductionPathogenicityGenetics
20079269[Construction of the hemagglutinin-2-deficient mutant of Porphyromonas gingivalis].Lin M, Yang QB, Yang SHZhonghua Kou Qiang Yi Xue Za Zhi2009Alleles, *Erythrocyte Aggregation, Hemagglutinins/*genetics, Polymerase Chain Reaction, Porphyromonas gingivalis/*genetics
20118268Histidine kinase-mediated production and autoassembly of Porphyromonas gingivalis fimbriae.Nishikawa K, Duncan MJJ Bacteriol10.1128/JB.01474-092010Bacterial Proteins/genetics/*metabolism, Fimbriae Proteins/*metabolism, Fimbriae, Bacterial/*metabolism, *Gene Expression Regulation, Bacterial, Genetic Complementation Test, Histidine Kinase, Porphyromonas gingivalis/enzymology/metabolism/*physiology, Protein Kinases/genetics/*metabolism, Sequence Deletion, Signal TransductionMetabolismBiotechnology
20337893Porphyromonas gingivalis stimulates the release of nitric oxide by inducing expression of inducible nitric oxide synthases and inhibiting endothelial nitric oxide synthases.Sun W, Wu J, Lin L, Huang Y, Chen Q, Ji YJ Periodontal Res10.1111/j.1600-0765.2009.01249.x2010Bacterial Adhesion/physiology, Blotting, Western, Cell Line, Cell Shape, Cytoplasm/microbiology, Endothelial Cells/enzymology/microbiology, Endothelium, Vascular/enzymology/microbiology, Enzyme Induction, Enzyme Inhibitors/*metabolism, Fimbriae, Bacterial/physiology, Humans, Microscopy, Electron, Transmission, Microscopy, Phase-Contrast, Nitric Oxide/*metabolism, Nitric Oxide Synthase Type II/*biosynthesis, Nitric Oxide Synthase Type III/*antagonists & inhibitors, Porphyromonas gingivalis/enzymology/*metabolism, Vacuoles/microbiologyEnzymologyMetabolism
20380884Mixture of periodontopathogenic bacteria influences interaction with KB cells.Kirschbaum M, Schultze-Mosgau S, Pfister W, Eick SAnaerobe10.1016/j.anaerobe.2010.03.0092010*Bacterial Adhesion, Bacteroidetes/growth & development/*pathogenicity, Coculture Techniques, Epithelial Cells/immunology/*microbiology, Fusobacterium nucleatum/growth & development/*pathogenicity, Humans, Interleukins/*metabolism, KB Cells, Periodontal Diseases/*microbiology, Treponema denticola/growth & development/*pathogenicityPathogenicityMetabolism
20430367Systemic use of selective iNOS inhibitor 1400W or non-selective NOS inhibitor l-NAME differently affects systemic nitric oxide formation after oral Porphyromonas gingivalis inoculation in mice.Nemec A, Pavlica Z, Petelin M, Crossley DA, Sentjurc M, Jerin A, Erzen D, Zdovc I, Hitti T, Skaleric UArch Oral Biol10.1016/j.archoralbio.2010.04.0032010Amidines/*pharmacology, Animals, Aorta, Thoracic/metabolism, Benzylamines/*pharmacology, Enzyme Inhibitors/*pharmacology, Female, Free Radical Scavengers/*metabolism, Kidney/metabolism, Liver/metabolism, Lung/metabolism, Mice, Mice, Inbred BALB C, Models, Animal, Mouth/*microbiology, Mouth Mucosa/microbiology, Myocardium/metabolism, NG-Nitroarginine Methyl Ester/*pharmacology, Nitrates/blood, Nitric Oxide/*metabolism, Nitric Oxide Synthase Type II/*antagonists & inhibitors, Nitrites/blood, Porphyromonas gingivalis/*physiology, Random Allocation, Spleen/metabolism, Tissue DistributionMetabolism
20519492High antibody levels to P. gingivalis in cardiovascular disease.Bohnstedt S, Cullinan MP, Ford PJ, Palmer JE, Leishman SJ, Westerman B, Marshall RI, West MJ, Seymour GJJ Dent Res10.1177/00220345103708172010Adolescent, Adult, Aged, Analysis of Variance, Antibodies, Bacterial/*blood, Cardiovascular Diseases/*blood/microbiology, Case-Control Studies, Chronic Periodontitis/*blood/microbiology, Cross-Sectional Studies, Female, Humans, Immunoenzyme Techniques, Immunoglobulin G/blood, Male, Middle Aged, Porphyromonas gingivalis/classification/immunology/*pathogenicity, Risk Factors, Species Specificity, Statistics, Nonparametric, Young AdultPhylogenyPathogenicity
20530728FimB regulates FimA fimbriation in Porphyromonas gingivalis.Nagano K, Hasegawa Y, Murakami Y, Nishiyama S, Yoshimura FJ Dent Res10.1177/00220345103700892010Bacterial Adhesion/genetics/physiology, Fimbriae Proteins/genetics/*physiology, Fimbriae, Bacterial/genetics/*metabolism, Porphyromonas gingivalis/genetics/*physiology, Species SpecificityPhylogenyMetabolism
20558141Analysis of immunostimulatory activity of Porphyromonas gingivalis fimbriae conferred by Toll-like receptor 2.Aoki Y, Tabeta K, Murakami Y, Yoshimura F, Yamazaki KBiochem Biophys Res Commun10.1016/j.bbrc.2010.06.0402010Antibodies, Blocking/immunology, Cell Line, Endopeptidase K/metabolism, Fimbriae Proteins/*immunology, Fimbriae, Bacterial/*immunology, Hot Temperature, Humans, Interleukin-1 Receptor-Associated Kinases/metabolism, Lipopeptides/immunology, Macrophages/*immunology, Porphyromonas gingivalis/*immunology, Protein Denaturation, Toll-Like Receptor 2/antagonists & inhibitors/*biosynthesis, Tumor Necrosis Factor-alpha/biosynthesisPathogenicityMetabolism
20568993A monoclonal antibody against fimA type II Porphyromonas gingivalis inhibits IL-8 production in human gingival fibroblasts.Hijiya T, Shibata Y, Hayakawa M, Abiko YHybridoma (Larchmt)10.1089/hyb.2009.01092010Animals, Antibodies, Monoclonal/*immunology/isolation & purification/*pharmacology, Antibody Specificity, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Fibroblasts/metabolism, Fimbriae Proteins/*immunology, Gingiva/cytology/metabolism, Humans, Hybridomas, Immunotherapy, Interleukin-8/*antagonists & inhibitors/immunology/metabolism, Lipopolysaccharides/immunology/pharmacology, Mice, Mice, Inbred BALB C, Periodontitis/*immunology/microbiology/*therapy, Porphyromonas gingivalis/*immunologyMetabolismPathogenicity
20572922Trypsin-like protease-active extracellular protein extracts from Porphyromonas gingivalis ATCC 33277 induce apoptosis in bovine aortic endothelial cells.Tian N, Ouyang XYJ Periodontal Res10.1111/j.1600-0765.2010.01280.x2010Animals, Aorta/cytology/*drug effects, *Apoptosis/drug effects, Bacterial Proteins/*pharmacology, Cattle, Cell Adhesion/drug effects, Cells, Cultured, Culture Media, Conditioned/pharmacology, Endothelial Cells/drug effects, Endothelium, Vascular/cytology/*drug effects, Enzyme Activation/drug effects, Integrin beta1/metabolism, Mitogen-Activated Protein Kinases/metabolism, Porphyromonas gingivalis/*enzymology, Trypsin/*pharmacology, Trypsin Inhibitors/pharmacology, Tubulin/metabolism, Virulence Factors/pharmacologyPathogenicityMetabolism
20576685Identification of bistable populations of Porphyromonas gingivalis that differ in epithelial cell invasion.Suwannakul S, Stafford GP, Whawell SA, Douglas CWIMicrobiology (Reading)10.1099/mic.0.038075-02010Adhesins, Bacterial/*metabolism, Bacteroidaceae Infections/*microbiology, Cell Line, Cysteine Endopeptidases/*metabolism, Epithelial Cells/*microbiology, Gene Expression Profiling, Gingipain Cysteine Endopeptidases, Humans, Hydrogen Peroxide/metabolism, Mutation, Oligonucleotide Array Sequence Analysis, Oxidative Stress, Peptide Hydrolases/metabolism, Phenotype, Porphyromonas gingivalis/enzymology/genetics/*pathogenicity, VirulenceMetabolismPathogenicity
20646228NO production in RAW264 cells stimulated with Porphyromonas gingivalis extracellular vesicles.Imayoshi R, Cho T, Kaminishi HOral Dis10.1111/j.1601-0825.2010.01708.x2011Animals, Bacterial Outer Membrane Proteins/*immunology, Cells, Cultured, Exocytosis, Lipopolysaccharides/immunology, Macrophages/immunology/*metabolism, Mice, Nitric Oxide/*metabolism, Nitric Oxide Synthase Type II/*metabolism, Peptide Hydrolases/immunology, Porphyromonas gingivalis/*pathogenicity, Secretory VesiclesMetabolismBiotechnology
20657724Porphyromonas gingivalis resistance to polymyxin B is determined by the lipid A 4'-phosphatase, PGN_0524.Coats SR, To TT, Jain S, Braham PH, Darveau RPInt J Oral Sci10.4248/IJOS.090622009Anti-Bacterial Agents/*pharmacology, Chromosome Mapping, DNA Transposable Elements/genetics, Drug Resistance, Bacterial/*genetics, E-Selectin/analysis/immunology, Endothelial Cells/immunology/microbiology, Gene Deletion, Humans, Lipid A/analysis/immunology, Lipopolysaccharides/analysis/immunology, Mutagenesis, Insertional/genetics, Open Reading Frames/genetics, Phosphoric Monoester Hydrolases/genetics/*physiology, Polymyxin B/*pharmacology, Porphyromonas gingivalis/*enzymology/genetics, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Toll-Like Receptor 4/analysis/immunology, Virulence Factors/physiologyPathogenicityEnzymology
20805334Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats.Bainbridge B, Verma RK, Eastman C, Yehia B, Rivera M, Moffatt C, Bhattacharyya I, Lamont RJ, Kesavalu LInfect Immun10.1128/IAI.00703-102010Alveolar Bone Loss/immunology/*microbiology/pathology, Animals, Antibodies, Bacterial/blood, Bacteroidaceae Infections/immunology/*microbiology/pathology, Disease Models, Animal, Female, Humans, Immunoglobulin G/blood, Inflammation/immunology/microbiology/pathology, Periodontal Diseases/immunology/*microbiology/pathology, Phosphoric Monoester Hydrolases/genetics/*metabolism, Porphyromonas gingivalis/enzymology/genetics/immunology/*pathogenicity, Rats, Rats, Sprague-DawleyPathogenicityEnzymology
20825555Porphorymonas gingivalis induces intracellular adhesion molecule-1 expression in endothelial cells through the nuclear factor-kappaB pathway, but not through the p38 MAPK pathway.Zhang D, Zheng H, Zhao J, Lin L, Li C, Liu J, Pan YJ Periodontal Res10.1111/j.1600-0765.2010.01305.x2010Active Transport, Cell Nucleus, Analysis of Variance, Cell Line, Cell Nucleus/metabolism, Endothelial Cells/metabolism/*microbiology, Humans, I-kappa B Proteins/metabolism, Inflammation Mediators/metabolism, Intercellular Adhesion Molecule-1/*biosynthesis/genetics, NF-KappaB Inhibitor alpha, NF-kappa B/*metabolism, Periodontitis/metabolism/*microbiology, Phosphorylation, Porphyromonas gingivalis/genetics/*physiology, Signal Transduction, Species Specificity, Transcription Factor RelA/biosynthesis, Umbilical Veins/cytology, Virulence Factors, p38 Mitogen-Activated Protein Kinases/*metabolismMetabolismPathogenicity
21189086Fimbriae of Porphyromonas gingivalis are important for initial invasion of osteoblasts, but not for inhibition of their differentiation and mineralization.Zhang W, Ju J, Rigney T, Tribble GDJ Periodontol10.1902/jop.2010.1005012010Animals, Bacterial Adhesion/physiology, Calcification, Physiologic, Cell Differentiation, Cell Proliferation, Cells, Cultured, Fimbriae Proteins/genetics, Fimbriae, Bacterial/genetics/*physiology, Gene Knockout Techniques, Mice, Mice, Inbred Strains, Osteoblasts/*microbiology, Porphyromonas gingivalis/*physiology, Species SpecificityPhylogeny
21245264The atherogenic bacterium Porphyromonas gingivalis evades circulating phagocytes by adhering to erythrocytes.Belstrom D, Holmstrup P, Damgaard C, Borch TS, Skjodt MO, Bendtzen K, Nielsen CHInfect Immun10.1128/IAI.01036-102011Adolescent, Adult, Aged, Atherosclerosis/immunology/*microbiology, Bacterial Adhesion/*immunology, Cell Adhesion, Cell Separation, Complement Activation/immunology, Complement C3/immunology, Erythrocytes/cytology/metabolism/*microbiology, Female, Flow Cytometry, Humans, Male, Middle Aged, Phagocytes/*immunology, Porphyromonas gingivalis/*immunology, Young AdultPathogenicityMetabolism
21527470Characterization of the Porphyromonas gingivalis conjugative transposon CTnPg1: determination of the integration site and the genes essential for conjugal transfer.Naito M, Sato K, Shoji M, Yukitake H, Ogura Y, Hayashi T, Nakayama KMicrobiology (Reading)10.1099/mic.0.047803-02011Attachment Sites, Microbiological/genetics, Bacterial Proteins/genetics, *Conjugation, Genetic, DNA Topoisomerases, Type I/metabolism, *DNA Transposable Elements, DNA, Bacterial/genetics, Gene Transfer, Horizontal, *Genes, Bacterial, Integrases/genetics/metabolism, Periodontal Diseases/microbiology, Polymerase Chain Reaction, Porphyromonas gingivalis/enzymology/*genetics, Rec A Recombinases/genetics/metabolismMetabolismEnzymology
21803908Time course of gene expression during Porphyromonas gingivalis strain ATCC 33277 biofilm formation.Yamamoto R, Noiri Y, Yamaguchi M, Asahi Y, Maezono H, Ebisu SAppl Environ Microbiol10.1128/AEM.00746-112011Biofilms/*growth & development, *Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Porphyromonas gingivalis/genetics/growth & development/*physiology, Time Factors
21842144Influence of gaseous ozone in peri-implantitis: bactericidal efficacy and cellular response. An in vitro study using titanium and zirconia.Hauser-Gerspach I, Vadaszan J, Deronjic I, Gass C, Meyer J, Dard M, Waltimo T, Stubinger S, Mauth CClin Oral Investig10.1007/s00784-011-0603-22011Acid Etching, Dental/methods, Anti-Bacterial Agents/*pharmacology, Anti-Infective Agents, Local/pharmacology, Bacterial Adhesion/drug effects, Cell Adhesion/drug effects, Cell Culture Techniques, Cell Line, Tumor, Cell Movement/drug effects, Cell Proliferation/drug effects, Cell Shape/drug effects, Chlorhexidine/pharmacology, Dental Etching/methods, Dental Materials/*chemistry, Dental Polishing/methods, Humans, Microscopy, Electron, Scanning, Osteoblasts/*drug effects, Oxidants/*pharmacology, Ozone/*pharmacology, Peri-Implantitis/*microbiology, Porphyromonas gingivalis/*drug effects, Saliva/chemistry, Streptococcus sanguis/*drug effects, Surface Properties, Time Factors, Titanium/*chemistry, Yttrium/chemistry, Zirconium/*chemistryPathogenicity
21864411Comparison of the virulence of exopolysaccharide-producing Prevotella intermedia to exopolysaccharide non-producing periodontopathic organisms.Yamanaka T, Yamane K, Furukawa T, Matsumoto-Mashimo C, Sugimori C, Nambu T, Obata N, Walker CB, Leung KP, Fukushima HBMC Infect Dis10.1186/1471-2334-11-2282011Abscess/microbiology/pathology, Animals, Immune Evasion, Male, Mice, Mice, Inbred BALB C, Phagocytosis, Polysaccharides, Bacterial/*metabolism, Porphyromonas gingivalis/immunology/*metabolism/*pathogenicity, Prevotella intermedia/immunology/*metabolism/*pathogenicity, Virulence, Virulence Factors/*metabolismMetabolism
21905903The bactericidal effects of an acidified sodium chlorite-containing oral moisturizing gel: a pilot study.Kuroyama I, Osato S, Ogawa TJ Oral Implantol10.1563/AAID-JOI-D-11-000872011Acids, Aged, Bacteria, Anaerobic/*drug effects, Chlorides/*pharmacology, Dental Disinfectants/*pharmacology, Female, Gels, Gingival Crevicular Fluid/microbiology, Humans, Hydrogen-Ion Concentration, Lubricants/chemistry/pharmacology, Male, Middle Aged, Mouthwashes/chemistry/*pharmacology, Pilot ProjectsPathogenicity
22035412Porphyromonas gingivalis promotes monocyte migration by activating MMP-9.Zhou J, Zhang J, Chao JJ Periodontal Res10.1111/j.1600-0765.2011.01427.x2011Cathepsins/antagonists & inhibitors, Cell Culture Techniques, Cell Line, Cell Movement/drug effects/physiology, Chemotaxis, Leukocyte/drug effects/physiology, Culture Media, Conditioned, Cysteine Proteinase Inhibitors/pharmacology, Dipeptides/pharmacology, Dose-Response Relationship, Drug, Enzyme Activation/drug effects, Enzyme Precursors/metabolism, Humans, Leupeptins/pharmacology, Lipopolysaccharide Receptors/analysis, Lipopolysaccharides/pharmacology, Matrix Metalloproteinase 9/drug effects/*metabolism, Matrix Metalloproteinase Inhibitors, Monocytes/enzymology/immunology/*microbiology, Porphyromonas gingivalis/*physiology, Protease Inhibitors/pharmacology, Tissue Inhibitor of Metalloproteinase-1/metabolismPathogenicityMetabolism
22109358[Cloning and expression of peptidylarginine deiminase of Porphyromonas gingivalis].Li A, Zhu CH, Shi JF, Wei H, Liu J, Gou JZShanghai Kou Qiang Yi Xue2011Cells, Cultured, *Cloning, Molecular, Escherichia coli, Genetic Vectors, Hydrolases, Plasmids, Polymerase Chain Reaction, *Porphyromonas gingivalis, Protein-Arginine DeiminasesEnzymology
22144476VimA-dependent modulation of acetyl coenzyme A levels and lipid A biosynthesis can alter virulence in Porphyromonas gingivalis.Aruni AW, Lee J, Osbourne D, Dou Y, Roy F, Muthiah A, Boskovic DS, Fletcher HMInfect Immun10.1128/IAI.06062-112011Acetyl Coenzyme A/genetics/*metabolism, Adhesins, Bacterial/metabolism, Amino Acid Sequence, Amino Acids/metabolism, Bacterial Proteins/genetics/*metabolism, Cysteine Endopeptidases/metabolism, Cytoskeleton, Epithelial Cells/cytology/microbiology, Gene Expression Regulation, Bacterial/*physiology, Gingipain Cysteine Endopeptidases, HeLa Cells, Humans, Isoleucine/metabolism, Lipid A/*biosynthesis, Molecular Sequence Data, Neuraminidase/metabolism, Phylogeny, Porphyromonas gingivalis/genetics/*metabolism/*pathogenicity, Protein Transport, VirulenceMetabolismPathogenicity
22203875In Vitro Antibacterial Activity of Galls of Quercus infectoria Olivier against Oral Pathogens.Basri DF, Tan LS, Shafiei Z, Zin NMEvid Based Complement Alternat Med10.1155/2012/6327962011
22443638Virulence genes of Porphyromonas gingivalis W83 in chronic periodontitis.Lin L, Li C, Liu J, Zhang D, Zhao J, Kou Y, Yu N, Pan YActa Odontol Scand10.1080/000163509028418902009Adult, Aged, Alveolar Bone Loss/microbiology, Bacteriological Techniques, Bacteroidaceae Infections/microbiology, Carbocyanines, Chronic Periodontitis/*microbiology, DNA Probes, DNA, Bacterial/genetics, Female, Fluorescent Dyes, Genes, Bacterial/*genetics, Gingival Hemorrhage/microbiology, Humans, Male, Middle Aged, Nucleic Acid Hybridization/methods, Oligonucleotide Array Sequence Analysis, Periodontal Attachment Loss/microbiology, Periodontal Pocket/microbiology, Porphyromonas gingivalis/classification/*genetics/pathogenicity, Tooth Mobility/microbiology, Virulence Factors/*geneticsPathogenicityPhylogeny
22655910Periodontal and systemic responses in various mice models of experimental periodontitis: respective roles of inflammation duration and Porphyromonas gingivalis infection.Saadi-Thiers K, Huck O, Simonis P, Tilly P, Fabre JE, Tenenbaum H, Davideau JLJ Periodontol10.1902/jop.2012.1105402012Alveolar Bone Loss/metabolism/pathology, Animals, Cathepsin B/metabolism, *Disease Models, Animal, Gastric Lavage, Inflammation/*physiopathology, Interleukin-1beta/blood, Interleukin-6/blood, Ligation, Matrix Metalloproteinase 9/metabolism, Mice, Mice, Inbred C57BL, Osteoclasts/pathology, Periodontitis/*enzymology/*microbiology/pathology, Porphyromonas gingivalis/*physiology, Time Factors, VirulenceMetabolismPathogenicity
22771792Strain-specific colonization patterns and serum modulation of multi-species oral biofilm development.Biyikoglu B, Ricker A, Diaz PIAnaerobe10.1016/j.anaerobe.2012.06.0032012Actinomyces/growth & development, Bacterial Adhesion, Bacteriological Techniques, Biofilms/*drug effects, Biota, Culture Media/metabolism, Fusobacterium nucleatum/*growth & development, Humans, Microbial Interactions, Microbial Viability, Porphyromonas gingivalis/*growth & development, Saliva/metabolism, Serum/*metabolism, Species SpecificityPathogenicityMetabolism
22847803Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in mice.Adamowicz K, Wang H, Jotwani R, Zeller I, Potempa J, Scott DAMol Med10.2119/molmed.2012.001802012Alveolar Bone Loss/*enzymology/*microbiology/pathology/prevention & control, Animals, Glycogen Synthase Kinase 3/*antagonists & inhibitors/metabolism, Glycogen Synthase Kinase 3 beta, Indoles/pharmacology/therapeutic use, Inflammation/complications/pathology, Interleukin-17/metabolism, Maleimides/pharmacology/therapeutic use, Maxilla/drug effects/pathology, Mice, Neutrophil Infiltration/drug effects, Porphyromonas gingivalis/drug effects/*physiology, Toll-Like Receptors/metabolismPathogenicityMetabolism
22885479[Virulent properties of Porphyromonas gingivalis clinical strains].Li YP, Liu DL, Shu R, Zhou YBShanghai Kou Qiang Yi Xue2012Abscess, Animals, Humans, Mice, Mice, Inbred BALB C, Models, Animal, *Porphyromonas gingivalis, VirulencePathogenicity
22919670Deep sequencing of Porphyromonas gingivalis and comparative transcriptome analysis of a LuxS mutant.Hirano T, Beck DA, Demuth DR, Hackett M, Lamont RJFront Cell Infect Microbiol10.3389/fcimb.2012.000792012Bacterial Proteins/*genetics/*metabolism, Carbon-Sulfur Lyases/*genetics/*metabolism, Gene Deletion, *Gene Expression Profiling, *Gene Expression Regulation, Bacterial, High-Throughput Nucleotide Sequencing, Homoserine/analogs & derivatives/metabolism, Lactones/metabolism, Porphyromonas gingivalis/*genetics, Sequence Analysis, RNA, Signal Transduction/geneticsMetabolismTranscriptome
23002421Purification and characterization of a novel secondary fimbrial protein from Porphyromonas gulae.Oishi Y, Watanabe K, Kumada H, Ishikawa E, Hamada NJ Oral Microbiol10.3402/jom.v4i0.190762012Enzymology
23033940Porphyromonas gingivalis displays a competitive advantage over Aggregatibacter actinomycetemcomitans in co-cultured biofilm.Takasaki K, Fujise O, Miura M, Hamachi T, Maeda KJ Periodontal Res10.1111/jre.120062012Adhesins, Bacterial/physiology, Aggregatibacter actinomycetemcomitans/*growth & development/physiology, *Biofilms/growth & development, Coculture Techniques, Colony Count, Microbial, Cysteine Endopeptidases/physiology, Gingipain Cysteine Endopeptidases, *Microbial Interactions, Porphyromonas gingivalis/*growth & development/physiology, Proteolysis
23034475Porphyromonas gingivalis entry into gingival epithelial cells modulated by Fusobacterium nucleatum is dependent on lipid rafts.Saito A, Kokubu E, Inagaki S, Imamura K, Kita D, Lamont RJ, Ishihara KMicrob Pathog10.1016/j.micpath.2012.08.0052012Cell Line, *Endocytosis, Epithelial Cells/*microbiology, Fusobacterium nucleatum/*metabolism/*pathogenicity, Humans, Membrane Microdomains/*metabolism, *Microbial Interactions, Microscopy, Confocal, Microscopy, Electron, Scanning, Porphyromonas gingivalis/*pathogenicity, Time FactorsMetabolismPathogenicity
23049613Antibacterial Activity of Myristica fragrans against Oral Pathogens.Shafiei Z, Shuhairi NN, Md Fazly Shah Yap N, Harry Sibungkil CA, Latip JEvid Based Complement Alternat Med10.1155/2012/8253622012
23114059Identification of essential genes of the periodontal pathogen Porphyromonas gingivalis.Klein BA, Tenorio EL, Lazinski DW, Camilli A, Duncan MJ, Hu LTBMC Genomics10.1186/1471-2164-13-5782012Base Sequence, Chromosome Mapping, Computational Biology, DNA Primers/genetics, DNA Transposable Elements/genetics, *Gene Library, Genes, Essential/*genetics, High-Throughput Nucleotide Sequencing, Molecular Sequence Data, Mutagenesis/genetics, Polymerase Chain Reaction, Porphyromonas gingivalis/*geneticsGenetics
23134611Identification and characterization of novel glycoproteins involved in growth and biofilm formation by Porphyromonas gingivalis.Kishi M, Hasegawa Y, Nagano K, Nakamura H, Murakami Y, Yoshimura FMol Oral Microbiol10.1111/j.2041-1014.2012.00659.x2012Amino Acid Motifs, Bacterial Adhesion, Bacterial Outer Membrane Proteins/isolation & purification, Bacterial Proteins/*isolation & purification, Biofilms/*growth & development, Cell Fractionation, Coloring Agents, Electrophoresis, Gel, Two-Dimensional, Glycoproteins/*isolation & purification, Humans, Mass Spectrometry, Molecular Chaperones/isolation & purification, Mutation/genetics, Periplasm/chemistry/ultrastructure, Porphyromonas gingivalis/genetics/*growth & development/physiology, Proteome/isolation & purification, Repetitive Sequences, Amino Acid, Saliva/microbiology, Tacrolimus Binding Proteins/isolation & purificationEnzymologyPhylogeny
23279840Benzamidine derivatives inhibit the virulence of Porphyromonas gingivalis.Frohlich E, Kantyka T, Plaza K, Schmidt KH, Pfister W, Potempa J, Eick SMol Oral Microbiol10.1111/omi.120152012Adhesins, Bacterial/biosynthesis/genetics, Animals, Benzamidines/*pharmacology, Chaperonin 60/antagonists & inhibitors/biosynthesis/genetics, Chick Embryo, Chromatography, Affinity, Cyclohexanones/*pharmacology, Cysteine Endopeptidases/biosynthesis/genetics, Gingipain Cysteine Endopeptidases, Hot Temperature, Pentamidine/*pharmacology, Porphyromonas gingivalis/*drug effects/*pathogenicity, Virulence/drug effects, Virulence Factors/antagonists & inhibitors/biosynthesisStressPathogenicity
23279858Gingival fibroblast responsiveness is differentially affected by Porphyromonas gingivalis: implications for the pathogenesis of periodontitis.Scheres N, Crielaard WMol Oral Microbiol10.1111/omi.120162012Adhesins, Bacterial/immunology, Adult, Chemokine CCL2/biosynthesis/genetics/immunology, Chemokines/immunology, Chemotaxis/immunology, Cysteine Endopeptidases/immunology, Female, Fibroblasts/immunology/*microbiology, Gingipain Cysteine Endopeptidases, Gingiva/cytology/immunology/*microbiology, Gingivitis/immunology/microbiology, Humans, Interleukin-1beta/biosynthesis/immunology, Interleukin-6/biosynthesis/genetics/immunology, Interleukin-8/biosynthesis/genetics/immunology, Male, Middle Aged, Periodontitis/*immunology/*microbiology, Porphyromonas gingivalis/immunology/*pathogenicity, Statistics, Nonparametric, Virulence FactorsPathogenicity
23305098Integrin alpha5beta1-fimbriae binding and actin rearrangement are essential for Porphyromonas gingivalis invasion of osteoblasts and subsequent activation of the JNK pathway.Zhang W, Ju J, Rigney T, Tribble GBMC Microbiol10.1186/1471-2180-13-52013Actins/*metabolism, Animals, Apoptosis, Cells, Cultured, *Endocytosis, Fimbriae, Bacterial/metabolism, *Host-Pathogen Interactions, Integrin alpha5beta1/*metabolism, *MAP Kinase Signaling System, Mice, Osteoblasts/*microbiology, Porphyromonas gingivalis/*pathogenicity, Protein BindingMetabolismPathogenicity
23405247The sinR ortholog PGN_0088 encodes a transcriptional regulator that inhibits polysaccharide synthesis in Porphyromonas gingivalis ATCC 33277 biofilms.Yamamoto R, Noiri Y, Yamaguchi M, Asahi Y, Maezono H, Kuboniwa M, Hayashi M, Ebisu SPLoS One10.1371/journal.pone.00560172013Bacillus subtilis/*physiology, Bacterial Proteins/genetics/*metabolism, *Biofilms, Blotting, Southern, DNA, Bacterial/genetics, Gene Expression Regulation, Bacterial, Microscopy, Electron, Scanning, Mutation/genetics, Polysaccharides, Porphyromonas gingivalis/*metabolism, Promoter Regions, Genetic/genetics, Transcription, Genetic/*physiologyMetabolismGenetics
23439308Porphyromonas gingivalis infection-associated periodontal bone resorption is dependent on receptor activator of NF-kappaB ligand.Han X, Lin X, Yu X, Lin J, Kawai T, LaRosa KB, Taubman MAInfect Immun10.1128/IAI.00043-132013Alveolar Bone Loss/immunology/metabolism/*microbiology, Animals, Bacteroidaceae Infections/*complications/immunology/metabolism, Bone Resorption/microbiology, Cell Proliferation, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Gingiva/metabolism, Immunoglobulin A/immunology, Immunoglobulin G/immunology, Lymphocytes/physiology, Maxillary Diseases/immunology/metabolism/*microbiology, Osteoclasts/physiology, *Porphyromonas gingivalis, RANK Ligand/*metabolism, RatsMetabolism
23441868Antimicrobial effect of photodynamic therapy using high-power blue light-emitting diode and red-dye agent on Porphyromonas gingivalis.Chui C, Aoki A, Takeuchi Y, Sasaki Y, Hiratsuka K, Abiko Y, Izumi YJ Periodontal Res10.1111/jre.120552013Anti-Infective Agents/*pharmacology, Bacterial Load/drug effects, Bacteriological Techniques, Coloring Agents/pharmacology, Erythrosine/pharmacology, Fluoresceins/pharmacology, Fluorescent Dyes/*pharmacology, Humans, Photochemotherapy/*instrumentation/methods, Photosensitizing Agents/*pharmacology, Porphyromonas gingivalis/*drug effects, Rose Bengal/pharmacology, Temperature, Tolonium Chloride/pharmacologyPathogenicity
23509024Identification of an O-antigen chain length regulator, WzzP, in Porphyromonas gingivalis.Shoji M, Yukitake H, Sato K, Shibata Y, Naito M, Aduse-Opoku J, Abiko Y, Curtis MA, Nakayama KMicrobiologyopen10.1002/mbo3.842013Bacterial Proteins/genetics/*metabolism, DNA Transposable Elements, Escherichia coli/genetics/metabolism, Genetic Complementation Test, Humans, Mutagenesis, Insertional, O Antigens/genetics/*metabolism, Porphyromonas gingivalis/genetics/*metabolism, Sequence Homology, Amino AcidMetabolismPathogenicity
23594193Microcalorimetric determination of the effects of amoxicillin, metronidazole, and their combination on in vitro biofilm.Astasov-Frauenhoffer M, Braissant O, Hauser-Gerspach I, Weiger R, Walter C, Zitzmann NU, Waltimo TJ Periodontol10.1902/jop.2013.1207332013Amoxicillin/administration & dosage/*pharmacology, Anaerobiosis, Anti-Bacterial Agents/administration & dosage/*pharmacology, Bacterial Adhesion, Bacterial Load/drug effects, Bacteriological Techniques, Biofilms/*drug effects/growth & development, Calorimetry/methods, Culture Media, Drug Combinations, Drug Resistance, Bacterial, Fluorescein-5-isothiocyanate, Fluorescent Dyes, Fusobacterium nucleatum/drug effects, Humans, In Vitro Techniques, Metronidazole/administration & dosage/*pharmacology, Microbial Sensitivity Tests, Microbial Viability/drug effects, Porphyromonas gingivalis/drug effects, Streptococcus sanguis/drug effects, Temperature, Time FactorsPathogenicityCultivation
23717416In Porphyromonas gingivalis VimF is involved in gingipain maturation through the transfer of galactose.Muthiah AS, Aruni W, Robles AG, Dou Y, Roy F, Fletcher HMPLoS One10.1371/journal.pone.00633672013Adhesins, Bacterial/*metabolism, Biofilms, Cloning, Molecular, Cysteine Endopeptidases/*metabolism, Enzyme Precursors/*metabolism, Galactose/*metabolism, Galactosyltransferases/chemistry/genetics/*metabolism, Gene Knockout Techniques, Gingipain Cysteine Endopeptidases, Glycosylation, Kinetics, Phenotype, Porphyromonas gingivalis/*enzymology/genetics/growth & development/ultrastructure, Protein Processing, Post-TranslationalMetabolismEnzymology
23844074The unique hmuY gene sequence as a specific marker of Porphyromonas gingivalis.Gmiterek A, Wojtowicz H, Mackiewicz P, Radwan-Oczko M, Kantorowicz M, Chomyszyn-Gajewska M, Fraszczak M, Bielecki M, Olczak M, Olczak TPLoS One10.1371/journal.pone.00677192013Adult, Aged, Bacterial Proteins/chemistry/*genetics/metabolism, Bacteroidaceae Infections/*microbiology, Base Sequence, Biomarkers/analysis, Case-Control Studies, Chronic Periodontitis/*microbiology, Female, Heme/metabolism, Hemeproteins/metabolism, Humans, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Porphyromonas gingivalis/classification/*genetics/isolation & purification, Sequence AlignmentPhylogenyMetabolism
23844365Acute toxicity and the effect of andrographolide on Porphyromonas gingivalis-induced hyperlipidemia in rats.Al Batran R, Al-Bayaty F, Al-Obaidi MM, Abdulla MABiomed Res Int10.1155/2013/5940122013Animals, Antioxidants/metabolism, Biomarkers/metabolism, Diterpenes/*toxicity, Glutathione Peroxidase/metabolism, Hyperlipidemias/blood/*microbiology/pathology, Kidney/drug effects/pathology, Lipid Peroxidation/drug effects, Lipids/blood, Liver/drug effects/pathology, Male, Malondialdehyde/metabolism, Porphyromonas gingivalis/*physiology, Rats, Rats, Sprague-Dawley, Superoxide Dismutase/metabolism, *Toxicity Tests, AcuteMetabolismPathogenicity
24039921A two-component system regulates hemin acquisition in Porphyromonas gingivalis.Scott JC, Klein BA, Duran-Pinedo A, Hu L, Duncan MJPLoS One10.1371/journal.pone.00733512013Amino Acid Sequence, Bacterial Proteins/chemistry/*genetics/metabolism, Bacteroidaceae Infections/metabolism/*microbiology, Gene Expression Regulation, Bacterial, Genes, Bacterial, Hemin/*metabolism, Histidine Kinase, *Host-Pathogen Interactions, Humans, Iron/metabolism, Molecular Sequence Data, Mutation, Porphyromonas gingivalis/genetics/*physiology, Protein Kinases/chemistry/*genetics/metabolism, Signal TransductionMetabolismPathogenicity
24118823Localization and function of the accessory protein Mfa3 in Porphyromonas gingivalis Mfa1 fimbriae.Hasegawa Y, Nagano K, Ikai R, Izumigawa M, Yoshida Y, Kitai N, Lamont RJ, Murakami Y, Yoshimura FMol Oral Microbiol10.1111/omi.120402013Bacterial Proteins/*analysis/chemistry/genetics, Biofilms/growth & development, Fimbriae Proteins/*analysis/chemistry/genetics/*physiology, Fimbriae, Bacterial/chemistry/*physiology, Mutation, Porphyromonas gingivalis/chemistry/genetics/*physiology/ultrastructure
24147843Altered antigenic profiling and infectivity of Porphyromonas gingivalis in smokers and non-smokers with periodontitis.Zeller I, Hutcherson JA, Lamont RJ, Demuth DR, Gumus P, Nizam N, Buduneli N, Scott DAJ Periodontol10.1902/jop.2013.1303362013Adult, Aggressive Periodontitis/immunology/*microbiology, Antibodies, Bacterial/immunology, Antigens, Bacterial/*immunology, Bacterial Proteins/immunology, Bacteroidaceae Infections/immunology/microbiology, Chronic Periodontitis/immunology/*microbiology, Cotinine/analysis, DNA, Bacterial/analysis, Dental Plaque Index, Female, Fimbriae Proteins/immunology, Humans, Immunoglobulin G/immunology, Male, Middle Aged, Periodontal Index, Phenotype, Pili, Sex/immunology, Porphyromonas gingivalis/genetics/*immunology/pathogenicity, Saliva/chemistry, Smoking/*immunology, TobaccoPathogenicityPhenotype
24151590In-vivo effect of andrographolide on alveolar bone resorption induced by Porphyromonas gingivalis and its relation with antioxidant enzymes.Al Batran R, Al-Bayaty FH, Al-Obaidi MMBiomed Res Int10.1155/2013/2763292013Alveolar Bone Loss/*drug therapy/microbiology/pathology, Animals, Diterpenes/*administration & dosage, Humans, Mandible/*drug effects/pathology, Porphyromonas gingivalis/pathogenicity, RatsPathogenicityEnzymology
24284127Lethal photosensitization of Porphyromonas gingivalis by their endogenous porphyrins under anaerobic conditions: an in vitro study.Hope CK, Hindley JA, Khan Z, de Jong Ede J, Higham SMPhotodiagnosis Photodyn Ther10.1016/j.pdpdt.2013.08.0062013Anaerobiosis/physiology/radiation effects, Apoptosis/*physiology/*radiation effects, Dose-Response Relationship, Radiation, Light, Oxygen/metabolism, Photosensitizing Agents/metabolism, Porphyrins/*metabolism, Porphyromonas gingivalis/drug effects/*physiology/*radiation effects, Radiation DosageMetabolismPathogenicity
24398682Identification and characterization of prokaryotic dipeptidyl-peptidase 5 from Porphyromonas gingivalis.Ohara-Nemoto Y, Rouf SM, Naito M, Yanase A, Tetsuo F, Ono T, Kobayakawa T, Shimoyama Y, Kimura S, Nakayama K, Saiki K, Konishi K, Nemoto TKJ Biol Chem10.1074/jbc.M113.5273332014Aspergillus fumigatus/enzymology/genetics, Catalysis, *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/chemistry/genetics/metabolism, Fungal Proteins/chemistry/genetics/metabolism, *Periplasm/enzymology/genetics, *Periplasmic Proteins/chemistry/genetics/metabolism, *Porphyromonas gingivalis/enzymology/genetics, Sequence Homology, Amino AcidEnzymologyMetabolism
24458367In vitro activity of Carvacrol against titanium-adherent oral biofilms and planktonic cultures.Ciandrini E, Campana R, Federici S, Manti A, Battistelli M, Falcieri E, Papa S, Baffone WClin Oral Investig10.1007/s00784-013-1179-92014Anti-Infective Agents/*pharmacology, Bacteria/classification/*drug effects, Bacterial Adhesion/drug effects, Biofilms/*drug effects, Cymenes, Flow Cytometry, In Vitro Techniques, Microbial Sensitivity Tests, Monoterpenes/*pharmacology, Plankton/*drug effects, *TitaniumPathogenicityPhylogeny
24469122[Construction of recombinant for generation of Porphyromonas gingivalis minor accessory proteins FimCDE deficient strain].Li JJ, Gao X, Li KY, Wang WMShanghai Kou Qiang Yi Xue2013China, *Fimbriae Proteins, Humans, *Plasmids, *Porphyromonas gingivalisPathogenicity
24473989Photodynamic antimicrobial effect of safranine O on an ex vivo periodontal biofilm.Voos AC, Kranz S, Tonndorf-Martini S, Voelpel A, Sigusch H, Staudte H, Albrecht V, Sigusch BWLasers Surg Med10.1002/lsm.222172014Aggregatibacter actinomycetemcomitans/physiology, Anti-Bacterial Agents/pharmacology/*therapeutic use, Biofilms/*drug effects, Chlorhexidine/pharmacology/therapeutic use, Chronic Disease, Fusobacterium nucleatum/physiology, Humans, Periodontitis/*drug therapy/microbiology, Phenazines/pharmacology/*therapeutic use, *Photochemotherapy, Photosensitizing Agents/pharmacology/*therapeutic use, Porphyromonas gingivalis/physiology, Streptococcus gordonii/physiology, Treatment OutcomePathogenicity
24532232Importance of biofilm formation and dipeptidyl peptidase IV for the pathogenicity of clinical Porphyromonas gingivalis isolates.Clais S, Boulet G, Kerstens M, Horemans T, Teughels W, Quirynen M, Lanckacker E, De Meester I, Lambeir AM, Delputte P, Maes L, Cos PPathog Dis10.1111/2049-632X.121562014Abscess/microbiology, Animals, Biofilms/*growth & development, Dipeptidyl Peptidase 4/*biosynthesis, Disease Models, Animal, Enzyme Activation, Female, Humans, Mice, Periodontitis/microbiology, Porphyromonas gingivalis/pathogenicity/*physiology, VirulencePathogenicity
24608607[The expression of CD(4+) T cells in different bacteria strain-induced mice periodontitis].Wang LY, Jin Y, Lin XPShanghai Kou Qiang Yi Xue2014Alveolar Bone Loss, Animals, *Disease Models, Animal, Gingiva, Mice, Mice, Inbred C57BL, *Periodontitis, Porphyromonas gingivalis, *T-Lymphocytes
24626479Genetic exchange of fimbrial alleles exemplifies the adaptive virulence strategy of Porphyromonas gingivalis.Kerr JE, Abramian JR, Dao DH, Rigney TW, Fritz J, Pham T, Gay I, Parthasarathy K, Wang BY, Zhang W, Tribble GDPLoS One10.1371/journal.pone.00916962014Alleles, Fimbriae Proteins/genetics/metabolism, Fimbriae, Bacterial/*genetics, *Gene Transfer, Horizontal, Genetic Variation, Genotype, Humans, Periodontitis/*genetics/microbiology/pathology, Phenotype, Porphyromonas gingivalis/*genetics/pathogenicity, Virulence/geneticsGeneticsPathogenicity
24661327Porphyromonas gingivalis gingipain is involved in the detachment and aggregation of Aggregatibacter actinomycetemcomitans biofilm.Haraguchi A, Miura M, Fujise O, Hamachi T, Nishimura FMol Oral Microbiol10.1111/omi.120512014Adhesins, Bacterial/physiology, Aggregatibacter actinomycetemcomitans/*physiology, Bacterial Adhesion, *Biofilms, Hemagglutinins, Humans, Periodontal Diseases/microbiology, Porphyromonas gingivalis/*physiologyPathogenicity
24731418[The comparison of the ability of polysaccharide from different Porphyromonas gingivalis in inducing THP-1 cells to produce cytokines].Wang Y, Yumoto H, Liu D, Matsuo T, Shu RZhonghua Kou Qiang Yi Xue Za Zhi2014Cytokines/*metabolism, Interleukin-1beta, Interleukin-8, Lipopolysaccharides/*physiology, Porphyromonas gingivalis/*metabolism, Tumor Necrosis Factor-alphaMetabolism
24778902A periodontitis-associated multispecies model of an oral biofilm.Park JH, Lee JK, Um HS, Chang BS, Lee SYJ Periodontal Implant Sci10.5051/jpis.2014.44.2.792014
24820781[Analysis of capsule related surface properties of Porphyromonas gingivalis isolates].Zhou Y, Liu D, Li Y, Wang Y, Shu RZhonghua Kou Qiang Yi Xue Za Zhi2014*Bacterial Capsules, *Biofilms, Hydrophobic and Hydrophilic Interactions, Porphyromonas gingivalis/*isolation & purification, Surface PropertiesEnzymologyPhylogeny
24864137Susceptibility of Porphyromonas gingivalis and Streptococcus mutans to Antibacterial Effect from Mammea americana.Herrera Herrera A, Franco Ospina L, Fang L, Diaz Caballero AAdv Pharmacol Sci10.1155/2014/3848152014
24881201[Effects of Porphyromonas gingivalis infection on intercellular adhesion molecule-1 expression in rat vascular smooth muscle cells].Dai J, Lin J, Bi L, Jiao L, Wang QHua Xi Kou Qiang Yi Xue Za Zhi2014Animals, Cells, Cultured, *Intercellular Adhesion Molecule-1, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, *Porphyromonas gingivalis, RNA, Messenger, Rats
24887636Porphyromonas gingivalis stimulates IL-6 and IL-8 secretion in GMSM-K, HSC-3 and H413 oral epithelial cells.Yee M, Kim S, Sethi P, Duzgunes N, Konopka KAnaerobe10.1016/j.anaerobe.2014.05.0112014Cell Line, Coculture Techniques, Epithelial Cells/*immunology/*microbiology, *Host-Pathogen Interactions, Humans, Interleukin-6/*metabolism, Interleukin-8/*metabolism, Porphyromonas gingivalis/*immunologyPathogenicityMetabolism
24921431kgp, rgpA, and rgpB DNA vaccines induce antibody responses in experimental peri-implantitis.Guo M, Wang Z, Fan X, Bian Y, Wang T, Zhu L, Lan JJ Periodontol10.1902/jop.2014.1402402014Adhesins, Bacterial/genetics/*immunology, Administration, Intranasal, Animals, Antibodies, Bacterial/*immunology, Cysteine Endopeptidases/genetics/*immunology, Dental Implants/microbiology, Disease Models, Animal, Dogs, Genetic Vectors/genetics, Gingipain Cysteine Endopeptidases, Hemagglutinins/genetics/*immunology, Immunization/methods, Immunoglobulin A/immunology, Immunoglobulin G/immunology, Injections, Injections, Intramuscular, Male, Peri-Implantitis/*immunology/microbiology/prevention & control, Plasmids/genetics, Porphyromonas gingivalis/immunology, Salivary Glands/immunology, Vaccines, DNA/administration & dosage/*immunology
24981961Similar physiological effects in Porphyromonas gingivalis ATCC 33277 under hemin-excess and hemin-limited concentrations are putatively associated to different hydrogen peroxide function.Cueno ME, Tamura M, Ohya M, Ochiai KAnaerobe10.1016/j.anaerobe.2014.06.0112014Adhesins, Bacterial/metabolism, Butyrates/metabolism, Cysteine Endopeptidases/metabolism, Gingipain Cysteine Endopeptidases, Hemin/*metabolism, Hydrogen Peroxide/*metabolism, Porphyromonas gingivalis/growth & development/metabolism/*physiology, *Stress, Physiological, Superoxide Dismutase/metabolismMetabolism
25000206Structural significance of the beta1K396 residue found in the Porphyromonas gingivalis sialidase beta-propeller domain: a computational study with implications for novel therapeutics against periodontal disease.Cueno ME, Kamio N, Imai K, Ohya M, Tamura M, Ochiai KOMICS10.1089/omi.2013.01522014Bacterial Proteins/*chemistry, Binding Sites, Computational Biology, Humans, Imaging, Three-Dimensional, Models, Molecular, N-Acetylneuraminic Acid/chemistry/metabolism, Neuraminidase/*chemistry, Periodontal Diseases/enzymology/*therapy, Porphyromonas gingivalis/*enzymology, Protein Structure, Tertiary, Sequence Analysis, Protein, Sequence HomologyPathogenicityEnzymology
25037882Gingipains from Porphyromonas gingivalis play a significant role in induction and regulation of CXCL8 in THP-1 cells.Jayaprakash K, Khalaf H, Bengtsson TBMC Microbiol10.1186/1471-2180-14-1932014Adhesins, Bacterial/*immunology/metabolism, Cysteine Endopeptidases/*immunology/metabolism, Enzyme-Linked Immunosorbent Assay, Gene Expression Profiling, Gingipain Cysteine Endopeptidases, *Host-Pathogen Interactions, Humans, Interleukin-8/*immunology/metabolism, Monocytes/*immunology/*microbiology, Porphyromonas gingivalis/*immunology, Real-Time Polymerase Chain ReactionMetabolismPathogenicity
25055828Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis.Palm E, Khalaf H, Bengtsson TMol Oral Microbiol10.1111/omi.120732014Adhesins, Bacterial/genetics/*metabolism, Cells, Cultured, Cysteine Endopeptidases/genetics/*metabolism, Enzyme-Linked Immunosorbent Assay, Fibroblasts/*immunology/metabolism/*microbiology, Gingipain Cysteine Endopeptidases, Gingiva/cytology/*immunology, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism, Inflammation, Interleukin-8/metabolism, Periodontitis/immunology/metabolism/*microbiology, Porphyromonas gingivalis/*enzymology/pathogenicity, Proto-Oncogene Proteins c-jun/metabolism, Real-Time Polymerase Chain Reaction, Secretory Leukocyte Peptidase Inhibitor/genetics, Transforming Growth Factor beta/metabolismMetabolismPathogenicity
25064760Ameliorating effects of Juzentaihoto on restraint stress and P. gingivalis-induced alveolar bone loss.Takeda O, Toyama T, Watanabe K, Sato T, Sasaguri K, Akimoto S, Sato S, Kawata T, Hamada NArch Oral Biol10.1016/j.archoralbio.2014.06.0102014Alveolar Bone Loss/microbiology/*prevention & control, Animals, Biomarkers/analysis, Cell Differentiation, Cell Survival, Drugs, Chinese Herbal/*pharmacology, Male, Mice, Osteoclasts/drug effects, Periodontitis/drug therapy/microbiology, Porphyromonas gingivalis/*drug effects, Rats, Rats, Sprague-Dawley, Restraint, PhysicalPathogenicityStress
25176110Peptidylarginine deiminase from Porphyromonas gingivalis contributes to infection of gingival fibroblasts and induction of prostaglandin E2 -signaling pathway.Gawron K, Bereta G, Nowakowska Z, Lazarz-Bartyzel K, Lazarz M, Szmigielski B, Mizgalska D, Buda A, Koziel J, Oruba Z, Chomyszyn-Gajewska M, Potempa JMol Oral Microbiol10.1111/omi.120812014Adhesins, Bacterial/metabolism, Alanine/genetics, Aspirin/pharmacology, Bacterial Adhesion, Cells, Cultured, Cyclooxygenase 2/genetics/metabolism, Cysteine/genetics, Cysteine Endopeptidases/metabolism, Dinoprostone/*biosynthesis/metabolism, Fibroblasts/metabolism/*microbiology, Gene Knockout Techniques, Gingipain Cysteine Endopeptidases, Gingiva/cytology/*microbiology, Humans, Hydrolases/*metabolism, Immunoassay, Intramolecular Oxidoreductases/genetics/metabolism, Mutation, Porphyromonas gingivalis/enzymology/genetics/*pathogenicity, Prostaglandin-E Synthases, Protein-Arginine Deiminases, Real-Time Polymerase Chain Reaction, Signal TransductionMetabolismPathogenicity
25183268Antimicrobial activity against periodontopathogenic bacteria, antioxidant and cytotoxic effects of various extracts from endemic Thermopsis turcica.Bali EB, Acik L, Akca G, Sarper M, Elci MP, Avcu F, Vural MAsian Pac J Trop Biomed10.12980/APJTB.4.2014APJTB-2013-00102014
25240641P. gingivalis lipopolysaccharide intensifies inflammation post-myocardial infarction through matrix metalloproteinase-9.DeLeon-Pennell KY, de Castro Bras LE, Iyer RP, Bratton DR, Jin YF, Ripplinger CM, Lindsey MLJ Mol Cell Cardiol10.1016/j.yjmcc.2014.09.0072014Animals, Bacteroidaceae Infections/blood/enzymology/immunology, Cell Movement, Female, Gene Expression, Inflammation Mediators/metabolism, Lipopolysaccharides/*pharmacology, Macrophages/immunology, Male, Matrix Metalloproteinase 9/*blood/genetics, Mice, Inbred C57BL, Mice, Knockout, Myocardial Infarction/blood/enzymology/*immunology, Periodontal Diseases/blood/complications/microbiology, Porphyromonas gingivalis/*immunologyPathogenicityEnzymology
25336411Inhibitory effects of French pine bark extract, Pycnogenol(R), on alveolar bone resorption and on the osteoclast differentiation.Sugimoto H, Watanabe K, Toyama T, Takahashi SS, Sugiyama S, Lee MC, Hamada NPhytother Res10.1002/ptr.52452014Acid Phosphatase, Alveolar Bone Loss/*prevention & control, Animals, Anti-Bacterial Agents/pharmacology, Bone and Bones/drug effects, Cell Differentiation/drug effects, Cell Line, Cells, Cultured, Epithelial Cells/drug effects, Flavonoids/*pharmacology, Gingiva/cytology, Humans, Isoenzymes, Male, Mice, Inbred BALB C, Osteoclasts/*drug effects, Periodontitis/microbiology/prevention & control, Pinus/*chemistry, Plant Bark/chemistry, Plant Extracts, Porphyromonas gingivalis/drug effects, Rats, Sprague-Dawley, Tartrate-Resistant Acid PhosphatasePathogenicityEnzymology
25353706The profile of Porphyromonas gingivalis kgp biotype and fimA genotype mosaic in subgingival plaque samples.Nadkarni MA, Chhour KL, Chapple CC, Nguyen KA, Hunter NFEMS Microbiol Lett10.1111/1574-6968.126312014Adhesins, Bacterial/*genetics, Adult, Bacterial Proteins/genetics, Bacteroidaceae Infections/*microbiology, Cysteine Endopeptidases/*genetics, Dental Plaque/*microbiology, Female, Fimbriae Proteins/*genetics, Genotype, Gingipain Cysteine Endopeptidases, Humans, Male, Periodontitis/*microbiology, Porphyromonas gingivalis/classification/enzymology/*genetics/*isolation & purification, Young AdultGeneticsPathogenicity
25384405Essential oils and isolated compounds from Lippia alba leaves and flowers: antimicrobial activity and osteoclast apoptosis.Juiz PJ, Lucchese AM, Gambari R, Piva R, Penolazzi L, Di Ciano M, Uetanabaro AP, Silva F, Avila-Campos MJInt J Mol Med10.3892/ijmm.2014.19952014Anti-Infective Agents/chemistry/pharmacology, Apoptosis/drug effects, Cells, Cultured, Flowers/*chemistry, Humans, Lippia/*chemistry, Oils, Volatile/chemistry/*pharmacology, Osteoclasts/drug effects, Plant Extracts/chemistry/*pharmacology, Plant Leaves/*chemistryPathogenicity
25460194In-vitro activity of taurolidine on single species and a multispecies population associated with periodontitis.Zollinger L, Schnyder S, Nietzsche S, Sculean A, Eick SAnaerobe10.1016/j.anaerobe.2014.11.0082014Anti-Bacterial Agents/pharmacology, Anti-Infective Agents/*pharmacology, Bacteria/drug effects, Biofilms/drug effects, Humans, Microbial Sensitivity Tests, Periodontitis/drug therapy/*microbiology, Taurine/*analogs & derivatives/pharmacology, Thiadiazines/*pharmacologyPathogenicity
25494328Identification of Dipeptidyl-Peptidase (DPP)5 and DPP7 in Porphyromonas endodontalis, Distinct from Those in Porphyromonas gingivalis.Nishimata H, Ohara-Nemoto Y, Baba TT, Hoshino T, Fujiwara T, Shimoyama Y, Kimura S, Nemoto TKPLoS One10.1371/journal.pone.01142212014Amino Acid Sequence, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/chemistry/*metabolism, Enzyme-Linked Immunosorbent Assay, Isoenzymes/chemistry/*metabolism, Porphyromonas/classification/*enzymology, Sequence Homology, Amino Acid, Species SpecificityPhylogenyMetabolism
25500494Inhibition of polysaccharide synthesis by the sinR orthologue PGN_0088 is indirectly associated with the penetration of Porphyromonas gingivalis biofilms by macrolide antibiotics.Yamamoto R, Noiri Y, Yamaguchi M, Asahi Y, Maezono H, Ebisu S, Hayashi MMicrobiology (Reading)10.1099/mic.0.0000132014Anti-Bacterial Agents/*pharmacology, Bacterial Proteins/genetics/*metabolism, *Biofilms/drug effects, Macrolides/*pharmacology, Polysaccharides/*biosynthesis, Porphyromonas gingivalis/drug effects/genetics/*metabolismMetabolismPathogenicity
25616643Association of the invasion ability of Porphyromonas gingivalis with the severity of periodontitis.Baek KJ, Ji S, Kim YC, Choi YVirulence10.1080/21505594.2014.10007642015Adhesins, Bacterial/metabolism, Adult, Amino Acid Sequence, Cytokines/immunology/*metabolism, Female, Fimbriae Proteins/chemistry/genetics/metabolism, Flow Cytometry, Humans, Male, Middle Aged, Mutation, Periodontitis/immunology/*microbiology, Phylogeny, Porphyromonas gingivalis/classification/isolation & purification/*metabolism/*pathogenicity, Proteolysis, Sequence Analysis, DNAMetabolismPhylogeny
25681404Potential use of gallium-doped phosphate-based glass material for periodontitis treatment.Sahdev R, Ansari TI, Higham SM, Valappil SPJ Biomater Appl10.1177/08853282155719522015Animals, Anti-Bacterial Agents/administration & dosage/*pharmacology, Bacteroidaceae Infections/*drug therapy/immunology/microbiology, Biocompatible Materials/*chemistry, Gallium/administration & dosage/*pharmacology, Glass/chemistry, Humans, Male, Matrix Metalloproteinase 13/immunology, Matrix Metalloproteinase Inhibitors/administration & dosage/pharmacology, Periodontitis/*drug therapy/immunology/microbiology, Phosphates/*chemistry, Porphyromonas gingivalis/*drug effects, Rats, Rats, Sprague-DawleyPathogenicity
25742153Characterization of the tripartite drug efflux pumps of Porphyromonas gingivalis aTCC 33277.Inoue T, Nakayama M, Taguchi Y, Kano K, Ono M, Shimizu Y, Kuroda T, Ohara NNew Microbiol2015ATP-Binding Cassette Transporters/genetics/metabolism, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/*genetics/metabolism, Bacteroidaceae Infections/*microbiology, Drug Resistance, Bacterial, Humans, Phylogeny, Porphyromonas gingivalis/drug effects/*genetics/isolation & purification/metabolismPathogenicityMetabolism
25869817The role of phagocytosis, oxidative burst and neutrophil extracellular traps in the interaction between neutrophils and the periodontal pathogen Porphyromonas gingivalis.Jayaprakash K, Demirel I, Khalaf H, Bengtsson TMol Oral Microbiol10.1111/omi.120992015Adhesins, Bacterial/*metabolism, Cells, Cultured, Cysteine Endopeptidases/*metabolism, Extracellular Traps/immunology/*microbiology, Gingipain Cysteine Endopeptidases, Host-Pathogen Interactions, Humans, Interleukin-8/genetics/immunology, Microbial Viability, Mutation, Neutrophils/*immunology/ultrastructure, *Phagocytosis, Porphyromonas gingivalis/*immunology/*pathogenicity/physiology/ultrastructure, Reactive Oxygen Species/metabolism, Real-Time Polymerase Chain Reaction, *Respiratory BurstMetabolismPathogenicity
26001707A Major Fimbrilin Variant of Mfa1 Fimbriae in Porphyromonas gingivalis.Nagano K, Hasegawa Y, Yoshida Y, Yoshimura FJ Dent Res10.1177/00220345155882752015Amino Acid Sequence, Bacterial Proteins, Blotting, Western, Electrophoresis, Polyacrylamide Gel, Fimbriae Proteins/*genetics, Fimbriae, Bacterial/chemistry/*physiology, Gene Deletion, Membrane Proteins/genetics, Microscopy, Electron, Transmission, Polymerase Chain Reaction, Porphyromonas gingivalis/chemistry/genetics/*physiologyEnzymology
26041027Novel antimicrobial peptide specifically active against Porphyromonas gingivalis.Suwandecha T, Srichana T, Balekar N, Nakpheng T, Pangsomboon KArch Microbiol10.1007/s00203-015-1126-z2015Amino Acid Sequence, Amino Acids, Anti-Infective Agents/*pharmacology/toxicity, Bacteriocins/pharmacology, Cell Membrane/drug effects/ultrastructure, Endopeptidases/pharmacology, Erythrocytes/drug effects, Humans, Microscopy, Electron, Transmission, Peptides/chemical synthesis/*pharmacology/toxicity, Porphyromonas gingivalis/*drug effectsPathogenicity
26142460The impact of virulence factors of Porphyromonas gingivalis on wound healing in vitro.Laheij AM, van Loveren C, Deng D, de Soet JJJ Oral Microbiol10.3402/jom.v7.275432015
26249670Porphyromonas gingivalis biofilm formation in different titanium surfaces, an in vitro study.Di Giulio M, Traini T, Sinjari B, Nostro A, Caputi S, Cellini LClin Oral Implants Res10.1111/clr.126592015Biofilms/*growth & development, *Dental Implants, In Vitro Techniques, Porphyromonas gingivalis/*growth & development, Surface Properties, *Titanium
26319981Antibacterial TAP-mimic electrospun polymer scaffold: effects on P. gingivalis-infected dentin biofilm.Albuquerque MT, Evans JD, Gregory RL, Valera MC, Bottino MCClin Oral Investig10.1007/s00784-015-1577-22015Anti-Bacterial Agents/*pharmacology, Biofilms/*drug effects, Ciprofloxacin/pharmacology, Dentin/*drug effects/*microbiology, Drug Combinations, Humans, In Vitro Techniques, Metronidazole/pharmacology, Minocycline/pharmacology, Nanofibers, Polydioxanone, Polymers, Porphyromonas gingivalis/*drug effectsPathogenicity
26321825Correlation of salivary immunoglobulin A against lipopolysaccharide of Porphyromonas gingivalis with clinical periodontal parameters.Pudakalkatti PS, Baheti ASContemp Clin Dent10.4103/0976-237X.1618592015
26358096Comparison of inherently essential genes of Porphyromonas gingivalis identified in two transposon-sequencing libraries.Hutcherson JA, Gogeneni H, Yoder-Himes D, Hendrickson EL, Hackett M, Whiteley M, Lamont RJ, Scott DAMol Oral Microbiol10.1111/omi.121352015Bacterial Proteins/*genetics, Chromosome Mapping/methods, *DNA Transposable Elements, *Gene Library, *Genes, Bacterial, Genes, Essential, Heat-Shock Proteins/*genetics, High-Throughput Nucleotide Sequencing/methods, Lipopolysaccharides/biosynthesis, Mutagenesis, Insertional, Mutation, Periodontal Diseases/microbiology, Porphyromonas gingivalis/*genetics/growth & development, Pyrimidines/metabolism, Sigma Factor/*geneticsMetabolism
26387643Comparative genomics and proteomics of 13 Porphyromonas gingivalis strains.Chen T, Siddiqui H, Olsen IJ Oral Microbiol10.3402/jom.v7.290082015Genetics
26387647Development and evaluation of a saliva-based chair-side diagnostic for the detection of Porphyromonas gingivalis.O'Brien-Simpson NM, Burgess K, Brammar GC, Darby IB, Reynolds ECJ Oral Microbiol10.3402/jom.v7.291292015
26406499Intraspecies Variability Affects Heterotypic Biofilms of Porphyromonas gingivalis and Prevotella intermedia: Evidences of Strain-Dependence Biofilm Modulation by Physical Contact and by Released Soluble Factors.Barbosa GM, Colombo AV, Rodrigues PH, Simionato MRPLoS One10.1371/journal.pone.01386872015Bacterial Adhesion, Biofilms/*growth & development, Biomass, Dysbiosis/microbiology, Humans, Periodontitis/microbiology, Porphyromonas gingivalis/classification/*physiology, Prevotella intermedia/classification/genetics/*physiologyPathogenicityPhylogeny
26448788Identification and characterization of a minisatellite contained within a novel miniature inverted-repeat transposable element (MITE) of Porphyromonas gingivalis.Klein BA, Chen T, Scott JC, Koenigsberg AL, Duncan MJ, Hu LTMob DNA10.1186/s13100-015-0049-12015
26639491Coumarins and flavonoid from Murraya paniculata (L.) Jack: Antibacterial and anti-inflammation activity.Rodanant P, Khetkam P, Suksamrarn A, Kuvatanasuchati JPak J Pharm Sci2015Anti-Bacterial Agents/isolation & purification/*pharmacology/toxicity, Anti-Inflammatory Agents/isolation & purification/*pharmacology/toxicity, Cell Survival/drug effects, Coumarins/isolation & purification/*pharmacology/toxicity, Dose-Response Relationship, Drug, Fibroblasts/drug effects/immunology/metabolism, Flavonoids/isolation & purification/*pharmacology/toxicity, Humans, Inflammation/immunology/metabolism/*prevention & control, Inhibitory Concentration 50, Monocytes/drug effects/immunology/metabolism, Phytotherapy, Plant Extracts/isolation & purification/*pharmacology/toxicity, Plant Leaves, Plants, Medicinal, Porphyromonas gingivalis/*drug effects/growth & development, *Rutaceae/chemistry, U937 CellsPathogenicityEnzymology
26733202A Porphyromonas gingivalis Periplasmic Novel Exopeptidase, Acylpeptidyl Oligopeptidase, Releases N-Acylated Di- and Tripeptides from Oligopeptides.Nemoto TK, Ohara-Nemoto Y, Bezerra GA, Shimoyama Y, Kimura SJ Biol Chem10.1074/jbc.M115.6875662016Acylation, Amino Acid Sequence, Bacteroidaceae Infections/*microbiology, Exopeptidases/analysis/*metabolism, Humans, Models, Molecular, Molecular Sequence Data, Oligopeptides/chemistry/*metabolism, Peptide Hydrolases/analysis/*metabolism, Porphyromonas gingivalis/chemistry/cytology/*enzymology/metabolism, Protein Conformation, Protein MultimerizationMetabolismPathogenicity
27008259Lactobacillus rhamnosus could inhibit Porphyromonas gingivalis derived CXCL8 attenuation.Mendi A, Kose S, Uckan D, Akca G, Yilmaz D, Aral L, Gultekin SE, Eroglu T, Kilic E, Uckan SJ Appl Oral Sci10.1590/1678-7757201501452016Bacterial Adhesion/immunology, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunity, Innate, Interferon-gamma/analysis/immunology, Interleukin-10, Interleukin-8/*analysis/immunology, Lactobacillus rhamnosus/*physiology, Mesenchymal Stem Cells/*microbiology, Periodontitis/microbiology, Porphyromonas gingivalis/*immunology, Probiotics/*pharmacology, Statistics, Nonparametric, Toll-Like Receptor 4/analysis/immunology, Young AdultPathogenicity
27009305Antibacterial effect of silver (I) carbohydrate complexes on oral pathogenic key species in vitro.Reise M, Gottschaldt M, Matz C, Volpel A, Jandt KD, Schubert US, Sigusch BWBMC Oral Health10.1186/s12903-016-0201-42016Aggregatibacter actinomycetemcomitans/drug effects, Anti-Bacterial Agents/*pharmacology, Carbohydrates/*pharmacology, Cells, Cultured, Enterococcus faecalis/drug effects, Fibroblasts/drug effects, Fusobacterium nucleatum/drug effects, Gingiva/cytology, Humans, Microbial Sensitivity Tests, Porphyromonas gingivalis/drug effects, Silver/*pharmacology, Streptococcus mutans/drug effectsPathogenicity
27021243Determination of Active Phagocytosis of Unopsonized Porphyromonas gingivalis by Macrophages and Neutrophils Using the pH-Sensitive Fluorescent Dye pHrodo.Lenzo JC, O'Brien-Simpson NM, Cecil J, Holden JA, Reynolds ECInfect Immun10.1128/IAI.01482-152016Animals, Antibodies, Bacterial, Cell Line, Fluorescent Dyes/*chemistry, Host Specificity, Humans, Hydrogen-Ion Concentration, Immunity, Innate, Macrophages/*immunology/microbiology, Mice, Neutrophils/*immunology/microbiology, Opsonin Proteins, *Phagocytosis, Porphyromonas gingivalis/growth & development/*immunology, Spectrometry, Fluorescence, Staining and Labeling/methodsPathogenicity
27032997A dual-species microbial model for studying the dynamics between oral streptococci and periodontal pathogens during biofilm development on titanium surfaces by flow cytometry.Manti A, Ciandrini E, Campana R, Dominici S, Ciacci C, Federici S, Sisti D, Rocchi MB, Papa S, Baffone WRes Microbiol10.1016/j.resmic.2016.03.0042016Biofilms/*growth & development, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Fusobacterium nucleatum/growth & development/*physiology, Gentian Violet/analysis, *Microbial Interactions, Mouth/*microbiology, Porphyromonas gingivalis/growth & development/*physiology, Staining and Labeling, Streptococcus/growth & development/*physiology, *Titanium
27051954[Cloning, expression, and purification of c-di-AMP metabolism-related genes from Porphyromonas gingivalis].Wei Q, Xingqun C, Xuedong Z, Yuqing LHua Xi Kou Qiang Yi Xue Za Zhi2015Bacterial Proteins/*biosynthesis/genetics/*isolation & purification, *Cloning, Molecular, Dinucleoside Phosphates, Escherichia coli/genetics, Genetic Vectors, Plasmids, Polymerase Chain Reaction, Porphyromonas gingivalis/*genetics, Recombinant ProteinsEnzymologyMetabolism
27056232Draft Genome Sequence of Low-Passage Clinical Isolate Porphyromonas gingivalis MP4-504.To TT, Liu Q, Watling M, Bumgarner RE, Darveau RP, McLean JSGenome Announc10.1128/genomeA.00256-162016Genetics
27118478Copaifera reticulata oleoresin: Chemical characterization and antibacterial properties against oral pathogens.Bardaji DK, da Silva JJ, Bianchi TC, de Souza Eugenio D, de Oliveira PF, Leandro LF, Rogez HL, Venezianni RC, Ambrosio SR, Tavares DC, Bastos JK, Martins CHAnaerobe10.1016/j.anaerobe.2016.04.0172016Anti-Bacterial Agents/chemistry/isolation & purification/*pharmacology, Bridged Bicyclo Compounds/isolation & purification, Cell Line, Cell Survival/drug effects, Dental Caries/microbiology, Fabaceae/*chemistry, Fibroblasts/cytology/drug effects, Humans, Lactobacillus casei/drug effects/growth & development/isolation & purification, Microbial Sensitivity Tests, Monocyclic Sesquiterpenes, Periodontitis/microbiology, Plant Extracts/chemistry/isolation & purification/*pharmacology, Porphyromonas gingivalis/*drug effects/growth & development/isolation & purification, Prevotella nigrescens/*drug effects/growth & development/isolation & purification, Sesquiterpenes/isolation & purification, Streptococcus mutans/drug effects/growth & development/isolation & purification, Streptococcus salivarius/drug effects/growth & development/isolation & purification, Terpenes/isolation & purificationEnzymologyPhylogeny
27354442Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis.Lenzo JC, O'Brien-Simpson NM, Orth RK, Mitchell HL, Dashper SG, Reynolds ECInfect Immun10.1128/IAI.01500-152016Alveolar Bone Loss/immunology/microbiology, Animals, Bacteroidaceae Infections/immunology/microbiology, Cell Line, Disease Models, Animal, Epithelial Cells/immunology/microbiology, Female, Humans, Interleukin-6/immunology, Macrophages/immunology/microbiology, Mice, Mice, Inbred BALB C, Periodontitis/*microbiology, Porphyromonas/*immunology/*pathogenicity, Porphyromonas gingivalis/*immunology/*pathogenicity, Virulence/*immunology, Virulence Factors/*immunologyPathogenicity
27452156Assessment of the antibacterial, cytotoxic and mutagenic potential of the phenolic-rich hydroalcoholic extract from Copaifera trapezifolia Hayne leaves.Leandro LF, Moraes TDS, de Oliveira PF, Alves JM, Senedese JM, Ozelin SD, Resende FA, De Grandis RA, Varanda EA, Bastos JK, Tavares DC, Martins CHGJ Med Microbiol10.1099/jmm.0.0003162016Animals, Anti-Bacterial Agents/isolation & purification/*pharmacology/*toxicity, Biofilms/drug effects, Biological Products/*pharmacology/*toxicity, Cell Line, Cell Survival/drug effects, Cricetinae, Fabaceae/*chemistry, Humans, Male, Mice, Microbial Sensitivity Tests, Microbial Viability/drug effects, Mutagenicity Tests, Peptostreptococcus/drug effects/physiology, Plant Extracts/isolation & purification/*pharmacology/*toxicity, Plant Leaves/chemistry, Porphyromonas gingivalis/drug effects/physiologyPathogenicityEnzymology
27526459[Qualitative analysis of bis-(3'-5')-cyclic dimeric adenosine monophosphate of Porphyromonas gingivalis by high performance liquid chromatography coupled with mass spectrometry].Yongmei T, Xiaojun Y, Juan D, Wanghong Z, Xiaodan C, Jin HHua Xi Kou Qiang Yi Xue Za Zhi2016Chromatography, High Pressure Liquid, Cyclic AMP/chemistry/*metabolism, Periodontitis, Porphyromonas gingivalis/*metabolism, *Tandem Mass SpectrometryMetabolismProteome
27597534Inhibitory effect of 1,25-dihydroxyvitamin D3 on Porphyromonas gingivalis-induced inflammation and bone resorption in vivo.Li ZF, Cao LH, Wang Y, Zhang Z, Fan MW, Xu QAArch Oral Biol10.1016/j.archoralbio.2016.08.0292016Animals, Bone Resorption/*metabolism/microbiology, Cytokines/metabolism, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Gene Expression/drug effects, Inflammation/metabolism/microbiology, Inflammation Mediators/*metabolism, Male, Mice, Mice, Inbred BALB C, Osteoclasts/drug effects, Porphyromonas gingivalis/*drug effects, RANK Ligand/metabolism, Real-Time Polymerase Chain Reaction, Skull/*drug effects/microbiology, Vitamin D/*analogs & derivatives/pharmacology, X-Ray MicrotomographyPathogenicityMetabolism
27667515Two new limonoids isolated from the fuits of Melia toosendan.Zhang Q, Zheng QH, Liang JY, Li QS, Min ZDChin J Nat Med10.1016/S1875-5364(16)30082-62016Anti-Bacterial Agents/chemistry/*isolation & purification/pharmacology, Drugs, Chinese Herbal/chemistry/*isolation & purification, Fruit/chemistry, Limonins/chemistry/*isolation & purification, Magnetic Resonance Spectroscopy, Melia/*chemistry, Molecular Structure, Porphyromonas gingivalis/drug effects/growth & development, Spectrometry, Mass, Electrospray IonizationEnzymologyPhylogeny
27722787Bacterial invasion into radicular dentine-an in vitro study.Stauffacher S, Lussi A, Nietzsche S, Neuhaus KW, Eick SClin Oral Investig10.1007/s00784-016-1960-72016Actinomyces/isolation & purification, Bacterial Load, Coculture Techniques, Dental Pulp Cavity/*microbiology, Dentin/*microbiology, Fusobacterium nucleatum/isolation & purification, Humans, In Vitro Techniques, Microscopy, Electron, Scanning, Porphyromonas gingivalis/isolation & purification, Prevotella intermedia/isolation & purification, Species Specificity, Streptococcus gordonii/isolation & purification, Streptococcus sanguis/isolation & purificationPhylogenyEnzymology
27799940Inhibitory Effect of Enterococcus faecium WB2000 on Volatile Sulfur Compound Production by Porphyromonas gingivalis.Suzuki N, Higuchi T, Nakajima M, Fujimoto A, Morita H, Yoneda M, Hanioka T, Hirofuji TInt J Dent10.1155/2016/82416812016Biotechnology
27978916[Analysis of virulence factors of Porphyromonas endodontalis based on comparative proteomics technique].Li H, Ji H, Wu SS, Hou BXZhonghua Kou Qiang Yi Xue Za Zhi10.3760/cma.j.issn.1002-0098.2016.12.0092016Lipoproteins, *Porphyromonas endodontalis, Porphyromonas gingivalis, Proteomics, Tandem Mass Spectrometry, Virulence, Virulence FactorsProteome
28051836The Porphyromonas gingivalis hemagglutinins HagB and HagC are major mediators of adhesion and biofilm formation.Connolly E, Millhouse E, Doyle R, Culshaw S, Ramage G, Moran GPMol Oral Microbiol10.1111/omi.121512016Adhesins, Bacterial/genetics/*physiology, Animals, Bacterial Proteins/*genetics/physiology, Biofilms/*growth & development, Cell Line, Tumor, Cysteine Endopeptidases/physiology, Epithelial Cells/microbiology, Erythrocytes/microbiology, Gingipain Cysteine Endopeptidases, Hemagglutinins/genetics/physiology, Host-Parasite Interactions, Humans, Lectins/genetics/physiology, Mouth/microbiology, Porphyromonas gingivalis/genetics/*physiology, Sequence Deletion, SheepPathogenicity
28083982Novel reuterin-related compounds suppress odour by periodontopathic bacteria.Fujiwara N, Murakami K, Nakao M, Toguchi M, Yumoto H, Amoh T, Hirota K, Matsuo T, Sano S, Ozaki K, Miyake YOral Dis10.1111/odi.126382017Anti-Bacterial Agents/*pharmacology/therapeutic use, Biomarkers/metabolism, Fusobacterium nucleatum/*drug effects/metabolism, Glyceraldehyde/*analogs & derivatives/pharmacology/therapeutic use, Halitosis/*microbiology/prevention & control, Humans, Odorants/*analysis, Porphyromonas gingivalis/*drug effects/metabolism, Propane/*pharmacology/therapeutic use, Sulfhydryl Compounds/metabolismMetabolismPathogenicity
28104533Antimicrobial activity of stable hemiaminals against Porphyromonas gingivalis.Olczak T, Smiga M, Kwiecien A, Bielecki M, Wrobel R, Olczak M, Ciunik ZAnaerobe10.1016/j.anaerobe.2017.01.0052017Anti-Bacterial Agents/chemical synthesis/*pharmacology, Coculture Techniques, Epithelial Cells/microbiology/physiology, HeLa Cells, Humans, Microbial Sensitivity Tests, Microbial Viability/drug effects, Models, Molecular, Molecular Structure, Porphyromonas gingivalis/*drug effects/growth & development, Triazoles/chemical synthesis/*pharmacologyPathogenicity
28205451Sialylation of Porphyromonas gingivalis LPS and its effect on bacterial-host interactions.Zaric SS, Lappin MJ, Fulton CR, Lundy FT, Coulter WA, Irwin CRInnate Immun10.1177/17534259176942452017Bacteroidaceae Infections/*immunology, Cell Line, Fibroblasts/*immunology/microbiology, Gingiva/*pathology, Host-Pathogen Interactions, Humans, Immunity, Innate, Interleukin-8/metabolism, Lipid A/chemistry, Lipopolysaccharides/chemistry/*immunology, Monocytes/*immunology/microbiology, Mutation/genetics, N-Acetylneuraminic Acid/chemistry/*metabolism, O Antigens/chemistry, Periodontal Diseases/*immunology, Porphyromonas gingivalis/genetics/immunology/*metabolism, Protein Processing, Post-Translational, Sialic Acid Binding Ig-like Lectin 3/metabolismPathogenicityMetabolism
28212613Porphyromonas gingivalis can invade periodontal ligament stem cells.Pan C, Liu J, Wang H, Song J, Tan L, Zhao HBMC Microbiol10.1186/s12866-017-0950-52017Adolescent, Adult, Antigens, Surface, Bacteroidaceae Infections/microbiology, Cell Cycle, Cell Differentiation, Cells, Cultured, Female, Host-Pathogen Interactions, Humans, Immunohistochemistry, Male, Microscopy, Electron, Transmission, Periodontal Ligament/growth & development/*microbiology/pathology, Periodontitis/*microbiology/pathology, Porphyromonas gingivalis/genetics/*pathogenicity, *Stem Cells/pathology, Young AdultPathogenicityGenetics
28261563In silico Comparison of 19 Porphyromonas gingivalis Strains in Genomics, Phylogenetics, Phylogenomics and Functional Genomics.Chen T, Siddiqui H, Olsen IFront Cell Infect Microbiol10.3389/fcimb.2017.000282017Computational Biology/methods, Databases, Nucleic Acid, Genes, Bacterial, *Genome, Bacterial, *Genomics/methods, Molecular Sequence Annotation, *Phylogeny, Porphyromonas gingivalis/*classification/*genetics, RNA, Ribosomal, 16S, Sequence Analysis, DNAPhylogenyGenetics
28296909Novel fimbrilin PGN_1808 in Porphyromonas gingivalis.Nagano K, Hasegawa Y, Yoshida Y, Yoshimura FPLoS One10.1371/journal.pone.01735412017Amino Acid Sequence, Bacterial Proteins/chemistry/*metabolism, Chromatography, Gel, Chromatography, Ion Exchange, Electrophoresis, Polyacrylamide Gel, Fimbriae Proteins/chemistry/*metabolism, Mass Spectrometry, Microscopy, Electron, Transmission, Models, Molecular, Porphyromonas gingivalis/chemistry/*metabolism, Protein ConformationMetabolismEnzymology
28369099Comparative gene expression analysis of Porphyromonas gingivalis ATCC 33277 in planktonic and biofilms states.Romero-Lastra P, Sanchez MC, Ribeiro-Vidal H, Llama-Palacios A, Figuero E, Herrera D, Sanz MPLoS One10.1371/journal.pone.01746692017Biofilms/*growth & development, Dental Plaque/microbiology, Durapatite, Gene Expression Profiling, Humans, Microscopy, Confocal, Microscopy, Electron, Scanning, Periodontitis/microbiology, Plankton/*growth & development, Porphyromonas gingivalis/*genetics/metabolism/pathogenicity, RNA, Bacterial/*geneticsPathogenicityMetabolism
28484050Using Tn-seq To Identify Pigmentation-Related Genes of Porphyromonas gingivalis: Characterization of the Role of a Putative Glycosyltransferase.Klein BA, Cornacchione LP, Collins M, Malamy MH, Duncan MJ, Hu LTJ Bacteriol10.1128/JB.00832-162017Bacterial Proteins/genetics/metabolism, Cell Division, DNA Transposable Elements/*genetics, Down-Regulation, Gene Expression Regulation, Bacterial/physiology, Gene Expression Regulation, Enzymologic/physiology, Genes, Bacterial, Glycosyltransferases/genetics/*metabolism, Mutation, Nucleic Acid Amplification Techniques, Pigments, Biological/genetics/*metabolism, Porphyromonas gingivalis/genetics/*metabolismMetabolism
28637951Porphyromonas gingivalis-induced IL-33 down-regulates hCAP-18/LL-37 production in human gingival epithelial cells.Tada H, Shimizu T, Matsushita K, Takada HBiomed Res10.2220/biomedres.38.1672017Antimicrobial Cationic Peptides/*genetics/metabolism, Bacteroidaceae Infections/immunology/metabolism/microbiology, Cell Line, Down-Regulation, Epithelial Cells/metabolism/microbiology, Gene Expression/immunology, Gene Expression Regulation/*immunology, Gingiva/microbiology/pathology, Host-Pathogen Interactions, Humans, Immunity, Innate, Interleukin-33/*genetics/metabolism, Porphyromonas gingivalis/*immunologyMetabolismPathogenicity
28668193Diaminopimelic acid (DAP) analogs bearing isoxazoline moiety as selective inhibitors against meso-diaminopimelate dehydrogenase (m-Ddh) from Porphyromonas gingivalis.Ma H, Stone VN, Wang H, Kellogg GE, Xu P, Zhang YBioorg Med Chem Lett10.1016/j.bmcl.2017.06.0562017Amino Acid Oxidoreductases/*antagonists & inhibitors/metabolism, Anti-Bacterial Agents/chemical synthesis/chemistry/*pharmacology, Diaminopimelic Acid/chemical synthesis/chemistry/*pharmacology, Dose-Response Relationship, Drug, Enzyme Inhibitors/chemical synthesis/chemistry/*pharmacology, Isoxazoles/chemistry/*pharmacology, Microbial Sensitivity Tests, Models, Molecular, Molecular Structure, Porphyromonas gingivalis/*drug effects/enzymology, Structure-Activity RelationshipEnzymologyMetabolism
28804534mTOR Inhibition Rejuvenates the Aging Gingival Fibroblasts through Alleviating Oxidative Stress.Xia Y, Sun M, Xie Y, Shu ROxid Med Cell Longev10.1155/2017/62926302017Aging/*physiology, Antioxidants/*metabolism, Apoptosis/drug effects, Blotting, Western, Cell Cycle/drug effects, Cell Proliferation/drug effects, Cellular Senescence/drug effects, Fibroblasts/drug effects/*metabolism, Fluorescent Antibody Technique, Gingiva/*cytology, Humans, Oxidative Stress, Reactive Oxygen Species/metabolism, Real-Time Polymerase Chain Reaction, Signal Transduction/drug effects, Sirolimus/pharmacology, TOR Serine-Threonine Kinases/*metabolismPathogenicityMetabolism
28826733Periopathogens differ in terms of the susceptibility to toluidine blue O-mediated photodynamic inactivation.Oruba Z, Labuz P, Macyk W, Chomyszyn-Gajewska MPhotodiagnosis Photodyn Ther10.1016/j.pdpdt.2017.08.0082017Aggregatibacter actinomycetemcomitans/*drug effects, Dose-Response Relationship, Drug, Drug Resistance, Bacterial, Fusobacterium nucleatum/*drug effects, Humans, Microscopy, Electron, Scanning, Photochemotherapy/*methods, Photosensitizing Agents/*pharmacology, Porphyromonas gingivalis/*drug effects, Tolonium Chloride/*pharmacologyPathogenicity
29278706Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in vitro.Azuma MM, Balani P, Boisvert H, Gil M, Egashira K, Yamaguchi T, Hasturk H, Duncan M, Kawai T, Movila ABiochem Biophys Res Commun10.1016/j.bbrc.2017.12.1372017Acid Ceramidase/chemistry/*metabolism, Bacteroidaceae Infections/*enzymology, Epithelial Cells/*enzymology/*microbiology, Female, Humans, Male, Middle Aged, Periodontitis/*enzymology/*microbiology, Periodontium/enzymology/microbiology, Porphyromonas gingivalis/*physiologyEnzymologyPathogenicity
29482504Porphyromonas gingivalis ATCC 33277 promotes intercellular adhesion molecule-1 expression in endothelial cells and monocyte-endothelial cell adhesion through macrophage migration inhibitory factor.Xu W, Pan Y, Xu Q, Wu Y, Pan J, Hou J, Lin L, Tang X, Li C, Liu J, Zhang DBMC Microbiol10.1186/s12866-018-1156-12018*Cell Adhesion, Cell Survival, Cytokines/metabolism, Endothelial Cells/*metabolism, Humans, Intercellular Adhesion Molecule-1/*metabolism, Intramolecular Oxidoreductases/metabolism, Macrophage Migration-Inhibitory Factors/*metabolism, Monocytes/*metabolism, Periodontitis/microbiology, Porphyromonas gingivalis/*metabolism/pathogenicity, THP-1 CellsMetabolismPathogenicity
29505064IS1598 (IsPg4) distributed to abscess-forming strains of Porphyromonas gingivalis may enhance virulence through upregulation of nrdD-like gene expression.Sonoi N, Maeda H, Murauchi T, Yamamoto T, Omori K, Kokeguchi S, Naruishi K, Takashiba SNew Microbiol2018Abscess/microbiology, Bacterial Proteins/genetics/*metabolism, Gene Expression Regulation, Enzymologic, Genes, Bacterial, Genome, Bacterial, Humans, Mutagenesis, Insertional, Porphyromonas gingivalis/*classification/*pathogenicity, RNA, Messenger/genetics/metabolism, Ribonucleotide Reductases/genetics/*metabolism, Up-Regulation/*physiology, VirulenceMetabolismGenetics
29744138Antibodies produced in vitro in the detection of periodontal bacteria by using surface plasmon resonance analysis.Nakka SS, Lonn J, Starkhammar Johansson C, Bengtsson T, Nayeri FClin Exp Dent Res10.1002/cre2.62015
30040860Tolerance induced by Porphyromonas gingivalis may occur independently of TLR2 and TLR4.Lu W, Gu JY, Zhang YY, Gong DJ, Zhu YM, Sun YPLoS One10.1371/journal.pone.02009462018Adult, Cell Line, Cytokines/biosynthesis, Female, Gene Expression Regulation, Humans, *Immune Tolerance, Macrophages/immunology/metabolism/microbiology, Male, Middle Aged, Periodontitis/immunology/metabolism/microbiology, Porphyromonas gingivalis/*physiology, Toll-Like Receptor 2/*metabolism, Toll-Like Receptor 4/*metabolismPathogenicityMetabolism
30168624Porphyromonas gingivalis-induced inflammatory responses in THP1 cells are altered by native and modified low-density lipoproteins in a strain-dependent manner.Jayaprakash K, Demirel I, Khalaf H, Bengtsson TAPMIS10.1111/apm.128602018CD36 Antigens/genetics/immunology, Caspase 1/genetics/immunology, Coculture Techniques, Gene Expression Regulation, Humans, Interleukin-1beta/genetics/immunology, Lipoproteins, LDL/*pharmacology, Organ Specificity, Porphyromonas gingivalis/immunology/*metabolism/pathogenicity, Reactive Oxygen Species/agonists/immunology, THP-1 CellsPathogenicityMetabolism
30284741Probiotics alter the immune response of gingival epithelial cells challenged by Porphyromonas gingivalis.Albuquerque-Souza E, Balzarini D, Ando-Suguimoto ES, Ishikawa KH, Simionato MRL, Holzhausen M, Mayer MPAJ Periodontal Res10.1111/jre.126082018Antibiosis/*immunology, Bifidobacterium/*physiology, Cells, Cultured, Cellular Microenvironment/immunology, Epithelial Cells/*immunology/*microbiology, Gingiva/*cytology/*immunology, Humans, *Immunity, Innate, Interleukin-1beta/metabolism, Interleukin-8/metabolism, Lactobacillus/*physiology, Periodontitis/immunology/microbiology/*prevention & control/*therapy, Porphyromonas gingivalis/*immunology/metabolism/*pathogenicity, *Probiotics, Toll-Like Receptor 4/metabolism, Tumor Necrosis Factor-alpha/metabolismMetabolismPathogenicity
30356383Antimicrobial Activity of Piper marginatum Jacq and Ilex guayusa Loes on Microorganisms Associated with Periodontal Disease.Gamboa F, Munoz CC, Numpaque G, Sequeda-Castaneda LG, Gutierrez SJ, Tellez NInt J Microbiol10.1155/2018/41473832018
30397909Capsular-defective Porphyromonas gingivalis mutant strains induce less alveolar bone resorption than W50 wild-type strain due to a decreased Th1/Th17 immune response and less osteoclast activity.Monasterio G, Fernandez B, Castillo F, Rojas C, Cafferata EA, Rojas L, Alvarez C, Fernandez A, Hernandez M, Bravo D, Vernal RJ Periodontol10.1002/JPER.18-00792018*Alveolar Bone Loss, Animals, Disease Models, Animal, Mice, Osteoclasts, *Porphyromonas gingivalis, Th17 Cells, X-Ray Microtomography
30430852Kaurenoic acid and its sodium salt derivative: antibacterial activity against Porphyromonas gingivalis and their mechanism of action.Martins CH, Abrao F, Moraes TS, Oliveira PF, Tavares DC, Magalhaes LG, Galvao FC, Veneziani RC, Ambrosio SRFuture Microbiol10.2217/fmb-2018-01402018Anti-Bacterial Agents/chemistry/*pharmacology, Bacteroidaceae Infections/*drug therapy/microbiology, Biofilms/drug effects, Diterpenes/chemistry/*pharmacology, Humans, Microbial Viability/drug effects, Mikania/chemistry, Plant Extracts/chemistry, Plant Leaves/chemistry, Porphyromonas gingivalis/*drug effects/growth & development/isolation & purification, Pulpitis/drug therapy/microbiologyPathogenicityEnzymology
30593887Bimodal antibacterial system based on quaternary ammonium silane-coupled core-shell hollow mesoporous silica.Bai YM, Mao J, Li DX, Luo XJ, Chen J, Tay FR, Niu LNActa Biomater10.1016/j.actbio.2018.12.0372018Anti-Bacterial Agents/*pharmacology, Bacteria/drug effects, Cell Death/drug effects, Drug Liberation, Humans, Metronidazole/pharmacology, Microbial Sensitivity Tests, Microbial Viability/drug effects, Porosity, Quaternary Ammonium Compounds/*pharmacology, Silanes/*chemistry, Silicon Dioxide/*chemistry, X-Ray DiffractionPathogenicity
30629753Traumatic occlusion aggravates bone loss during periodontitis and activates Hippo-YAP pathway.Pan W, Yang L, Li J, Xue L, Wei W, Ding H, Deng S, Tian Y, Yue Y, Wang M, Hao L, Chen QJ Clin Periodontol10.1111/jcpe.130652019Animals, Cytokines, Mice, Mice, Inbred Strains, Osteoblasts, *Periodontitis, Porphyromonas gingivalis
30690740Inhibitory effects of azithromycin on the adherence ability of Porphyromonas gingivalis.Kan P, Sasaki H, Inaba K, Watanabe K, Hamada N, Minabe MJ Periodontol10.1002/JPER.18-05592019*Azithromycin, Bacterial Adhesion, Bacterial Proteins, Fimbriae Proteins, Fimbriae, Bacterial, Humans, *Porphyromonas gingivalisPathogenicity
30859419In silico analysis as a strategy to identify candidate epitopes with human IgG reactivity to study Porphyromonas gingivalis virulence factors.Dos Santos-Lima EKN, Cardoso KAPA, de Miranda PM, Pimentel ACM, de Carvalho-Filho PC, de Oliveira YA, de Moura-Costa LF, Olczak T, Gomes-Filho IS, Meyer RJ, Xavier MT, Trindade SCAMB Express10.1186/s13568-019-0757-x2019
30866810Comparative gene expression analysis of planktonic Porphyromonas gingivalis ATCC 33277 in the presence of a growing biofilm versus planktonic cells.Sanchez MC, Romero-Lastra P, Ribeiro-Vidal H, Llama-Palacios A, Figuero E, Herrera D, Sanz MBMC Microbiol10.1186/s12866-019-1423-92019Biofilms/*growth & development, Gene Expression Profiling, Genes, Bacterial, Oligonucleotide Array Sequence Analysis, Phenotype, Porphyromonas gingivalis/*genetics/*physiology, VirulencePhenotypeTranscriptome
30894985Effect of deletion of the rgpA gene on selected virulence of Porphyromonas gingivalis.Zhang R, Yang J, Wu J, Sun WB, Liu YJ Dent Sci10.1016/j.jds.2016.03.0042016
30895025Porphyromonas gingivalis oral infection promote T helper 17/Treg imbalance in the development of atherosclerosis.Yang J, Wu J, Zhang R, Yao M, Liu Y, Miao L, Sun WJ Dent Sci10.1016/j.jds.2016.10.0032016
31007866Characterization of the phosphotransacetylase-acetate kinase pathway for ATP production in Porphyromonas gingivalis.Yoshida Y, Sato M, Nonaka T, Hasegawa Y, Kezuka YJ Oral Microbiol10.1080/20002297.2019.15880862019Biotechnology
31007867Metatranscriptomic analysis of an in vitro biofilm model reveals strain-specific interactions among multiple bacterial species.Zhang Y, Shi W, Song Y, Wang JJ Oral Microbiol10.1080/20002297.2019.15996702019
31096585Dextran-Coated Zinc-Doped Hydroxyapatite for Biomedical Applications.Predoi D, Iconaru SL, Predoi MVPolymers (Basel)10.3390/polym110508862019
31134160Evaluation of Sodium Hypochlorite Irrigant, Bingpeng Irrigant, and Fufang Bingpeng Irrigant as Endodontic Irrigants During Passive Ultrasonic Irrigation.Shi Y, Deng Z, Yang Y, Cui L, Chen T, Hu M, Xie L, Yang JFront Cell Infect Microbiol10.3389/fcimb.2019.001452019Adolescent, Anti-Infective Agents/*administration & dosage, Cell Line/drug effects, Child, DNA, Bacterial/analysis, Dental Pulp Cavity/microbiology, Drugs, Chinese Herbal/administration & dosage, Enterococcus faecalis/drug effects, Fusobacterium nucleatum/drug effects, High-Throughput Screening Assays, Humans, Microbial Sensitivity Tests, Porphyromonas gingivalis/drug effects, Prevotella/drug effects, Root Canal Irrigants/*administration & dosage, Root Canal Preparation, Root Canal Therapy, Sodium Hypochlorite/*administration & dosage, Ultrasonic Therapy, Ultrasonics/*methodsPathogenicity
31137477In Vitro Effect of the Traditional Medicine Hainosan (Painongsan) on Porphyromonas gingivalis.Minami M, Takase H, Taira M, Makino TMedicines (Basel)10.3390/medicines60200582019
31185896PgFur participates differentially in expression of virulence factors in more virulent A7436 and less virulent ATCC 33277 Porphyromonas gingivalis strains.Smiga M, Stepien P, Olczak M, Olczak TBMC Microbiol10.1186/s12866-019-1511-x2019Bacterial Proteins/genetics/metabolism, Bacteroidaceae Infections/microbiology, Chronic Periodontitis/microbiology, Gene Expression Profiling/*methods, Gene Expression Regulation, Bacterial, Glycosylation, Humans, Iron/metabolism, Metalloproteins/*genetics/metabolism, Mutation, Oligonucleotide Array Sequence Analysis, Oxidative Stress, Porphyromonas gingivalis/*growth & development/metabolism/pathogenicity, THP-1 Cells, Virulence Factors/*genetics/metabolismMetabolismPathogenicity
31292785Antimicrobial efficacy of copper-doped titanium surfaces for dental implants.Astasov-Frauenhoffer M, Koegel S, Waltimo T, Zimmermann A, Walker C, Hauser-Gerspach I, Jung CJ Mater Sci Mater Med10.1007/s10856-019-6286-y2019Anti-Bacterial Agents/*pharmacology, Biofilms/drug effects, Cell Survival, Coated Materials, Biocompatible/*chemistry, Copper/*pharmacology, Dental Implants/*microbiology, Fibroblasts/drug effects, Gingiva/drug effects, Humans, Inhibitory Concentration 50, Keratinocytes/drug effects, Materials Testing, Osteoblasts/drug effects, Peri-Implantitis, Porphyromonas gingivalis, Surface Properties, Titanium/*pharmacologyPathogenicity
31312218In Vitro Evaluation of Bacterial Adhesion and Bacterial Viability of Streptococcus mutans, Streptococcus sanguinis, and Porphyromonas gingivalis on the Abutment Surface of Titanium and Zirconium Dental Implants.Meza-Siccha AS, Aguilar-Luis MA, Silva-Caso W, Mazulis F, Barragan-Salazar C, Del Valle-Mendoza JInt J Dent10.1155/2019/42929762019
31437202Gene expression of Porphyromonas gingivalis ATCC 33277 when growing in an in vitro multispecies biofilm.Romero-Lastra P, Sanchez MC, Llama-Palacios A, Figuero E, Herrera D, Sanz MPLoS One10.1371/journal.pone.02212342019Actinomyces/genetics, Aggregatibacter actinomycetemcomitans/genetics, Anaerobiosis/genetics, Biofilms/*growth & development, Culture Media/chemistry, Durapatite, Fusobacterium nucleatum/genetics, *Gene Expression Regulation, Bacterial, *Genes, Bacterial, Humans, Plankton/*genetics/growth & development, Porphyromonas gingivalis/*genetics/growth & development, RNA, Bacterial, Streptococcus oralis/genetics, *Transcriptome, Veillonella/geneticsPathogenicityTranscriptome
31529626Role of Porphyromonas gingivalis in oral squamous cell carcinoma development: A systematic review.Lafuente Ibanez de Mendoza I, Maritxalar Mendia X, Garcia de la Fuente AM, Quindos Andres G, Aguirre Urizar JMJ Periodontal Res10.1111/jre.126912019Animals, Carcinoma, Squamous Cell/*microbiology, Humans, Mouth Neoplasms/*microbiology, Porphyromonas gingivalis/*pathogenicityPathogenicity
31570556The Distinct Immune-Stimulatory Capacities of Porphyromonas gingivalis Strains 381 and ATCC 33277 Are Determined by the fimB Allele and Gingipain Activity.Coats SR, Kantrong N, To TT, Jain S, Genco CA, McLean JS, Darveau RPInfect Immun10.1128/IAI.00319-192019Bacteroidaceae Infections/immunology/microbiology, Cell Line, Tumor, Fimbriae Proteins/*genetics/*immunology, Gingipain Cysteine Endopeptidases/*metabolism, HEK293 Cells, Humans, Immunity, Innate/genetics/immunology, Interleukin-1beta/metabolism, Polymorphism, Single Nucleotide/genetics, Porphyromonas gingivalis/*genetics/*immunology, Signal Transduction/immunology, THP-1 Cells, Toll-Like Receptor 2/metabolismMetabolismPathogenicity
31742917Porphyromonas gingivalis genes conferring fitness in a tobacco-rich environment.Hutcherson JA, Gogenini H, Lamont GJ, Miller DP, Nowakowska Z, Lasica AM, Liu C, Potempa J, Lamont RJ, Yoder-Himes D, Scott DAMol Oral Microbiol10.1111/omi.122732019Gene Library, Genes, Essential, Humans, *Periodontal Diseases, *Porphyromonas gingivalis/genetics, TobaccoPathogenicity
31838319Novel synthetic peptide derived from Porphyromonas gingivalis Lys-gingipain detects IgG-mediated host response in periodontitis.Nobre Dos Santos-Lima EK, Araujo Paiva Andrade Cardoso K, Mares de Miranda P, Cirino de Carvalho-Filho P, Passos Rocha T, Ferreira de Moura-Costa L, Olczak T, Miranda Lopes Falcao M, Gomes-Filho IS, Meyer R, Tosta Xavier M, Castro Trindade SAnaerobe10.1016/j.anaerobe.2019.1021402019Bacteroidaceae Infections/immunology/*metabolism/*microbiology, Databases, Protein, Disease Susceptibility, Epitopes/immunology, Female, Gingipain Cysteine Endopeptidases/chemistry/immunology/*metabolism, Humans, Immunoglobulin G/blood/*immunology, Male, Models, Molecular, Peptide Fragments/chemistry/immunology/*metabolism, Periodontitis/*etiology, Porphyromonas gingivalis/*enzymology/immunology, Protein Transport, Structure-Activity RelationshipPathogenicityMetabolism
31932327Glycine Lipids of Porphyromonas gingivalis Are Agonists for Toll-Like Receptor 2.Nichols FC, Clark RB, Liu Y, Provatas AA, Dietz CJ, Zhu Q, Wang YH, Smith MBInfect Immun10.1128/IAI.00877-192020Animals, Cells, Cultured, Chromatography, High Pressure Liquid, Chromatography, Liquid, Humans, Immunologic Factors/isolation & purification/*metabolism, Lipopeptides/isolation & purification/*metabolism, Macrophages/drug effects, Mice, Porphyromonas gingivalis/*immunology, Tandem Mass Spectrometry, Toll-Like Receptor 2/*agonists, Tumor Necrosis Factor-alpha/metabolismPathogenicityMetabolism
31977126Effect of different Aggregatibacter actinomycetemcomitans strains on dual-species biofilms formed with Porphyromonas gingivalis or Dialister pneumosintes.Sha Q, Chen CEur J Oral Sci10.1111/eos.126822020*Aggregatibacter actinomycetemcomitans, Bacteroides, Biofilms, *Porphyromonas gingivalis, *Veillonellaceae
32205352Metronidazole-Treated Porphyromonas gingivalis Persisters Invade Human Gingival Epithelial Cells and Perturb Innate Responses.Wang C, Cheng T, Li X, Jin LAntimicrob Agents Chemother10.1128/AAC.02529-192020Cells, Cultured, Epithelial Cells, Gingiva, Humans, Metronidazole/pharmacology, *Periodontitis, *Porphyromonas gingivalisPathogenicity
32272214Hematoporphyrin monomethyl ether mediated sonodynamic antimicrobial chemotherapy on porphyromonas gingivalis in vitro.Zhang Y, Zhang H, Zhuang D, Bi L, Hu Z, Cao WMicrob Pathog10.1016/j.micpath.2020.1041922020Anti-Bacterial Agents/*pharmacology, Drug Therapy/*methods, Hematoporphyrins/*pharmacology, Humans, Porphyromonas gingivalis/*drug effects, Reactive Oxygen Species, Ultrasonic WavesPathogenicity
32815129Purification of Native Mfa1 Fimbriae from Porphyromonas gingivalis.Hasegawa Y, Nagano K, Murakami Y, Lamont RJMethods Mol Biol10.1007/978-1-0716-0939-2_82021Bacterial Adhesion/genetics, Bacterial Proteins/genetics/*metabolism, Electrophoresis, Polyacrylamide Gel/methods, Fimbriae Proteins/genetics/*metabolism, Fimbriae, Bacterial/genetics/*metabolism, Humans, Immunoblotting/methods, Mutation/genetics, Porphyromonas gingivalis/genetics/*metabolismMetabolismEnzymology
32937181Reassessment of minimal media reveals differences in growth among Porphyromonas gingivalis standard strains.Saiki K, Urano-Tashiro Y, Takahashi YJ Oral Biosci10.1016/j.job.2020.09.0042020Animals, Cattle, *Chronic Periodontitis, Culture Media, *Porphyromonas gingivalis, Reference Standards, Reproducibility of ResultsCultivation
32939976Comprehensive profiling of protein lysine acetylation and its overlap with lysine succinylation in the Porphyromonas gingivalis fimbriated strain ATCC 33277.Zeng J, Wu L, Chen Q, Wang L, Qiu W, Zheng X, Yin X, Liu J, Ren Y, Li YMol Oral Microbiol10.1111/omi.123122020Acetylation, Chromatography, Liquid, *Lysine/metabolism, *Porphyromonas gingivalis/metabolism/pathogenicity, Protein Processing, Post-Translational, Tandem Mass SpectrometryMetabolismProteome
32944156Probiotics alter biofilm formation and the transcription of Porphyromonas gingivalis virulence-associated genes.Ishikawa KH, Mita D, Kawamoto D, Nicoli JR, Albuquerque-Souza E, Lorenzetti Simionato MR, Mayer MPAJ Oral Microbiol10.1080/20002297.2020.18055532020
33047890A novel gingipain regulatory gene in Porphyromonas gingivalis mediates host cell detachment and inhibition of wound closure.Liu H, Huang L, Cai Y, Bikker FJ, Wei X, Mei Deng DMicrobiologyopen10.1002/mbo3.11282020Adhesins, Bacterial/*genetics, Biofilms/growth & development, Cell Adhesion/*genetics, Cell Line, Culture Media, Conditioned/pharmacology, Epithelial Cells/microbiology, Gene Deletion, Gingipain Cysteine Endopeptidases/*genetics/metabolism, Hemagglutination/genetics, Humans, Pigmentation/genetics, Porphyromonas gingivalis/*genetics/*metabolism, Wound Healing/*geneticsPathogenicityCultivation
33065303In vitro antimicrobial effect of curcumin-based photodynamic therapy on Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.Pan H, Wang D, Zhang FPhotodiagnosis Photodyn Ther10.1016/j.pdpdt.2020.1020552020Aggregatibacter actinomycetemcomitans, *Curcumin/pharmacology, *Photochemotherapy/methods, Photosensitizing Agents/pharmacology, Porphyromonas gingivalis
33157496Gingival fibroblasts dynamically reprogram cellular metabolism during infection of Porphyromonas gingivalis.Su W, Shi J, Zhao Y, Li H, Lei LArch Oral Biol10.1016/j.archoralbio.2020.1049632020Bacteroidaceae Infections/*metabolism, Cells, Cultured, Fibroblasts/*metabolism/*microbiology, Gingiva/*cytology, Humans, Inflammation, Metabolome, Porphyromonas gingivalis/*pathogenicity, Real-Time Polymerase Chain ReactionPathogenicityMetabolism
33178622LL-37-Induced Autophagy Contributed to the Elimination of Live Porphyromonas gingivalis Internalized in Keratinocytes.Yang X, Niu L, Pan Y, Feng X, Liu J, Guo Y, Pan C, Geng F, Tang XFront Cell Infect Microbiol10.3389/fcimb.2020.5617612020Autophagy, Humans, Immune System, Keratinocytes, *Periodontitis, *Porphyromonas gingivalisPathogenicity
33282294Porphyromonas gingivalis and Lactobacillus rhamnosus GG regulate the Th17/Treg balance in colitis via TLR4 and TLR2.Jia L, Wu R, Han N, Fu J, Luo Z, Guo L, Su Y, Du J, Liu YClin Transl Immunology10.1002/cti2.12132020
33607998Combination effect of laser diode for photodynamic therapy with doxycycline on a wistar rat model of periodontitis.Astuti SD, Utomo IB, Setiawatie EM, Khasanah M, Purnobasuki H, Arifianto D, Alamsyah KABMC Oral Health10.1186/s12903-021-01435-02021Animals, Doxycycline/therapeutic use, Lasers, Semiconductor/therapeutic use, *Periodontitis/drug therapy, *Photochemotherapy, Rats, Rats, Wistar
33654123Oleoresins and naturally occurring compounds of Copaifera genus as antibacterial and antivirulence agents against periodontal pathogens.Abrao F, Silva TS, Moura CL, Ambrosio SR, Veneziani RCS, de Paiva REF, Bastos JK, Martins CHGSci Rep10.1038/s41598-021-84480-72021Aggregatibacter actinomycetemcomitans/*physiology, Anti-Bacterial Agents/chemistry/*pharmacology, Biofilms/*drug effects/growth & development, Fabaceae/*chemistry, Microbial Sensitivity Tests, Periodontitis/drug therapy/microbiology, Plant Extracts/chemistry/*pharmacology, Porphyromonas gingivalis/*physiologyPathogenicity
33711535Rose bengal-mediated photodynamic inactivation against periodontopathogens in vitro.Wang D, Pan H, Yan Y, Zhang FPhotodiagnosis Photodyn Ther10.1016/j.pdpdt.2021.1022502021Aggregatibacter actinomycetemcomitans, *Photochemotherapy/methods, Photosensitizing Agents/pharmacology, Porphyromonas gingivalis, *Rose Bengal/pharmacology
33820889Development and Optimization of a Rapid Colorimetric Membrane Immunoassay for Porphyromonas gingivalis.Lee J, Choi MK, Kim J, Chun S, Kim HG, Lee H, Kim J, Lee D, Han SH, Yoon DYJ Microbiol Biotechnol10.4014/jmb.2103.030292021Bacteriological Techniques/*methods, Colorimetry, Gingipain Cysteine Endopeptidases/immunology, Humans, Immunoenzyme Techniques, Limit of Detection, Periodontitis/diagnosis/microbiology, Porphyromonas gingivalis/immunology/*isolation & purificationPathogenicityEnzymology
33965605Antimicrobial photodynamic therapy effectively reduces Porphyromonas gingivalis infection in gingival fibroblasts and keratinocytes: An in vitro study.Oruba Z, Gawron K, Bereta GP, Sroka A, Potempa J, Chomyszyn-Gajewska MPhotodiagnosis Photodyn Ther10.1016/j.pdpdt.2021.1023302021Anti-Bacterial Agents, *Anti-Infective Agents, Fibroblasts, Humans, Keratinocytes, *Photochemotherapy/methods, Photosensitizing Agents/pharmacology, Porphyromonas gingivalisPathogenicity
34058722Effect of probiotic Lactobacillus rhamnosus by-products on gingival epithelial cells challenged with Porphyromonas gingivalis.Vale GC, Mayer MPAArch Oral Biol10.1016/j.archoralbio.2021.1051742021Epithelial Cells, Gingiva, Humans, *Lactobacillus rhamnosus, Porphyromonas gingivalis, *Probiotics/pharmacologyPathogenicity
34158697In vitro antimicrobial effect of chloroaluminum phthalocyanine nanoemulsion on periodontal bacteria.Rey LPL, Pinto SML, Muelhmann LA, Mendez LM, Sandoval LVHJ Indian Soc Periodontol10.4103/jisp.jisp_433_202021
34303315Novel Indigenous Probiotic Lactobacillus reuteri Strain Produces Anti-biofilm Reuterin against Pathogenic Periodontal Bacteria.Widyarman AS, Theodorea CFEur J Dent10.1055/s-0041-17315912021
34393436Identification of aspirin and diclofenac binding proteins in the red complex pathogens.Babu G, Priya VV, Krishnaa PK, Gayathri R, Priyadharsini JVBioinformation10.6026/973206300171922021
34659955Presence of Specific Periodontal Pathogens in Prostate Gland Diagnosed With Chronic Inflammation and Adenocarcinoma.Alluri LSC, Paes Batista da Silva A, Verma S, Fu P, Shen DL, MacLennan G, Gupta S, Bissada NFCureus10.7759/cureus.177422021Pathogenicity
34675462Protein targets in the red complex organisms binding with an herbal compound silymarin.Faiz N, Pothapur KK, Vishnupriya V, Gayathri R, Priyadharsini JVBioinformation10.6026/973206300167592020
34684091Effects of Colocasia antiquorum var. Esculenta Extract In Vitro and In Vivo against Periodontal Disease.Moon SH, Shin SJ, Tae HJ, Oh SH, Bae JMMedicina (Kaunas)10.3390/medicina571010542021Animals, *Colocasia, Mice, Mice, Inbred BALB C, *Periodontal Diseases/drug therapy, Plant Extracts/pharmacology/therapeutic use, Porphyromonas gingivalis
34745052Eradication of Porphyromonas gingivalis Persisters Through Colloidal Bismuth Subcitrate Synergistically Combined With Metronidazole.Wang C, Li X, Cheng T, Sun H, Jin LFront Microbiol10.3389/fmicb.2021.7481212021
34760804Possible Role of Porphyromonas gingivalis in the Regulation of E2F1, CDK11, and iNOS Gene Expression in Neuronal Cell Cycle: A Preliminary Study.Bachtiar EW, Septiwidyati TRJ Int Soc Prev Community Dent10.4103/jispcd.JISPCD_108_212021
34803257Identification of protein targets in red complex organisms binding with resveratrol.Pothapur KK, Vishnu Priya V, Rengasamy G, Jayaseelan VPBioinformation10.6026/973206300168372020
34842665Preparation and In Vitro Characterization of Gels Based on Bromelain, Whey and Quince Extract.Mazilu A, Popescu V, Sarosi C, Dumitrescu RS, Chisnoiu AM, Moldovan M, Dumitrescu LS, Prodan D, Carpa R, Gheorghe GF, Chisnoiu RMGels10.3390/gels70401912021
35203789Antimicrobial Activity of Eucalyptus globulus, Azadirachta indica, Glycyrrhiza glabra, Rheum palmatum Extracts and Rhein against Porphyromonas gingivalis.Muller-Heupt LK, Vierengel N, Gross J, Opatz T, Deschner J, von Loewenich FDAntibiotics (Basel)10.3390/antibiotics110201862022
35250977Computational Design of a Multi-Epitope Vaccine Against Porphyromonas gingivalis.Shaker B, Ahmad S, Shen J, Kim HW, Na DFront Immunol10.3389/fimmu.2022.8068252022*Bacterial Vaccines, *Bacteroidaceae Infections/prevention & control, Chronic Periodontitis/prevention & control, Computational Biology, Epitopes, T-Lymphocyte, Humans, Molecular Docking Simulation, Molecular Dynamics Simulation, *Porphyromonas gingivalis/immunology, Toll-Like Receptor 2, Vaccines, SubunitPathogenicity
35359079[Effects of Porphyromonas gingivalis injected through tail vein on the expressions of biomarkers in neural stem cells and neurons of wild-type rats hippocampus].Yu JJ, Lei S, Li FL, Chen SS, Tang XLZhonghua Kou Qiang Yi Xue Za Zhi10.3760/cma.j.cn112144-20220214-000592022Animals, Biomarkers/metabolism, Hippocampus/metabolism, Male, Nestin/metabolism, *Neural Stem Cells/metabolism, Neurons/metabolism, *Porphyromonas gingivalis/metabolism, Rats, Rats, Sprague-Dawley, Tail/metabolismMetabolism
35432342TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae.Wielento A, Bereta GP, Lagosz-Cwik KB, Eick S, Lamont RJ, Grabiec AM, Potempa JFront Immunol10.3389/fimmu.2022.8236852022Dinoprostone/metabolism, Humans, *Periodontitis/metabolism, *Porphyromonas gingivalis, Protein-Arginine Deiminases/metabolism, Toll-Like Receptor 2/metabolismMetabolismPathogenicity
35463645Correlation Analysis of Gut Microbiota and Serum Metabolome With Porphyromonas gingivalis-Induced Metabolic Disorders.Dong Z, Lv W, Zhang C, Chen SFront Cell Infect Microbiol10.3389/fcimb.2022.8589022022Animals, *Gastrointestinal Microbiome, *Metabolic Diseases/etiology, Metabolome, Mice, Mice, Inbred C57BL, Porphyromonas gingivalis
35505575A murine periodontitis model using coaggregation between human pathogens and a predominant mouse oral commensal bacterium.Liu M, Choi YJ Periodontal Implant Sci10.5051/jpis.21043602182022
35519507Human Oral Keratinocytes Challenged by Streptococcus sanguinis and Porphyromonas gingivalis Differentially Affect the Chemotactic Activity of THP-1 Monocytes.Li H, Seneviratne CJ, Jin LInt J Microbiol10.1155/2022/91120392022
35580388Porphyromonas gingivalis outer membrane vesicles modulate cytokine and chemokine production by gingipain-dependent mechanisms in human macrophages.Castillo Y, Castellanos JE, Lafaurie GI, Castillo DMArch Oral Biol10.1016/j.archoralbio.2022.1054532022Adhesins, Bacterial/metabolism/pharmacology, *Chemokine CCL5/metabolism, Cysteine Endopeptidases/metabolism, Cytokines/metabolism, Gingipain Cysteine Endopeptidases, Humans, Interleukin-6/metabolism, Interleukin-8/metabolism, Macrophages/metabolism, *Porphyromonas gingivalis/metabolism, Tumor Necrosis Factor-alpha/metabolism, U937 CellsMetabolismPathogenicity
35851207Probiotic candidates among dairy Lactobacilli and Streptococcus thermophiles strains for control of the oral pathogen Porphyromonas gingivalis.Michaylova M, Yungareva T, Urshev Z, Dermendzieva Y, Yaneva B, Dobrev IFolia Med (Plovdiv)10.3897/folmed.63.e565512021Anti-Bacterial Agents, Lactic Acid/metabolism, Lactobacillus, Porphyromonas gingivalis, *Probiotics/pharmacology, *Streptococcus thermophilus/metabolismMetabolism
36015254High Molecular Weight Hyaluronic Acid Reduces the Expression of Virulence Genes fimA, mfa1, hagA, rgpA, and kgp in the Oral Pathogen Porphyromonas gingivalis.Alharbi MS, Alshehri FAPharmaceutics10.3390/pharmaceutics140816282022
36060644Aberrant pulmonary immune response of obese mice to periodontal infection.Zhou W, Xuan D, Yu T, Zhang JOpen Life Sci10.1515/biol-2022-00892022
36084351Characterization and potential oral probiotic properties of Lactobacillus plantarum FT 12 and Lactobacillus brevis FT 6 isolated from Malaysian fermented food.Mohd-Zubri NS, Ramasamy K, Abdul-Rahman NZArch Oral Biol10.1016/j.archoralbio.2022.1055152022Amylases, Anti-Bacterial Agents/pharmacology, *Anti-Infective Agents, *Fatigue Syndrome, Chronic, *Fermented Foods, Humans, Hydrogen-Ion Concentration, *Levilactobacillus brevis/physiology, *Lactobacillus plantarum/physiology, *Probiotics/pharmacology, SugarsPathogenicity
36103977Calcium ions and vitamin B(12) are growth factors for Porphyromonas gingivalis.Saiki K, Urano-Tashiro Y, Yamanaka Y, Takahashi YJ Oral Biosci10.1016/j.job.2022.09.0012022*Porphyromonas gingivalis, *Vitamin B 12/pharmacology, Calcium Chloride/pharmacology, Ions/metabolism, Intercellular Signaling Peptides and Proteins/metabolism, Vitamins/metabolismMetabolism
36116685Purification of RgpA from external outer membrane vesicles of Porphyromonas gingivalis.Castillo DM, Castillo Y, Delgadillo NA, Neuta Y, Lafaurie GI, Romero-Sanchez C, Castellanos JEAnaerobe10.1016/j.anaerobe.2022.1026472022Rats, Animals, *Porphyromonas gingivalis/metabolism, *Cysteine Endopeptidases/metabolism, Gingipain Cysteine Endopeptidases, Adhesins, Bacterial/metabolism, Hemagglutinins/chemistry/metabolismMetabolismEnzymology
36273428Selective Inhibition of the Periodontal Pathogen Porphyromonas gingivalis by Third-Generation Zafirlukast Derivatives.Howard KC, Garneau-Tsodikova SJ Med Chem10.1021/acs.jmedchem.2c014712022Animals, *Porphyromonas gingivalis, Microbial Sensitivity Tests, Biofilms, *Periodontal Diseases/drug therapy, Anti-Bacterial Agents/pharmacology, Mammals
36312320Activation of bone marrow-derived dendritic cells and CD4(+) T cell differentiation by outer membrane vesicles of periodontal pathogens.Lim Y, Kim HY, An SJ, Choi BKJ Oral Microbiol10.1080/20002297.2022.21235502022
36312752Antimicrobial and anti-inflammatory activity of Cystatin C on human gingival fibroblast incubated with Porphyromonas gingivalis.Blancas-Luciano BE, Becker-Fauser I, Zamora-Chimal J, Delgado-Dominguez J, Ruiz-Remigio A, Leyva-Huerta ER, Portilla-Robertson J, Fernandez-Presas AMPeerJ10.7717/peerj.142322022Pathogenicity
36333926Transcriptional analysis of the mfa-cluster genes in Porphyromonas gingivalis strains with one and two mfa5 genes.Fujita M, Chiu CH, Nagano KMol Oral Microbiol10.1111/omi.123992022
36363792Analysis of Chemical Structure and Antibiofilm Properties of Exopolysaccharides from Lactiplantibacillus plantarum EIR/IF-1 Postbiotics.Karaca B, Haliscelik O, Gursoy M, Kiran F, Loimaranta V, Soderling E, Gursoy UKMicroorganisms10.3390/microorganisms101122002022

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68367Automatically annotated from API 20A
68380Automatically annotated from API rID32A
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