Name: Bifidobacterium longum subsp. infantis S12
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 1743

Type strain:

Species: Bifidobacterium longum subsp. infantis

Strain Designation: S12

Culture col. no.: DSM 20088, ATCC 15697, NCTC 11817, JCM 1222, BCRC 14602, BCRC 15416, CCM 4990, CCUG 18368, CECT 4551, CGMCC 1.1853, CGMCC 1.2202, CIP 64.67, KCTC 3249, KCTC 3270, LMG 8811, NCFB 2205, NCDO 2205

Strain history: CIP <- 1964, Lab. Ident., Inst. Pasteur, Paris, France, Bifidobacterium infantis, biotype V <- M. Sebald, Inst. Pasteur, Paris, France <- H. Werner <- G. Reuter: strain S12

NCBI tax ID(s): 391904 (strain), 1682 (subspecies)

SI-ID 7401

LMG 8811, ATCC 15697, CCUG 18368, JCM 1222, LMG 10499, LMG 11046, NCFB 2205, NCTC 11817, LMG 13203, CCUG 30512, NCDO 2205, CCRC 14602, CCRC 15416, NCIMB 702205, CIP 64.67, CECT 4551, KCTC 3249, KCTC 3270, AS 1.1853, AS 1.2202, CCM 4990, NCAIM B.01821, BCRC 14602, BCRC 15416, HAMBI 1374, HAMBI 555, HAMBI 574, NRRL B-41661, DSM 20088, CGMCC 1.1853, CGMCC 1.2202, VTT E-97796, VTT E-021916, CCUG 30512 B

Other strains from Bifidobacterium longum subsp. infantis

Section

Bifidobacterium longum subsp. infantis S12 is an anaerobe, mesophilic bacterium that was isolated from intestine of infant.

anaerobe
mesophilic
16S sequence
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Actinomycetota*
	Class	*Actinomycetes*
	Order	*Bifidobacteriales*
	Family	*Bifidobacteriaceae*
	Genus	*Bifidobacterium*
	Species	**Bifidobacterium longum subsp. infantis**
	Full Scientific Name (LPSN)	Bifidobacterium longum subsp. infantis (Reuter 1963) Mattarelli et al. 2008

Synonym

Bifidobacterium infantis

Information on morphological and physiological properties Morphology

[Ref.: #120651]	Gram stain	positive
[Ref.: #69480]	Gram stain	positive Confidence in %100

[Ref.: #120651]	Cell shape	rod-shaped

[Ref.: #120651]	Motility	no
[Ref.: #69480]	Motility	no Confidence in %93.332

Information on culture and growth conditions Culture and growth conditions

[Ref.: #8514]

Culture medium

BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58)

[Ref.: #8514]

Culture medium growth

[Ref.: #8514]

Culture medium link

Medium recipe at MediaDive

[Ref.: #8514]

Culture medium composition

expand / minimize

[Ref.: #37702]

Culture medium

MEDIUM 20 - for Anaerobic bacteria

[Ref.: #37702]

Culture medium growth

[Ref.: #37702]

Culture medium composition

expand / minimize

[Ref.: #120651]

Culture medium

CIP Medium 20

[Ref.: #120651]

Culture medium growth

[Ref.: #120651]

Culture medium link

Medium recipe provided by DSMZ

		Temperature
[Ref.: #8514]	growth	37 °C
[Ref.: #37702]	growth	37 °C
[Ref.: #67770]	growth	37 °C

[Ref.: #8514]	Temperature range	mesophilic
[Ref.: #37702]	Temperature range	mesophilic
[Ref.: #67770]	Temperature range	mesophilic

Information on physiology and metabolism Physiology and metabolism

[Ref.: #8514]	Oxygen tolerance	anaerobe
[Ref.: #69480]	Oxygen tolerance	anaerobe Confidence in %98.787

[Ref.: #69481]	Ability of spore formation	no Confidence in %99
[Ref.: #69480]	Ability of spore formation	no Confidence in %99.976

[Ref.: #8514]	Murein short key	A21.03
[Ref.: #8514]	Murein types	A3ß L-Orn-L-Ser-L-Ala-L-Thr-L-Ala

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68371]	amygdalin ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	cellobiose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-arabinose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-arabitol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-fructose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-fucose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-galactose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-glucose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-lyxose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-mannitol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-ribose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-sorbitol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-tagatose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	D-xylose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	erythritol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #120651]	esculin ChEBI	-	hydrolysis
[Ref.: #68371]	galactitol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	gentiobiose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	gluconate ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	glycerol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-arabinose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-arabitol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-fucose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-rhamnose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-sorbose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	L-xylose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	lactose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	maltose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	melezitose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	melibiose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	methyl alpha-D-glucopyranoside ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	methyl alpha-D-mannoside ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	methyl beta-D-xylopyranoside ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	myo-inositol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #120651]	nitrate ChEBI	-	reduction
[Ref.: #120651]	nitrite ChEBI	-	reduction
[Ref.: #68371]	Potassium 2-ketogluconate ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	Potassium 5-ketogluconate ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	raffinose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	ribitol ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	starch ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #68371]	sucrose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	trehalose ChEBI	-	builds acid from	* from API 50CH acid
[Ref.: #120651]	tributyrin ChEBI	+	hydrolysis
[Ref.: #68371]	turanose ChEBI	+	builds acid from	* from API 50CH acid
[Ref.: #68371]	xylitol ChEBI	-	builds acid from	* from API 50CH acid
	Only first 10 entries are displayed. Click here to see all.

	Metabolite production	Metabolite	Production
[Ref.: #120651]		indole ChEBI	no

	Enzyme	Enzyme activity	EC number
[Ref.: #68382]	acid phosphatase	+	3.1.3.2	* from API zym
[Ref.: #68382]	alkaline phosphatase	-	3.1.3.1	* from API zym
[Ref.: #68382]	alpha-chymotrypsin	-	3.4.21.1	* from API zym
[Ref.: #68382]	alpha-fucosidase	-	3.2.1.51	* from API zym
[Ref.: #68382]	alpha-galactosidase	+	3.2.1.22	* from API zym
[Ref.: #68382]	alpha-glucosidase	+	3.2.1.20	* from API zym
[Ref.: #68382]	alpha-mannosidase	-	3.2.1.24	* from API zym
[Ref.: #120651]	amylase	-
[Ref.: #120651]	beta-galactosidase	+	3.2.1.23
[Ref.: #68382]	beta-galactosidase	+	3.2.1.23	* from API zym
[Ref.: #68382]	beta-glucosidase	+	3.2.1.21	* from API zym
[Ref.: #68382]	beta-glucuronidase	-	3.2.1.31	* from API zym
[Ref.: #120651]	caseinase	-	3.4.21.50
[Ref.: #120651]	catalase	-	1.11.1.6
[Ref.: #68382]	cystine arylamidase	-	3.4.11.3	* from API zym
[Ref.: #120651]	DNase	-
[Ref.: #68382]	esterase (C 4)	+		* from API zym
[Ref.: #68382]	esterase lipase (C 8)	+		* from API zym
[Ref.: #120651]	gelatinase	-
[Ref.: #120651]	lecithinase	-
[Ref.: #68382]	leucine arylamidase	+	3.4.11.1	* from API zym
[Ref.: #120651]	lipase	-
[Ref.: #68382]	lipase (C 14)	-		* from API zym
[Ref.: #68382]	N-acetyl-beta-glucosaminidase	+	3.2.1.52	* from API zym
[Ref.: #68382]	naphthol-AS-BI-phosphohydrolase	+		* from API zym
[Ref.: #120651]	oxidase	-
[Ref.: #120651]	protease	-
[Ref.: #68382]	trypsin	-	3.4.21.4	* from API zym
[Ref.: #120651]	tween esterase	-
[Ref.: #120651]	urease	-	3.5.1.5
[Ref.: #68382]	valine arylamidase	-		* from API zym
	Only first 10 entries are displayed. Click here to see all.

API® 50CH acid:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	ControlQ	Acid from glycerolGLY	Acid from erythritolERY	Acid from D-arabinoseDARA	Acid from L-arabinoseLARA	Acid from D-riboseRIB	Acid from D-xyloseDXYL	Acid from L-xyloseLXYL	Acid from D-adonitolADO	Acid from methyl beta-D-xylopyranosideMDX	Acid from D-galactoseGAL	Acid from D-glucoseGLU	Acid from D-fructoseFRU	Acid from D-mannoseMNE	Acid from L-sorboseSBE	Acid from L-rhamnoseRHA	Acid from dulcitolDUL	Acid from inositolINO	Acid from D-mannitolMAN	Acid from D-sorbitolSOR	Acid from methyl alpha-D-mannopyranosideMDM	Acid from methyl alpha-D-glucopyranosideMDG	Acid from N-acetyl-glucosamineNAG	Acid from amygdalinAMY	Acid from arbutinARB	Acid from esculinESC	Acid from salicinSAL	Acid from cellobioseCEL	Acid from maltoseMAL	Acid from lactoseLAC	Acid from melibioseMEL	Acid from sucroseSAC	Acid from trehaloseTRE	Acid from inulinINU	Acid from melezitoseMLZ	Acid from raffinoseRAF	Acid from starchAMD	Acid from glycogenGLYG	Acid from xylitolXLT	Acid from gentiobioseGEN	Acid from turanoseTUR	Acid from D-lyxoseLYX	Acid from D-tagatoseTAG	Acid from D-fucoseDFUC	Acid from L-fucoseLFUC	Acid from D-arabitolDARL	Acid from L-arabitolLARL	Acid from gluconateGNT	Acid from 2-Ketogluconate2KG	Acid from 5-Ketogluconate5KG
[Ref.: #8514]	14515	-	-	-	+	-	+	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	+	+	-	+	+	+	-	+	+	+	+	-	+/-	-	+	-	-	-	-	+	-	-	-	+	-	-	-	-	-
[Ref.: #8514]	14514	-	-	-	+	-	+	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	+	-	-	-	+	+	-	+	+	+	+	-	-	-	+	-	-	-	-	+	-	-	-	+	-	-	-	-	-
[Ref.: #8514]	14513	-	-	-	+	-	+	-	-	-	-	+	+	+	-	-	-	-	-	-	-	-	+	-	-	-	+	-	-	+	+	+	+	-	-	-	+	-	-	-	-	+	-	-	-	+	-	-	-	-	-
[Ref.: #8514]	14512	-	-	-	+	-	+	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	+	+	-	+	+	+	-	+	+	+	+	-	+/-	-	+	-	-	-	-	+	-	-	-	+	-	-	-	-	-
[Ref.: #8514]	14511	-	-	-	+	-	+	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	+	+	-	-	+	+	-	+	+	+	+	-	+	-	+	-	+	-	-	+	-	-	-	+	-	-	-	-	-
[Ref.: #8514]	14510	-	-	-	+	-	+	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	+	+	-	+	+/-	+	-	+	+	+	+	-	+	-	+	-	-	-	-	+	-	-	-	+	-	-	-	-	-

API® zym:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Control	2-naphthyl phosphateAlkaline phosphatase	2-naphthyl butyrateEsterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	2-naphthyl myristateLipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	N-benzoyl-DL-arginine-2-naphthylamideTrypsin	N-glutaryl-phenylalanine-2-naphthylamidealpha- Chymotrypsin	2-naphthyl phosphateAcid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	6-Br-2-naphthyl-alphaD-galactpyranosidealpha- Galactosidase	2-naphthyl-betaD-galactpyranosidebeta- Galactosidase	Naphthol-AS-BI-betaD-glucuronidebeta- Glucuronidase	2-naphthyl-alphaD-glucopyranosidealpha- Glucosidase	6-Br-2-naphthyl-betaD-glucopyranosidebeta- Glucosidase	1-naphthyl-N-acetyl-betaD-glucosaminideN-acetyl-beta- glucosaminidase	6-Br-2-naphthyl-alphaD-mannopyranosidealpha- Mannosidase	2-naphthyl-alphaL-fucopyranosidealpha- Fucosidase
[Ref.: #120651]	13065	-	-	+	+	-	+	-	-	-	-	+	+	+	+	-	+	+	+	-	-

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #8514]	Sample type/isolated from	intestine of infant

[Ref.: #67770]	Sample type/isolated from	Intestine of infant

[Ref.: #120651]	Sample type/isolated from	Human, Infant, intestine
* marker position based on {}

Isolation sources categories

#Host	#Human	#Child
#Host Body-Site	#Gastrointestinal tract	-

What are isolation sources categories?

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #8514]	Biosafety level	1	Risk group (German classification) According to TRBA 466
[Ref.: #120651]	Biosafety level	1	Risk group (French classification)

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

16S Sequence information:

Only first 5 entries are displayed. Click here to see all.

	Sequence accession description	Seq. accession number	Sequence length (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #67770]	Bifidobacterium infantis 16S ribosomal RNA	M58738	1474	ENA	1682 tax ID
[Ref.: #67770]	Bifidobacterium longum subsp. infantis gene for 16S ribosomal RNA, partial sequence, strain: JCM 1222	LC071820	1452	ENA	391904 tax ID
[Ref.: #20218]	B.infantis (CIP 6469) DNA sequence for 16S rRNA	X70974	1458	ENA	391904 tax ID	*
[Ref.: #20218]	Bifidobacterium longum subsp. infantis strain DSM 20088 16S ribosomal RNA gene, partial sequence	HQ012021	940	ENA	391904 tax ID	*
[Ref.: #20218]	Bifidobacterium longum bv. Infantis gene for 16S rRNA, partial sequence, strain: ATCC 15697	D86184	1515	ENA	391904 tax ID	*
[Ref.: #20218]	Bifidobacterium infantis ATCC 15697 16S-23S intergenic spacer, partial sequence	U09792	477	ENA	391904 tax ID	*
[Ref.: #20218]	Bifidobacterium sp. 16S and 23S rRNA genes and ITS	X89111	2013	ENA	391904 tax ID	*
[Ref.: #20218]	Bifidobacterium infantis (ATCC 15697) 16S ribosomal RNA gene, partial	M84783	642	ENA	1682 tax ID	*

Genome sequence information:

Only first 5 entries are displayed. Click here to see all.

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #67770]	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	GCA_000771105	contig	GenBank	391904 tax ID
[Ref.: #66792]	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	GCA_000020425	complete	GenBank	391904 tax ID	*
[Ref.: #66792]	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	GCA_000269965	complete	GenBank	391904 tax ID	*
[Ref.: #66792]	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222	391904.5	complete	PATRIC	391904 tax ID	*
[Ref.: #66792]	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222	391904.8	complete	PATRIC	391904 tax ID	*
[Ref.: #66792]	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	391904.20	wgs	PATRIC	391904 tax ID	*

[Ref.: #8514]	GC-content	60.8 mol%
[Ref.: #67770]	GC-content	60.8 mol%	thermal denaturation, midpoint method (Tm)

Data predicted using genome information as a basis Genome-based predictions

	Trait	Prediction	Confidence in %	In training data
	Predictions from GenomeNet Sporulation v. 1 based on: Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 JCM 1222 NCBI: GCA_000269965.1
[Ref.: #69481]	spore-forming	no	99	no

	Trait	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ATCC 15697 NCBI: GCA_000020425.1
[Ref.: #69480]	motile	no	93.78	no
[Ref.: #69480]	flagellated	no	96.875	no
[Ref.: #69480]	gram-positive	yes	91.071	no
[Ref.: #69480]	anaerobic	yes	96.223	yes
[Ref.: #69480]	aerobic	no	94.556	no
[Ref.: #69480]	halophile	no	73.4	no
[Ref.: #69480]	spore-forming	no	96.22	no
[Ref.: #69480]	thermophile	no	97.097	yes
[Ref.: #69480]	glucose-util	yes	88.589	no
[Ref.: #69480]	glucose-ferment	yes	86.418	no

Availability in culture collections External links

[Ref.: #8514]

Culture collection no.

DSM 20088, ATCC 15697, NCTC 11817, JCM 1222, BCRC 14602, BCRC 15416, CCM 4990, CCUG 18368, CECT 4551, CGMCC 1.1853, CGMCC 1.2202, CIP 64.67, KCTC 3249, KCTC 3270, LMG 8811, NCFB 2205, NCDO 2205

[Ref.: #71390]

SI-ID 7401

Literature:

Only first 10 entries are displayed. Click here to see all.

Topic	Title	Authors	Journal	DOI	Year
Pathogenicity	The mechanism of probiotic action of human milk N-glycome towards B. infantis ATCC 15697 and identification of the principal functional components.	Mao H, Li S, Yin B, Lin X, Guo J, Wang T, Voglmeir J, Liu L	Food Chem	10.1016/j.foodchem.2022.132532	2022	*
Phylogeny	Phylogenetic, Functional and Safety Features of 1950s B. infantis Strains.	Duboux S, Ngom-Bru C, De Bruyn F, Bogicevic B	Microorganisms	10.3390/microorganisms10020203	2022	*
Pathogenicity	Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile.	Hirano R, Sakanaka M, Yoshimi K, Sugimoto N, Eguchi S, Yamauchi Y, Nara M, Maeda S, Ami Y, Gotoh A, Katayama T, Iida N, Kato T, Ohno H, Fukiya S, Yokota A, Nishimoto M, Kitaoka M, Nakai H, Kurihara S	Gut Microbes	10.1080/19490976.2021.1973835	2021	*
Metabolism	Generating a fucose permease deletion mutant in Bifidobacterium longum subspecies infantis ATCC 15697.	Higgins MA, Ryan KS	Anaerobe	10.1016/j.anaerobe.2021.102320	2021	*
Phylogeny	Five novel bifidobacterial species isolated from faeces of primates in two Czech zoos: Bifidobacterium erythrocebi sp. nov., Bifidobacterium moraviense sp. nov., Bifidobacterium oedipodis sp. nov., Bifidobacterium olomucense sp. nov. and Bifidobacterium panos sp. nov.	Neuzil-Bunesova V, Lugli GA, Modrackova N, Vlkova E, Bolechova P, Burtscher J, Longhi G, Mancabelli L, Killer J, Domig K, Ventura M	Int J Syst Evol Microbiol	10.1099/ijsem.0.004573	2020	*
Biotechnology	Riboflavin Biosynthesis and Overproduction by a Derivative of the Human Gut Commensal Bifidobacterium longum subsp. infantis ATCC 15697.	Solopova A, Bottacini F, Venturi Degli Esposti E, Amaretti A, Raimondi S, Rossi M, van Sinderen D	Front Microbiol	10.3389/fmicb.2020.573335	2020	*
Metabolism	Strain-specific strategies of 2'-fucosyllactose, 3-fucosyllactose, and difucosyllactose assimilation by Bifidobacterium longum subsp. infantis Bi-26 and ATCC 15697.	Zabel BE, Gerdes S, Evans KC, Nedveck D, Singles SK, Volk B, Budinoff C	Sci Rep	10.1038/s41598-020-72792-z	2020	*
Pathogenicity	A Whey Fraction Rich in Immunoglobulin G Combined with Bifidobacterium longum subsp. infantis ATCC 15697 Exhibits Synergistic Effects against Campylobacter jejuni.	Quinn EM, Kilcoyne M, Walsh D, Joshi L, Hickey RM	Int J Mol Sci	10.3390/ijms21134632	2020	*
Metabolism	1,6-alpha-L-Fucosidases from Bifidobacterium longum subsp. infantis ATCC 15697 Involved in the Degradation of Core-fucosylated N -Glycan.	Ashida H, Fujimoto T, Kurihara S, Nakamura M, Komeno M, Huang Y, Katayama T, Kinoshita T, Takegawa K	J Appl Glycosci (1999)	10.5458/jag.jag.JAG-2019_0016	2020	*
Metabolism	Structural Identity of Galactooligosaccharide Molecules Selectively Utilized by Single Cultures of Probiotic Bacterial Strains.	Boger M, van Leeuwen SS, Lammerts van Bueren A, Dijkhuizen L	J Agric Food Chem	10.1021/acs.jafc.9b05968	2019	*
Genetics	Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients.	Rong H, Xie XH, Zhao J, Lai WT, Wang MB, Xu D, Liu YH, Guo YY, Xu SX, Deng WF, Yang QF, Xiao L, Zhang YL, He FS, Wang S, Liu TB	J Psychiatr Res	10.1016/j.jpsychires.2019.03.017	2019	*
Biotechnology	Use of design of experiments to optimize the production of microbial probiotic biofilms.	Speranza B, Liso A, Corbo MR	PeerJ	10.7717/peerj.4826	2018	*
Metabolism	Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli.	Thongaram T, Hoeflinger JL, Chow J, Miller MJ	J Dairy Sci	10.3168/jds.2017-12753	2017	*
Enzymology	Recent advances in immobilization strategies for glycosidases.	Karav S, Cohen JL, Barile D, de Moura Bell JM	Biotechnol Prog	10.1002/btpr.2385	2016	*
Metabolism	Functional characterization of a novel beta-fructofuranosidase from Bifidobacterium longum subsp. infantis ATCC 15697 on structurally diverse fructans.	Avila-Fernandez A, Cuevas-Juarez E, Rodriguez-Alegria ME, Olvera C, Lopez-Munguia A	J Appl Microbiol	10.1111/jam.13154	2016	*
Metabolism	Oligosaccharides Released from Milk Glycoproteins Are Selective Growth Substrates for Infant-Associated Bifidobacteria.	Karav S, Le Parc A, Leite Nobrega de Moura Bell JM, Frese SA, Kirmiz N, Block DE, Barile D, Mills DA	Appl Environ Microbiol	10.1128/AEM.00547-16	2016	*
Metabolism	Deciphering bifidobacterial-mediated metabolic interactions and their impact on gut microbiota by a multi-omics approach.	Turroni F, Milani C, Duranti S, Mancabelli L, Mangifesta M, Viappiani A, Lugli GA, Ferrario C, Gioiosa L, Ferrarini A, Li J, Palanza P, Delledonne M, van Sinderen D, Ventura M	ISME J	10.1038/ismej.2015.236	2016	*
Phylogeny	Bifidobacterium eulemuris sp. nov., isolated from faeces of black lemurs (Eulemur macaco).	Michelini S, Modesto M, Pisi AM, Filippini G, Sandri C, Spiezio C, Biavati B, Sgorbati B, Mattarelli P	Int J Syst Evol Microbiol	10.1099/ijsem.0.000924	2016	*
Pathogenicity	Interaction of mouse splenocytes and macrophages with bacterial strains in vitro: the effect of age in the immune response.	Van Beek AA, Hoogerland JA, Belzer C, De Vos P, De Vos WM, Savelkoul HF, Leenen PJ	Benef Microbes	10.3920/BM2015.0094	2015	*
Metabolism	Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria.	Garrido D, Ruiz-Moyano S, Lemay DG, Sela DA, German JB, Mills DA	Sci Rep	10.1038/srep13517	2015	*
Enzymology	Functional analysis of the type II toxin-antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697.	Averina O, Alekseeva M, Shkoporov A, Danilenko V	Anaerobe	10.1016/j.anaerobe.2015.07.007	2015	*
Enzymology	A novel endo-beta-N-acetylglucosaminidase releases specific N-glycans depending on different reaction conditions.	Parc AL, Karav S, De Moura Bell JMLN, Frese SA, Liu Y, Mills DA, Block DE, Barile D	Biotechnol Prog	10.1002/btpr.2133	2015	*
Enzymology	Comparing substrate specificity of two UDP-sugar pyrophosphorylases and efficient one-pot enzymatic synthesis of UDP-GlcA and UDP-GalA.	Guo Y, Fang J, Li T, Li X, Ma C, Wang X, Wang PG, Li L	Carbohydr Res	10.1016/j.carres.2015.04.001	2015	*
Pathogenicity	Enzymatic production of HMO mimics by the sialylation of galacto-oligosaccharides.	Wang Y, Jiang K, Ma H, Zeng W, Wang PG, Yao N, Han W, Cheng J, Wang W	Food Chem	10.1016/j.foodchem.2015.02.064	2015	*
Metabolism	Multi-functional glycoside hydrolase: Blon_0625 from Bifidobacterium longum subsp. infantis ATCC 15697.	Matsumoto T, Shimada S, Hata Y, Tanaka T, Kondo A	Enzyme Microb Technol	10.1016/j.enzmictec.2014.10.001	2014	*
Pathogenicity	Microencapsulated Bifidobacterium longum subsp. infantis ATCC 15697 favorably modulates gut microbiota and reduces circulating endotoxins in F344 rats.	Rodes L, Saha S, Tomaro-Duchesneau C, Prakash S	Biomed Res Int	10.1155/2014/602832	2014	*
Metabolism	Distinct substrate specificities of three glycoside hydrolase family 42 beta-galactosidases from Bifidobacterium longum subsp. infantis ATCC 15697.	Viborg AH, Katayama T, Abou Hachem M, Andersen MC, Nishimoto M, Clausen MH, Urashima T, Svensson B, Kitaoka M	Glycobiology	10.1093/glycob/cwt104	2013	*
Metabolism	Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis by suppressing IL-17A response: involvement of intestinal epithelial costimulatory molecules.	Miyauchi E, Ogita T, Miyamoto J, Kawamoto S, Morita H, Ohno H, Suzuki T, Tanabe S	PLoS One	10.1371/journal.pone.0079735	2013	*
Enzymology	Enrichment of Bifidobacterium longum subsp. infantis ATCC 15697 within the human gut microbiota using alginate-poly-L-lysine-alginate microencapsulation oral delivery system: an in vitro analysis using a computer-controlled dynamic human gastrointestinal model.	Rodes L, Tomaro-Duchesneau C, Saha S, Paul A, Malhotra M, Marinescu D, Shao W, Kahouli I, Prakash S	J Microencapsul	10.3109/02652048.2013.834990	2013	*
Pathogenicity	Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response.	Kavanaugh DW, O'Callaghan J, Butto LF, Slattery H, Lane J, Clyne M, Kane M, Joshi L, Hickey RM	PLoS One	10.1371/journal.pone.0067224	2013	*
Metabolism	Antimicrobial potential for the combination of bovine lactoferrin or its hydrolysate with lactoferrin-resistant probiotics against foodborne pathogens.	Chen PW, Jheng TT, Shyu CL, Mao FC	J Dairy Sci	10.3168/jds.2012-6112	2013	*
Phylogeny	Isolation of a bifidogenic peptide from the pepsin hydrolysate of bovine lactoferrin.	Oda H, Wakabayashi H, Yamauchi K, Sato T, Xiao JZ, Abe F, Iwatsuki K	Appl Environ Microbiol	10.1128/AEM.03343-12	2013	*
Metabolism	Utilization of galactooligosaccharides by Bifidobacterium longum subsp. infantis isolates.	Garrido D, Ruiz-Moyano S, Jimenez-Espinoza R, Eom HJ, Block DE, Mills DA	Food Microbiol	10.1016/j.fm.2012.10.003	2012	*
Pathogenicity	Identification and accurate quantitation of biological oligosaccharide mixtures.	Strum JS, Kim J, Wu S, De Leoz ML, Peacock K, Grimm R, German JB, Mills DA, Lebrilla CB	Anal Chem	10.1021/ac301128s	2012	*
Enzymology	A highly efficient galactokinase from Bifidobacterium infantis with broad substrate specificity.	Li L, Liu Y, Wang W, Cheng J, Zhao W, Wang P	Carbohydr Res	10.1016/j.carres.2012.04.022	2012	*
Metabolism	Novel phytases from Bifidobacterium pseudocatenulatum ATCC 27919 and Bifidobacterium longum subsp. infantis ATCC 15697.	Tamayo-Ramos JA, Sanz-Penella JM, Yebra MJ, Monedero V, Haros M	Appl Environ Microbiol	10.1128/AEM.00782-12	2012	*
Metabolism	Release and utilization of N-acetyl-D-glucosamine from human milk oligosaccharides by Bifidobacterium longum subsp. infantis.	Garrido D, Ruiz-Moyano S, Mills DA	Anaerobe	10.1016/j.anaerobe.2012.04.012	2012	*
Enzymology	Bifidobacterium longum subsp. infantis ATCC 15697 alpha-fucosidases are active on fucosylated human milk oligosaccharides.	Sela DA, Garrido D, Lerno L, Wu S, Tan K, Eom HJ, Joachimiak A, Lebrilla CB, Mills DA	Appl Environ Microbiol	10.1128/AEM.06762-11	2011	*
Metabolism	Physiology of consumption of human milk oligosaccharides by infant gut-associated bifidobacteria.	Asakuma S, Hatakeyama E, Urashima T, Yoshida E, Katayama T, Yamamoto K, Kumagai H, Ashida H, Hirose J, Kitaoka M	J Biol Chem	10.1074/jbc.M111.248138	2011	*
Metabolism	Substrate promiscuity of N-acetylhexosamine 1-kinases.	Li Y, Yu H, Chen Y, Lau K, Cai L, Cao H, Tiwari VK, Qu J, Thon V, Wang PG, Chen X	Molecules	10.3390/molecules16086396	2011	*
Metabolism	Broad conservation of milk utilization genes in Bifidobacterium longum subsp. infantis as revealed by comparative genomic hybridization.	LoCascio RG, Desai P, Sela DA, Weimer B, Mills DA	Appl Environ Microbiol	10.1128/AEM.00675-10	2010	*
Genetics	The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome.	Sela DA, Chapman J, Adeuya A, Kim JH, Chen F, Whitehead TR, Lapidus A, Rokhsar DS, Lebrilla CB, German JB, Price NP, Richardson PM, Mills DA	Proc Natl Acad Sci U S A	10.1073/pnas.0809584105	2008	*
Phylogeny	Proposal to reclassify the three biotypes of Bifidobacterium longum as three subspecies: Bifidobacterium longum subsp. longum subsp. nov., Bifidobacterium longum subsp. infantis comb. nov. and Bifidobacterium longum subsp. suis comb. nov.	Mattarelli P, Bonaparte C, Pot B, Biavati B	Int J Syst Evol Microbiol	10.1099/ijs.0.65319-0	2008	*
Metabolism	Myo-inositol hexakisphosphate degradation by Bifidobacterium infantis ATCC 15697.	Haros M, Bielecka M, Honke J, Sanz Y	Int J Food Microbiol	10.1016/j.ijfoodmicro.2007.02.021	2007	*
Pathogenicity	Growth inhibition of intestinal bacteria and mutagenicity of 2-, 3-, 4-aminobiphenyls, benzidine, and biphenyl.	Chung KT, Adris P	Toxicol In Vitro	10.1016/s0887-2333(02)00131-5	2003	*
Enzymology	Characterization of a purified beta-fructofuranosidase from Bifidobacterium infantis ATCC 15697.	Warchol M, Perrin S, Grill JP, Schneider F	Lett Appl Microbiol	10.1046/j.1472-765x.2002.01224.x	2002	*
Metabolism	Cholesterol assimilation by lactic acid bacteria and bifidobacteria isolated from the human gut.	Pereira DI, Gibson GR	Appl Environ Microbiol	10.1128/AEM.68.9.4689-4693.2002	2002	*
Metabolism	Fermentations of fructo-oligosaccharides and their components by Bifidobacterium infantis ATCC 15697 on batch culture in semi-synthetic medium.	Perrin S, Warchol M, Grill JP, Schneider F	J Appl Microbiol	10.1046/j.1365-2672.2001.01317.x	2001	*
Enzymology	Intra- and extracellular beta-galactosidases from Bifidobacterium bifidum and B. infantis: molecular cloning, heterologous expression, and comparative characterization.	Moller PL, Jorgensen F, Hansen OC, Madsen SM, Stougaard P	Appl Environ Microbiol	10.1128/AEM.67.5.2276-2283.2001	2001	*
Metabolism	Mechanism of inhibition of tannic acid and related compounds on the growth of intestinal bacteria.	Chung KT, Lu Z, Chou MW	Food Chem Toxicol	10.1016/s0278-6915(98)00086-6	1998	*
Pathogenicity	Effect of bifidogenic factors on growth characteristics of bifidobacteria in infant formulas.	Dubey UK, Mistry VV	J Dairy Sci	10.3168/jds.S0022-0302(96)76469-X	1996	*
Pathogenicity	Growth characteristics of bifidobacteria in infant formulas.	Dubey UK, Mistry VV	J Dairy Sci	10.3168/jds.S0022-0302(96)76468-8	1996	*
Phylogeny	Isolation and structural analysis of polysaccharide containing galactofuranose from the cell walls of Bifidobacterium infantis.	Tone-Shimokawa Y, Toida T, Kawashima T	J Bacteriol	10.1128/jb.178.1.317-320.1996	1996	*
Pathogenicity	Current status of melanoma treatment with interferon, cytokines and other biologic response modifiers in Japan.	Ishihara K, Hayasaka K, Yamazaki N	J Invest Dermatol	10.1111/1523-1747.ep13076752	1989	*
Stress	Characterizing the release of bioactive N-glycans from dairy products by a novel endo-beta-N-acetylglucosaminidase.	Karav S, Bell JM, Le Parc A, Liu Y, Mills DA, Block DE, Barile D	Biotechnol Prog	10.1002/btpr.2135	2015	*
Metabolism	Release of bifidogenic N-glycans from native bovine colostrum proteins by an endo-beta-N-acetylglucosaminidase.	Bunyatratchata A, Parc AL, de Moura Bell JMLN, Cohen JL, Duman H, Arslan A, Kaplan M, Barile D, Karav S	Enzyme Microb Technol	10.1016/j.enzmictec.2022.110138	2022	*
	A postbiotic consisting of heat-treated lactobacilli has a bifidogenic effect in pure culture and in human fermented faecal communities.	Warda AK, Clooney AG, Ryan F, de Almeida Bettio PH, Di Benedetto G, Ross RP, Hill C	Appl Environ Microbiol	10.1128/AEM.02459-20	2021	*
	Bifidobacterium longum subsp. infantis ATCC 15697 and Goat Milk Oligosaccharides Show Synergism In Vitro as Anti-Infectives against Campylobacter jejuni.	Quinn EM, Slattery H, Walsh D, Joshi L, Hickey RM	Foods	10.3390/foods9030348	2020	*
	Mining Milk for Factors which Increase the Adherence of Bifidobacterium longum subsp. infantis to Intestinal Cells.	Quinn EM, Slattery H, Thompson AP, Kilcoyne M, Joshi L, Hickey RM	Foods	10.3390/foods7120196	2018	*
	Survival of bifidobacteria in yogurt and simulated gastric juice following immobilization in gellan-xanthan beads.	Sun W, Griffiths MW	Int J Food Microbiol	10.1016/s0168-1605(00)00327-5	2000	*

References

#8514

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 20088

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#20218

Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )

#37702 ; Curators of the CIP;

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#67770 Japan Collection of Microorganism (JCM) ; Curators of the JCM;

#68371

Automatically annotated from API 50CH acid .

#68382

Automatically annotated from API zym .

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#69481

Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch: Predictions based on the model GenomeNet Sporulation v. 1 . ( DOI 10.21203/rs.3.rs-2527258/v1 )

#71390

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID7401.1 )

#120651 Collection of Institut Pasteur ; Curators of the CIP; CIP 64.67
* These data were automatically processed and therefore are not curated

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Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 JCM 1222

Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ATCC 15697

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