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Strain identifier

BacDive ID: 11752

Type strain: Yes

Species: Aggregatibacter actinomycetemcomitans

Strain history: <- ATCC; ATCC 33384 <- NCTC; NCTC 9710 <- P. Holm;

NCBI tax ID(s): 1120957 (strain), 714 (species)

For citation purpose refer to the digital object identifier (doi) of the current version.
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General

@ref: 3255

BacDive-ID: 11752

DSM-Number: 8324

keywords: genome sequence, 16S sequence, Bacteria, microaerophile, mesophilic, human pathogen

description: Aggregatibacter actinomycetemcomitans DSM 8324 is a microaerophile, mesophilic human pathogen that was isolated from abscess.

NCBI tax id

NCBI tax idMatching level
1120957strain
714species

strain history: <- ATCC; ATCC 33384 <- NCTC; NCTC 9710 <- P. Holm;

doi: 10.13145/bacdive11752.20221219.7.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/pseudomonadota
  • domain: Bacteria
  • phylum: Pseudomonadota
  • class: Gammaproteobacteria
  • order: Pasteurellales
  • family: Pasteurellaceae
  • genus: Aggregatibacter
  • species: Aggregatibacter actinomycetemcomitans
  • full scientific name: Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006
  • synonyms

    @refsynonym
    20215Actinobacillus actinomycetemcomitans
    20215Haemophilus actinomycetemcomitans
    20215Bacterium actinomycetemcomitans

@ref: 3255

domain: Bacteria

phylum: Proteobacteria

class: Gammaproteobacteria

order: Pasteurellales

family: Pasteurellaceae

genus: Aggregatibacter

species: Aggregatibacter actinomycetemcomitans

full scientific name: Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006

type strain: yes

Morphology

cell morphology

  • @ref: 69480
  • gram stain: negative
  • confidence: 98.458

colony morphology

  • @ref: 3255
  • type of hemolysis: gamma
  • incubation period: 1-2 days

Culture and growth conditions

culture medium

@refnamegrowthlinkcomposition
3255BHI MEDIUM (DSMZ Medium 215)yeshttps://mediadive.dsmz.de/medium/215Name: BHI MEDIUM (DSMZ Medium 215) Composition: Brain heart infusion 37.0 g/l Distilled water
3255COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)yeshttps://mediadive.dsmz.de/medium/693Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
37729MEDIUM 10 - Chocolate medium for Actinobacillus pleuropneumoniae, Capnocytophaga cynodegmi, Haemophilus and NeisseriayesDistilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml);PolyVitex mischung (10.000 ml)

culture temp

@refgrowthtypetemperaturerange
3255positivegrowth37mesophilic
37729positivegrowth37mesophilic
45918positivegrowth37mesophilic

Physiology and metabolism

oxygen tolerance

@refoxygen tolerance
3255microaerophile
45918microaerophile

spore formation

  • @ref: 69480
  • spore formation: no
  • confidence: 98.732

halophily

  • @ref: 69480
  • halophily level: non-halophilic
  • confidence: 93.8

metabolite utilization

@refChebi-IDmetaboliteutilization activitykind of utilization tested
6838116199urea-hydrolysis
6838116443D-tagatose-builds acid from
68381320055methyl beta-D-glucopyranoside-builds acid from
683816731melezitose-builds acid from
6838128053melibiose-builds acid from
6838117306maltose+builds acid from
6838127941pullulan-builds acid from
6838128087glycogen-builds acid from
68381606565hippurate-hydrolysis
6838140585alpha-cyclodextrin-builds acid from
6838118333D-arabitol-builds acid from
6838130849L-arabinose-builds acid from
6838117992sucrose-builds acid from
6838116634raffinose-builds acid from
6838127082trehalose-builds acid from
6838117716lactose-builds acid from
6838130911sorbitol-builds acid from
6838116899D-mannitol+builds acid from
6838116988D-ribose-builds acid from
6838129016arginine-hydrolysis
6837727897tryptophan-energy source
6837716199urea-hydrolysis
6837718257ornithine-degradation
6837717992sucrose-builds acid from
6837717634D-glucose+builds acid from
6836925115malate-assimilation
6836917128adipate-assimilation
6836927689decanoate-assimilation
6836924265gluconate-assimilation
6836917306maltose-assimilation
6836959640N-acetylglucosamine-assimilation
6836916899D-mannitol-assimilation
6836916024D-mannose-assimilation
6836930849L-arabinose-assimilation
683695291gelatin-hydrolysis
683694853esculin-hydrolysis
6836916199urea-hydrolysis
6836929016arginine-hydrolysis
6836917634D-glucose-fermentation
6836927897tryptophan-energy source
6836917632nitrate+reduction

metabolite production

@refChebi-IDmetaboliteproduction
6838115688acetoinno
6837735581indoleno
6836935581indoleno

metabolite tests

@refChebi-IDmetabolitevoges-proskauer-testindole test
6838115688acetoin-
6837735581indole-
6836935581indole-

enzymes

@refvalueactivityec
3255catalase+1.11.1.6
68381urease-3.5.1.5
68381beta-mannosidase-3.2.1.25
68381glycyl tryptophan arylamidase+
68381N-acetyl-beta-glucosaminidase-3.2.1.52
68381pyrrolidonyl arylamidase-3.4.19.3
68381beta-galactosidase-3.2.1.23
68381Alanyl-Phenylalanyl-Proline arylamidase-
68381alkaline phosphatase+3.1.3.1
68381alpha-galactosidase-3.2.1.22
68381beta-glucuronidase-3.2.1.31
68381beta-glucosidase-3.2.1.21
68381arginine dihydrolase-3.5.3.6
68377tryptophan deaminase-4.1.99.1
68377beta-galactosidase-3.2.1.23
68377urease-3.5.1.5
68377ornithine decarboxylase-4.1.1.17
68369cytochrome oxidase+1.9.3.1
68369gelatinase-
68369beta-glucosidase-3.2.1.21
68369urease-3.5.1.5
68369arginine dihydrolase-3.5.3.6

fatty acid profile

  • @reffatty acidpercentageECL
    45918C10:00.710
    45918C12:00.512
    45918C14:024.814
    45918C16:02516
    45918C14:0 3OH/C16:1 ISO I12.115.485
    45918C16:1 ω7c34.515.819
    45918C18:2 ω6,9c/C18:0 ANTE1.517.724
    45918unknown 14.503114.503
  • type of FA analysis: whole cell analysis
  • method/protocol: CCUG
  • @reffatty acidpercentageECL
    45918C14:024.914
    45918C16:031.416
    45918C18:01.118
    45918C14:0 3OH/C16:1 ISO I9.515.485
    45918C16:1 ω7c32.215.819
    45918C18:2 ω6,9c/C18:0 ANTE117.724
  • type of FA analysis: whole cell analysis
  • method/protocol: CCUG

API 20NE

@refNO3TRPGLU_ FermADH ArgUREESCGELPNPGGLU_ AssimARAMNEMANNAGMALGNTCAPADIMLTCITPACOX
3255+-------+/------------+

API NH

@refPENGLUFRUMALSACODCURELIPPALbeta GALProAGGTIND
45918-++-----+--+-
3255-+++----+--+-
3255+++----+--+--
3255++-----+--+--
3255+++----+--+--
3255++-----+--+--
3255-+++----+--+-
3255-+++----+--+-
3255-++-----+--+-
3255-+++----+--+-
3255-+++----+--+-
3255-++-----+--+-

API rID32STR

@refADH Argbeta GLUbeta GARbeta GURalpha GALPALRIBMANSORLACTRERAFSACLARADARLCDEXVPAPPAbeta GALPyrAbeta NAGGTAHIPGLYGPULMALMELMLZMbeta DGTAGbeta MANURE
3255-----+-+-------------+---+------
3255-----+-+----------+------

Isolation, sampling and environmental information

isolation

@refsample typecountryorigin.countrycontinent
3255abscessDenmarkDNKEurope
45918Human abscess

isolation source categories

  • Cat1: #Host Body-Site
  • Cat2: #Other
  • Cat3: #Abscess

taxonmaps

  • @ref: 69479
  • File name: preview.99_3227.png
  • url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_18;96_321;97_406;98_465;99_3227&stattab=map
  • Last taxonomy: Aggregatibacter actinomycetemcomitans subclade
  • 16S sequence: M75039
  • Sequence Identity:
  • Total samples: 2538
  • soil counts: 17
  • aquatic counts: 29
  • animal counts: 2477
  • plant counts: 15

Safety information

risk assessment

  • @ref: 3255
  • pathogenicity human: yes
  • pathogenicity animal: yes
  • biosafety level: 2
  • biosafety level comment: Risk group (German classification)

Sequence information

16S sequences

@refdescriptionaccessionlengthdatabaseNCBI tax ID
20218Aggregatibacter actinomycetemcomitans partial 16S rRNA gene, strain HG683T/NCTC9710T, serovar CFN5479751211ena714
20218A.actinomycetemcomitans 16S rRNA, V3-V4-V5 variable regions, segment 1M23304100ena714
20218Actinobacillus actinomycetemcomitans 16S rRNA, V3-V4-V5 variable regions, segment 2M23305345ena714
20218Aggregatibacter actinomycetemcomitans strain ATCC 33384 16S ribosomal RNA gene, partial sequenceM750391484ena714
20218Actinobacillus actinomycetemcomitans ATCC 33384 16S rRNA gene and 16S-23S spacer, partial sequence, and tRNA-Glu gene, complete sequenceU07777261ena714
3255Actinobacillus actinomycetemcomitans strain CCUG 13227 16S ribosomal RNA gene, partial sequenceDQ223309439ena714

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Aggregatibacter actinomycetemcomitans DSM 8324 DSM 8324GCA_000372365contigncbi1120957
66792Aggregatibacter actinomycetemcomitans DSM 83241120957.3wgspatric1120957
66792Aggregatibacter actinomycetemcomitans sv. C DSM 83242515154019draftimg1120957
66792Crocosphaera subtropica ATCC 51142 ATCC 51142GCA_000017845completepatric43989

GC content

  • @ref: 3255
  • GC-content: 47.1
  • method: thermal denaturation, midpoint method (Tm)

External links

@ref: 3255

culture collection no.: DSM 8324, ATCC 33384, CCUG 13227, CIP 52.106, NCTC 9710

straininfo link

@refpassport
20218http://www.straininfo.net/strains/160938
20218http://www.straininfo.net/strains/109245
20218http://www.straininfo.net/strains/126396
20218http://www.straininfo.net/strains/233991
20218http://www.straininfo.net/strains/109246

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Enzymology1821458Fc-binding components: a virulence factor in Actinobacillus actinomycetemcomitans?Tolo K, Helgeland KOral Microbiol Immunol10.1111/j.1399-302x.1991.tb00509.x1991Aggregatibacter actinomycetemcomitans/*immunology/pathogenicity, Antibodies, Bacterial/*immunology, Bacterial Proteins/*immunology, Electrophoresis, Polyacrylamide Gel, Granulocytes/immunology, Humans, Immunoblotting, Immunoglobulin Fc Fragments/*immunology, Immunoglobulin G/immunology, Opsonin Proteins/immunology, Periodontitis/immunology/microbiology, Phagocytosis/*immunology, Protein Binding, Receptors, Fc/*immunology, VirulencePathogenicity
Enzymology1870068Incidence of periodontitis recurrence in treated patients with and without cultivable Actinobacillus actinomycetemcomitans, Prevotella intermedia, and Porphyromonas gingivalis: a prospective study.Listgarten MA, Slots J, Nowotny AH, Oler J, Rosenberg J, Gregor B, Sullivan PJ Periodontol10.1902/jop.1991.62.6.3771991Actinobacillus/*isolation & purification, Adult, Bacteroides/*isolation & purification, Bicuspid, Capnocytophaga/isolation & purification, Dental Plaque Index, Eikenella corrodens/isolation & purification, Female, Humans, Incidence, Longitudinal Studies, Male, Molar, Periodontal Index, Periodontal Pocket/microbiology/pathology, Periodontitis/microbiology/pathology/*therapy, Prospective Studies, Recurrence, Risk Factors, Sensitivity and SpecificityPhylogeny
Phylogeny18855666-Deoxy-D-talan and 6-deoxy-L-talan. Novel serotype-specific polysaccharide antigens from Actinobacillus actinomycetemcomitans.Shibuya N, Amano K, Azuma J, Nishihara T, Kitamura Y, Noguchi T, Koga TJ Biol ChemS0021-9258(18)55299-61991Actinobacillus/classification/*immunology, Antigens, Bacterial/*chemistry/immunology/isolation & purification, Carbohydrate Sequence, Gas Chromatography-Mass Spectrometry, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Molecular Structure, Polysaccharides/*chemistry/immunology, Polysaccharides, Bacterial/*chemistry/immunology/isolation & purification, SerotypingEnzymology
Metabolism1987032Murine macrophage interleukin-1 release by capsularlike serotype-specific polysaccharide antigens of Actinobacillus actinomycetemcomitans.Takahashi T, Nishihara T, Ishihara Y, Amano K, Shibuya N, Moro I, Koga TInfect Immun10.1128/iai.59.1.18-23.19911991Actinobacillus/*immunology, Animals, Antigens, Bacterial/*immunology, Interleukin-1/*metabolism, Interleukin-6/biosynthesis, Lipopolysaccharides/pharmacology, Macrophages/*metabolism, Mice, Polysaccharides, Bacterial/*immunology
Pathogenicity2135121[Chemical analysis and immunochemical characterization of serotype-specific antigens from the strains of Actinobacillus actinomycetemcomitans which were frequently found in the periodontal pockets of the patients of localized juvenile periodontitis].Amano KAichi Gakuin Daigaku Shigakkai Shi1990Aggregatibacter actinomycetemcomitans/*immunology, Aggressive Periodontitis/immunology/*microbiology, Antigens, Bacterial/*chemistry/immunology, Humans, Immunodiffusion, Periodontal Pocket/*microbiology, Polysaccharides, Bacterial
Phylogeny2528615Inhibitory effects of rabbit antisera on mitogenic activity of Actinobacillus actinomycetemcomitans lipopolysaccharide.Nishihara T, Maki E, Ishihara Y, Kato H, Noguchi T, Koga TJ Periodontal Res10.1111/j.1600-0765.1989.tb02001.x1989*Actinobacillus/classification, Animals, Antibodies, Bacterial/*physiology, Enzyme-Linked Immunosorbent Assay, Immune Sera/*immunology, Immunoglobulins/immunology, Immunosuppressive Agents/*physiology, Lipid A/*immunology, Lipopolysaccharides/*immunology, *Lymphocyte Activation, Mice, Mice, Inbred C3H, Mice, Inbred Strains, Rabbits, Spleen/*cytology/immunology
Metabolism6407997Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease.Zambon JJ, Slots J, Genco RJInfect Immun10.1128/iai.41.1.19-27.19831983Actinobacillus/*classification/immunology/metabolism, Actinobacillus Infections/*microbiology, Antigens, Bacterial/immunology, Fluorescent Antibody Technique, Humans, Immunodiffusion, Periodontitis/*microbiology, Serotyping, Xylose/metabolismPathogenicity
Transcriptome8050714Prevalence and distribution of bacteriophage phi Aa DNA in strains of Actinobacillus actinomycetemcomitans.Stevens RH, Preus HR, Dokko B, Russell DT, Furgang D, Schreiner HC, Goncharoff P, Figurski DH, Fine DHFEMS Microbiol Lett10.1111/j.1574-6968.1994.tb06909.x1994*Aggregatibacter actinomycetemcomitans, Bacteriophages/*genetics, DNA Probes, DNA, Viral/*analysis, Sensitivity and Specificity, Sequence Analysis, DNA, Species SpecificityPhylogeny
Phylogeny8233565Multivariate chemosystematics demonstrate two groups of Actinobacillus actinomycetemcomitans strains.Brondz I, Olsen IOral Microbiol Immunol10.1111/j.1399-302x.1993.tb00654.x1993Aggregatibacter actinomycetemcomitans/*chemistry/*classification, Bacterial Typing Techniques, Chromatography, Gas, Haemophilus/chemistry/classification, Multivariate Analysis, Pasteurella/chemistry/classification
Pathogenicity8406888Association of Actinobacillus actinomycetemcomitans leukotoxin with nucleic acids on the bacterial cell surface.Ohta H, Hara H, Fukui K, Kurihara H, Murayama Y, Kato KInfect Immun10.1128/iai.61.11.4878-4884.19931993Aggregatibacter actinomycetemcomitans/*chemistry/pathogenicity, Bacterial Toxins/*analysis, DNA, Bacterial/*analysis, Exotoxins/*analysis/toxicity, Humans, Neutrophils/drug effects, Osmolar Concentration, Sodium Chloride/pharmacology
Pathogenicity8708945Production of inflammatory mediators and cytokines by human gingival fibroblasts following bacterial challenge.Dongari-Bagtzoglou AI, Ebersole JLJ Periodontal Res10.1111/j.1600-0765.1996.tb00469.x1996Aggregatibacter actinomycetemcomitans/classification/immunology/*physiology, Campylobacter/immunology/*physiology, Cells, Cultured, Cytokines/*biosynthesis, Dinoprostone/biosynthesis, Fibroblasts/immunology/*metabolism/microbiology, Gingiva/immunology/*metabolism/microbiology, Humans, Immunization, Inflammation Mediators/*metabolism, Interleukin-1/biosynthesis, Interleukin-6/biosynthesis, Interleukin-8/biosynthesis, Periodontitis/immunology/metabolism/microbiology, Periodontium/immunology, SerotypingMetabolism
Pathogenicity8751884cis Elements and trans factors are both important in strain-specific regulation of the leukotoxin gene in Actinobacillus actinomycetemcomitans.Kolodrubetz D, Spitznagel J Jr, Wang B, Phillips LH, Jacobs C, Kraig EInfect Immun10.1128/iai.64.9.3451-3460.19961996Aggregatibacter actinomycetemcomitans/*genetics, Bacterial Toxins/*genetics, Base Sequence, Cytotoxins/genetics, DNA Primers/chemistry, Exotoxins/*genetics, *Gene Expression Regulation, Bacterial, Genes, Bacterial, Molecular Sequence Data, Promoter Regions, Genetic, RNA, Bacterial/genetics, RNA, Messenger/geneticsGenetics
Metabolism8997720The regulatory effect of fermentable sugar levels on the production of leukotoxin by Actinobacillus actinomycetemcomitans.Mizoguchi K, Ohta H, Miyagi A, Kurihara H, Takashiba S, Kato K, Murayama Y, Fukui KFEMS Microbiol Lett10.1111/j.1574-6968.1997.tb10187.x1997Aggregatibacter actinomycetemcomitans/*metabolism, Bacterial Toxins/*biosynthesis/chemistry, *Carbohydrate Metabolism, Exotoxins/*biosynthesis/chemistry, Fermentation, Kinetics, Molecular WeightPathogenicity
Metabolism9423883Molecular characterization of an outer membrane protein of Actinobacillus actinomycetemcomitans belonging to the OmpA family.White PA, Nair SP, Kim MJ, Wilson M, Henderson BInfect Immun10.1128/IAI.66.1.369-372.19981998Aggregatibacter actinomycetemcomitans/*genetics/immunology, Aggressive Periodontitis/blood/immunology/microbiology, Amino Acid Sequence, Bacterial Outer Membrane Proteins/*genetics/immunology/metabolism, Base Sequence, Blotting, Western, Cloning, Molecular, Escherichia coli/genetics/metabolism, *Escherichia coli Proteins, Gene Expression, Gene Library, Humans, Molecular Sequence Data, Plasmids, Restriction Mapping, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Amino AcidEnzymology
Pathogenicity9573812In vitro antimicrobial susceptibility of periodontopathic Actinobacillus actinomycetemcomitans to roxithromycin and erythromycin.Piccolomini R, Di Bonaventura G, Catamo G, Picciani C, Paolantonio MOral Microbiol Immunol10.1111/j.1399-302x.1997.tb00740.x1997Adolescent, Adult, Aggregatibacter actinomycetemcomitans/*drug effects/isolation & purification, Aggressive Periodontitis/*microbiology, Anti-Bacterial Agents/*pharmacology, Child, Dose-Response Relationship, Drug, Erythromycin/*pharmacology, Female, Humans, Male, Microbial Sensitivity Tests/methods/statistics & numerical data, Periodontitis/*microbiology, Roxithromycin/*pharmacologyEnzymology
Metabolism9805002A gene cluster for 6-deoxy-L-talan synthesis in Actinobacillus actinomycetemcomitans.Nakano Y, Yoshida Y, Yamashita Y, Koga TBiochim Biophys Acta10.1016/s0167-4781(98)00174-21998Aggregatibacter actinomycetemcomitans/classification/*genetics, Antigens, Bacterial/*biosynthesis/genetics, Base Sequence, DNA Primers, Fucose/metabolism, *Genes, Bacterial, Molecular Sequence Data, *Multigene Family, Polymerase Chain Reaction, Polysaccharides/*biosynthesis/genetics, Restriction Mapping, Rhamnose/metabolism, SerotypingGenetics
Enzymology9916112Cloning of the gene encoding the Actinobacillus actinomycetemcomitans serotype b OmpA-like outer membrane protein.Komatsuzawa H, Kawai T, Wilson ME, Taubman MA, Sugai M, Suginaka HInfect Immun10.1128/IAI.67.2.942-945.19991999Aggregatibacter actinomycetemcomitans/*genetics, Amino Acid Sequence, Animals, Bacterial Outer Membrane Proteins/*genetics, Base Sequence, Cloning, Molecular, DNA, Bacterial, Escherichia coli, Gene Expression, Genes, Bacterial, Mice, Mice, Inbred BALB C, Molecular Sequence DataGenetics
Phylogeny10588502Bacterial adhesion of Actinobacillus actinomycetemcomitans serotypes to titanium implants: SEM evaluation. A preliminary report.Okte E, Sultan N, Dogan B, Asikainen SJ Periodontol10.1902/jop.1999.70.11.13761999Aggregatibacter actinomycetemcomitans/classification/*physiology, *Bacterial Adhesion, Blade Implantation, Dental Implants/*microbiology, Microscopy, Electron, Scanning, Species Specificity
Genetics10673051Genetic analysis of the gene cluster responsible for synthesis of serotype e-specific polysaccharide antigen in Actinobacillus actinomycetemcomitans.Yoshida Y, Nakano Y, Suzuki N, Nakao H, Yamashita Y, Koga TBiochim Biophys Acta10.1016/s0167-4781(99)00192-x1999Aggregatibacter actinomycetemcomitans/*genetics/immunology, Antigens, Bacterial/*biosynthesis, Base Sequence, DNA Primers, Molecular Sequence Data, *Multigene Family, Open Reading Frames, Polysaccharides/*biosynthesis
Enzymology10702238Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans.Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga TJ Biol Chem10.1074/jbc.275.10.68062000Aggregatibacter actinomycetemcomitans/*enzymology/genetics, Amino Acid Sequence, Deoxy Sugars/*metabolism, *Hexoses, Molecular Sequence Data, Multigene Family, Nucleoside Diphosphate Sugars/*metabolism, Polysaccharides, Bacterial/*biosynthesis, Sugar Alcohol Dehydrogenases/*genetics, Thymine Nucleotides/*metabolismMetabolism
Pathogenicity10803129Absence of an especially toxic clone among isolates of Actinobacillus actinomycetemcomitans recovered from army recruits.Macheleidt A, Muller HP, Eger T, Putzker M, Fuhrmann A, Zoller LClin Oral Investig10.1007/s0078400500961999Adolescent, Adult, Aggregatibacter actinomycetemcomitans/*genetics/*pathogenicity, Aggressive Periodontitis/ethnology/microbiology, Bacterial Toxins/*genetics, Blacks/*genetics, Clone Cells, DNA, Bacterial/analysis, Exotoxins/*genetics, Genes, Bacterial/genetics, Humans, Military Personnel, Periodontitis/ethnology/*microbiology, Polymerase Chain Reaction, Promoter Regions, Genetic/genetics, Sequence Deletion, United States/epidemiology, Virulence, Whites/geneticsGenetics
Pathogenicity11073137Phagocytosis of periodontopathogenic bacteria by crevicular granulocytes is depressed in progressive periodontitis.Eick S, Pfister W, Sigusch B, Straube EInfection10.1007/s1501000700232000Aggregatibacter actinomycetemcomitans/*pathogenicity, Aggressive Periodontitis/*immunology/microbiology, Gingival Crevicular Fluid/*immunology, Humans, Neutrophils/*immunology, Phagocytosis, Porphyromonas gingivalis/*pathogenicity
Enzymology11981879Molecular genotyping of isolates of Actinobacillus actinomycetemcomitans by pulsed-field gel electrophoresis after separate digestion with Sse8387I and XhoI.Matsuda M, Takayama K, Haga S, Kagawa S, Ohta H, Fukui K, Moore JEJ Basic Microbiol10.1002/1521-4028(200205)42:2<137::AID-JOBM137>3.0.CO;2-82002Aggregatibacter actinomycetemcomitans/classification/*genetics/*isolation & purification, Bacterial Typing Techniques/*methods, Deoxyribonucleases, Type II Site-Specific/*metabolism, *Electrophoresis, Gel, Pulsed-Field/methods, Genotype, Species SpecificityPhylogeny
Metabolism14622348The production of 6-deoxy-L-talan from Actinobacillus actinomycetemcomitans via bacterial coupling in vitro.Suzuki N, Nakano YOral Microbiol Immunol10.1046/j.0902-0055.2003.00088.x2003Aggregatibacter actinomycetemcomitans/*genetics/metabolism, Antigens, Bacterial/biosynthesis/*genetics, Escherichia coli/*genetics, Genetic Vectors/genetics, Glucosephosphates/metabolism, Humans, Plasmids/genetics, Polysaccharides/biosynthesis/*genetics, Thymine Nucleotides/metabolism, Transformation, Bacterial/*geneticsPathogenicity
Phylogeny15152825Relationship of Actinobacillus actinomycetemcomitans serotype b to aggressive periodontitis: frequency in pure cultured isolates.Yang HW, Asikainen S, Dogan B, Suda R, Lai CHJ Periodontol10.1902/jop.2004.75.4.5922004Acute Disease, Adolescent, Adult, Age Factors, Aggregatibacter actinomycetemcomitans/*classification/*pathogenicity, Aggressive Periodontitis/classification/microbiology, Chronic Disease, Dental Plaque/microbiology, Female, Fluorescent Antibody Technique, Indirect, Humans, Male, Periodontitis/*classification/*microbiology, SerotypingPathogenicity
Pathogenicity15562909Efficacy of antibiotics against periodontopathogenic bacteria within epithelial cells: an in vitro study.Eick S, Pfister WJ Periodontol10.1902/jop.2004.75.10.13272004Aggregatibacter actinomycetemcomitans/*drug effects/growth & development, Anti-Bacterial Agents/administration & dosage/*pharmacology, Anti-Infective Agents/administration & dosage/pharmacology, Aza Compounds/administration & dosage/pharmacology, Clindamycin/administration & dosage/pharmacology, Colony Count, Microbial, Doxycycline/administration & dosage/pharmacology, Fluoroquinolones, Humans, Intracellular Space/*microbiology, KB Cells, Metronidazole/administration & dosage/pharmacology, Microbial Sensitivity Tests, Moxifloxacin, Periodontitis/microbiology, Periodontium/*microbiology/ultrastructure, Porphyromonas gingivalis/*drug effects/growth & development, Quinolines/administration & dosage/pharmacology, Streptococcus constellatus/*drug effects/growth & development, Time Factors
Phylogeny15693826Relationship of Actinobacillus actinomycetemcomitans serotypes to periodontal condition: prevalence and proportions in subgingival plaque.Yang HW, Huang YF, Chan Y, Chou MYEur J Oral Sci10.1111/j.1600-0722.2004.00192.x2005Actinobacillus Infections/classification, Adolescent, Adult, Aggregatibacter actinomycetemcomitans/*classification, Chronic Disease, Colony Count, Microbial, Dental Plaque/*microbiology, Fluorescent Antibody Technique, Indirect, Humans, Periodontal Pocket/microbiology, Periodontitis/classification/*microbiology, SerotypingPathogenicity
Pathogenicity15857070Inhibitory effects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitans ATCC 33384 by neutrophils.Hung SL, Cheng YY, Peng JL, Chang LY, Liu TY, Chen YTJ Periodontol10.1902/jop.2005.76.3.3732005Aggregatibacter actinomycetemcomitans/*immunology, Areca/*adverse effects, Arecoline/administration & dosage/adverse effects, Catechin/administration & dosage/adverse effects, Cell Survival/drug effects, Cells, Cultured, Coloring Agents, Dose-Response Relationship, Drug, Flow Cytometry, Humans, Indicators and Reagents, Microscopy, Confocal, Neutrophils/*drug effects/immunology/microbiology, Nuts/*adverse effects, Phagocytosis/*drug effects, Plant Extracts/administration & dosage/*adverse effects, Propidium, Trypan Blue
Phylogeny15880099Identification of Actinobacillus actinomycetemcomitans using species-specific 16S rDNA primers.Kim SG, Kim SH, Kim MK, Kim HS, Kook JKJ Microbiol21592005Aggregatibacter actinomycetemcomitans/genetics/*isolation & purification, DNA Primers, DNA, Ribosomal/*genetics, Polymerase Chain Reaction/*methods, RNA, Ribosomal, 16S/*genetics, Sensitivity and SpecificityEnzymology
Phylogeny16957111Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates.Norskov-Lauritsen N, Kilian MInt J Syst Evol Microbiol10.1099/ijs.0.64207-02006Actinobacillus/*classification/enzymology/genetics, DNA, Bacterial/*analysis, Haemophilus/*classification/enzymology/genetics, Molecular Sequence Data, Nicotinamide Phosphoribosyltransferase, Pentosyltransferases/*genetics, RNA, Ribosomal, 16SEnzymology
Pathogenicity19031495Variability in the response of human dendritic cells stimulated with Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans.Vernal R, Leon R, Herrera D, Garcia-Sanz JA, Silva, Sanz MJ Periodontal Res10.1111/j.1600-0765.2007.01073.x2008Aggregatibacter actinomycetemcomitans/*immunology, B7-1 Antigen/biosynthesis, B7-2 Antigen/biosynthesis, Bacteriological Techniques, Cell Differentiation, Cytokines/*biosynthesis, Dendritic Cells/cytology/*immunology/metabolism/*microbiology, Humans, Interleukins/biosynthesis, Lymphotoxin-alpha/biosynthesis, Porphyromonas gingivalis/*immunology, Reverse Transcriptase Polymerase Chain Reaction, Th1 Cells/immunology, Tumor Necrosis Factor-alpha/biosynthesisMetabolism
24298462Effects of Areca Nut Extracts on Phagocytosis of Actinobacillus actinomycete mcomitans ATCC 33384 by Neutrophils in Patients with Chronic Periondontitis.Patil KG, Metgud SCJ Clin Diagn Res10.7860/JCDR/2013/5694.34562013
Pathogenicity24473989Photodynamic antimicrobial effect of safranine O on an ex vivo periodontal biofilm.Voos AC, Kranz S, Tonndorf-Martini S, Voelpel A, Sigusch H, Staudte H, Albrecht V, Sigusch BWLasers Surg Med10.1002/lsm.222172014Aggregatibacter actinomycetemcomitans/physiology, Anti-Bacterial Agents/pharmacology/*therapeutic use, Biofilms/*drug effects, Chlorhexidine/pharmacology/therapeutic use, Chronic Disease, Fusobacterium nucleatum/physiology, Humans, Periodontitis/*drug therapy/microbiology, Phenazines/pharmacology/*therapeutic use, *Photochemotherapy, Photosensitizing Agents/pharmacology/*therapeutic use, Porphyromonas gingivalis/physiology, Streptococcus gordonii/physiology, Treatment Outcome
24778902A periodontitis-associated multispecies model of an oral biofilm.Park JH, Lee JK, Um HS, Chang BS, Lee SYJ Periodontal Implant Sci10.5051/jpis.2014.44.2.792014
Pathogenicity27009305Antibacterial effect of silver (I) carbohydrate complexes on oral pathogenic key species in vitro.Reise M, Gottschaldt M, Matz C, Volpel A, Jandt KD, Schubert US, Sigusch BWBMC Oral Health10.1186/s12903-016-0201-42016Aggregatibacter actinomycetemcomitans/drug effects, Anti-Bacterial Agents/*pharmacology, Carbohydrates/*pharmacology, Cells, Cultured, Enterococcus faecalis/drug effects, Fibroblasts/drug effects, Fusobacterium nucleatum/drug effects, Gingiva/cytology, Humans, Microbial Sensitivity Tests, Porphyromonas gingivalis/drug effects, Silver/*pharmacology, Streptococcus mutans/drug effects
27135005Comparative Evaluation of Antimicrobial Activity of Pomegranate-Containing Mouthwash Against Oral-Biofilm Forming Organisms: An Invitro Microbial Study.Dabholkar CS, Shah M, Kathariya R, Bajaj M, Doshi YJ Clin Diagn Res10.7860/JCDR/2016/16478.74752016
27834173Effects of Aggregatibacter actinomycetemcomitans leukotoxin on neutrophil migration and extracellular trap formation.Hirschfeld J, Roberts HM, Chapple IL, Parcina M, Jepsen S, Johansson A, Claesson RJ Oral Microbiol10.3402/jom.v8.330702016
Metabolism28216095Real-time quantitative reverse transcription-PCR analysis of expression stability of Aggregatibacter actinomycetemcomitans fimbria-associated gene in response to photodynamic therapy.Pourhajibagher M, Monzavi A, Chiniforush N, Monzavi MM, Sobhani S, Shahabi S, Bahador APhotodiagnosis Photodyn Ther10.1016/j.pdpdt.2017.02.0092017Aggregatibacter actinomycetemcomitans/genetics/*metabolism/*radiation effects, Bacterial Load, Bacterial Outer Membrane Proteins/genetics/*metabolism, Biomarkers/metabolism, Cell Survival/drug effects/radiation effects, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Fimbriae Proteins/genetics/metabolism, Fimbriae, Bacterial/genetics/metabolism, Gene Expression Regulation, Bacterial/*drug effects/*radiation effects, Photochemotherapy/*methods, Photosensitizing Agents/administration & dosage, Radiation Dosage, Real-Time Polymerase Chain Reaction/methods, Treatment OutcomePathogenicity
30090117Inhibitory Effects of Antimicrobial Photodynamic Therapy with Curcumin on Biofilm-Associated Gene Expression Profile of Aggregatibacter actinomycetemcomitans.Pourhajibagher M, Chiniforush N, Monzavi A, Barikani H, Monzavi MM, Sobhani S, Shahabi S, Bahador AJ Dent (Tehran)2018
31858084Effect of Antimicrobial Photodynamic Therapy Using Indocyanine Green Doped with Chitosan Nanoparticles on Biofilm Formation-Related Gene Expression of Aggregatibacter actinomycetemcomitans.Rad MR, Pourhajibagher M, Rokn AR, Barikani HR, Bahador AFront Dent10.18502/fid.v16i3.15902019
34158697In vitro antimicrobial effect of chloroaluminum phthalocyanine nanoemulsion on periodontal bacteria.Rey LPL, Pinto SML, Muelhmann LA, Mendez LM, Sandoval LVHJ Indian Soc Periodontol10.4103/jisp.jisp_433_202021

Reference

@idauthorscataloguedoi/urltitlejournalpubmed
3255Curators of the DSMZLeibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 8324)https://www.dsmz.de/collection/catalogue/details/culture/DSM-8324
20215Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.10.1099/ijsem.0.004332List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ
20218Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.10.1016/j.syapm.2013.11.002StrainInfo introduces electronic passports for microorganisms.Syst Appl Microbiol. 37: 42-50 201424321274
37729Curators of the CIPhttps://brclims.pasteur.fr/brcWeb/souche/detail/1/13722
45918Curators of the CCUGCulture Collection University of Gothenburg (CCUG) (CCUG 13227)https://www.ccug.se/strain?id=13227
66792Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesAutomatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
68369Automatically annotated from API 20NE
68377Automatically annotated from API NH
68381Automatically annotated from API rID32STR
69479João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.https://microbeatlas.org/MicrobeAtlas 1.0 beta
69480Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesPredictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)