Name: Saccharopolyspora erythraea M-5-12559
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 13444

Type strain:

Species: Saccharopolyspora erythraea

Strain Designation: M-5-12559

Culture col. no.: DSM 40517, AS 4.166, ATCC 11635, CBS 727.72, HUT 6087, IAM 0045, IFO 13426, ISP 5517, JCM 4026, JCM 4748, KCC S-0026, NBRC 13426, NCIB 8594, NRRL 2338, NRRL B-16947, RIA 1387, VKM Ac-1189, BCRC 13429, CECT 3200, CGMCC 4.1478, CGMCC 4.1660, HAMBI 938, IFO 12597, IMSNU 20121, IMSNU 21004, KCTC 9053, MTCC 1103, NBIMCC 3384, NBRC 12597, NCIMB 8594, PCM 2456, RIA 120

Strain history: KCC S-0748 <-- IFO 13426 <-- SAJ <-- ISP 5517 <-- Eli Lilly & Co.; M5-12559.

NCBI tax ID(s): 405948 (strain), 1836 (species)

SI-ID 389270

ATCC 11635, HUT 6087, IAM 0045, IFO 13426, NCIB 8594, NRRL 2338, DSM 40517, JCM 4026, JCM 4748, CCRC 13429, NCIMB 8594, NRRL B-16947, VKM Ac-1189, NRRL B-2338, IFO 12597, CBS 727.72, CECT 3200, KCTC 9053, AS 4.166, NBRC 13426, NBRC 12597, BCRC 13429, HAMBI 938, KACC 20098, NBIMCC 3384, NCIM 2620, CGMCC 4.1478, CGMCC 4.1660

Other strains from Saccharopolyspora erythraea

S. erythraea DSM 41009, ATCC 11912, IMRU 3036, ...
S. erythraea STH00022(ZIMET), FERM-P4808, HKI ...
S. erythraea STI43932(IMET), FERM-P5081, ANR-58, ...
S. erythraea ST004146(HKI),
S. erythraea ST008124(HKI), IMET 43533, ISP ...
S. erythraea ST008125(HKI), G-162,
S. erythraea ST008510(HKI), 39, AM33351/NTg061,
S. erythraea ST008518(HKI), F198/S383, 48,
S. erythraea STH00041(ZIMET), MA-144-M1, HKI ...

Section

Saccharopolyspora erythraea M-5-12559 is a spore-forming, mesophilic bacterium that produces antibiotic compounds and was isolated from soil.

antibiotic compound production
spore-forming
mesophilic
16S sequence
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Actinomycetota*
	Class	*Actinomycetes*
	Order	*Pseudonocardiales*
	Family	*Pseudonocardiaceae*
	Genus	*Saccharopolyspora*
	Species	**Saccharopolyspora erythraea**
	Full Scientific Name (LPSN)	Saccharopolyspora erythraea (Waksman 1923) Labeda 1987

	Synonym	Streptomyces erythraeus
	Synonym	"Actinomyces* erythreus"*

Information on morphological and physiological properties Morphology

[Ref.: #69480]	Gram stain	positive Confidence in %100

[Ref.: #69480]	Motility	no Confidence in %91.135

Multimedia content

[Ref.: #9612]

Intellectual property rights:

[Ref.: #9612]

Caption:

Medium 65 28°C

[Ref.: #9612]

Intellectual property rights:

Information on culture and growth conditions Culture and growth conditions

[Ref.: #9612]

Culture medium

GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)

[Ref.: #9612]

Culture medium growth

[Ref.: #9612]

Culture medium link

Medium recipe at MediaDive

[Ref.: #9612]

Culture medium composition

expand / minimize

		Temperature
[Ref.: #9612]	growth	28 °C
[Ref.: #18604]	optimum	30 °C
[Ref.: #67770]	growth	28 °C

[Ref.: #9612]	Temperature range	mesophilic
[Ref.: #18604]	Temperature range	mesophilic
[Ref.: #67770]	Temperature range	mesophilic

Information on physiology and metabolism Physiology and metabolism

[Ref.: #69481]	Ability of spore formation	yes Confidence in %100
[Ref.: #69480]	Ability of spore formation	yes Confidence in %100

[Ref.: #9612]	Name of produced compound	erythromycin complex (A, B, C)
[Ref.: #20216]	Name of produced compound	Erythromycin complex A
[Ref.: #20216]	Name of produced compound	Erythromycin complex B
[Ref.: #20216]	Name of produced compound	Erythromycin complex C

	Halophily	Salt	Tested relation		Salt conc.
[Ref.: #18604]		NaCl		maximum	2.5	%

[Ref.: #67770]

Observation

quinones: MK-9(H₄), MK-10(H₄)

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68368]	amygdalin ChEBI	-	fermentation	* from API 20E
[Ref.: #18604]	arabinose ChEBI	+
[Ref.: #68368]	arginine ChEBI	-	hydrolysis	* from API 20E
[Ref.: #18604]	cellulose ChEBI	+
[Ref.: #68368]	D-glucose ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	D-mannitol ChEBI	-	fermentation	* from API 20E
[Ref.: #18604]	fructose ChEBI	+
[Ref.: #18604]	glucose ChEBI	+
[Ref.: #68368]	L-arabinose ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	L-rhamnose ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	lysine ChEBI	-	degradation	* from API 20E
[Ref.: #18604]	mannitol ChEBI	+
[Ref.: #68368]	melibiose ChEBI	-	fermentation	* from API 20E
[Ref.: #18604]	myo-inositol ChEBI	+
[Ref.: #68368]	myo-inositol ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	nitrate ChEBI	-	reduction	* from API 20E
[Ref.: #68368]	ornithine ChEBI	-	degradation	* from API 20E
[Ref.: #18604]	raffinose ChEBI	+
[Ref.: #18604]	rhamnose ChEBI	+
[Ref.: #68368]	sorbitol ChEBI	-	fermentation	* from API 20E
[Ref.: #18604]	sucrose ChEBI	+
[Ref.: #68368]	sucrose ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	tryptophan ChEBI	-	energy source	* from API 20E
[Ref.: #68368]	urea ChEBI	+	hydrolysis	* from API 20E
[Ref.: #18604]	xylose ChEBI	+
	Only first 10 entries are displayed. Click here to see all.

	Metabolite	Production
[Ref.: #67770]	erythromycin A ChEBI	yes
[Ref.: #67770]	erythromycin B ChEBI	yes
[Ref.: #68368]	dinitrogen ChEBI	no	* from API 20E
[Ref.: #68368]	hydrogen sulfide ChEBI	no	* from API 20E
[Ref.: #68368]	indole ChEBI	no	* from API 20E
[Ref.: #68368]	nitrite ChEBI	no	* from API 20E

	Physiological tests	Metabolite	Indole test
[Ref.: #68368]		indole ChEBI	-	* from API 20E

	Enzyme	Enzyme activity	EC number
[Ref.: #68382]	alkaline phosphatase	+	3.1.3.1	* from API zym
[Ref.: #68382]	alpha-fucosidase	-	3.2.1.51	* from API zym
[Ref.: #68382]	alpha-galactosidase	-	3.2.1.22	* from API zym
[Ref.: #68382]	alpha-glucosidase	+	3.2.1.20	* from API zym
[Ref.: #68382]	alpha-mannosidase	-	3.2.1.24	* from API zym
[Ref.: #68368]	arginine dihydrolase	-	3.5.3.6	* from API 20E
[Ref.: #68368]	beta-galactosidase	-	3.2.1.23	* from API 20E
[Ref.: #68382]	beta-glucuronidase	-	3.2.1.31	* from API zym
[Ref.: #68382]	esterase (C 4)	-		* from API zym
[Ref.: #68382]	lipase (C 14)	-		* from API zym
[Ref.: #68368]	lysine decarboxylase	-	4.1.1.18	* from API 20E
[Ref.: #68368]	ornithine decarboxylase	-	4.1.1.17	* from API 20E
[Ref.: #68368]	tryptophan deaminase	-	4.1.99.1	* from API 20E
[Ref.: #68368]	urease	+	3.5.1.5	* from API 20E
	Only first 10 entries are displayed. Click here to see all.

API® 20E:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	beta-GalactosidaseONPG	Arginine dihydrolaseADH (Arg)	Lysine decarboxylaseLDC (Lys)	Ornithine decarboxylaseODC	Citrate utilizationCIT	H2S productionH2S	Urease/urea hydrolysisURE	Tryptophan deaminaseTDA (Trp)	Indole productionIND	Acetoin production (Voges Proskauer test)VP	Gelatinase/gelatin hydrolysisGEL	Fermentation/oxidation of D-glucoseGLU	Fermentation/oxidation of D-mannitolMAN	Fermentation/oxidation of inositolINO	Fermentation/oxidation of sorbitolSor	Fermentation/oxidation of L-rhamnoseRHA	Fermentation/oxidation of sucroseSAC	Fermentation/oxidation of melibioseMEL	Fermentation/oxidation of amygdalinAMY	Fermentation/oxidation of L-arabinoseARA	Cytochrome oxidaseOX	Nitrite productionNO2	Reduction to N2N2	MotilityMOB	Growth on MacConkey mediumMAC	Oxidative catabolisation of D-glucoseOF-O	Fermentation of D-glucoseOF-F
[Ref.: #18604]	159	-	-	-	-	+	-	+	-	-	+	+	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.
[Ref.: #9612]	17845	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	not determinedn.d.	-	-	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.

API® zym:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Control	2-naphthyl phosphateAlkaline phosphatase	2-naphthyl butyrateEsterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	2-naphthyl myristateLipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	N-benzoyl-DL-arginine-2-naphthylamideTrypsin	N-glutaryl-phenylalanine-2-naphthylamidealpha- Chymotrypsin	2-naphthyl phosphateAcid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	6-Br-2-naphthyl-alphaD-galactpyranosidealpha- Galactosidase	2-naphthyl-betaD-galactpyranosidebeta- Galactosidase	Naphthol-AS-BI-betaD-glucuronidebeta- Glucuronidase	2-naphthyl-alphaD-glucopyranosidealpha- Glucosidase	6-Br-2-naphthyl-betaD-glucopyranosidebeta- Glucosidase	1-naphthyl-N-acetyl-betaD-glucosaminideN-acetyl-beta- glucosaminidase	6-Br-2-naphthyl-alphaD-mannopyranosidealpha- Mannosidase	2-naphthyl-alphaL-fucopyranosidealpha- Fucosidase
[Ref.: #18604]	244	not determinedn.d.	+	-	+	-	not determinedn.d.	+	+	+	+	+	+	-	+	-	+	-	+	-	-
[Ref.: #9612]	14052	-	+	-	+/-	-	+/-	-	-	-	-	-	-	-	-	-	+	+	-	-	-

	Pathway	Enzyme coverage	Annotated reactions
	Pathway annotation	Computationally determined by
[Ref.: #66794]	butanoate fermentation	100	4 of 4
[Ref.: #66794]	cis-vaccenate biosynthesis	100	2 of 2
[Ref.: #66794]	glycine betaine biosynthesis	100	5 of 5
[Ref.: #66794]	molybdenum cofactor biosynthesis	100	9 of 9
[Ref.: #66794]	formaldehyde oxidation	100	3 of 3
[Ref.: #66794]	chorismate metabolism	100	9 of 9
[Ref.: #66794]	coenzyme A metabolism	100	4 of 4
[Ref.: #66794]	palmitate biosynthesis	100	22 of 22
[Ref.: #66794]	adipate degradation	100	2 of 2
[Ref.: #66794]	Entner Doudoroff pathway	100	10 of 10
[Ref.: #66794]	3-chlorocatechol degradation	100	5 of 5
[Ref.: #66794]	acetate fermentation	100	4 of 4
[Ref.: #66794]	enterobactin biosynthesis	100	3 of 3
[Ref.: #66794]	teichoic acid biosynthesis	100	1 of 1
[Ref.: #66794]	propanol degradation	100	7 of 7
[Ref.: #66794]	vitamin K metabolism	100	5 of 5
[Ref.: #66794]	valine metabolism	100	9 of 9
[Ref.: #66794]	ketogluconate metabolism	100	8 of 8
[Ref.: #66794]	serine metabolism	100	9 of 9
[Ref.: #66794]	kanosamine biosynthesis II	100	2 of 2
[Ref.: #66794]	pentose phosphate pathway	100	11 of 11
[Ref.: #66794]	methylglyoxal degradation	100	5 of 5
[Ref.: #66794]	lipoate biosynthesis	100	5 of 5
[Ref.: #66794]	phenylacetate degradation (aerobic)	100	5 of 5
[Ref.: #66794]	reductive acetyl coenzyme A pathway	100	7 of 7
[Ref.: #66794]	ppGpp biosynthesis	100	4 of 4
[Ref.: #66794]	ribulose monophosphate pathway	100	2 of 2
[Ref.: #66794]	cardiolipin biosynthesis	100	7 of 7
[Ref.: #66794]	L-lactaldehyde degradation	100	3 of 3
[Ref.: #66794]	CDP-diacylglycerol biosynthesis	100	2 of 2
[Ref.: #66794]	aspartate and asparagine metabolism	100	9 of 9
[Ref.: #66794]	4-hydroxymandelate degradation	100	9 of 9
[Ref.: #66794]	taurine degradation	100	1 of 1
[Ref.: #66794]	suberin monomers biosynthesis	100	2 of 2
[Ref.: #66794]	biotin biosynthesis	100	4 of 4
[Ref.: #66794]	ceramide biosynthesis	100	1 of 1
[Ref.: #66794]	ethanol fermentation	100	2 of 2
[Ref.: #66794]	threonine metabolism	100	10 of 10
[Ref.: #66794]	anapleurotic synthesis of oxalacetate	100	1 of 1
[Ref.: #66794]	CO2 fixation in Crenarchaeota	100	9 of 9
[Ref.: #66794]	lactate fermentation	100	4 of 4
[Ref.: #66794]	glycogen metabolism	100	5 of 5
[Ref.: #66794]	UDP-GlcNAc biosynthesis	100	3 of 3
[Ref.: #66794]	cellulose degradation	100	5 of 5
[Ref.: #66794]	folate polyglutamylation	100	1 of 1
[Ref.: #66794]	degradation of sugar acids	96	24 of 25
[Ref.: #66794]	citric acid cycle	92.86	13 of 14
[Ref.: #66794]	leucine metabolism	92.31	12 of 13
[Ref.: #66794]	phenylalanine metabolism	92.31	12 of 13
[Ref.: #66794]	proline metabolism	90.91	10 of 11
[Ref.: #66794]	myo-inositol biosynthesis	90	9 of 10
[Ref.: #66794]	4-hydroxyphenylacetate degradation	90	9 of 10
[Ref.: #66794]	propionate fermentation	90	9 of 10
[Ref.: #66794]	glutamate and glutamine metabolism	89.29	25 of 28
[Ref.: #66794]	NAD metabolism	88.89	16 of 18
[Ref.: #66794]	allantoin degradation	88.89	8 of 9
[Ref.: #66794]	vitamin B12 metabolism	88.24	30 of 34
[Ref.: #66794]	dTDPLrhamnose biosynthesis	87.5	7 of 8
[Ref.: #66794]	isoleucine metabolism	87.5	7 of 8
[Ref.: #66794]	purine metabolism	87.23	82 of 94
[Ref.: #66794]	flavin biosynthesis	86.67	13 of 15
[Ref.: #66794]	heme metabolism	85.71	12 of 14
[Ref.: #66794]	ubiquinone biosynthesis	85.71	6 of 7
[Ref.: #66794]	glutathione metabolism	85.71	12 of 14
[Ref.: #66794]	pyrimidine metabolism	84.44	38 of 45
[Ref.: #66794]	tryptophan metabolism	84.21	32 of 38
[Ref.: #66794]	selenocysteine biosynthesis	83.33	5 of 6
[Ref.: #66794]	glycolate and glyoxylate degradation	83.33	5 of 6
[Ref.: #66794]	degradation of hexoses	83.33	15 of 18
[Ref.: #66794]	glycolysis	82.35	14 of 17
[Ref.: #66794]	degradation of pentoses	82.14	23 of 28
[Ref.: #66794]	ethylmalonyl-CoA pathway	80	4 of 5
[Ref.: #66794]	peptidoglycan biosynthesis	80	12 of 15
[Ref.: #66794]	hydrogen production	80	4 of 5
[Ref.: #66794]	gallate degradation	80	4 of 5
[Ref.: #66794]	elloramycin biosynthesis	80	4 of 5
[Ref.: #66794]	starch degradation	80	8 of 10
[Ref.: #66794]	metabolism of amino sugars and derivatives	80	4 of 5
[Ref.: #66794]	factor 420 biosynthesis	80	4 of 5
[Ref.: #66794]	alanine metabolism	79.31	23 of 29
[Ref.: #66794]	arginine metabolism	79.17	19 of 24
[Ref.: #66794]	photosynthesis	78.57	11 of 14
[Ref.: #66794]	d-mannose degradation	77.78	7 of 9
[Ref.: #66794]	lipid metabolism	77.42	24 of 31
[Ref.: #66794]	vitamin B1 metabolism	76.92	10 of 13
[Ref.: #66794]	urea cycle	76.92	10 of 13
[Ref.: #66794]	methionine metabolism	76.92	20 of 26
[Ref.: #66794]	histidine metabolism	75.86	22 of 29
[Ref.: #66794]	degradation of sugar alcohols	75	12 of 16
[Ref.: #66794]	gluconeogenesis	75	6 of 8
[Ref.: #66794]	cyclohexanol degradation	75	3 of 4
[Ref.: #66794]	glycogen biosynthesis	75	3 of 4
[Ref.: #66794]	sulfopterin metabolism	75	3 of 4
[Ref.: #66794]	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
[Ref.: #66794]	non-pathway related	73.68	28 of 38
[Ref.: #66794]	d-xylose degradation	72.73	8 of 11
[Ref.: #66794]	oxidative phosphorylation	72.53	66 of 91
[Ref.: #66794]	tetrahydrofolate metabolism	71.43	10 of 14
[Ref.: #66794]	tyrosine metabolism	71.43	10 of 14
[Ref.: #66794]	phenol degradation	70	14 of 20
[Ref.: #66794]	isoprenoid biosynthesis	69.23	18 of 26
[Ref.: #66794]	methane metabolism	66.67	2 of 3
[Ref.: #66794]	acetyl CoA biosynthesis	66.67	2 of 3
[Ref.: #66794]	cysteine metabolism	66.67	12 of 18
[Ref.: #66794]	lysine metabolism	66.67	28 of 42
[Ref.: #66794]	cyanate degradation	66.67	2 of 3
[Ref.: #66794]	acetoin degradation	66.67	2 of 3
[Ref.: #66794]	nitrate assimilation	66.67	6 of 9
[Ref.: #66794]	IAA biosynthesis	66.67	2 of 3
[Ref.: #66794]	octane oxidation	66.67	2 of 3
[Ref.: #66794]	polyamine pathway	65.22	15 of 23
[Ref.: #66794]	cholesterol biosynthesis	63.64	7 of 11
[Ref.: #66794]	metabolism of disaccharids	63.64	7 of 11
[Ref.: #66794]	vitamin B6 metabolism	63.64	7 of 11
[Ref.: #66794]	C4 and CAM-carbon fixation	62.5	5 of 8
[Ref.: #66794]	carnitine metabolism	62.5	5 of 8
[Ref.: #66794]	sulfate reduction	61.54	8 of 13
[Ref.: #66794]	glycine metabolism	60	6 of 10
[Ref.: #66794]	coenzyme M biosynthesis	60	6 of 10
[Ref.: #66794]	D-cycloserine biosynthesis	60	3 of 5
[Ref.: #66794]	carotenoid biosynthesis	59.09	13 of 22
[Ref.: #66794]	aclacinomycin biosynthesis	57.14	4 of 7
[Ref.: #66794]	androgen and estrogen metabolism	56.25	9 of 16
[Ref.: #66794]	daunorubicin biosynthesis	55.56	5 of 9
[Ref.: #66794]	ascorbate metabolism	54.55	12 of 22
[Ref.: #66794]	phenylpropanoid biosynthesis	53.85	7 of 13
[Ref.: #66794]	phosphatidylethanolamine bioynthesis	53.85	7 of 13
[Ref.: #66794]	3-phenylpropionate degradation	53.33	8 of 15
[Ref.: #66794]	toluene degradation	50	2 of 4
[Ref.: #66794]	sphingosine metabolism	50	3 of 6
[Ref.: #66794]	chlorophyll metabolism	50	9 of 18
[Ref.: #66794]	resorcinol degradation	50	1 of 2
[Ref.: #66794]	phenylmercury acetate degradation	50	1 of 2
[Ref.: #66794]	pantothenate biosynthesis	50	3 of 6
[Ref.: #66794]	mannosylglycerate biosynthesis	50	1 of 2
[Ref.: #66794]	quinate degradation	50	1 of 2
[Ref.: #66794]	vitamin E metabolism	50	2 of 4
[Ref.: #66794]	degradation of aromatic, nitrogen containing compounds	50	6 of 12
[Ref.: #66794]	aminopropanol phosphate biosynthesis	50	1 of 2
[Ref.: #66794]	alginate biosynthesis	50	2 of 4
[Ref.: #66794]	bile acid biosynthesis, neutral pathway	47.06	8 of 17
[Ref.: #66794]	lipid A biosynthesis	44.44	4 of 9
[Ref.: #66794]	benzoyl-CoA degradation	42.86	3 of 7
[Ref.: #66794]	creatinine degradation	40	2 of 5
[Ref.: #66794]	bacilysin biosynthesis	40	2 of 5
[Ref.: #66794]	arachidonate biosynthesis	40	2 of 5
[Ref.: #66794]	methanogenesis from CO2	33.33	4 of 12
[Ref.: #66794]	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
[Ref.: #66794]	sulfoquinovose degradation	33.33	1 of 3
[Ref.: #66794]	arachidonic acid metabolism	27.78	5 of 18
[Ref.: #66794]	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
[Ref.: #66794]	catecholamine biosynthesis	25	1 of 4
[Ref.: #66794]	CMP-KDO biosynthesis	25	1 of 4
		Only first 10 entries are displayed. Click here to see all.

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #9612]	Sample type/isolated from	soil
[Ref.: #9612]	Country	Philippines
[Ref.: #9612]	Country ISO 3 Code	PHL
[Ref.: #9612]	Continent	Asia

[Ref.: #67770]	Sample type/isolated from	Soil
[Ref.: #67770]	Country	Philippines
[Ref.: #67770]	Country ISO 3 Code	PHL
[Ref.: #67770]	Continent	Asia
* marker position based on {}

Isolation sources categories

#Environmental

#Terrestrial

#Soil

What are isolation sources categories?

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #18604]	Biosafety level	1	German classification
[Ref.: #9612]	Biosafety level	1	Risk group (German classification) According to TRBA 466

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

16S Sequence information:

	Sequence accession description	Seq. accession number	Sequence length (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #20218]	Saccharopolyspora erythraea gene for 16S ribosomal RNA, partial sequence, strain: JCM 4748	D44332	121	ENA	405948 tax ID	*
[Ref.: #20218]	Saccharopolyspora erythraea 16S rRNA (part.)	X53198	1327	ENA	405948 tax ID	*

Genome sequence information:

Only first 5 entries are displayed. Click here to see all.

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #67770]	Saccharopolyspora erythraea NRRL 2338	GCA_000171635	contig	GenBank	405948 tax ID
[Ref.: #67770]	Saccharopolyspora erythraea NRRL 2338 DSM 40517	GCA_002564065	contig	GenBank	405948 tax ID
[Ref.: #66792]	Saccharopolyspora erythraea NRRL 2338 (Prj:17885)	405948.14	wgs	PATRIC	405948 tax ID	*
[Ref.: #66792]	Saccharopolyspora erythraea NRRL 2338 strain DSM 40517	405948.30	wgs	PATRIC	405948 tax ID	*
[Ref.: #66792]	Saccharopolyspora erythraea DSM 40517	2630968997	draft	JGI IMG/M	405948 tax ID	*
[Ref.: #66792]	Saccharopolyspora erythraea NRRL 2338	640069329	complete	JGI IMG/M	405948 tax ID	*

[Ref.: #67770]

GC-content

71.1 mol%

genome sequence analysis

Data predicted using genome information as a basis Genome-based predictions

	Trait	Prediction	Confidence in %	In training data
	Predictions from GenomeNet Sporulation v. 1 based on: Saccharopolyspora erythraea NRRL 2338 NRRL 2338 NCBI: GCA_000062885.1
[Ref.: #69481]	spore-forming	yes	100	no

	Trait	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Saccharopolyspora erythraea NRRL 2338 NRRL 2338 NCBI: GCA_000062885.1
[Ref.: #69480]	motile	no	93.656	no
[Ref.: #69480]	flagellated	no	97.602	no
[Ref.: #69480]	gram-positive	yes	90.133	no
[Ref.: #69480]	anaerobic	no	98.224	no
[Ref.: #69480]	aerobic	yes	90.53	no
[Ref.: #69480]	halophile	no	58.76	no
[Ref.: #69480]	spore-forming	yes	92.184	no
[Ref.: #69480]	thermophile	no	96.408	yes
[Ref.: #69480]	glucose-util	yes	87.853	no
[Ref.: #69480]	glucose-ferment	no	90.928	yes

Availability in culture collections External links

[Ref.: #9612]

Culture collection no.

DSM 40517, AS 4.166, ATCC 11635, CBS 727.72, HUT 6087, IAM 0045, IFO 13426, ISP 5517, JCM 4026, JCM 4748, KCC S-0026, NBRC 13426, NCIB 8594, NRRL 2338, NRRL B-16947, RIA 1387, VKM Ac-1189, BCRC 13429, CECT 3200, CGMCC 4.1478, CGMCC 4.1660, HAMBI 938, IFO 12597, IMSNU 20121, IMSNU 21004, KCTC 9053, MTCC 1103, NBIMCC 3384, NBRC 12597, NCIMB 8594, PCM 2456, RIA 120

[Ref.: #82636]

SI-ID 389270

Literature:

Only first 10 entries are displayed. Click here to see all.

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Identification and Characterization of a Novel N- and O-Glycosyltransferase from Saccharopolyspora erythraea.	Gutacker F, Schmidt-Bohli YI, Strobel T, Qiu D, Jessen H, Paululat T, Bechthold A	Molecules	10.3390/molecules25153400	2020	*
Metabolism	Two amino acids missing of MtrA resulted in increased erythromycin level and altered phenotypes in Saccharopolyspora erythraea.	Pan Q, Tong Y, Han YJ, Ye BC	Appl Microbiol Biotechnol	10.1007/s00253-019-09825-9	2019	*
Metabolism	Precursor Supply for Erythromycin Biosynthesis: Engineering of Propionate Assimilation Pathway Based on Propionylation Modification.	You D, Wang MM, Yin BC, Ye BC	ACS Synth Biol	10.1021/acssynbio.8b00396	2019	*
Metabolism	Metabolic Engineering Strategies Based on Secondary Messengers (p)ppGpp and C-di-GMP To Increase Erythromycin Yield in Saccharopolyspora erythraea.	Xu Z, You D, Tang LY, Zhou Y, Ye BC	ACS Synth Biol	10.1021/acssynbio.8b00372	2019	*
Metabolism	Integrated omics approaches provide strategies for rapid erythromycin yield increase in Saccharopolyspora erythraea.	Karnicar K, Drobnak I, Petek M, Magdevska V, Horvat J, Vidmar R, Baebler S, Rotter A, Jamnik P, Fujs S, Turk B, Fonovic M, Gruden K, Kosec G, Petkovic H	Microb Cell Fact	10.1186/s12934-016-0496-5	2016	*
Enzymology	Lysine epsilon-aminotransferases: kinetic constants, substrate specificities, and the variation in active site residues.	Seo JH, Kim EM, Chae A, Kim BG	Enzyme Microb Technol	10.1016/j.enzmictec.2015.12.001	2015	*
Biotechnology	Strain improvement and optimization studies for enhanced production of erythromycin in bagasse based medium using Saccharopolyspora erythraea MTCC 1103.	Subathra Devi C, Saini A, Rastogi S, Jemimah Naine S, Mohanasrinivasan V	3 Biotech	10.1007/s13205-013-0186-5	2013	*
Metabolism	Identification and characterization of a new erythromycin biosynthetic gene cluster in Actinopolyspora erythraea YIM90600, a novel erythronolide-producing halophilic actinomycete isolated from salt field.	Chen D, Feng J, Huang L, Zhang Q, Wu J, Zhu X, Duan Y, Xu Z	PLoS One	10.1371/journal.pone.0108129	2014	*
Metabolism	Characterization of new class III lantibiotics--erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing.	Voller GH, Krawczyk JM, Pesic A, Krawczyk B, Nachtigall J, Sussmuth RD	Chembiochem	10.1002/cbic.201200118	2012	*
Genetics	Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain.	Peano C, Tala A, Corti G, Pasanisi D, Durante M, Mita G, Bicciato S, De Bellis G, Alifano P	Microb Cell Fact	10.1186/1475-2859-11-32	2012	*
Metabolism	Identifying modules of coexpressed transcript units and their organization of Saccharopolyspora erythraea from time series gene expression profiles.	Chang X, Liu S, Yu YT, Li YX, Li YY	PLoS One	10.1371/journal.pone.0012126	2010	*
Phenotype	Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production.	Carata E, Peano C, Tredici SM, Ferrari F, Tala A, Corti G, Bicciato S, De Bellis G, Alifano P	Microb Cell Fact	10.1186/1475-2859-8-18	2009	*
Phylogeny	Sciscionella marina gen. nov., sp. nov., a marine actinomycete isolated from a sediment in the northern South China Sea.	Tian XP, Zhi XY, Qiu YQ, Zhang YQ, Tang SK, Xu LH, Zhang S, Li WJ	Int J Syst Evol Microbiol	10.1099/ijs.0.001982-0	2009	*
Metabolism	Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.	Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H	Proc Natl Acad Sci U S A	10.1073/pnas.0802312105	2008	*
Biotechnology	Decreasing the hyphal branching rate of Saccharopolyspora erythraea NRRL 2338 leads to increased resistance to breakage and increased antibiotic production.	Wardell JN, Stocks SM, Thomas CR, Bushell ME	Biotechnol Bioeng	10.1002/bit.10210	2002	*
Enzymology	A unique chitinase with dual active sites and triple substrate binding sites from the hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1.	Tanaka T, Fujiwara S, Nishikori S, Fukui T, Takagi M, Imanaka T	Appl Environ Microbiol	10.1128/AEM.65.12.5338-5344.1999	1999	*
Phylogeny	Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity.	Pacey MS, Dirlam JP, Geldart RW, Leadlay PF, McArthur HA, McCormick EL, Monday RA, O'Connell TN, Staunton J, Winchester TJ	J Antibiot (Tokyo)	10.7164/antibiotics.51.1029	1998	*
Metabolism	Physical-genetic map of the erythromycin-producing organism Saccharopolyspora erythraea.	Reeves AR, Post DA, Vanden Boom TJ	Microbiology (Reading)	10.1099/00221287-144-8-2151	1998	*
Metabolism	Biosynthesis of erythromycin: origin of the methyl protons.	Kajiwara M, Uegaki R, Iida K, Wada Y	Chem Pharm Bull (Tokyo)	10.1248/cpb.42.1522	1994	*
Phylogeny	Distribution of oxoacyl synthase homology sequences within Streptomyces DNA.	Kuczek K, Mordarski M, Goodfellow M	FEMS Microbiol Lett	10.1111/j.1574-6968.1994.tb06847.x	1994	*
Enzymology	[Plasmid pSE21 of Streptomyces erythraeus strains].	Grigor'ev AE, Belova TS, Naidenova MI, Danilenko VN	Antibiot Khimioter		1990	*
Genetics	Site-specific integration in Saccharopolyspora erythraea and multisite integration in Streptomyces lividans of actinomycete plasmid pSE101.	Brown DP, Chiang SJ, Tuan JS, Katz L	J Bacteriol	10.1128/jb.170.5.2287-2295.1988	1988	*
	Complete gene expression profiling of Saccharopolyspora erythraea using GeneChip DNA microarrays.	Peano C, Bicciato S, Corti G, Ferrari F, Rizzi E, Bonnal RJ, Bordoni R, Albertini A, Bernardi LR, Donadio S, De Bellis G	Microb Cell Fact	10.1186/1475-2859-6-37	2007	*
	[Development of a system of plasmid transfer in the strains Streptomyces avermitilis ATCC 31272 and Saccharopolyspora erythraea ATCC 11635 by the method of intergeneric conjugation].	Voeikova TA, Emel'ianova LK, Kudriavtseva EA	Genetika		2003	*
	Characterization of bacteriophage phi C69 of Saccharopolyspora erythraea and demonstration of heterologous actinophage propagation by transfection of Streptomyces and Saccharopolyspora.	Katz L, Chiang SJ, Tuan JS, Zablen LB	J Gen Microbiol	10.1099/00221287-134-7-1765	1988	*

References

#9612

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40517

#18604

Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig .

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#20216

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut (HKI) Curators of the HKI: Collection Description Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut (HKI) .

#20218

Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#66794

Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )

#67770 Japan Collection of Microorganism (JCM) ; Curators of the JCM;

#68368

Automatically annotated from API 20E .

#68382

Automatically annotated from API zym .

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#69481

Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch: Predictions based on the model GenomeNet Sporulation v. 1 . ( DOI 10.21203/rs.3.rs-2527258/v1 )

#82636

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID389270.1 )

* These data were automatically processed and therefore are not curated

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Saccharopolyspora erythraea NRRL 2338 NRRL 2338

Saccharopolyspora erythraea NRRL 2338 NRRL 2338

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